Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9Y884 (SKH1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MAP kinase kinase skh1/pek1
EC=2.7.12.2
Gene names
Name:skh1
Synonyms:mkk1, pek1
ORF Names:SPBC543.07
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the mkh1 signal transduction pathway that plays a role in cell wall integrity. Activates spm1/pmk1 via phosphorylation. Ref.1 Ref.2

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Activated by mkh1.

Sequence similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363MAP kinase kinase skh1/pek1
PRO_0000086655

Regions

Domain79 – 343265Protein kinase
Nucleotide binding85 – 939ATP By similarity

Sites

Active site2061Proton acceptor By similarity
Binding site1081ATP By similarity

Amino acid modifications

Modified residue2341Phosphoserine By similarity
Modified residue2381Phosphothreonine By similarity

Experimental info

Sequence conflict1111L → K in BAA82312. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9Y884 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 141EA6B8C1D036DC

FASTA36340,707
        10         20         30         40         50         60 
MSKKPVLNLD TSNGFSEEYI SHPERNDNQG IVEITDLVFS SESKLTQRKE SRDSKTFVPS 

        70         80         90        100        110        120 
FLEELDDDHL HELVTNGGIL YMNSLGEGVS GSVRKCRIRG TQMIFAMKTV LAAPNTALQK 

       130        140        150        160        170        180 
QLLRELKINR SCTSPYIVKY YGACYNNAEC QLNIAMEYCG AGSLDAIYKR VRSQGGRTGE 

       190        200        210        220        230        240 
RPLGKIAFGV LSGLSYLHDR KIIHRDIKPS NILLTSKGQV KLCDFGVSGE LVNSLAGTFT 

       250        260        270        280        290        300 
GTSYYMAPER ISGGSYTISS DIWSLGLTLM EVALNRFPFP PEGSPPPMPI ELLSYIINMP 

       310        320        330        340        350        360 
PPLLPQEPGI KWSKSFQHFL CVCLDKDKTR RPGPQKMLTH PWVKAFERIH VDMEEFLRQV 


WSD

« Hide

References

« Hide 'large scale' references
[1]"Skh1, the MAPKK component of the mkh1 signaling pathway in Schizosaccharomyces pombe."
Loewith R., Hubberstey A., Young D.
J. Cell Sci. 113:153-160(2000) [PubMed: 10591634] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]"The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch."
Sugiura R., Toda T., Susheela D., Shuntoh H., Kuno T.
Nature 399:479-483(1999) [PubMed: 10365961] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[3]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF157632 Genomic DNA. Translation: AAD41399.1.
D82023 Genomic DNA. Translation: BAA82312.1.
CU329671 Genomic DNA. Translation: CAC05249.1.
PIRT51294.
T51992.
RefSeqNP_596795.1. NM_001023815.1.

3D structure databases

ProteinModelPortalQ9Y884.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9Y884.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC543.07.1; SPBC543.07.1:pep; SPBC543.07.
GeneID2540919.
GenomeReviewsGene locus skh1 in contig CU329671_GR.
KEGGspo:SPBC543.07.
NMPDRfig|4896.1.peg.2661.

Organism-specific databases

GeneDB_SpombeSPBC543.07.

Phylogenomic databases

eggNOGfuNOG04753.
GeneTreeEFGT00050000000597.
HOGENOMHBG755340.
OMAINADPNP.
OrthoDBEOG4D29ZP.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-004776-MONOMER.
BRENDA2.7.12.2. 5615.

Gene expression databases

ArrayExpressQ9Y884.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_kinase-like_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR002290. Ser/Thr_kinase_dom.
[Graphical view]
KOK08294.
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSKH1_SCHPO
AccessionPrimary (citable) accession number: Q9Y884
Secondary accession number(s): Q9UUK6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1999
Last modified: December 14, 2011
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents