Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP cyclohydrolase MptA

Gene

mptA

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion per subunit.UniRule annotation

Pathwayi: 5,6,7,8-tetrahydromethanopterin biosynthesis

This protein is involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei147May be catalytically importantUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00065.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase MptAUniRule annotation (EC:3.5.4.39UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IVUniRule annotation
Gene namesi
Name:mptAUniRule annotation
Ordered Locus Names:APE_2308
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477381 – 283GTP cyclohydrolase MptAAdd BLAST283

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272557.APE_2308.

Structurei

3D structure databases

ProteinModelPortaliQ9Y9I0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04301. Archaea.
COG1469. LUCA.
HOGENOMiHOG000280680.
KOiK17488.
OMAiPCSQGMS.

Family and domain databases

HAMAPiMF_01527_A. GTP_cyclohydrol_A. 1 hit.
InterProiIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y9I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVQDLKPPK PLYLERVGFR GVRRRALLET PEGPVTLDLE LDVFVDLDRS
60 70 80 90 100
KRGVHLSRNI EAVEAVVSER RARSIEGLLR SIAKELLSRH GYAEKATVRA
110 120 130 140 150
RTRYYIDLEA AGVKGREPVD VAVTVSLTRS GGERWRVAVS VKGMTVCPSA
160 170 180 190 200
QSTIAEAEGI SDPSRAPSHS QKVLLKGTVD TGKVMVRIED LARALLQSFS
210 220 230 240 250
APTFTLLKKP QEARLILEAF TRPMFVEDVV REAAWRIAAI PYIPGEALLQ
260 270 280
VEAVSLESIH PHDLVAMLRS RVSEVRSLAS RSV
Length:283
Mass (Da):31,307
Last modified:November 1, 1999 - v1
Checksum:i2B64504072385916
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA81320.1.
PIRiH72457.

Genome annotation databases

EnsemblBacteriaiBAA81320; BAA81320; APE_2308.
KEGGiape:APE_2308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA81320.1.
PIRiH72457.

3D structure databases

ProteinModelPortaliQ9Y9I0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272557.APE_2308.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA81320; BAA81320; APE_2308.
KEGGiape:APE_2308.

Phylogenomic databases

eggNOGiarCOG04301. Archaea.
COG1469. LUCA.
HOGENOMiHOG000280680.
KOiK17488.
OMAiPCSQGMS.

Enzyme and pathway databases

UniPathwayiUPA00065.

Family and domain databases

HAMAPiMF_01527_A. GTP_cyclohydrol_A. 1 hit.
InterProiIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMPTA_AERPE
AccessioniPrimary (citable) accession number: Q9Y9I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.