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Q9Y9I9

- GSA_AERPE

UniProt

Q9Y9I9 - GSA_AERPE

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciAPER272557:GJD6-1551-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
    Short name:
    GSA
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferase
    Short name:
    GSA-AT
    Gene namesi
    Name:hemL
    Ordered Locus Names:APE_2299.1
    OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
    Taxonomic identifieri272557 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
    ProteomesiUP000002518: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000120476Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei266 – 2661N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi272557.APE_2299.1.

    Structurei

    Secondary structure

    1
    429
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 1410
    Turni15 – 173
    Helixi19 – 213
    Beta strandi22 – 243
    Helixi25 – 295
    Beta strandi31 – 333
    Beta strandi37 – 426
    Beta strandi44 – 474
    Beta strandi52 – 576
    Helixi58 – 603
    Helixi70 – 8112
    Helixi91 – 10414
    Beta strandi109 – 1157
    Helixi116 – 13116
    Beta strandi135 – 1406
    Helixi148 – 1503
    Beta strandi151 – 1533
    Beta strandi163 – 1664
    Helixi171 – 1744
    Beta strandi177 – 1815
    Helixi185 – 19511
    Helixi196 – 1983
    Beta strandi199 – 2046
    Beta strandi206 – 2083
    Beta strandi210 – 2123
    Helixi218 – 23114
    Beta strandi234 – 2396
    Turni240 – 2456
    Helixi250 – 2556
    Beta strandi260 – 2656
    Helixi266 – 2694
    Beta strandi275 – 2795
    Helixi281 – 2844
    Turni288 – 2903
    Beta strandi291 – 2933
    Turni298 – 3014
    Helixi303 – 31816
    Helixi321 – 34323
    Beta strandi347 – 3526
    Beta strandi355 – 3606
    Helixi368 – 3714
    Helixi376 – 38813
    Helixi409 – 42719

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EPJX-ray1.70A2-429[»]
    2ZSLX-ray1.70A2-429[»]
    2ZSMX-ray2.30A/B/C2-429[»]
    ProteinModelPortaliQ9Y9I9.
    SMRiQ9Y9I9. Positions 4-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y9I9.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y9I9-1 [UniParc]FASTAAdd to Basket

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    MASGEKSRML FERTKELFPG GVNSPVRAAV KPYPFYVKRG EGAYLYTVDG    50
    ARIVDLVLAY GPLILGHKHP RVLEAVEEAL ARGWLYGAPG EAEVLLAEKI 100
    LGYVKRGGMI RFVNSGTEAT MTAIRLARGY TGRDLILKFD GCYHGSHDAV 150
    LVAAGSAAAH YGVPTSAGVP EAVARLTLVT PYNDVEALER VFAEYGDRIA 200
    GVIVEPVIAN AGVIPPRREF LAALQRLSRE SGALLILDEV VTGFRLGLEG 250
    AQGYFNIEGD IIVLGKIIGG GFPVGAVAGS REVMSLLTPQ GKVFNAGTFN 300
    AHPITMAAGL ATLKALEEEP VYSVSREAAK ALEEAASEVL DRTGLPYTIN 350
    RVESMMQLFI GVEEVSNAAQ ARKADKKFYV KLHEEMLRRG VFIAPSNLEA 400
    VFTGLPHQGE ALEIAVEGLR SSLKTVLGS 429
    Length:429
    Mass (Da):45,954
    Last modified:July 10, 2007 - v2
    Checksum:i6CC7C5A97EE1F65C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA81311.2.
    PIRiG72456.
    RefSeqiNP_148523.2. NC_000854.2.
    WP_010866923.1. NC_000854.2.

    Genome annotation databases

    EnsemblBacteriaiBAA81311; BAA81311; APE_2299.1.
    GeneIDi1445331.
    KEGGiape:APE_2299.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA81311.2 .
    PIRi G72456.
    RefSeqi NP_148523.2. NC_000854.2.
    WP_010866923.1. NC_000854.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EPJ X-ray 1.70 A 2-429 [» ]
    2ZSL X-ray 1.70 A 2-429 [» ]
    2ZSM X-ray 2.30 A/B/C 2-429 [» ]
    ProteinModelPortali Q9Y9I9.
    SMRi Q9Y9I9. Positions 4-429.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272557.APE_2299.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA81311 ; BAA81311 ; APE_2299.1 .
    GeneIDi 1445331.
    KEGGi ape:APE_2299.1.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci APER272557:GJD6-1551-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9Y9I9.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

    Entry informationi

    Entry nameiGSA_AERPE
    AccessioniPrimary (citable) accession number: Q9Y9I9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3