Reviewed,
UniProtKB/Swiss-Prot Q9YAS4 (HMDH_AERPE)
Last modified
February 9, 2010.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase Short name=HMG-CoA reductase EC=1.1.1.34 | ||||
| Gene names |
| ||||
| Organism | Aeropyrum pernix [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 56636 [NCBI] | ||||
| Taxonomic lineage | Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum |
Protein attributes
| Sequence length | 421 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Converts HMG-CoA to mevalonate By similarity. |
| Catalytic activity | (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH. |
| Pathway | |
| Sequence similarities | Belongs to the HMG-CoA reductase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Isoprene biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | coenzyme A metabolic process Inferred from electronic annotation. Source: InterPro isoprenoid biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: InterPro |
| Molecular function | NADP or NADPH binding Inferred from electronic annotation. Source: InterPro hydroxymethylglutaryl-CoA reductase (NADPH) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 421 | 421 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | PRO_0000114458 | |||||
Sites | |||||||||
| Active site | 109 | 1 | Charge relay system By similarity | ||||||
| Active site | 240 | 1 | Charge relay system By similarity | ||||||
| Active site | 315 | 1 | Charge relay system By similarity | ||||||
| Active site | 410 | 1 | Proton donor By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. Kikuchi H.DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BA000002 Genomic DNA. Translation: BAA80874.1. |
| PIR | E72573. |
| RefSeq | NP_148225.1. |
3D structure databases | |
| SMR | Q9YAS4. Positions 12-406. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1446303. |
| GenomeReviews | Gene locus APE_1869 in contig BA000002_GR. |
| KEGG | ape:APE_1869. |
| NMPDR | fig|272557.1.peg.1333. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG604528. |
| OMA | AHFANII. |
Enzyme and pathway databases | |
| BioCyc | APER272557:APE1869-MONOMER. |
| BRENDA | 1.1.1.34. 256344. |
Family and domain databases | |
| InterPro | IPR002202. HMG_CoA_Rdtase_cat. IPR004554. HMG_CoA_Rdtase_I_cat. IPR009023. HMG_CoA_Rdtase_NAD(P)-bd. IPR009029. HMG_CoA_Rdtase_sub-bd. [Graphical view] |
| Gene3D | G3DSA:3.90.770.10. HMG-CoA_red. 1 hit. |
| PANTHER | PTHR10572. HMG-CoA_red. 1 hit. |
| Pfam | PF00368. HMG-CoA_red. 1 hit. [Graphical view] |
| PRINTS | PR00071. HMGCOARDTASE. |
| TIGRFAMs | TIGR00533. HMG_CoA_R_NADP. 1 hit. |
| PROSITE | PS00066. HMG_COA_REDUCTASE_1. 1 hit. PS00318. HMG_COA_REDUCTASE_2. 1 hit. PS01192. HMG_COA_REDUCTASE_3. False negative. PS50065. HMG_COA_REDUCTASE_4. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HMDH_AERPE | ||||||||
| Accession | Primary (citable) accession number: Q9YAS4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


