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Q9Y924

- SYW_AERPE

UniProt

Q9Y924 - SYW_AERPE

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Protein
Tryptophan--tRNA ligase
Gene
trpS, APE_2461.1
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPER272557:GJD6-1652-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Ordered Locus Names:APE_2461.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Tryptophan--tRNA ligaseUniRule annotation
PRO_0000136718Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_2461.1.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni12 – 176
Helixi18 – 225
Turni23 – 253
Helixi29 – 324
Helixi33 – 386
Helixi45 – 484
Beta strandi51 – 577
Helixi58 – 669
Beta strandi72 – 776
Helixi85 – 9915
Beta strandi103 – 1086
Helixi110 – 1156
Helixi121 – 13010
Helixi133 – 1397
Turni143 – 1453
Beta strandi147 – 1504
Helixi151 – 1533
Helixi156 – 16510
Helixi171 – 1788
Helixi183 – 19715
Helixi198 – 2003
Helixi202 – 2043
Beta strandi210 – 2156
Helixi216 – 2183
Helixi219 – 23113
Turni232 – 2354
Beta strandi242 – 2465
Beta strandi254 – 2563
Helixi262 – 2643
Helixi272 – 2809
Helixi290 – 2967
Helixi300 – 3023
Helixi304 – 3118
Helixi317 – 32812
Helixi334 – 36431

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A04X-ray1.97A1-372[»]
3A05X-ray2.20A1-372[»]
ProteinModelPortaliQ9Y924.

Miscellaneous databases

EvolutionaryTraceiQ9Y924.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi79 – 879"HIGH" regionUniRule annotation
Motifi256 – 2605"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000224743.
KOiK01867.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y924-1 [UniParc]FASTAAdd to Basket

« Hide

MAAERLDPWG AVEIKDYDRL LRTFGIRPFS EVLPLLRKAG MEPSFLMRRG    50
IIFGHRDFDK ILEAKARGER VAVLTGFMPS GKFHFGHKLT VDQLIYLQKN 100
GFKVFVAIAD AEAFAVRRIG REEAVRIAVE EYIANMIALG LDPKDTEFYF 150
QTNRGTPYFR LIQLFSGKVT AAEMEAIYGE LTPAKMMASL TQAADILHVQ 200
LDEYGGYRHV VVPVGADQDP HLRLTRDLAD RMAGVVELER PASTYHKLQP 250
GLDGRKMSSS RPDSTIFLTD PPEVARNKLF RALTGGRATA EEQRRLGGVP 300
EVCSVYHMDL YHLMPDDGEV KHIYTSCRLG KILCGECKQI AWEKLERFLA 350
EHQSRLEKAK TIAWKLVEPP RF 372
Length:372
Mass (Da):42,154
Last modified:July 10, 2007 - v2
Checksum:i90E3D4F2E8121A2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA81476.2.
PIRiD72477.
RefSeqiNP_148625.2. NC_000854.2.
WP_010867022.1. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA81476; BAA81476; APE_2461.1.
GeneIDi1445433.
KEGGiape:APE_2461.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA81476.2 .
PIRi D72477.
RefSeqi NP_148625.2. NC_000854.2.
WP_010867022.1. NC_000854.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3A04 X-ray 1.97 A 1-372 [» ]
3A05 X-ray 2.20 A 1-372 [» ]
ProteinModelPortali Q9Y924.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272557.APE_2461.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA81476 ; BAA81476 ; APE_2461.1 .
GeneIDi 1445433.
KEGGi ape:APE_2461.1.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000224743.
KOi K01867.

Enzyme and pathway databases

BioCyci APER272557:GJD6-1652-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9Y924.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_A. Trp_tRNA_synth_A.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiSYW_AERPE
AccessioniPrimary (citable) accession number: Q9Y924
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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