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Q9Y933 (GUAA_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing]
EC=6.3.5.2
Alternative name(s):
GMP synthetase
Glutamine amidotransferase
Gene names
Name:guaA
Ordered Locus Names:APE_2452
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_00344

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_00344

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_00344

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512GMP synthase [glutamine-hydrolyzing] HAMAP MF_00344
PRO_0000140215

Regions

Domain9 – 198190Glutamine amidotransferase type-1
Domain199 – 387189GMPS ATP-PPase
Nucleotide binding226 – 2327ATP By similarity

Sites

Active site871Nucleophile By similarity
Active site1731 By similarity
Active site1751 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Y933 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 7F5DE439B4C87368

FASTA51255,735
        10         20         30         40         50         60 
MAKTLDSPGV LVVDFGGQYA HLIARRIREL GVYSEIVPAT SLDALGEALP RAAGVVLSGG 

        70         80         90        100        110        120 
PGSVWGSRHD EAAAMVLQLG KPVLGICYGH QLLAKVLGGE VGRSPLPEFG PTEVEVLDYG 

       130        140        150        160        170        180 
ILLNGLPSRF KVWMSHYDAV LRPPGEAKVL ARTPGSPVAA MELWGRVFGV QWHPEVRHTQ 

       190        200        210        220        230        240 
YGREVLDNWL SLVGAPRTWR PGDMVSELVE SVKKEVGDAL AVAAVSGGVD STVAALIAKK 

       250        260        270        280        290        300 
AIGSRLYPVF IDHGLHPEGE VERVVKLLSR LGLEPVMVDA GEEFLAALEG VGDPEEKRRV 

       310        320        330        340        350        360 
VGRVYAEVLE RAARDIGAEY LVQGTIYPDV IESGARPGAD TIKTHHNVGG LPKDMRLKLV 

       370        380        390        400        410        420 
EPLRYFYKDE VRLLAEKLGV PRELIWKQPV PGPGLAVRVE GPITREKLRI VRRADAIVRE 

       430        440        450        460        470        480 
EVEAAGLGGK LWQYFAVLTA SMATGVRGDS RSYGYVVAVR AVESVDAMTA KPAELPWWLL 

       490        500        510 
ERIARRITSE IPEVVRVVYD ITSKPPSTIE WE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000002 Genomic DNA. Translation: BAA81467.1.
PIRC72476.
RefSeqNP_148620.1. NC_000854.2.

3D structure databases

ProteinModelPortalQ9Y933.
SMRQ9Y933. Positions 202-512.
ModBaseSearch...

Protein family/group databases

MEROPSC26.A17.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1445429.
GenomeReviewsGene locus APE_2452 in contig BA000002_GR.
KEGGape:APE_2452.
NMPDRfig|272557.1.peg.1728.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG391775.
OMADGRTYEY.
PhylomeDBQ9Y933.
ProtClustDBPRK00074.

Enzyme and pathway databases

BioCycAPER272557:APE2452-MONOMER.

Family and domain databases

HAMAPMF_00344. GMP_synthase.
[Tree]
InterProIPR017926. GATASE_1.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK01951.
PfamPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00884. GuaA_Cterm. 1 hit.
TIGR00888. GuaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAA_AERPE
AccessionPrimary (citable) accession number: Q9Y933
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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