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Protein

Superoxide dismutase [Mn/Fe]

Gene

sod

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarity, Fe2+By similarityNote: Binds 1 Mn2+ or Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi31Manganese or ironBy similarity1
Metal bindingi79Manganese or ironBy similarity1
Metal bindingi165Manganese or ironBy similarity1
Metal bindingi169Manganese or ironBy similarity1

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW
  • superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Manganese, Metal-binding

Enzyme and pathway databases

BRENDAi1.15.1.1. 171.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn/Fe] (EC:1.15.1.1)
Gene namesi
Name:sod
Ordered Locus Names:APE_0741
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001600051 – 214Superoxide dismutase [Mn/Fe]Add BLAST214

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-8549588,EBI-8549588

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

MINTiMINT-8075653.
STRINGi272557.APE_0741.

Structurei

Secondary structure

1214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni16 – 22Combined sources7
Helixi25 – 33Combined sources9
Helixi35 – 54Combined sources20
Helixi62 – 82Combined sources21
Turni83 – 85Combined sources3
Beta strandi92 – 94Combined sources3
Helixi98 – 108Combined sources11
Helixi111 – 123Combined sources13
Beta strandi126 – 136Combined sources11
Turni137 – 140Combined sources4
Beta strandi141 – 148Combined sources8
Turni149 – 151Combined sources3
Beta strandi159 – 165Combined sources7
Helixi168 – 170Combined sources3
Helixi172 – 175Combined sources4
Helixi179 – 186Combined sources8
Helixi187 – 189Combined sources3
Helixi192 – 205Combined sources14
Helixi207 – 209Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AK1X-ray1.57A/B/C/D1-214[»]
3AK2X-ray1.35A/B/C/D1-214[»]
3AK3X-ray1.48A/B/C/D1-214[»]
ProteinModelPortaliQ9Y8H8.
SMRiQ9Y8H8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y8H8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG04147. Archaea.
COG0605. LUCA.
HOGENOMiHOG000013583.
KOiK04564.
OMAiEQVYDHQ.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y8H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSFKRYELP PLPYNYNALE PYIIEEIMKL HHQKHHNTYV KGANAALEKI
60 70 80 90 100
EKHLKGEIQI DVRAVMRDFS FNYAGHIMHT IFWPNMAPPG KGGGTPGGRV
110 120 130 140 150
ADLIEKQFGG FEKFKALFSA AAKTVEGVGW GVLAFDPLTE ELRILQVEKH
160 170 180 190 200
NVLMTAGLVP ILVIDVWEHA YYLQYKNDRG SYVENWWNVV NWDDVEKRLE
210
QALNNAKPLY LLPQ
Length:214
Mass (Da):24,577
Last modified:November 1, 1999 - v1
Checksum:i641122779485DF0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012621 Genomic DNA. Translation: BAA76442.1.
BA000002 Genomic DNA. Translation: BAA79718.1.
PIRiF72664.

Genome annotation databases

EnsemblBacteriaiBAA79718; BAA79718; APE_0741.
KEGGiape:APE_0741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012621 Genomic DNA. Translation: BAA76442.1.
BA000002 Genomic DNA. Translation: BAA79718.1.
PIRiF72664.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AK1X-ray1.57A/B/C/D1-214[»]
3AK2X-ray1.35A/B/C/D1-214[»]
3AK3X-ray1.48A/B/C/D1-214[»]
ProteinModelPortaliQ9Y8H8.
SMRiQ9Y8H8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8075653.
STRINGi272557.APE_0741.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA79718; BAA79718; APE_0741.
KEGGiape:APE_0741.

Phylogenomic databases

eggNOGiarCOG04147. Archaea.
COG0605. LUCA.
HOGENOMiHOG000013583.
KOiK04564.
OMAiEQVYDHQ.

Enzyme and pathway databases

BRENDAi1.15.1.1. 171.

Miscellaneous databases

EvolutionaryTraceiQ9Y8H8.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSODF_AERPE
AccessioniPrimary (citable) accession number: Q9Y8H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.