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Protein

Putative thymidylate kinase

Gene

tmk

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Could be inactive due to a defective ATP-binding site.Curated

Catalytic activityi

ATP + dTMP = ADP + dTDP.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative thymidylate kinase (EC:2.7.4.9)
Alternative name(s):
dTMP kinase
Gene namesi
Name:tmk
Ordered Locus Names:APE_2090
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001553811 – 208Putative thymidylate kinaseAdd BLAST208

Proteomic databases

PRIDEiQ9YA48

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_2090

Structurei

3D structure databases

ProteinModelPortaliQ9YA48
SMRiQ9YA48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 15Defective ATP-bindingSequence analysis8

Sequence similaritiesi

Belongs to the thymidylate kinase family.Curated

Phylogenomic databases

eggNOGiarCOG01891 Archaea
COG0125 LUCA
HOGENOMiHOG000229077
KOiK00943
OMAiFLYTADH
OrthoDBiPOG093Z0A1C

Family and domain databases

HAMAPiMF_00165 Thymidylate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR018095 Thymidylate_kin_CS
IPR018094 Thymidylate_kinase
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00041 DTMP_kinase, 1 hit
PROSITEiView protein in PROSITE
PS01331 THYMIDYLATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9YA48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIVALEGID GSGVSTHSRL LHARLAGAGV KSCLWKEPTE GPVGRLIRGF
60 70 80 90 100
LRSTEGVDSD LMALLFAADR LWGLRLGVVE RCGGSPEVLV VDRYKYSSLA
110 120 130 140 150
YQGVGSGLEW VDAVNRKAPE AEILVYIDVP TEVALRRITA RERREVFETP
160 170 180 190 200
EFLERVKSMY EEVLRLARAR GVKVIRVEGV RGGVERGIED VQGEIAERVF

EALGLARA
Length:208
Mass (Da):22,945
Last modified:November 1, 1999 - v1
Checksum:iED155CE4ECA3382F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA Translation: BAA81101.1
PIRiE72514

Genome annotation databases

EnsemblBacteriaiBAA81101; BAA81101; APE_2090
KEGGiape:APE_2090
PATRICifig|272557.25.peg.1394

Similar proteinsi

Entry informationi

Entry nameiKTHY_AERPE
AccessioniPrimary (citable) accession number: Q9YA48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health