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Protein

GTP cyclohydrolase MptA

Gene

mptA

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion per subunit.UniRule annotation

Pathwayi: 5,6,7,8-tetrahydromethanopterin biosynthesis

This protein is involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei147May be catalytically importantUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00065

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase MptAUniRule annotation (EC:3.5.4.39UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IVUniRule annotation
Gene namesi
Name:mptAUniRule annotation
Ordered Locus Names:APE_2308
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477381 – 283GTP cyclohydrolase MptAAdd BLAST283

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272557.APE_2308

Structurei

3D structure databases

ProteinModelPortaliQ9Y9I0
SMRiQ9Y9I0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04301 Archaea
COG1469 LUCA
HOGENOMiHOG000280680
KOiK17488
OMAiHNQRGRG
OrthoDBiPOG093Z06SZ

Family and domain databases

HAMAPiMF_01527_A GTP_cyclohydrol_A, 1 hit
InterProiView protein in InterPro
IPR003801 GTP_cyclohydrolase_FolE2/MptA
IPR022840 GTP_cyclohydrolase_MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit
TIGRFAMsiTIGR00294 TIGR00294, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y9I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVQDLKPPK PLYLERVGFR GVRRRALLET PEGPVTLDLE LDVFVDLDRS
60 70 80 90 100
KRGVHLSRNI EAVEAVVSER RARSIEGLLR SIAKELLSRH GYAEKATVRA
110 120 130 140 150
RTRYYIDLEA AGVKGREPVD VAVTVSLTRS GGERWRVAVS VKGMTVCPSA
160 170 180 190 200
QSTIAEAEGI SDPSRAPSHS QKVLLKGTVD TGKVMVRIED LARALLQSFS
210 220 230 240 250
APTFTLLKKP QEARLILEAF TRPMFVEDVV REAAWRIAAI PYIPGEALLQ
260 270 280
VEAVSLESIH PHDLVAMLRS RVSEVRSLAS RSV
Length:283
Mass (Da):31,307
Last modified:November 1, 1999 - v1
Checksum:i2B64504072385916
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA Translation: BAA81320.1
PIRiH72457

Genome annotation databases

EnsemblBacteriaiBAA81320; BAA81320; APE_2308
KEGGiape:APE_2308

Similar proteinsi

Entry informationi

Entry nameiMPTA_AERPE
AccessioniPrimary (citable) accession number: Q9Y9I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health