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Protein

Ubiquitin-conjugating enzyme E2 15

Gene

ubc15

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Has a role in the formation of chromatin structures that influence the localization of transcriptional silencing factors.PROSITE-ProRule annotation1 Publication

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei90Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • negative regulation of chromatin silencing at silent mating-type cassette Source: PomBase
  • negative regulation of chromatin silencing at telomere Source: PomBase
  • protein polyubiquitination Source: GO_Central
  • ubiquitin-dependent protein catabolic process Source: GO_Central

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 15 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 15
Ubiquitin carrier protein 15
Ubiquitin-protein ligase 15
Gene namesi
Name:ubc15
ORF Names:SPBC1105.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1105.09.
PomBaseiSPBC1105.09. ubc15.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825891 – 167Ubiquitin-conjugating enzyme E2 15Add BLAST167

Proteomic databases

MaxQBiQ9Y818.
PRIDEiQ9Y818.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276539. 32 interactors.
STRINGi4896.SPBC1105.09.1.

Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 17Combined sources13
Beta strandi25 – 31Combined sources7
Beta strandi34 – 43Combined sources10
Turni49 – 52Combined sources4
Beta strandi54 – 60Combined sources7
Turni63 – 66Combined sources4
Beta strandi71 – 74Combined sources4
Beta strandi87 – 89Combined sources3
Helixi92 – 94Combined sources3
Beta strandi101 – 105Combined sources5
Helixi117 – 129Combined sources13
Helixi139 – 147Combined sources9
Helixi149 – 167Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KNLX-ray2.50C/F1-167[»]
ProteinModelPortaliQ9Y818.
SMRiQ9Y818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233454.
InParanoidiQ9Y818.
KOiK10575.
OMAiFITPMWH.
OrthoDBiEOG092C50OL.
PhylomeDBiQ9Y818.

Family and domain databases

CDDicd00195. UBCc. 1 hit.
Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSASEQLL RKQLKEIQKN PPQGFSVGLV DDKSIFEWEV MIIGPEDTLY
60 70 80 90 100
EGGFFHATLS FPQDYPLMPP KMKFTTEIWH PNVHPNGEVC ISILHPPGDD
110 120 130 140 150
KYGYEDAGER WLPVHSPETI LISVISMLSS PNDESPANID AAKEFRENPQ
160
EFKKRVRRLV RRSIEMI
Length:167
Mass (Da):19,106
Last modified:November 1, 1999 - v1
Checksum:i2289FD04069E1707
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB50972.1.
PIRiT39286.
RefSeqiNP_596465.1. NM_001022384.2.

Genome annotation databases

EnsemblFungiiSPBC1105.09.1; SPBC1105.09.1:pep; SPBC1105.09.
GeneIDi2539995.
KEGGispo:SPBC1105.09.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUBC15_SCHPO
AccessioniPrimary (citable) accession number: Q9Y818
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: November 1, 1999
Last modified: July 5, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  4. SIMILARITY comments
    Index of protein domains and families