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Q9Y8D9

- SODC_ASPFU

UniProt

Q9Y8D9 - SODC_ASPFU

Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 copper ion per subunit.By similarity
    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi47 – 471CopperBy similarity
    Metal bindingi49 – 491CopperBy similarity
    Metal bindingi64 – 641CopperBy similarity
    Metal bindingi64 – 641ZincBy similarity
    Metal bindingi72 – 721ZincBy similarity
    Metal bindingi81 – 811ZincBy similarity
    Metal bindingi84 – 841ZincBy similarity
    Metal bindingi121 – 1211CopperBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. superoxide dismutase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Antioxidant, Oxidoreductase

    Keywords - Ligandi

    Copper, Metal-binding, Zinc

    Enzyme and pathway databases

    BRENDAi1.15.1.1. 508.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
    Gene namesi
    Name:sodC
    ORF Names:AFUA_5G09240
    OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
    Taxonomic identifieri330879 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000002530: Chromosome 5

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. intracellular Source: ASPGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 154153Superoxide dismutase [Cu-Zn]PRO_0000164108Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi58 ↔ 147By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ9Y8D9.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi5085.CADAFUAP00006737.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y8D9.
    SMRiQ9Y8D9. Positions 2-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Cu-Zn superoxide dismutase family.Curated

    Phylogenomic databases

    eggNOGiCOG2032.
    HOGENOMiHOG000263447.
    KOiK04565.
    OrthoDBiEOG7HQNMC.

    Family and domain databases

    Gene3Di2.60.40.200. 1 hit.
    InterProiIPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view]
    PfamiPF00080. Sod_Cu. 1 hit.
    [Graphical view]
    PRINTSiPR00068. CUZNDISMTASE.
    SUPFAMiSSF49329. SSF49329. 1 hit.
    PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y8D9-1 [UniParc]FASTAAdd to Basket

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    MVKAVAVLRG DSKITGTVTF EQADENSPTT VSWNIKGNDP NAKRGFHVHQ    50
    FGDNTNGCTS AGPHFNPYGK THGAPEDSER HVGDLGNFET DAEGNAVGSK 100
    QDKLIKLIGA ESVLGRTLVV HAGTDDLGRG GNEESKKTGN AGARPACGVI 150
    GIAA 154
    Length:154
    Mass (Da):15,967
    Last modified:January 23, 2007 - v3
    Checksum:iFB2FC504140DDED6
    GO

    Sequence cautioni

    The sequence EAL91677.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81Missing in AAL38991. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF128886 mRNA. Translation: AAD42060.1.
    AF281057 Genomic DNA. Translation: AAL38991.1.
    AAHF01000003 Genomic DNA. Translation: EAL91677.1. Sequence problems.
    RefSeqiXP_753715.1. XM_748622.1.

    Genome annotation databases

    GeneIDi3511006.
    KEGGiafm:AFUA_5G09240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF128886 mRNA. Translation: AAD42060.1 .
    AF281057 Genomic DNA. Translation: AAL38991.1 .
    AAHF01000003 Genomic DNA. Translation: EAL91677.1 . Sequence problems.
    RefSeqi XP_753715.1. XM_748622.1.

    3D structure databases

    ProteinModelPortali Q9Y8D9.
    SMRi Q9Y8D9. Positions 2-152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5085.CADAFUAP00006737.

    Proteomic databases

    PRIDEi Q9Y8D9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3511006.
    KEGGi afm:AFUA_5G09240.

    Phylogenomic databases

    eggNOGi COG2032.
    HOGENOMi HOG000263447.
    KOi K04565.
    OrthoDBi EOG7HQNMC.

    Enzyme and pathway databases

    BRENDAi 1.15.1.1. 508.

    Family and domain databases

    Gene3Di 2.60.40.200. 1 hit.
    InterProi IPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view ]
    Pfami PF00080. Sod_Cu. 1 hit.
    [Graphical view ]
    PRINTSi PR00068. CUZNDISMTASE.
    SUPFAMi SSF49329. SSF49329. 1 hit.
    PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Production and characterization of recombinant Aspergillus fumigatus Cu,Zn superoxide dismutase and its recognition by immune human sera."
      Holdom M.D., Lechenne B., Hay R.J., Hamilton A.J., Monod M.
      J. Clin. Microbiol. 38:558-562(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Homogeneity in 3-dimensional structure of Cu,Zn superoxide dismutases of Aspergillus fumigatus, Aspergillus flavus and Aspergillus nidulans."
      Holdom M.D., Hobby P., Lechenne B., Zaugg C., Sutton B., Monod M., Hamilton A.J.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
      Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
      , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
      Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

    Entry informationi

    Entry nameiSODC_ASPFU
    AccessioniPrimary (citable) accession number: Q9Y8D9
    Secondary accession number(s): Q4WUP9, Q8X1S8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 98 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3