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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:APE_2317.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197121 – 574Glutamate--tRNA ligaseAdd BLAST574

Proteomic databases

PRIDEiQ9Y9H1

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_2317.1

Structurei

3D structure databases

ProteinModelPortaliQ9Y9H1
SMRiQ9Y9H1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi109 – 119"HIGH" regionUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04302 Archaea
COG0008 LUCA
HOGENOMiHOG000073585
KOiK01885
OMAiMRFAPNP
OrthoDBiPOG093Z013J

Family and domain databases

Gene3Di2.40.240.10, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_02076 Glu_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR004526 Glu-tRNA-synth_arc/euk
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd
IPR020056 Rbsml_L25/Gln-tRNA_synth_N
IPR011035 Ribosomal_L25/Gln-tRNA_synth
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PF03950 tRNA-synt_1c_C, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF50715 SSF50715, 1 hit
TIGRFAMsiTIGR00463 gltX_arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y9H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSEDLERLL LGYALRDAVK HGGRASVGSV MSMLLGDHPE LRSRAREIAS
60 70 80 90 100
LAARVVEQVN SMPAGEQKRL LSEQYPELAR FEEQREKGDK GLPPLPGAVE
110 120 130 140 150
GRVKLRFAPN PDFVIHMGNA RPAIVNHEYA RMYKGRMVLR FEDTDPRTKT
160 170 180 190 200
PLREAYDLIR QDLKWLGVSW DEEYIQSLRM EVFYSVARRA IERGCAYVDN
210 220 230 240 250
CGREGKELLS RGEYCPTRDL GPEDNLELFE KMLEGEFYEG EAVVRMKTDP
260 270 280 290 300
RHPNPSLRDW VAMRIIDTEK HPHPLVGSRY LVWPTYNFAV SVDDHMMEIT
310 320 330 340 350
HVLRGKEHQL NTEKQLAVYR CMGWRPPYFI HFGRLKLEGF ILSKSKIRKL
360 370 380 390 400
LEERPGEFMG YDDPRFGTIA GLRRRGVLAE AIRQIILEVG VKPTDATISW
410 420 430 440 450
ANLAAANRKL LDERADRIMY VEDPVEMEVE LAQVECRAAE IPFHPSRPQR
460 470 480 490 500
KRRITLCTGD KVLLTREDAV EGRQLRLMGL SNFTVSQGIL REVDPSLEYA
510 520 530 540 550
RRMKLPIVQW VKKGGEASVE VLEPVELELR RHQGYAEDAI RGYGVDSRLQ
560 570
FVRYGFVRVD SVEDGVYRVI YTHK
Length:574
Mass (Da):66,034
Last modified:April 30, 2003 - v2
Checksum:i8C86B100C8F01176
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA Translation: BAA81329.2
PIRiA72459

Genome annotation databases

EnsemblBacteriaiBAA81329; BAA81329; APE_2317.1
KEGGiape:APE_2317.1
PATRICifig|272557.25.peg.1546

Similar proteinsi

Entry informationi

Entry nameiSYE_AERPE
AccessioniPrimary (citable) accession number: Q9Y9H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 30, 2003
Last modified: May 23, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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