Q9Y9L0 (TDXH_AERPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable peroxiredoxin
EC=1.11.1.15

Gene names

Ordered Locus Names:

APE_2278

Organism

Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]

Taxonomic identifier

272557 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_00401
Sequence similarities	Belongs to the AhpC/TSA family. TDXH subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Molecular function	antioxidant activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 250

250

Probable peroxiredoxin HAMAP MF_00401

PRO_0000135153

Regions

Domain

6 – 163

158

Thioredoxin

Sites

Active site

50

1

By similarity

Secondary structure

1

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250

Helix Strand Turn

Details...

Beta strand

3 – 5

3

Beta strand

15 – 19

5

Beta strand

22 – 26

5

Helix

28 – 31

4

Turn

32 – 34

3

Beta strand

36 – 41

6

Helix

48 – 66

19

Beta strand

69 – 77

9

Helix

79 – 92

14

Beta strand

101 – 103

3

Helix

108 – 112

5

Beta strand

121 – 123

3

Beta strand

126 – 131

6

Beta strand

135 – 143

9

Helix

151 – 167

17

Turn

173 – 176

4

Turn

179 – 181

3

Helix

193 – 200

8

Turn

201 – 203

3

Beta strand

205 – 209

5

Beta strand

212 – 215

4

Helix

220 – 234

15

Helix

241 – 244

4

Sequences

	Sequence		Length	Mass (Da)
	Q9Y9L0 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 0457F2852D051E7A	FASTA	250	28,703
	10 20 30 40 50 60 MPGSIPLIGE RFPEMEVTTD HGVIKLPDHY VSQGKWFVLF SHPADFTPVC TTEFVSFARR 70 80 90 100 110 120 YEDFQRLGVD LIGLSVDSVF SHIKWKEWIE RHIGVRIPFP IIADPQGTVA RRLGLLHAES 130 140 150 160 170 180 ATHTVRGVFI VDARGVIRTM LYYPMELGRL VDEILRIVKA LKLGDSLKRA VPADWPNNEI 190 200 210 220 230 240 IGEGLIVPPP TTEDQARARM ESGQYRCLDW WFCWDTPASR DDVEEARRYL RRAAEKPAKL 250 LYEEARTHLH

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

+

Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BA000002 Genomic DNA. Translation: BAA81290.1.

PIR

B72454.

RefSeq

NP_148509.1. NC_000854.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1X0R	X-ray	2.00	A/B/C/D/E/F/G/H/I/J	2-250	[»]
2CV4	X-ray	2.30	A/B/C/D/E/F/G/H/I/J	1-250	[»]
2E2G	X-ray	2.40	A/B/C/D/E/F/G/H/I/J	1-250	[»]
2E2M	X-ray	2.60	A/B/C/D/E/F/G/H/I/J	1-250	[»]
2NVL	X-ray	2.36	A/B/C/D/E/F/G/H/I/J	1-250	[»]
2ZCT	X-ray	1.70	A/B/C/D/E/F/G/H/I/J	2-250	[»]
3A2V	X-ray	1.65	A/B/C/D/E/F/G/H/I/J	2-250	[»]
3A2W	X-ray	2.30	A/B/C/D/E/F/G/H/I/J	2-250	[»]
3A2X	X-ray	1.90	A/B/C/D/E/F/G/H/I/J	2-250	[»]
3A5W	X-ray	2.20	A/B/C/D/E/F/G/H/I/J	2-250	[»]

ProteinModelPortal

Q9Y9L0.

SMR

Q9Y9L0. Positions 2-245.

DisProt

DP00037.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-29934N.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1445316.

GenomeReviews

Gene locus APE_2278 in contig BA000002_GR.

KEGG

ape:APE_2278.

NMPDR

fig|272557.1.peg.1617.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

HBG493509.

OMA

GEKFPEV.

PhylomeDB

Q9Y9L0.

Enzyme and pathway databases

BioCyc

APER272557:APE2278-MONOMER.

Family and domain databases

HAMAP

MF_00401. Peroxiredoxin.
[Tree]

InterPro

IPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR022915. Peroxiredoxin_TDXH_put.
IPR012336. Thioredoxin-like_fold.
[Graphical view]

Gene3D

G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.

KO

K03386.

Pfam

PF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]

PIRSF

PIRSF000239. AHPC. 1 hit.

SUPFAM

SSF52833. Thiordxn-like_fd. 1 hit.

PROSITE

PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

TDXH_AERPE

Accession

Primary (citable) accession number: Q9Y9L0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	November 1, 1999
Last modified:	December 14, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program