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Q9YA15

- GCSPA_AERPE

UniProt

Q9YA15 - GCSPA_AERPE

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, APE_2124.1
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciAPER272557:GJD6-1431-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:APE_2124.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_0000166982Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi272557.APE_2124.1.

Structurei

3D structure databases

ProteinModelPortaliQ9YA15.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9YA15-1 [UniParc]FASTAAdd to Basket

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MEHPWIPNSH KAILDEMLEA IGVSSVDDLY RDIPPTILLS PEEWDSLPIG    50
EGRPLSEAEV LARINDILSR NKYFTDPPPF VGGGVWPRYV PSVVKALITR 100
GEFLTAYTPY QAEISQGLMQ ALFEYQSLVA ELLEMEVVNA SLYDWSSAVG 150
EAMLMARRVT RRNRVLVPET MNPLHLETAT TYAYGGGIRV EKVRVDRETG 200
FIDLEDLESR LSQGDTAALY MEYPSSYTGV IDENVEAAGE AVHKAGGLFI 250
LGVEPVSMAI LKPPGRLGAD IAVGDGQPLG LGLNYGGPYL GVFAVRWDGR 300
LVRQMPGRLI GMTVDAEGRR AFAMILQTRE QHIRRAKATS NITTNEALMA 350
IAAAVYLSLL GPQGLREVAE ASWYMSHYAA KRLSELRGVE APLLEGEFIM 400
DFTVRLPMDA GVARRRLLEK GVLAGIPLGG FSFFSDNDML LTVTEAHTRR 450
HVDLLVNLLD SVLGG 465
Length:465
Mass (Da):51,103
Last modified:July 10, 2007 - v2
Checksum:i922E4FEC815313F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA81135.2.
PIRiG72518.
RefSeqiNP_148401.2. NC_000854.2.
WP_010866808.1. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA81135; BAA81135; APE_2124.1.
GeneIDi1445209.
KEGGiape:APE_2124.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA81135.2 .
PIRi G72518.
RefSeqi NP_148401.2. NC_000854.2.
WP_010866808.1. NC_000854.2.

3D structure databases

ProteinModelPortali Q9YA15.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272557.APE_2124.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA81135 ; BAA81135 ; APE_2124.1 .
GeneIDi 1445209.
KEGGi ape:APE_2124.1.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.

Enzyme and pathway databases

BioCyci APER272557:GJD6-1431-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiGCSPA_AERPE
AccessioniPrimary (citable) accession number: Q9YA15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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