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Q9Y9I9

- GSA_AERPE

UniProt

Q9Y9I9 - GSA_AERPE

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

Cofactori

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAPER272557:GJD6-1551-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:APE_2299.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000120476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei266 – 2661N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_2299.1.

Structurei

Secondary structure

1
429
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1410Combined sources
Turni15 – 173Combined sources
Helixi19 – 213Combined sources
Beta strandi22 – 243Combined sources
Helixi25 – 295Combined sources
Beta strandi31 – 333Combined sources
Beta strandi37 – 426Combined sources
Beta strandi44 – 474Combined sources
Beta strandi52 – 576Combined sources
Helixi58 – 603Combined sources
Helixi70 – 8112Combined sources
Helixi91 – 10414Combined sources
Beta strandi109 – 1157Combined sources
Helixi116 – 13116Combined sources
Beta strandi135 – 1406Combined sources
Helixi148 – 1503Combined sources
Beta strandi151 – 1533Combined sources
Beta strandi163 – 1664Combined sources
Helixi171 – 1744Combined sources
Beta strandi177 – 1815Combined sources
Helixi185 – 19511Combined sources
Helixi196 – 1983Combined sources
Beta strandi199 – 2046Combined sources
Beta strandi206 – 2083Combined sources
Beta strandi210 – 2123Combined sources
Helixi218 – 23114Combined sources
Beta strandi234 – 2396Combined sources
Turni240 – 2456Combined sources
Helixi250 – 2556Combined sources
Beta strandi260 – 2656Combined sources
Helixi266 – 2694Combined sources
Beta strandi275 – 2795Combined sources
Helixi281 – 2844Combined sources
Turni288 – 2903Combined sources
Beta strandi291 – 2933Combined sources
Turni298 – 3014Combined sources
Helixi303 – 31816Combined sources
Helixi321 – 34323Combined sources
Beta strandi347 – 3526Combined sources
Beta strandi355 – 3606Combined sources
Helixi368 – 3714Combined sources
Helixi376 – 38813Combined sources
Helixi409 – 42719Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EPJX-ray1.70A2-429[»]
2ZSLX-ray1.70A2-429[»]
2ZSMX-ray2.30A/B/C2-429[»]
ProteinModelPortaliQ9Y9I9.
SMRiQ9Y9I9. Positions 4-429.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y9I9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y9I9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASGEKSRML FERTKELFPG GVNSPVRAAV KPYPFYVKRG EGAYLYTVDG
60 70 80 90 100
ARIVDLVLAY GPLILGHKHP RVLEAVEEAL ARGWLYGAPG EAEVLLAEKI
110 120 130 140 150
LGYVKRGGMI RFVNSGTEAT MTAIRLARGY TGRDLILKFD GCYHGSHDAV
160 170 180 190 200
LVAAGSAAAH YGVPTSAGVP EAVARLTLVT PYNDVEALER VFAEYGDRIA
210 220 230 240 250
GVIVEPVIAN AGVIPPRREF LAALQRLSRE SGALLILDEV VTGFRLGLEG
260 270 280 290 300
AQGYFNIEGD IIVLGKIIGG GFPVGAVAGS REVMSLLTPQ GKVFNAGTFN
310 320 330 340 350
AHPITMAAGL ATLKALEEEP VYSVSREAAK ALEEAASEVL DRTGLPYTIN
360 370 380 390 400
RVESMMQLFI GVEEVSNAAQ ARKADKKFYV KLHEEMLRRG VFIAPSNLEA
410 420
VFTGLPHQGE ALEIAVEGLR SSLKTVLGS
Length:429
Mass (Da):45,954
Last modified:July 10, 2007 - v2
Checksum:i6CC7C5A97EE1F65C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA81311.2.
PIRiG72456.
RefSeqiNP_148523.2. NC_000854.2.
WP_010866923.1. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA81311; BAA81311; APE_2299.1.
GeneIDi1445331.
KEGGiape:APE_2299.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA81311.2 .
PIRi G72456.
RefSeqi NP_148523.2. NC_000854.2.
WP_010866923.1. NC_000854.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EPJ X-ray 1.70 A 2-429 [» ]
2ZSL X-ray 1.70 A 2-429 [» ]
2ZSM X-ray 2.30 A/B/C 2-429 [» ]
ProteinModelPortali Q9Y9I9.
SMRi Q9Y9I9. Positions 4-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272557.APE_2299.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA81311 ; BAA81311 ; APE_2299.1 .
GeneIDi 1445331.
KEGGi ape:APE_2299.1.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci APER272557:GJD6-1551-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9Y9I9.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiGSA_AERPE
AccessioniPrimary (citable) accession number: Q9Y9I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 10, 2007
Last modified: November 26, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3