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Q9Y924

- SYW_AERPE

UniProt

Q9Y924 - SYW_AERPE

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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPER272557:GJD6-1652-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:APE_2461.1
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Tryptophan--tRNA ligasePRO_0000136718Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_2461.1.

Structurei

Secondary structure

1
372
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni12 – 176Combined sources
Helixi18 – 225Combined sources
Turni23 – 253Combined sources
Helixi29 – 324Combined sources
Helixi33 – 386Combined sources
Helixi45 – 484Combined sources
Beta strandi51 – 577Combined sources
Helixi58 – 669Combined sources
Beta strandi72 – 776Combined sources
Helixi85 – 9915Combined sources
Beta strandi103 – 1086Combined sources
Helixi110 – 1156Combined sources
Helixi121 – 13010Combined sources
Helixi133 – 1397Combined sources
Turni143 – 1453Combined sources
Beta strandi147 – 1504Combined sources
Helixi151 – 1533Combined sources
Helixi156 – 16510Combined sources
Helixi171 – 1788Combined sources
Helixi183 – 19715Combined sources
Helixi198 – 2003Combined sources
Helixi202 – 2043Combined sources
Beta strandi210 – 2156Combined sources
Helixi216 – 2183Combined sources
Helixi219 – 23113Combined sources
Turni232 – 2354Combined sources
Beta strandi242 – 2465Combined sources
Beta strandi254 – 2563Combined sources
Helixi262 – 2643Combined sources
Helixi272 – 2809Combined sources
Helixi290 – 2967Combined sources
Helixi300 – 3023Combined sources
Helixi304 – 3118Combined sources
Helixi317 – 32812Combined sources
Helixi334 – 36431Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A04X-ray1.97A1-372[»]
3A05X-ray2.20A1-372[»]
ProteinModelPortaliQ9Y924.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y924.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi79 – 879"HIGH" region
Motifi256 – 2605"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000224743.
KOiK01867.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y924-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAERLDPWG AVEIKDYDRL LRTFGIRPFS EVLPLLRKAG MEPSFLMRRG
60 70 80 90 100
IIFGHRDFDK ILEAKARGER VAVLTGFMPS GKFHFGHKLT VDQLIYLQKN
110 120 130 140 150
GFKVFVAIAD AEAFAVRRIG REEAVRIAVE EYIANMIALG LDPKDTEFYF
160 170 180 190 200
QTNRGTPYFR LIQLFSGKVT AAEMEAIYGE LTPAKMMASL TQAADILHVQ
210 220 230 240 250
LDEYGGYRHV VVPVGADQDP HLRLTRDLAD RMAGVVELER PASTYHKLQP
260 270 280 290 300
GLDGRKMSSS RPDSTIFLTD PPEVARNKLF RALTGGRATA EEQRRLGGVP
310 320 330 340 350
EVCSVYHMDL YHLMPDDGEV KHIYTSCRLG KILCGECKQI AWEKLERFLA
360 370
EHQSRLEKAK TIAWKLVEPP RF
Length:372
Mass (Da):42,154
Last modified:July 10, 2007 - v2
Checksum:i90E3D4F2E8121A2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA81476.2.
PIRiD72477.
RefSeqiNP_148625.2. NC_000854.2.
WP_010867022.1. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA81476; BAA81476; APE_2461.1.
GeneIDi1445433.
KEGGiape:APE_2461.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000002 Genomic DNA. Translation: BAA81476.2 .
PIRi D72477.
RefSeqi NP_148625.2. NC_000854.2.
WP_010867022.1. NC_000854.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3A04 X-ray 1.97 A 1-372 [» ]
3A05 X-ray 2.20 A 1-372 [» ]
ProteinModelPortali Q9Y924.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272557.APE_2461.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA81476 ; BAA81476 ; APE_2461.1 .
GeneIDi 1445433.
KEGGi ape:APE_2461.1.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000224743.
KOi K01867.

Enzyme and pathway databases

BioCyci APER272557:GJD6-1652-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9Y924.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_A. Trp_tRNA_synth_A.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiSYW_AERPE
AccessioniPrimary (citable) accession number: Q9Y924
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 10, 2007
Last modified: November 26, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3