Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y924

- SYW_AERPE

UniProt

Q9Y924 - SYW_AERPE

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAPER272557:GJD6-1652-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Ordered Locus Names:APE_2461.1
    OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
    Taxonomic identifieri272557 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
    ProteomesiUP000002518: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Tryptophan--tRNA ligasePRO_0000136718Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272557.APE_2461.1.

    Structurei

    Secondary structure

    1
    372
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni12 – 176
    Helixi18 – 225
    Turni23 – 253
    Helixi29 – 324
    Helixi33 – 386
    Helixi45 – 484
    Beta strandi51 – 577
    Helixi58 – 669
    Beta strandi72 – 776
    Helixi85 – 9915
    Beta strandi103 – 1086
    Helixi110 – 1156
    Helixi121 – 13010
    Helixi133 – 1397
    Turni143 – 1453
    Beta strandi147 – 1504
    Helixi151 – 1533
    Helixi156 – 16510
    Helixi171 – 1788
    Helixi183 – 19715
    Helixi198 – 2003
    Helixi202 – 2043
    Beta strandi210 – 2156
    Helixi216 – 2183
    Helixi219 – 23113
    Turni232 – 2354
    Beta strandi242 – 2465
    Beta strandi254 – 2563
    Helixi262 – 2643
    Helixi272 – 2809
    Helixi290 – 2967
    Helixi300 – 3023
    Helixi304 – 3118
    Helixi317 – 32812
    Helixi334 – 36431

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3A04X-ray1.97A1-372[»]
    3A05X-ray2.20A1-372[»]
    ProteinModelPortaliQ9Y924.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y924.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi79 – 879"HIGH" region
    Motifi256 – 2605"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000224743.
    KOiK01867.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_A. Trp_tRNA_synth_A.
    InterProiIPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Y924-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAERLDPWG AVEIKDYDRL LRTFGIRPFS EVLPLLRKAG MEPSFLMRRG    50
    IIFGHRDFDK ILEAKARGER VAVLTGFMPS GKFHFGHKLT VDQLIYLQKN 100
    GFKVFVAIAD AEAFAVRRIG REEAVRIAVE EYIANMIALG LDPKDTEFYF 150
    QTNRGTPYFR LIQLFSGKVT AAEMEAIYGE LTPAKMMASL TQAADILHVQ 200
    LDEYGGYRHV VVPVGADQDP HLRLTRDLAD RMAGVVELER PASTYHKLQP 250
    GLDGRKMSSS RPDSTIFLTD PPEVARNKLF RALTGGRATA EEQRRLGGVP 300
    EVCSVYHMDL YHLMPDDGEV KHIYTSCRLG KILCGECKQI AWEKLERFLA 350
    EHQSRLEKAK TIAWKLVEPP RF 372
    Length:372
    Mass (Da):42,154
    Last modified:July 10, 2007 - v2
    Checksum:i90E3D4F2E8121A2B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA81476.2.
    PIRiD72477.
    RefSeqiNP_148625.2. NC_000854.2.
    WP_010867022.1. NC_000854.2.

    Genome annotation databases

    EnsemblBacteriaiBAA81476; BAA81476; APE_2461.1.
    GeneIDi1445433.
    KEGGiape:APE_2461.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA81476.2 .
    PIRi D72477.
    RefSeqi NP_148625.2. NC_000854.2.
    WP_010867022.1. NC_000854.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3A04 X-ray 1.97 A 1-372 [» ]
    3A05 X-ray 2.20 A 1-372 [» ]
    ProteinModelPortali Q9Y924.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272557.APE_2461.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA81476 ; BAA81476 ; APE_2461.1 .
    GeneIDi 1445433.
    KEGGi ape:APE_2461.1.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000224743.
    KOi K01867.

    Enzyme and pathway databases

    BioCyci APER272557:GJD6-1652-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9Y924.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_A. Trp_tRNA_synth_A.
    InterProi IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

    Entry informationi

    Entry nameiSYW_AERPE
    AccessioniPrimary (citable) accession number: Q9Y924
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3