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Q9Y9I9 (GSA_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate-1-semialdehyde 2,1-aminomutase

Short name=GSA
EC=5.4.3.8
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT
Gene names
Name:hemL
Ordered Locus Names:APE_2299.1
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutamate-1-semialdehyde 2,1-aminomutase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

transaminase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375
PRO_0000120476

Amino acid modifications

Modified residue2661N6-(pyridoxal phosphate)lysine By similarity

Secondary structure

............................................................................ 429
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9Y9I9 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: 6CC7C5A97EE1F65C

FASTA42945,954
        10         20         30         40         50         60 
MASGEKSRML FERTKELFPG GVNSPVRAAV KPYPFYVKRG EGAYLYTVDG ARIVDLVLAY 

        70         80         90        100        110        120 
GPLILGHKHP RVLEAVEEAL ARGWLYGAPG EAEVLLAEKI LGYVKRGGMI RFVNSGTEAT 

       130        140        150        160        170        180 
MTAIRLARGY TGRDLILKFD GCYHGSHDAV LVAAGSAAAH YGVPTSAGVP EAVARLTLVT 

       190        200        210        220        230        240 
PYNDVEALER VFAEYGDRIA GVIVEPVIAN AGVIPPRREF LAALQRLSRE SGALLILDEV 

       250        260        270        280        290        300 
VTGFRLGLEG AQGYFNIEGD IIVLGKIIGG GFPVGAVAGS REVMSLLTPQ GKVFNAGTFN 

       310        320        330        340        350        360 
AHPITMAAGL ATLKALEEEP VYSVSREAAK ALEEAASEVL DRTGLPYTIN RVESMMQLFI 

       370        380        390        400        410        420 
GVEEVSNAAQ ARKADKKFYV KLHEEMLRRG VFIAPSNLEA VFTGLPHQGE ALEIAVEGLR 


SSLKTVLGS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000002 Genomic DNA. Translation: BAA81311.2.
PIRG72456.
RefSeqNP_148523.2. NC_000854.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2EPJX-ray1.70A2-429[»]
2ZSLX-ray1.70A2-429[»]
2ZSMX-ray2.30A/B/C2-429[»]
ProteinModelPortalQ9Y9I9.
SMRQ9Y9I9. Positions 4-429.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272557.APE_2299.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA81311; BAA81311; APE_2299.1.
GeneID1445331.
KEGGape:APE_2299.1.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0001.
HOGENOMHOG000020210.
KOK01845.

Enzyme and pathway databases

BioCycAPER272557:GJD6-1551-MONOMER.
UniPathwayUPA00251; UER00317.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPMF_00375. HemL_aminotrans_3.
InterProIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR11986. PTHR11986. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR00713. hemL. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9Y9I9.

Entry information

Entry nameGSA_AERPE
AccessionPrimary (citable) accession number: Q9Y9I9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 10, 2007
Last modified: May 14, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways