Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:APE_2124.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669821 – 465Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST465

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272557.APE_2124.1

Structurei

3D structure databases

ProteinModelPortaliQ9YA15
SMRiQ9YA15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00077 Archaea
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OrthoDBiPOG093Z02N9

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q9YA15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHPWIPNSH KAILDEMLEA IGVSSVDDLY RDIPPTILLS PEEWDSLPIG
60 70 80 90 100
EGRPLSEAEV LARINDILSR NKYFTDPPPF VGGGVWPRYV PSVVKALITR
110 120 130 140 150
GEFLTAYTPY QAEISQGLMQ ALFEYQSLVA ELLEMEVVNA SLYDWSSAVG
160 170 180 190 200
EAMLMARRVT RRNRVLVPET MNPLHLETAT TYAYGGGIRV EKVRVDRETG
210 220 230 240 250
FIDLEDLESR LSQGDTAALY MEYPSSYTGV IDENVEAAGE AVHKAGGLFI
260 270 280 290 300
LGVEPVSMAI LKPPGRLGAD IAVGDGQPLG LGLNYGGPYL GVFAVRWDGR
310 320 330 340 350
LVRQMPGRLI GMTVDAEGRR AFAMILQTRE QHIRRAKATS NITTNEALMA
360 370 380 390 400
IAAAVYLSLL GPQGLREVAE ASWYMSHYAA KRLSELRGVE APLLEGEFIM
410 420 430 440 450
DFTVRLPMDA GVARRRLLEK GVLAGIPLGG FSFFSDNDML LTVTEAHTRR
460
HVDLLVNLLD SVLGG
Length:465
Mass (Da):51,103
Last modified:July 10, 2007 - v2
Checksum:i922E4FEC815313F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA Translation: BAA81135.2
PIRiG72518

Genome annotation databases

EnsemblBacteriaiBAA81135; BAA81135; APE_2124.1
KEGGiape:APE_2124.1
PATRICifig|272557.25.peg.1413

Similar proteinsi

Entry informationi

Entry nameiGCSPA_AERPE
AccessioniPrimary (citable) accession number: Q9YA15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: July 10, 2007
Last modified: April 25, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health