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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei18SubstrateUniRule annotation1
Binding sitei43SubstrateUniRule annotation1
Active sitei75Proton donorUniRule annotation1
Binding sitei130SubstrateUniRule annotation1
Binding sitei206Substrate; via amide nitrogenUniRule annotation1
Binding sitei207SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:APE_2348
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346071 – 244Orotidine 5'-phosphate decarboxylaseAdd BLAST244

Proteomic databases

PRIDEiQ9Y9D9

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272557.APE_2348

Structurei

3D structure databases

ProteinModelPortaliQ9Y9D9
SMRiQ9Y9D9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 82Substrate bindingUniRule annotation10
Regioni182 – 192Substrate bindingUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00081 Archaea
COG0284 LUCA
HOGENOMiHOG000226069
KOiK01591
OMAiEMSHPGA
OrthoDBiPOG093Z0B4G

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01200_A OMPdecase_type1_A, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR32119:SF2 PTHR32119:SF2, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y9D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPPAVGEAV KRVIVALDPA RRGDVDRLLD MARLVCGVGA GIKVGLPMLA
60 70 80 90 100
LGGSEALAEA ARLCKGGGLR VLDLKLADIG YIMRLAAESL SRGFDAAIAH
110 120 130 140 150
AFVGYEGGLV ELKKTLDGLG ARLVLVVSMS HPGSREVLDP CLDKLLAVAR
160 170 180 190 200
RVEPWGVVAP ATRPEVVARV RETLPTTVIL SPGVGAQGGK PGDAICLGGA
210 220 230 240
DYEIVGRMVA GSPDPVSALR GVAEYIAARC PEKLLHSSTG NGPS
Length:244
Mass (Da):25,126
Last modified:November 1, 1999 - v1
Checksum:i70400604692A497D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA Translation: BAA81361.1
PIRiA72463

Genome annotation databases

EnsemblBacteriaiBAA81361; BAA81361; APE_2348
KEGGiape:APE_2348
PATRICifig|272557.25.peg.1569

Similar proteinsi

Entry informationi

Entry nameiPYRF_AERPE
AccessioniPrimary (citable) accession number: Q9Y9D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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