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Q9YA15 (GCSPA_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:APE_2124.1
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_0000166982

Sequences

Sequence LengthMass (Da)Tools
Q9YA15 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: 922E4FEC815313F8

FASTA46551,103
        10         20         30         40         50         60 
MEHPWIPNSH KAILDEMLEA IGVSSVDDLY RDIPPTILLS PEEWDSLPIG EGRPLSEAEV 

        70         80         90        100        110        120 
LARINDILSR NKYFTDPPPF VGGGVWPRYV PSVVKALITR GEFLTAYTPY QAEISQGLMQ 

       130        140        150        160        170        180 
ALFEYQSLVA ELLEMEVVNA SLYDWSSAVG EAMLMARRVT RRNRVLVPET MNPLHLETAT 

       190        200        210        220        230        240 
TYAYGGGIRV EKVRVDRETG FIDLEDLESR LSQGDTAALY MEYPSSYTGV IDENVEAAGE 

       250        260        270        280        290        300 
AVHKAGGLFI LGVEPVSMAI LKPPGRLGAD IAVGDGQPLG LGLNYGGPYL GVFAVRWDGR 

       310        320        330        340        350        360 
LVRQMPGRLI GMTVDAEGRR AFAMILQTRE QHIRRAKATS NITTNEALMA IAAAVYLSLL 

       370        380        390        400        410        420 
GPQGLREVAE ASWYMSHYAA KRLSELRGVE APLLEGEFIM DFTVRLPMDA GVARRRLLEK 

       430        440        450        460 
GVLAGIPLGG FSFFSDNDML LTVTEAHTRR HVDLLVNLLD SVLGG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000002 Genomic DNA. Translation: BAA81135.2.
PIRG72518.
RefSeqNP_148401.2. NC_000854.2.

3D structure databases

ProteinModelPortalQ9YA15.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272557.APE_2124.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA81135; BAA81135; APE_2124.1.
GeneID1445209.
KEGGape:APE_2124.1.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.

Enzyme and pathway databases

BioCycAPER272557:GJD6-1431-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_AERPE
AccessionPrimary (citable) accession number: Q9YA15
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: July 10, 2007
Last modified: May 14, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families