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Q9Y9H1

- SYE_AERPE

UniProt

Q9Y9H1 - SYE_AERPE

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Protein

Glutamate--tRNA ligase

Gene
gltX, APE_2317.1
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPER272557:GJD6-1563-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
Name:gltX
Ordered Locus Names:APE_2317.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 574574Glutamate--tRNA ligaseUniRule annotationPRO_0000119712Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_2317.1.

Structurei

3D structure databases

ProteinModelPortaliQ9Y9H1.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi109 – 11911"HIGH" regionUniRule annotationAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000073585.
KOiK01885.
OMAiAFRIIDT.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_A. Glu_tRNA_synth_A.
InterProiIPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y9H1-1 [UniParc]FASTAAdd to Basket

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MGSEDLERLL LGYALRDAVK HGGRASVGSV MSMLLGDHPE LRSRAREIAS    50
LAARVVEQVN SMPAGEQKRL LSEQYPELAR FEEQREKGDK GLPPLPGAVE 100
GRVKLRFAPN PDFVIHMGNA RPAIVNHEYA RMYKGRMVLR FEDTDPRTKT 150
PLREAYDLIR QDLKWLGVSW DEEYIQSLRM EVFYSVARRA IERGCAYVDN 200
CGREGKELLS RGEYCPTRDL GPEDNLELFE KMLEGEFYEG EAVVRMKTDP 250
RHPNPSLRDW VAMRIIDTEK HPHPLVGSRY LVWPTYNFAV SVDDHMMEIT 300
HVLRGKEHQL NTEKQLAVYR CMGWRPPYFI HFGRLKLEGF ILSKSKIRKL 350
LEERPGEFMG YDDPRFGTIA GLRRRGVLAE AIRQIILEVG VKPTDATISW 400
ANLAAANRKL LDERADRIMY VEDPVEMEVE LAQVECRAAE IPFHPSRPQR 450
KRRITLCTGD KVLLTREDAV EGRQLRLMGL SNFTVSQGIL REVDPSLEYA 500
RRMKLPIVQW VKKGGEASVE VLEPVELELR RHQGYAEDAI RGYGVDSRLQ 550
FVRYGFVRVD SVEDGVYRVI YTHK 574
Length:574
Mass (Da):66,034
Last modified:April 30, 2003 - v2
Checksum:i8C86B100C8F01176
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA81329.2.
PIRiA72459.
RefSeqiNP_148534.2. NC_000854.2.
WP_010866935.1. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA81329; BAA81329; APE_2317.1.
GeneIDi1445342.
KEGGiape:APE_2317.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA81329.2 .
PIRi A72459.
RefSeqi NP_148534.2. NC_000854.2.
WP_010866935.1. NC_000854.2.

3D structure databases

ProteinModelPortali Q9Y9H1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272557.APE_2317.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA81329 ; BAA81329 ; APE_2317.1 .
GeneIDi 1445342.
KEGGi ape:APE_2317.1.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000073585.
KOi K01885.
OMAi AFRIIDT.

Enzyme and pathway databases

BioCyci APER272557:GJD6-1563-MONOMER.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_A. Glu_tRNA_synth_A.
InterProi IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 1 hit.
TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiSYE_AERPE
AccessioniPrimary (citable) accession number: Q9Y9H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 30, 2003
Last modified: September 3, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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