SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9YA18

- GCSPB_AERPE

UniProt

Q9YA18 - GCSPB_AERPE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, APE_2121.1
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAPER272557:GJD6-1430-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:APE_2121.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_0000167025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei279 – 2791N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi272557.APE_2121.1.

Structurei

3D structure databases

ProteinModelPortaliQ9YA18.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YA18-1 [UniParc]FASTAAdd to Basket

« Hide

MWRQSRWNEP LITEMSRRGR RGALPPRPDE KVVKEVGPLK LPQSLARGSP    50
PSLPEVSEVE VVRHYTRLSQ MAYGVDNGPV PLGSCTMKYN PRVAARLAFD 100
PRLETLHPLQ DDETVQGVLE AIYMVQEWLR HITGMDACTV HPAAGSQGEL 150
AGVLMIKRFH EMRGDLDKRR VIIVPDSAHG TNPASAAMGG FQVVEVPTGD 200
DGNVDMEALK AAVGGDTAGL MITNPSTLGL FEENILEISR LVHEAGGLLY 250
YDGANLNGII GRARPGDMEF DIAHVNLHKT FSVPHGGGGP GSGPVCVKRV 300
EVVDGVTLED LLPGPRVVYS REEGLYRVRP PGRWSVGRLR AWIANTLAVL 350
WAYAYILAMG PQGLRLAGEV SVVNTNYFIR LMEGHWGYSL PYAPSRPRKH 400
EVVLSAKPLK RETGATAEDV AKGLLDAGLY APTIYFPLIV EEALMIEFTE 450
SETKENIEAY AARLKEIAEE ARRDPSTPRK WPRNTTSARV DNVRANHPRT 500
VTPTWRVEVL RRQGKLGPLR 520
Length:520
Mass (Da):57,349
Last modified:July 10, 2007 - v2
Checksum:i1CB6B187FBEE7B43
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA81132.2.
PIRiD72518.
RefSeqiNP_148400.2. NC_000854.2.
WP_010866807.1. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA81132; BAA81132; APE_2121.1.
GeneIDi1445208.
KEGGiape:APE_2121.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA81132.2 .
PIRi D72518.
RefSeqi NP_148400.2. NC_000854.2.
WP_010866807.1. NC_000854.2.

3D structure databases

ProteinModelPortali Q9YA18.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272557.APE_2121.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA81132 ; BAA81132 ; APE_2121.1 .
GeneIDi 1445208.
KEGGi ape:APE_2121.1.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.

Enzyme and pathway databases

BioCyci APER272557:GJD6-1430-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiGCSPB_AERPE
AccessioniPrimary (citable) accession number: Q9YA18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi