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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds 1 copper ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471CopperBy similarity
Metal bindingi49 – 491CopperBy similarity
Metal bindingi64 – 641CopperBy similarity
Metal bindingi64 – 641ZincBy similarity
Metal bindingi72 – 721ZincBy similarity
Metal bindingi81 – 811ZincBy similarity
Metal bindingi84 – 841ZincBy similarity
Metal bindingi121 – 1211CopperBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi1.15.1.1. 508.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Gene namesi
Name:sodC
ORF Names:AFUA_5G09240
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiFungiDB:Afu5g09240.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • intracellular Source: ASPGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 154153Superoxide dismutase [Cu-Zn]PRO_0000164108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 147By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9Y8D9.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9Y8D9.
SMRiQ9Y8D9. Positions 2-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Phylogenomic databases

HOGENOMiHOG000263447.
InParanoidiQ9Y8D9.
KOiK04565.
OrthoDBiEOG092C578I.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y8D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKAVAVLRG DSKITGTVTF EQADENSPTT VSWNIKGNDP NAKRGFHVHQ
60 70 80 90 100
FGDNTNGCTS AGPHFNPYGK THGAPEDSER HVGDLGNFET DAEGNAVGSK
110 120 130 140 150
QDKLIKLIGA ESVLGRTLVV HAGTDDLGRG GNEESKKTGN AGARPACGVI

GIAA
Length:154
Mass (Da):15,967
Last modified:January 23, 2007 - v3
Checksum:iFB2FC504140DDED6
GO

Sequence cautioni

The sequence EAL91677 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81Missing in AAL38991 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF128886 mRNA. Translation: AAD42060.1.
AF281057 Genomic DNA. Translation: AAL38991.1.
AAHF01000003 Genomic DNA. Translation: EAL91677.1. Sequence problems.
RefSeqiXP_753715.1. XM_748622.1.

Genome annotation databases

GeneIDi3511006.
KEGGiafm:AFUA_5G09240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF128886 mRNA. Translation: AAD42060.1.
AF281057 Genomic DNA. Translation: AAL38991.1.
AAHF01000003 Genomic DNA. Translation: EAL91677.1. Sequence problems.
RefSeqiXP_753715.1. XM_748622.1.

3D structure databases

ProteinModelPortaliQ9Y8D9.
SMRiQ9Y8D9. Positions 2-152.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9Y8D9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3511006.
KEGGiafm:AFUA_5G09240.

Organism-specific databases

EuPathDBiFungiDB:Afu5g09240.

Phylogenomic databases

HOGENOMiHOG000263447.
InParanoidiQ9Y8D9.
KOiK04565.
OrthoDBiEOG092C578I.

Enzyme and pathway databases

BRENDAi1.15.1.1. 508.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSODC_ASPFU
AccessioniPrimary (citable) accession number: Q9Y8D9
Secondary accession number(s): Q4WUP9, Q8X1S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.