Reviewed, UniProtKB/Swiss-Prot Q9Y8T0 (TRPE_AERPE)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	APE_2553.1

Organism

Aeropyrum pernix [Complete proteome] [HAMAP]

Taxonomic identifier

56636 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Aeropyrum

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	Anthranilate synthase component 1		PRO_0000154120

Sequences

	Sequence		Length	Mass (Da)
	Q9Y8T0-1 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 16E59013EFDFABED	FASTA	438	48,310
	10 20 30 40 50 60 MPSPPEPPLH WRDCRLEPIL GFPRPRELAK SLEVQGEEWI ALLESGGGLQ HRSRYSFLAW 70 80 90 100 110 120 GRRKSSETDA IRAYEELERL ADDKCRALPC RSPTFFLVSY EAVVGEEPWL SRLVGRHEWP 130 140 150 160 170 180 GMTAFSPEYV VVYDHAGGRV SVCPGDTPLP APASRKESFS AEGPTYETSR KGFEAMVADA 190 200 210 220 230 240 LERIRAGEAF QVVLSRVERY RVWGSLFSAY ERLADANPSP YLYYARLGGR VIIGSSPELL 250 260 270 280 290 300 VKLEAGRVET HPIAGTRPRG STPIEDIELE VELLNDEKER AEHVMLVDLA RNDITRVSIP 310 320 330 340 350 360 GTVQVTSFMD IERYETVMHI VSRVEGVTRP STTFVEALKA LHPAGTVSGA PKPRAMEIIA 370 380 390 400 410 420 ELEEEARGPY AGAIGVAGSS AGEAAIVLRS AWLLDDGETL EARAGAGIVY DSKPEREYME 430 TVQKLGSLKR ALGVDMCG

References

[1]

"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1." Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S. , Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H. DNA Res. 6:83-101(1999) [PubMed: 10382966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000002 Genomic DNA. Translation: BAA81570.2.
PIR	B72489.
RefSeq	NP_148690.2.
3D structure databases
SMR	Q9Y8T0. Positions 15-434.
ModBase	Search...
Genome annotation databases
GeneID	1445497.
GenomeReviews	Gene locus APE_2553.1 in contig BA000002_GR.
KEGG	ape:APE_2553.1.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG507440.
OMA	FAVEKYS.
Enzyme and pathway databases
BioCyc	APER272557:APE2553-MONOMER.
BRENDA	4.1.3.27. 256344.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
ProtoNet	Search...

Entry information

Entry name

TRPE_AERPE

Accession

Primary (citable) accession number: Q9Y8T0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	January 19, 2010
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)