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Q9Y8T7

- TRPC_AERPE

UniProt

Q9Y8T7 - TRPC_AERPE

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Protein
Indole-3-glycerol phosphate synthase
Gene
trpC, APE_2546
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciAPER272557:GJD6-1706-MONOMER.
UniPathwayiUPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
Gene namesi
Name:trpC
Ordered Locus Names:APE_2546
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
ProteomesiUP000002518: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Indole-3-glycerol phosphate synthaseUniRule annotation
PRO_0000154289Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272557.APE_2546.

Structurei

3D structure databases

ProteinModelPortaliQ9Y8T7.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpC family.

Phylogenomic databases

eggNOGiCOG0134.
HOGENOMiHOG000230462.
KOiK01609.
OMAiRICARTK.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00134_A. IGPS_A.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y8T7-1 [UniParc]FASTAAdd to Basket

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MRDSFLQKAI ASAKDRTSLL EEIAGNCSPK PGRPSLSSSI REWVYRVGGA    50
VIAEYKRCSP SAGAISTLDP VSYVQATRDA SAAYSVLTEP NWFCGSIELI 100
PYFARYKPVL AKDFIVSETQ IRIAACMGAS AALLIMEALT PRELQELAAA 150
ASRYGVEVLV ETPDASHAVE ASRLAPGSII GVNSRDLKTL RVDYEAMLRE 200
VSKAREQLPG EVILVAESGI DSPDKALKAF KAGAQAILVG TAFMKNPQLR 250
EKILAELLQI P 261
Length:261
Mass (Da):28,127
Last modified:November 1, 1999 - v1
Checksum:i5F5A0F2A0FD6508A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA81563.1.
PIRiC72488.
RefSeqiNP_148685.1. NC_000854.2.

Genome annotation databases

EnsemblBacteriaiBAA81563; BAA81563; APE_2546.
GeneIDi1445492.
KEGGiape:APE_2546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000002 Genomic DNA. Translation: BAA81563.1 .
PIRi C72488.
RefSeqi NP_148685.1. NC_000854.2.

3D structure databases

ProteinModelPortali Q9Y8T7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272557.APE_2546.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA81563 ; BAA81563 ; APE_2546 .
GeneIDi 1445492.
KEGGi ape:APE_2546.

Phylogenomic databases

eggNOGi COG0134.
HOGENOMi HOG000230462.
KOi K01609.
OMAi RICARTK.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00043 .
BioCyci APER272557:GJD6-1706-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00134_A. IGPS_A.
InterProi IPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00218. IGPS. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
PROSITEi PS00614. IGPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1.

Entry informationi

Entry nameiTRPC_AERPE
AccessioniPrimary (citable) accession number: Q9Y8T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3