Reviewed, UniProtKB/Swiss-Prot Q9Y8T7 (TRPC_AERPE)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	APE_2546

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Indole-3-glycerol phosphate synthase HAMAP MF_00134		PRO_0000154289

Sequences

	Sequence		Length	Mass (Da)
	Q9Y8T7-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 5F5A0F2A0FD6508A	FASTA	261	28,127
	10 20 30 40 50 60 MRDSFLQKAI ASAKDRTSLL EEIAGNCSPK PGRPSLSSSI REWVYRVGGA VIAEYKRCSP 70 80 90 100 110 120 SAGAISTLDP VSYVQATRDA SAAYSVLTEP NWFCGSIELI PYFARYKPVL AKDFIVSETQ 130 140 150 160 170 180 IRIAACMGAS AALLIMEALT PRELQELAAA ASRYGVEVLV ETPDASHAVE ASRLAPGSII 190 200 210 220 230 240 GVNSRDLKTL RVDYEAMLRE VSKAREQLPG EVILVAESGI DSPDKALKAF KAGAQAILVG 250 260 TAFMKNPQLR EKILAELLQI P

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000002 Genomic DNA. Translation: BAA81563.1.
PIR	C72488.
RefSeq	NP_148685.1.
3D structure databases
HSSP	HSSP built from PDB template 1A53 based on UniProtKB Q06121.
ModBase	Search...
Genome annotation databases
GeneID	1445492.
GenomeReviews	Gene locus APE_2546 in contig BA000002_GR.
KEGG	ape:APE_2546.
NMPDR	fig|272557.1.peg.1793.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9Y8T7.
OMA	PLLCKDF.
Enzyme and pathway databases
BRENDA	4.1.1.48. 256344.
Family and domain databases
HAMAP	MF_00134. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GPS_central. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
ProDom	PD001511. IGPS. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_AERPE

Accession

Primary (citable) accession number: Q9Y8T7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	November 3, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)