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Q9Y8D9

- SODC_ASPFU

UniProt

Q9Y8D9 - SODC_ASPFU

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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Binds 1 copper ion per subunit.By similarity
Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471CopperBy similarity
Metal bindingi49 – 491CopperBy similarity
Metal bindingi64 – 641CopperBy similarity
Metal bindingi64 – 641ZincBy similarity
Metal bindingi72 – 721ZincBy similarity
Metal bindingi81 – 811ZincBy similarity
Metal bindingi84 – 841ZincBy similarity
Metal bindingi121 – 1211CopperBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi1.15.1.1. 508.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Gene namesi
Name:sodC
ORF Names:AFUA_5G09240
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 5

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. intracellular Source: ASPGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 154153Superoxide dismutase [Cu-Zn]PRO_0000164108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 147By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9Y8D9.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUAP00006737.

Structurei

3D structure databases

ProteinModelPortaliQ9Y8D9.
SMRiQ9Y8D9. Positions 2-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263447.
InParanoidiQ9Y8D9.
KOiK04565.
OrthoDBiEOG7HQNMC.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y8D9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKAVAVLRG DSKITGTVTF EQADENSPTT VSWNIKGNDP NAKRGFHVHQ
60 70 80 90 100
FGDNTNGCTS AGPHFNPYGK THGAPEDSER HVGDLGNFET DAEGNAVGSK
110 120 130 140 150
QDKLIKLIGA ESVLGRTLVV HAGTDDLGRG GNEESKKTGN AGARPACGVI

GIAA
Length:154
Mass (Da):15,967
Last modified:January 23, 2007 - v3
Checksum:iFB2FC504140DDED6
GO

Sequence cautioni

The sequence EAL91677.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81Missing in AAL38991. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF128886 mRNA. Translation: AAD42060.1.
AF281057 Genomic DNA. Translation: AAL38991.1.
AAHF01000003 Genomic DNA. Translation: EAL91677.1. Sequence problems.
RefSeqiXP_753715.1. XM_748622.1.

Genome annotation databases

GeneIDi3511006.
KEGGiafm:AFUA_5G09240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF128886 mRNA. Translation: AAD42060.1 .
AF281057 Genomic DNA. Translation: AAL38991.1 .
AAHF01000003 Genomic DNA. Translation: EAL91677.1 . Sequence problems.
RefSeqi XP_753715.1. XM_748622.1.

3D structure databases

ProteinModelPortali Q9Y8D9.
SMRi Q9Y8D9. Positions 2-152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00006737.

Proteomic databases

PRIDEi Q9Y8D9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3511006.
KEGGi afm:AFUA_5G09240.

Phylogenomic databases

eggNOGi COG2032.
HOGENOMi HOG000263447.
InParanoidi Q9Y8D9.
KOi K04565.
OrthoDBi EOG7HQNMC.

Enzyme and pathway databases

BRENDAi 1.15.1.1. 508.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
PRINTSi PR00068. CUZNDISMTASE.
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Production and characterization of recombinant Aspergillus fumigatus Cu,Zn superoxide dismutase and its recognition by immune human sera."
    Holdom M.D., Lechenne B., Hay R.J., Hamilton A.J., Monod M.
    J. Clin. Microbiol. 38:558-562(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Homogeneity in 3-dimensional structure of Cu,Zn superoxide dismutases of Aspergillus fumigatus, Aspergillus flavus and Aspergillus nidulans."
    Holdom M.D., Hobby P., Lechenne B., Zaugg C., Sutton B., Monod M., Hamilton A.J.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiSODC_ASPFU
AccessioniPrimary (citable) accession number: Q9Y8D9
Secondary accession number(s): Q4WUP9, Q8X1S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3