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Q9Y8T7 (TRPC_AERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Indole-3-glycerol phosphate synthase

Short name=IGPS
EC=4.1.1.48
Gene names
Name:trpC
Ordered Locus Names:APE_2546
OrganismAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) [Complete proteome] [HAMAP]
Taxonomic identifier272557 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP-Rule MF_00134_A

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP-Rule MF_00134_A

Sequence similarities

Belongs to the TrpC family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionindole-3-glycerol-phosphate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Indole-3-glycerol phosphate synthase HAMAP-Rule MF_00134_A
PRO_0000154289

Sequences

Sequence LengthMass (Da)Tools
Q9Y8T7 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 5F5A0F2A0FD6508A

FASTA26128,127
        10         20         30         40         50         60 
MRDSFLQKAI ASAKDRTSLL EEIAGNCSPK PGRPSLSSSI REWVYRVGGA VIAEYKRCSP 

        70         80         90        100        110        120 
SAGAISTLDP VSYVQATRDA SAAYSVLTEP NWFCGSIELI PYFARYKPVL AKDFIVSETQ 

       130        140        150        160        170        180 
IRIAACMGAS AALLIMEALT PRELQELAAA ASRYGVEVLV ETPDASHAVE ASRLAPGSII 

       190        200        210        220        230        240 
GVNSRDLKTL RVDYEAMLRE VSKAREQLPG EVILVAESGI DSPDKALKAF KAGAQAILVG 

       250        260 
TAFMKNPQLR EKILAELLQI P 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000002 Genomic DNA. Translation: BAA81563.1.
PIRC72488.
RefSeqNP_148685.1. NC_000854.2.

3D structure databases

ProteinModelPortalQ9Y8T7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272557.APE_2546.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA81563; BAA81563; APE_2546.
GeneID1445492.
KEGGape:APE_2546.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0134.
HOGENOMHOG000230462.
KOK01609.
OMARICARTK.

Enzyme and pathway databases

BioCycAPER272557:GJD6-1706-MONOMER.
UniPathwayUPA00035; UER00043.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00134_A. IGPS_A.
InterProIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
PROSITEPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPC_AERPE
AccessionPrimary (citable) accession number: Q9Y8T7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways