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Protein

mRNA export factor mex67

Gene

mex67

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the export of mRNA from the nucleus to the cytoplasm.PROSITE-ProRule annotation2 Publications

GO - Molecular functioni

GO - Biological processi

  • poly(A)+ mRNA export from nucleus Source: PomBase
  • ribosomal large subunit export from nucleus Source: PomBase
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA export factor mex67
Gene namesi
Name:mex67
ORF Names:SPBC1921.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1921.03c.
PomBaseiSPBC1921.03c. mex67.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • mitotic spindle Source: PomBase
  • nuclear membrane Source: PomBase
  • nuclear pore Source: PomBase
  • nuclear RNA export factor complex Source: PomBase
  • nucleolus Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi460 – 4623VHG → AAA: No mRNA export from nucleus. 1 Publication
Mutagenesisi478 – 4792RT → AA: Reduced mRNA export from nucleus. 1 Publication
Mutagenesisi492 – 4932II → AA: Reduced mRNA export from nucleus. 1 Publication
Mutagenesisi494 – 4952ND → AA: Reduced mRNA export from nucleus. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596mRNA export factor mex67PRO_0000220541Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281Phosphoserine1 Publication
Modified residuei130 – 1301Phosphoserine1 Publication
Modified residuei133 – 1331Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y8G3.

PTM databases

iPTMnetiQ9Y8G3.

Interactioni

Subunit structurei

Interacts with mlo3 and rae1.1 Publication

Protein-protein interaction databases

BioGridi277250. 72 interactions.
MINTiMINT-4721496.

Structurei

3D structure databases

ProteinModelPortaliQ9Y8G3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati215 – 23622LRR 1Add
BLAST
Repeati241 – 26222LRR 2Add
BLAST
Repeati263 – 28220LRR 3Add
BLAST
Domaini283 – 33856LRRCTAdd
BLAST
Domaini338 – 499162NTF2PROSITE-ProRule annotationAdd
BLAST
Domaini543 – 59654TAP-CPROSITE-ProRule annotationAdd
BLAST

Domaini

The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus.By similarity
The NTF2 domain heterodimerizes with MTR2. The formation of this heterodimer is essential for mRNA export and binds to all of the nucleoporin-FG-repeats.
The RNA-binding domain is conserved in most NXF proteins but may be absent in yeasts.

Sequence similaritiesi

Belongs to the NXF family.Curated
Contains 3 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 NTF2 domain.PROSITE-ProRule annotation
Contains 1 TAP-C domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

InParanoidiQ9Y8G3.
KOiK14284.
OMAiTKGNVML.
OrthoDBiEOG092C3PB8.
PhylomeDBiQ9Y8G3.

Family and domain databases

CDDicd14342. UBA_TAP-C. 1 hit.
Gene3Di3.10.450.50. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
IPR030217. NXF_fam.
IPR005637. TAP_C_dom.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR10662. PTHR10662. 1 hit.
PfamiPF03943. TAP_C. 1 hit.
[Graphical view]
SMARTiSM00804. TAP_C. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF54427. SSF54427. 1 hit.
PROSITEiPS51450. LRR. 2 hits.
PS50177. NTF2_DOMAIN. 1 hit.
PS51281. TAP_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y8G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRKRERRN AVKENEMVID TPLEKRRTPG KPRATREPPI SVVITGHSKG
60 70 80 90 100
SEDDLISFVW RKVKVRLMNI SYSPASVTAV VKSQDFSRLN GLNGAAFAGD
110 120 130 140 150
HLAIRRVDGA SNVTQDYRKA KTKRSFRSVS APSLSALATQ AQRNVSKTLP
160 170 180 190 200
QSTNETIEKL RQFLQTRYQP ATKFLDLGNL QQDPLLKQMG ILAEASTKSK
210 220 230 240 250
MFPALMKVAS LNFPDVISVS LSDNNLQSVT AVTTLAQTWP KLLNLSLANN
260 270 280 290 300
RITSLSDLDP WSPKTKLPEL QELVLVGNPI VTTFANRAMD YQREMVSRFP
310 320 330 340 350
KLRLLDGNSI NSEIIASQST VPFPVYQSFF DKVETEQIVN SFLAAFFKGW
360 370 380 390 400
DENRSALVNQ LYSPNATFSI SLNASNVRTN FSQKTDTKKW GAYKMKSRNL
410 420 430 440 450
LYSQSQKESK SRLFNGHEEI SNAVKSLPAT AHDLSDRSQW VFDGWNLVLP
460 470 480 490 500
SVGAAIKIVV HGQFEEPQNK RLLRSFDRTL LILPGGSTGI LIINDLLVIR
510 520 530 540 550
SFAGSLGWLP GQSSVRTSNN AMSASASKPS DIVQPRPEQA MLDTRQQIVL
560 570 580 590
KIKAETGLND YYAHMCCEQN NWDYNSALAS FLELKSRNVI PAEAFS
Length:596
Mass (Da):66,535
Last modified:November 1, 1999 - v1
Checksum:iB84345BBC0DC3D83
GO

Sequence cautioni

The sequence BAA87120 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055036 Genomic DNA. Translation: AAD43831.1.
CU329671 Genomic DNA. Translation: CAB58969.1.
AB027816 Genomic DNA. Translation: BAA87120.1. Different initiation.
PIRiT43683.
RefSeqiNP_595996.1. NM_001021904.2.

Genome annotation databases

EnsemblFungiiSPBC1921.03c.1; SPBC1921.03c.1:pep; SPBC1921.03c.
GeneIDi2540727.
KEGGispo:SPBC1921.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055036 Genomic DNA. Translation: AAD43831.1.
CU329671 Genomic DNA. Translation: CAB58969.1.
AB027816 Genomic DNA. Translation: BAA87120.1. Different initiation.
PIRiT43683.
RefSeqiNP_595996.1. NM_001021904.2.

3D structure databases

ProteinModelPortaliQ9Y8G3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277250. 72 interactions.
MINTiMINT-4721496.

PTM databases

iPTMnetiQ9Y8G3.

Proteomic databases

MaxQBiQ9Y8G3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1921.03c.1; SPBC1921.03c.1:pep; SPBC1921.03c.
GeneIDi2540727.
KEGGispo:SPBC1921.03c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1921.03c.
PomBaseiSPBC1921.03c. mex67.

Phylogenomic databases

InParanoidiQ9Y8G3.
KOiK14284.
OMAiTKGNVML.
OrthoDBiEOG092C3PB8.
PhylomeDBiQ9Y8G3.

Miscellaneous databases

PROiQ9Y8G3.

Family and domain databases

CDDicd14342. UBA_TAP-C. 1 hit.
Gene3Di3.10.450.50. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
IPR030217. NXF_fam.
IPR005637. TAP_C_dom.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR10662. PTHR10662. 1 hit.
PfamiPF03943. TAP_C. 1 hit.
[Graphical view]
SMARTiSM00804. TAP_C. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF54427. SSF54427. 1 hit.
PROSITEiPS51450. LRR. 2 hits.
PS50177. NTF2_DOMAIN. 1 hit.
PS51281. TAP_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMEX67_SCHPO
AccessioniPrimary (citable) accession number: Q9Y8G3
Secondary accession number(s): Q9UU47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.