Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptide chain release factor subunit 1

Gene

prf1

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor subunit 1
Alternative name(s):
Translation termination factor aRF1
Gene namesi
Name:prf1
Ordered Locus Names:APE_1988.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001431681 – 373Peptide chain release factor subunit 1Add BLAST373

Interactioni

Subunit structurei

Heterodimer of two subunits, one of which binds GTP.By similarity

Protein-protein interaction databases

DIPiDIP-59468N.
STRINGi272557.APE_1988.1.

Structurei

Secondary structure

1373
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 10Combined sources3
Helixi14 – 24Combined sources11
Beta strandi30 – 32Combined sources3
Beta strandi34 – 39Combined sources6
Helixi45 – 58Combined sources14
Helixi59 – 61Combined sources3
Helixi65 – 82Combined sources18
Beta strandi93 – 98Combined sources6
Turni101 – 103Combined sources3
Beta strandi107 – 112Combined sources6
Beta strandi121 – 127Combined sources7
Helixi131 – 134Combined sources4
Beta strandi142 – 149Combined sources8
Beta strandi152 – 159Combined sources8
Beta strandi162 – 170Combined sources9
Helixi188 – 215Combined sources28
Beta strandi219 – 227Combined sources9
Helixi230 – 236Combined sources7
Helixi242 – 245Combined sources4
Helixi259 – 269Combined sources11
Helixi274 – 276Combined sources3
Helixi277 – 294Combined sources18
Beta strandi300 – 303Combined sources4
Helixi304 – 312Combined sources9
Beta strandi316 – 322Combined sources7
Helixi328 – 335Combined sources8
Turni336 – 339Combined sources4
Beta strandi341 – 345Combined sources5
Helixi352 – 359Combined sources8
Beta strandi362 – 366Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AGKX-ray2.10A1-373[»]
3VMFX-ray2.30B1-373[»]
ProteinModelPortaliQ9YAF1.
SMRiQ9YAF1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9YAF1.

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic release factor 1 family.Curated

Phylogenomic databases

eggNOGiarCOG01742. Archaea.
COG1503. LUCA.
HOGENOMiHOG000224682.
KOiK03265.
OMAiKTTRTHV.

Family and domain databases

Gene3Di3.30.1330.30. 2 hits.
3.30.960.10. 1 hit.
HAMAPiMF_00424. Rel_fact_arch_1. 1 hit.
InterProiIPR005140. eRF1_1_Pelota.
IPR005141. eRF1_2.
IPR005142. eRF1_3.
IPR029064. L30e-like.
IPR020918. Peptide_chain-rel_aRF1.
IPR004403. Peptide_chain-rel_eRF1/aRF1.
IPR024049. Release_factor_eRF1/aRF1_N.
[Graphical view]
PANTHERiPTHR10113. PTHR10113. 1 hit.
PfamiPF03464. eRF1_2. 1 hit.
PF03465. eRF1_3. 1 hit.
[Graphical view]
SMARTiSM01194. eRF1_1. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
SSF55481. SSF55481. 1 hit.
TIGRFAMsiTIGR03676. aRF1/eRF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YAF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGRLEERL TISKRELARL LKELKKWSAP ATVLLSLYIP PGRPLSDVMT
60 70 80 90 100
LLRQEYSITD NIKLKRTRQA VKRALSAAMD RLQMLTSTPP NGLVLFCGED
110 120 130 140 150
MSTGKFECFM FSPPEPIRVF YYRTDKRFIT DFLEDMVEDN NAIGIIIVER
160 170 180 190 200
DQATIGLLKG ARLEVLKELE GFVPGKHKMG GQSQRRYERI IEQMVDEFFK
210 220 230 240 250
KVGEEASNLL VPLAEKGVLK GVIVAGPGLA KQEFVEGNYL DYRLKKILAP
260 270 280 290 300
ELVDVAYQGL QGLKEAVMKA EKVVEAQMYR DAVNAMEEFK LHLAKGTGMI
310 320 330 340 350
VYGEKDVEAA LEMGAVKTLL IHESREDLEE WVEKAKSSGA QVIVVPESLA
360 370
EAEWFLKTFG GLAGILRFRI STV
Length:373
Mass (Da):41,950
Last modified:August 14, 2001 - v2
Checksum:i6BFD39299E876477
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA80998.2.
PIRiF72501.

Genome annotation databases

EnsemblBacteriaiBAA80998; BAA80998; APE_1988.1.
KEGGiape:APE_1988.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA80998.2.
PIRiF72501.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AGKX-ray2.10A1-373[»]
3VMFX-ray2.30B1-373[»]
ProteinModelPortaliQ9YAF1.
SMRiQ9YAF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59468N.
STRINGi272557.APE_1988.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA80998; BAA80998; APE_1988.1.
KEGGiape:APE_1988.1.

Phylogenomic databases

eggNOGiarCOG01742. Archaea.
COG1503. LUCA.
HOGENOMiHOG000224682.
KOiK03265.
OMAiKTTRTHV.

Miscellaneous databases

EvolutionaryTraceiQ9YAF1.

Family and domain databases

Gene3Di3.30.1330.30. 2 hits.
3.30.960.10. 1 hit.
HAMAPiMF_00424. Rel_fact_arch_1. 1 hit.
InterProiIPR005140. eRF1_1_Pelota.
IPR005141. eRF1_2.
IPR005142. eRF1_3.
IPR029064. L30e-like.
IPR020918. Peptide_chain-rel_aRF1.
IPR004403. Peptide_chain-rel_eRF1/aRF1.
IPR024049. Release_factor_eRF1/aRF1_N.
[Graphical view]
PANTHERiPTHR10113. PTHR10113. 1 hit.
PfamiPF03464. eRF1_2. 1 hit.
PF03465. eRF1_3. 1 hit.
[Graphical view]
SMARTiSM01194. eRF1_1. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
SSF55481. SSF55481. 1 hit.
TIGRFAMsiTIGR03676. aRF1/eRF1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRF1_AERPE
AccessioniPrimary (citable) accession number: Q9YAF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: November 2, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.