SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Y9I9

- GSA_AERPE

UniProt

Q9Y9I9 - GSA_AERPE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene
hemL, APE_2299.1
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAPER272557:GJD6-1551-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:APE_2299.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotationPRO_0000120476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei266 – 2661N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_2299.1.

Structurei

Secondary structure

1
429
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1410
Turni15 – 173
Helixi19 – 213
Beta strandi22 – 243
Helixi25 – 295
Beta strandi31 – 333
Beta strandi37 – 426
Beta strandi44 – 474
Beta strandi52 – 576
Helixi58 – 603
Helixi70 – 8112
Helixi91 – 10414
Beta strandi109 – 1157
Helixi116 – 13116
Beta strandi135 – 1406
Helixi148 – 1503
Beta strandi151 – 1533
Beta strandi163 – 1664
Helixi171 – 1744
Beta strandi177 – 1815
Helixi185 – 19511
Helixi196 – 1983
Beta strandi199 – 2046
Beta strandi206 – 2083
Beta strandi210 – 2123
Helixi218 – 23114
Beta strandi234 – 2396
Turni240 – 2456
Helixi250 – 2556
Beta strandi260 – 2656
Helixi266 – 2694
Beta strandi275 – 2795
Helixi281 – 2844
Turni288 – 2903
Beta strandi291 – 2933
Turni298 – 3014
Helixi303 – 31816
Helixi321 – 34323
Beta strandi347 – 3526
Beta strandi355 – 3606
Helixi368 – 3714
Helixi376 – 38813
Helixi409 – 42719

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EPJX-ray1.70A2-429[»]
2ZSLX-ray1.70A2-429[»]
2ZSMX-ray2.30A/B/C2-429[»]
ProteinModelPortaliQ9Y9I9.
SMRiQ9Y9I9. Positions 4-429.

Miscellaneous databases

EvolutionaryTraceiQ9Y9I9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y9I9-1 [UniParc]FASTAAdd to Basket

« Hide

MASGEKSRML FERTKELFPG GVNSPVRAAV KPYPFYVKRG EGAYLYTVDG    50
ARIVDLVLAY GPLILGHKHP RVLEAVEEAL ARGWLYGAPG EAEVLLAEKI 100
LGYVKRGGMI RFVNSGTEAT MTAIRLARGY TGRDLILKFD GCYHGSHDAV 150
LVAAGSAAAH YGVPTSAGVP EAVARLTLVT PYNDVEALER VFAEYGDRIA 200
GVIVEPVIAN AGVIPPRREF LAALQRLSRE SGALLILDEV VTGFRLGLEG 250
AQGYFNIEGD IIVLGKIIGG GFPVGAVAGS REVMSLLTPQ GKVFNAGTFN 300
AHPITMAAGL ATLKALEEEP VYSVSREAAK ALEEAASEVL DRTGLPYTIN 350
RVESMMQLFI GVEEVSNAAQ ARKADKKFYV KLHEEMLRRG VFIAPSNLEA 400
VFTGLPHQGE ALEIAVEGLR SSLKTVLGS 429
Length:429
Mass (Da):45,954
Last modified:July 10, 2007 - v2
Checksum:i6CC7C5A97EE1F65C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA81311.2.
PIRiG72456.
RefSeqiNP_148523.2. NC_000854.2.
WP_010866923.1. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA81311; BAA81311; APE_2299.1.
GeneIDi1445331.
KEGGiape:APE_2299.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA81311.2 .
PIRi G72456.
RefSeqi NP_148523.2. NC_000854.2.
WP_010866923.1. NC_000854.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EPJ X-ray 1.70 A 2-429 [» ]
2ZSL X-ray 1.70 A 2-429 [» ]
2ZSM X-ray 2.30 A/B/C 2-429 [» ]
ProteinModelPortali Q9Y9I9.
SMRi Q9Y9I9. Positions 4-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272557.APE_2299.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA81311 ; BAA81311 ; APE_2299.1 .
GeneIDi 1445331.
KEGGi ape:APE_2299.1.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci APER272557:GJD6-1551-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9Y9I9.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiGSA_AERPE
AccessioniPrimary (citable) accession number: Q9Y9I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi