Reviewed, UniProtKB/Swiss-Prot Q9YA72 (KHSE_AERPE)

Names and origin

Protein names

Recommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	APE_2067.1

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphorylation Inferred from electronic annotation. Source: InterPro threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Homoserine kinase HAMAP MF_00384		PRO_0000156638
Regions
	Nucleotide binding	92 – 102	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9YA72-1 [UniParc]. Last modified July 10, 2007. Version 3. Checksum: 6D6424FA879FFA96	FASTA	313	31,994
	10 20 30 40 50 60 MACSRARARA YSSAANLGPG FDALAVALDA YYDEVEVRVC SGGNSVYVDE VEGKFSSGVL 70 80 90 100 110 120 QGPNTAAEAV RGLLNMEGVE AEVGIRVYKG VPPGRGLGSS GASAAAAVAA VSHALALEVP 130 140 150 160 170 180 VDRLVFYAGL GERAAAGQPH FDNAAASILG GLAVVASDAA GKLRVFRVPF KAWFAVVTPM 190 200 210 220 230 240 NPVPQGKTGV MRKVLPENVS FRDAVRNFSR AAGIVAAAVN GDLKSMGALM MSDEIVEPRR 250 260 270 280 290 300 RSYVPCYTQV RKAALQAGAL GFSLSGAGPS MIALAPSSEA AREIAAAMEE SCICCDNPMT 310 VAAEPAPGAS VVG

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000002 Genomic DNA. Translation: BAA81077.2.
PIR	E72511.
RefSeq	NP_148358.2.
3D structure databases
HSSP	HSSP built from PDB template 1H72 based on UniProtKB Q58504.
ModBase	Search...
Genome annotation databases
GeneID	1445166.
GenomeReviews	Gene locus APE_2067.1 in contig BA000002_GR.
KEGG	ape:APE_2067.1.
NMPDR	fig|272557.1.peg.1466.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9YA72.
Enzyme and pathway databases
BRENDA	2.7.1.39. 256344.
Family and domain databases
HAMAP	MF_00384. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR000870. Homoserine_kin. IPR014721. Ribosomal_S5_D2-type_fold. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
TIGRFAMs	TIGR00191. thrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHSE_AERPE

Accession

Primary (citable) accession number: Q9YA72

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	July 10, 2007
Last modified:	June 16, 2009
This is version 58 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)