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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds 1 copper ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47CopperBy similarity1
Metal bindingi49CopperBy similarity1
Metal bindingi64CopperBy similarity1
Metal bindingi64ZincBy similarity1
Metal bindingi72ZincBy similarity1
Metal bindingi81ZincBy similarity1
Metal bindingi84ZincBy similarity1
Metal bindingi121CopperBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAntioxidant, Oxidoreductase
LigandCopper, Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi1.15.1.1 508

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Gene namesi
Name:sodC
ORF Names:AFUA_5G09240
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu5g09240

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001641082 – 154Superoxide dismutase [Cu-Zn]Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 147By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9Y8D9

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUBP00005560

Structurei

3D structure databases

ProteinModelPortaliQ9Y8D9
SMRiQ9Y8D9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Phylogenomic databases

HOGENOMiHOG000263447
InParanoidiQ9Y8D9
KOiK04565
OrthoDBiEOG092C578I

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
PRINTSiPR00068 CUZNDISMTASE
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00087 SOD_CU_ZN_1, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y8D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKAVAVLRG DSKITGTVTF EQADENSPTT VSWNIKGNDP NAKRGFHVHQ
60 70 80 90 100
FGDNTNGCTS AGPHFNPYGK THGAPEDSER HVGDLGNFET DAEGNAVGSK
110 120 130 140 150
QDKLIKLIGA ESVLGRTLVV HAGTDDLGRG GNEESKKTGN AGARPACGVI

GIAA
Length:154
Mass (Da):15,967
Last modified:January 23, 2007 - v3
Checksum:iFB2FC504140DDED6
GO

Sequence cautioni

The sequence EAL91677 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8Missing in AAL38991 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF128886 mRNA Translation: AAD42060.1
AF281057 Genomic DNA Translation: AAL38991.1
AAHF01000003 Genomic DNA Translation: EAL91677.1 Sequence problems.
RefSeqiXP_753715.1, XM_748622.1

Genome annotation databases

GeneIDi3511006
KEGGiafm:AFUA_5G09240

Similar proteinsi

Entry informationi

Entry nameiSODC_ASPFU
AccessioniPrimary (citable) accession number: Q9Y8D9
Secondary accession number(s): Q4WUP9, Q8X1S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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