Q9Y9I8 (Q9Y9I8_AERPE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Porphobilinogen synthase EMBL BAA81312.2
EC=4.2.1.24 EMBL BAA81312.2

Gene names

Name:	hemB EMBL BAA81312.2
Ordered Locus Names:	APE_2300.1

Organism

Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]

Taxonomic identifier

272557 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subunit structure

Homooctamer By similarity. PIRSR PIRSR001415-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-3 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase EMBL BAA81312.2
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tetrapyrrole biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	218	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	271	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	139	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	141	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	149	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	256	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	228	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	240	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	298	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	337	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	Q9Y9I8 [UniParc]. Last modified November 14, 2006. Version 2. Checksum: EBB9AC443FAD721A	FASTA	353	38,736
	10 20 30 40 50 60 MQRGSEAPLR ELTSAGFSFP RVRARRLRLH PGVRSLVAET RLDPSMFILP LFVEDGLKTP 70 80 90 100 110 120 KPLRGLPGHF KYPPESRELV ELVSRALYLG VRSFLVFGTP SMKSFEGAEA WSPRGPVQRA 130 140 150 160 170 180 IKFVRAELGW RPVIMADVCL CGYTDHGHCG YPRETPRGVL IENDKSIEAY GKISVSLAEA 190 200 210 220 230 240 GADFVAPSGM MDGQVAAIRS ALDNAGYTEV GIMSYSAKYA SGFYGPFRDV MDSAPRFGDR 250 260 270 280 290 300 RSYQMDPRNR FEAVKEVLLD AAEGADIVMV KPALSYLDVI SEVKRSVPWL PLAAYNVSGE 310 320 330 340 350 YLMLKAAAEK GLVDYETVML EILTSIARAG ADAVITYHAL EAAEALKSGK TPF

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000002 Genomic DNA. Translation: BAA81312.2.
PIR	H72456.
RefSeq	NP_148524.2. NC_000854.2.
3D structure databases
ProteinModelPortal	Q9Y9I8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1445332.
GenomeReviews	Gene locus APE_2300.1 in contig BA000002_GR.
KEGG	ape:APE_2300.1.
NMPDR	fig|272557.1.peg.1632.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285270.
OMA	HCGVVEN.
PhylomeDB	Q9Y9I8.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9Y9I8_AERPE

Accession

Primary (citable) accession number: Q9Y9I8

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)