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Q9Y9D8 (PYRE_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase
Short name=OPRT
Short name=OPRTase
EC=2.4.2.10
Gene names
Name:pyrE
Ordered Locus Names:APE_2349.1
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 186186Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_0000110776

Regions

Region121 – 12995-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site9615-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10215-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1251Orotate By similarity
Binding site1531Orotate By similarity

Secondary structure

1 ............................ 186
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9Y9D8 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: A05A8636B3A22B91

FASTA18619,638
        10         20         30         40         50         60 
MSHEELAEVL AKVLKKRGAV LRGDFVLSSG RRSSVYIDMR RLLGDESSYS VALDLLLEVG 

        70         80         90        100        110        120 
GQDLARSSAV IGVATGGLPW AAMLALRLSK PLGYVRPERK GHGTLSQVEG DPPKGRVVVV 

       130        140        150        160        170        180 
DDVATTGTSI AKSIEVLRSN GYTVGTALVL VDRGEGAGEL LARMGVRLVS VATLKTILEK 


LGWGGE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000002 Genomic DNA. Translation: BAA81362.2.
PIRB72463.
RefSeqNP_148558.2. NC_000854.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YZKX-ray1.80A/B/C/D10-186[»]
ProteinModelPortalQ9Y9D8.
SMRQ9Y9D8. Positions 9-185.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1445367.
GenomeReviewsGene locus APE_2349.1 in contig BA000002_GR.
KEGGape:APE_2349.1.
NMPDRfig|272557.1.peg.1666.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG404341.
ProtClustDBPRK00455.

Enzyme and pathway databases

BioCycAPER272557:APE2349-MONOMER.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRE_AERPE
AccessionPrimary (citable) accession number: Q9Y9D8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: July 10, 2007
Last modified: November 16, 2011
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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