Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Superoxide dismutase [Mn/Fe]

Gene

sod

Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarity, Fe2+By similarityNote: Binds 1 Mn2+ or Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi31Manganese or ironBy similarity1
Metal bindingi79Manganese or ironBy similarity1
Metal bindingi165Manganese or ironBy similarity1
Metal bindingi169Manganese or ironBy similarity1

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW
  • superoxide dismutase activity Source: UniProtKB-EC

Keywordsi

Molecular functionOxidoreductase
LigandIron, Manganese, Metal-binding

Enzyme and pathway databases

BRENDAi1.15.1.1 171

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn/Fe] (EC:1.15.1.1)
Gene namesi
Name:sod
Ordered Locus Names:APE_0741
OrganismiAeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Taxonomic identifieri272557 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000002518 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001600051 – 214Superoxide dismutase [Mn/Fe]Add BLAST214

Proteomic databases

PRIDEiQ9Y8H8

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-8549588,EBI-8549588

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

MINTiQ9Y8H8
STRINGi272557.APE_0741

Structurei

Secondary structure

1214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni16 – 22Combined sources7
Helixi25 – 33Combined sources9
Helixi35 – 54Combined sources20
Helixi62 – 82Combined sources21
Turni83 – 85Combined sources3
Beta strandi92 – 94Combined sources3
Helixi98 – 108Combined sources11
Helixi111 – 123Combined sources13
Beta strandi126 – 136Combined sources11
Turni137 – 140Combined sources4
Beta strandi141 – 148Combined sources8
Turni149 – 151Combined sources3
Beta strandi159 – 165Combined sources7
Helixi168 – 170Combined sources3
Helixi172 – 175Combined sources4
Helixi179 – 186Combined sources8
Helixi187 – 189Combined sources3
Helixi192 – 205Combined sources14
Helixi207 – 209Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AK1X-ray1.57A/B/C/D1-214[»]
3AK2X-ray1.35A/B/C/D1-214[»]
3AK3X-ray1.48A/B/C/D1-214[»]
ProteinModelPortaliQ9Y8H8
SMRiQ9Y8H8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y8H8

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG04147 Archaea
COG0605 LUCA
HOGENOMiHOG000013583
KOiK04564
OMAiKWGSFDK
OrthoDBiPOG093Z0AKF

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y8H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSFKRYELP PLPYNYNALE PYIIEEIMKL HHQKHHNTYV KGANAALEKI
60 70 80 90 100
EKHLKGEIQI DVRAVMRDFS FNYAGHIMHT IFWPNMAPPG KGGGTPGGRV
110 120 130 140 150
ADLIEKQFGG FEKFKALFSA AAKTVEGVGW GVLAFDPLTE ELRILQVEKH
160 170 180 190 200
NVLMTAGLVP ILVIDVWEHA YYLQYKNDRG SYVENWWNVV NWDDVEKRLE
210
QALNNAKPLY LLPQ
Length:214
Mass (Da):24,577
Last modified:November 1, 1999 - v1
Checksum:i641122779485DF0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012621 Genomic DNA Translation: BAA76442.1
BA000002 Genomic DNA Translation: BAA79718.1
PIRiF72664

Genome annotation databases

EnsemblBacteriaiBAA79718; BAA79718; APE_0741
KEGGiape:APE_0741
PATRICifig|272557.25.peg.534

Similar proteinsi

Entry informationi

Entry nameiSODF_AERPE
AccessioniPrimary (citable) accession number: Q9Y8H8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health