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Q9Y924 (SYW_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase
EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:APE_2461.1
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum ›

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136718

Regions

Motif79 – 879"HIGH" region HAMAP-Rule MF_00140
Motif256 – 2605"KMSKS" region HAMAP-Rule MF_00140

Secondary structure

1 .............................................................. 372
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9Y924 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: 90E3D4F2E8121A2B

FASTA37242,154
        10         20         30         40         50         60 
MAAERLDPWG AVEIKDYDRL LRTFGIRPFS EVLPLLRKAG MEPSFLMRRG IIFGHRDFDK 

        70         80         90        100        110        120 
ILEAKARGER VAVLTGFMPS GKFHFGHKLT VDQLIYLQKN GFKVFVAIAD AEAFAVRRIG 

       130        140        150        160        170        180 
REEAVRIAVE EYIANMIALG LDPKDTEFYF QTNRGTPYFR LIQLFSGKVT AAEMEAIYGE 

       190        200        210        220        230        240 
LTPAKMMASL TQAADILHVQ LDEYGGYRHV VVPVGADQDP HLRLTRDLAD RMAGVVELER 

       250        260        270        280        290        300 
PASTYHKLQP GLDGRKMSSS RPDSTIFLTD PPEVARNKLF RALTGGRATA EEQRRLGGVP 

       310        320        330        340        350        360 
EVCSVYHMDL YHLMPDDGEV KHIYTSCRLG KILCGECKQI AWEKLERFLA EHQSRLEKAK 

       370 
TIAWKLVEPP RF

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000002 Genomic DNA. Translation: BAA81476.2.
PIRD72477.
RefSeqNP_148625.2. NC_000854.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3A04X-ray1.97A1-372[»]
3A05X-ray2.20A1-372[»]
ProteinModelPortalQ9Y924.
ModBaseSearch...

Protein-protein interaction databases

STRING272557.APE_2461.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA81476; BAA81476; APE_2461.1.
GeneID1445433.
KEGGape:APE_2461.1.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000224743.
KOK01867.
ProtClustDBPRK12285.

Enzyme and pathway databases

BioCycAPER272557:GJD6-1652-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_A. Trp_tRNA_synth_A.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. False negative.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9Y924.

Entry information

Entry nameSYW_AERPE
AccessionPrimary (citable) accession number: Q9Y924
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 10, 2007
Last modified: May 1, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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