Reviewed, UniProtKB/Swiss-Prot Q9YA15 (GCSPA_AERPE)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	APE_2124.1

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_0000166982

Sequences

	Sequence		Length	Mass (Da)
	Q9YA15-1 [UniParc]. Last modified July 10, 2007. Version 2. Checksum: 922E4FEC815313F8	FASTA	465	51,103
	10 20 30 40 50 60 MEHPWIPNSH KAILDEMLEA IGVSSVDDLY RDIPPTILLS PEEWDSLPIG EGRPLSEAEV 70 80 90 100 110 120 LARINDILSR NKYFTDPPPF VGGGVWPRYV PSVVKALITR GEFLTAYTPY QAEISQGLMQ 130 140 150 160 170 180 ALFEYQSLVA ELLEMEVVNA SLYDWSSAVG EAMLMARRVT RRNRVLVPET MNPLHLETAT 190 200 210 220 230 240 TYAYGGGIRV EKVRVDRETG FIDLEDLESR LSQGDTAALY MEYPSSYTGV IDENVEAAGE 250 260 270 280 290 300 AVHKAGGLFI LGVEPVSMAI LKPPGRLGAD IAVGDGQPLG LGLNYGGPYL GVFAVRWDGR 310 320 330 340 350 360 LVRQMPGRLI GMTVDAEGRR AFAMILQTRE QHIRRAKATS NITTNEALMA IAAAVYLSLL 370 380 390 400 410 420 GPQGLREVAE ASWYMSHYAA KRLSELRGVE APLLEGEFIM DFTVRLPMDA GVARRRLLEK 430 440 450 460 GVLAGIPLGG FSFFSDNDML LTVTEAHTRR HVDLLVNLLD SVLGG

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000002 Genomic DNA. Translation: BAA81135.2.
PIR	G72518.
RefSeq	NP_148401.2.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1445209.
GenomeReviews	Gene locus APE_2124.1 in contig BA000002_GR.
KEGG	ape:APE_2124.1.
NMPDR	fig|272557.1.peg.1509.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9YA15.
Enzyme and pathway databases
BRENDA	1.4.4.2. 256344.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_AERPE

Accession

Primary (citable) accession number: Q9YA15

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	July 10, 2007
Last modified:	June 16, 2009
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)