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Q9Y8T7

- TRPC_AERPE

UniProt

Q9Y8T7 - TRPC_AERPE

Protein

Indole-3-glycerol phosphate synthase

Gene

trpC

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

    Pathwayi

    GO - Molecular functioni

    1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciAPER272557:GJD6-1706-MONOMER.
    UniPathwayiUPA00035; UER00043.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
    Short name:
    IGPS
    Gene namesi
    Name:trpC
    Ordered Locus Names:APE_2546
    OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
    Taxonomic identifieri272557 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
    ProteomesiUP000002518: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Indole-3-glycerol phosphate synthasePRO_0000154289Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272557.APE_2546.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y8T7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpC family.Curated

    Phylogenomic databases

    eggNOGiCOG0134.
    HOGENOMiHOG000230462.
    KOiK01609.
    OMAiRICARTK.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00134_A. IGPS_A.
    InterProiIPR013785. Aldolase_TIM.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00218. IGPS. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    PROSITEiPS00614. IGPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y8T7-1 [UniParc]FASTAAdd to Basket

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    MRDSFLQKAI ASAKDRTSLL EEIAGNCSPK PGRPSLSSSI REWVYRVGGA    50
    VIAEYKRCSP SAGAISTLDP VSYVQATRDA SAAYSVLTEP NWFCGSIELI 100
    PYFARYKPVL AKDFIVSETQ IRIAACMGAS AALLIMEALT PRELQELAAA 150
    ASRYGVEVLV ETPDASHAVE ASRLAPGSII GVNSRDLKTL RVDYEAMLRE 200
    VSKAREQLPG EVILVAESGI DSPDKALKAF KAGAQAILVG TAFMKNPQLR 250
    EKILAELLQI P 261
    Length:261
    Mass (Da):28,127
    Last modified:November 1, 1999 - v1
    Checksum:i5F5A0F2A0FD6508A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA81563.1.
    PIRiC72488.
    RefSeqiNP_148685.1. NC_000854.2.

    Genome annotation databases

    EnsemblBacteriaiBAA81563; BAA81563; APE_2546.
    GeneIDi1445492.
    KEGGiape:APE_2546.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000002 Genomic DNA. Translation: BAA81563.1 .
    PIRi C72488.
    RefSeqi NP_148685.1. NC_000854.2.

    3D structure databases

    ProteinModelPortali Q9Y8T7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272557.APE_2546.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA81563 ; BAA81563 ; APE_2546 .
    GeneIDi 1445492.
    KEGGi ape:APE_2546.

    Phylogenomic databases

    eggNOGi COG0134.
    HOGENOMi HOG000230462.
    KOi K01609.
    OMAi RICARTK.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00043 .
    BioCyci APER272557:GJD6-1706-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00134_A. IGPS_A.
    InterProi IPR013785. Aldolase_TIM.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00218. IGPS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    PROSITEi PS00614. IGPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

    Entry informationi

    Entry nameiTRPC_AERPE
    AccessioniPrimary (citable) accession number: Q9Y8T7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3