ID   KHSE_AERPE              Reviewed;         313 AA.
AC   Q9YA72;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 3.
DT   16-JUN-2009, entry version 58.
DE   RecName: Full=Homoserine kinase;
DE            Short=HSK;
DE            Short=HK;
DE            EC=2.7.1.39;
GN   Name=thrB; OrderedLocusNames=APE_2067.1;
OS   Aeropyrum pernix.
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=56636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K1;
RX   MEDLINE=99310339; PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y.,
RA   Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H.,
RA   Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H.,
RA   Takamiya M., Masuda S., Funahashi T., Tanaka T., Kudoh Y.,
RA   Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y.,
RA   Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic
RT   crenarchaeon, Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC       homoserine.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 4/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Homoserine kinase
CC       subfamily.
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DR   EMBL; BA000002; BAA81077.2; -; Genomic_DNA.
DR   PIR; E72511; E72511.
DR   RefSeq; NP_148358.2; -.
DR   HSSP; Q58504; 1H72.
DR   GeneID; 1445166; -.
DR   GenomeReviews; BA000002_GR; APE_2067.1.
DR   KEGG; ape:APE_2067.1; -.
DR   NMPDR; fig|272557.1.peg.1466; -.
DR   HOGENOM; Q9YA72; -.
DR   BRENDA; 2.7.1.39; 256344.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:HAMAP.
DR   GO; GO:0016310; P:phosphorylation; IEA:InterPro.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00384; -; 1.
DR   InterPro; IPR006204; GHMP_kinase.
DR   InterPro; IPR013750; GHMP_kinase_C.
DR   InterPro; IPR006203; GHMP_knse_ATP_bd_CS.
DR   InterPro; IPR000870; Homoserine_kin.
DR   InterPro; IPR014721; Ribosomal_S5_D2-type_fold.
DR   Gene3D; G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF000676; Homoser_kin; 1.
DR   PRINTS; PR00958; HOMSERKINASE.
DR   TIGRFAMs; TIGR00191; thrB; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm;
KW   Kinase; Nucleotide-binding; Threonine biosynthesis; Transferase.
FT   CHAIN         1    313       Homoserine kinase.
FT                                /FTId=PRO_0000156638.
FT   NP_BIND      92    102       ATP (Potential).
SQ   SEQUENCE   313 AA;  31994 MW;  6D6424FA879FFA96 CRC64;
     MACSRARARA YSSAANLGPG FDALAVALDA YYDEVEVRVC SGGNSVYVDE VEGKFSSGVL
     QGPNTAAEAV RGLLNMEGVE AEVGIRVYKG VPPGRGLGSS GASAAAAVAA VSHALALEVP
     VDRLVFYAGL GERAAAGQPH FDNAAASILG GLAVVASDAA GKLRVFRVPF KAWFAVVTPM
     NPVPQGKTGV MRKVLPENVS FRDAVRNFSR AAGIVAAAVN GDLKSMGALM MSDEIVEPRR
     RSYVPCYTQV RKAALQAGAL GFSLSGAGPS MIALAPSSEA AREIAAAMEE SCICCDNPMT
     VAAEPAPGAS VVG
//