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Q9YA18 (GCSPB_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene names
Name:gcvPB
Ordered Locus Names:APE_2121.1
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum

Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00713

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00713

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00713

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. C-terminal subunit subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 520520Probable glycine dehydrogenase (decarboxylating) subunit 2 HAMAP-Rule MF_00713
PRO_0000167025

Amino acid modifications

Modified residue2791N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9YA18 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: 1CB6B187FBEE7B43

FASTA52057,349
        10         20         30         40         50         60 
MWRQSRWNEP LITEMSRRGR RGALPPRPDE KVVKEVGPLK LPQSLARGSP PSLPEVSEVE 

        70         80         90        100        110        120 
VVRHYTRLSQ MAYGVDNGPV PLGSCTMKYN PRVAARLAFD PRLETLHPLQ DDETVQGVLE 

       130        140        150        160        170        180 
AIYMVQEWLR HITGMDACTV HPAAGSQGEL AGVLMIKRFH EMRGDLDKRR VIIVPDSAHG 

       190        200        210        220        230        240 
TNPASAAMGG FQVVEVPTGD DGNVDMEALK AAVGGDTAGL MITNPSTLGL FEENILEISR 

       250        260        270        280        290        300 
LVHEAGGLLY YDGANLNGII GRARPGDMEF DIAHVNLHKT FSVPHGGGGP GSGPVCVKRV 

       310        320        330        340        350        360 
EVVDGVTLED LLPGPRVVYS REEGLYRVRP PGRWSVGRLR AWIANTLAVL WAYAYILAMG 

       370        380        390        400        410        420 
PQGLRLAGEV SVVNTNYFIR LMEGHWGYSL PYAPSRPRKH EVVLSAKPLK RETGATAEDV 

       430        440        450        460        470        480 
AKGLLDAGLY APTIYFPLIV EEALMIEFTE SETKENIEAY AARLKEIAEE ARRDPSTPRK 

       490        500        510        520 
WPRNTTSARV DNVRANHPRT VTPTWRVEVL RRQGKLGPLR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000002 Genomic DNA. Translation: BAA81132.2.
PIRD72518.
RefSeqNP_148400.2. NC_000854.2.

3D structure databases

ProteinModelPortalQ9YA18.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272557.APE_2121.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA81132; BAA81132; APE_2121.1.
GeneID1445208.
KEGGape:APE_2121.1.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239368.
KOK00283.
ProtClustDBPRK04366.

Enzyme and pathway databases

BioCycAPER272557:GJD6-1430-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00713. GcvPB.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPB_AERPE
AccessionPrimary (citable) accession number: Q9YA18
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: July 10, 2007
Last modified: February 19, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families