Reviewed, UniProtKB/Swiss-Prot Q9YAE7 (OTC_AERPE)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	APE_1992.1

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_0000113061
Regions
	Region	59 – 63	5	Carbamoyl phosphate binding By similarity
	Region	272 – 275	4	Ornithine binding By similarity
Sites
	Binding site	110	1	Carbamoyl phosphate By similarity
	Binding site	137	1	Carbamoyl phosphate By similarity
	Site	33	1	Important for structural integrity By similarity
	Site	150	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9YAE7-1 [UniParc]. Last modified July 11, 2003. Version 2. Checksum: BFABF1C41D6425FC	FASTA	314	34,614
	10 20 30 40 50 60 MSLHRLRGRH LLWLADYTGE EIRHMVELTL EMKRRYYAGE RVIPVLRGRS VGLLFEKPST 70 80 90 100 110 120 RTRISLEVAV AQLGGHTVYM TPSETQLGRG ETVADTARVL SRYLDAIVAR VRSHKTLEEM 130 140 150 160 170 180 ARHASIPVIN GLSDLTHPLQ AIADMATILE KKGRLEGVKL AFVGDGADNV LHSLLLAGSK 190 200 210 220 230 240 LGLHITVATP PQIRPDERIL SIALKAAEES GGSVEIVSDP YEAVRGADVV YTDVWVSMGQ 250 260 270 280 290 300 ESMAEEKVQL LKPYQVNAKL MEATGGRAIF MHCLPAKRGQ EVTDEVIDGP WSAVWDQAEN 310 RLHAHKAVLS LLVP

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000002 Genomic DNA. Translation: BAA81002.2.
PIR	B72502.
RefSeq	NP_148311.2.
3D structure databases
HSSP	HSSP built from PDB template 1A1S based on UniProtKB Q51742.
ModBase	Search...
Genome annotation databases
GeneID	1445116.
GenomeReviews	Gene locus APE_1992.1 in contig BA000002_GR.
KEGG	ape:APE_1992.1.
NMPDR	fig|272557.1.peg.1419.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9YAE7.
OMA	ENRMHTA.
Enzyme and pathway databases
BRENDA	2.1.3.3. 256344.
Family and domain databases
HAMAP	MF_01109. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_AERPE

Accession

Primary (citable) accession number: Q9YAE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	July 11, 2003
Last modified:	November 3, 2009
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)