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Protein

Putative thymidylate kinase

Gene

tmk

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + dTMP = ADP + dTDP.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPER272557:GJD6-1412-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative thymidylate kinase (EC:2.7.4.9)
Alternative name(s):
dTMP kinase
Gene namesi
Name:tmk
Ordered Locus Names:APE_2090
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Putative thymidylate kinasePRO_0000155381Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_2090.

Structurei

3D structure databases

ProteinModelPortaliQ9YA48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 158Defective ATP-bindingSequence analysis

Sequence similaritiesi

Belongs to the thymidylate kinase family.Curated

Phylogenomic databases

eggNOGiarCOG01891. Archaea.
COG0125. LUCA.
HOGENOMiHOG000229077.
KOiK00943.
OMAiYEPMRLD.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9YA48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIVALEGID GSGVSTHSRL LHARLAGAGV KSCLWKEPTE GPVGRLIRGF
60 70 80 90 100
LRSTEGVDSD LMALLFAADR LWGLRLGVVE RCGGSPEVLV VDRYKYSSLA
110 120 130 140 150
YQGVGSGLEW VDAVNRKAPE AEILVYIDVP TEVALRRITA RERREVFETP
160 170 180 190 200
EFLERVKSMY EEVLRLARAR GVKVIRVEGV RGGVERGIED VQGEIAERVF

EALGLARA
Length:208
Mass (Da):22,945
Last modified:November 1, 1999 - v1
Checksum:iED155CE4ECA3382F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA81101.1.
PIRiE72514.

Genome annotation databases

EnsemblBacteriaiBAA81101; BAA81101; APE_2090.
KEGGiape:APE_2090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA81101.1.
PIRiE72514.

3D structure databases

ProteinModelPortaliQ9YA48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272557.APE_2090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA81101; BAA81101; APE_2090.
KEGGiape:APE_2090.

Phylogenomic databases

eggNOGiarCOG01891. Archaea.
COG0125. LUCA.
HOGENOMiHOG000229077.
KOiK00943.
OMAiYEPMRLD.

Enzyme and pathway databases

BioCyciAPER272557:GJD6-1412-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKTHY_AERPE
AccessioniPrimary (citable) accession number: Q9YA48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Could be inactive due to a defective ATP-binding site.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.