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Protein

Histone H3-like centromeric protein cnp1

Gene

cnp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.1 Publication

GO - Molecular functioni

GO - Biological processi

  • CENP-A containing chromatin organization Source: PomBase
  • kinetochore assembly Source: GO_Central
  • mitotic sister chromatid biorientation Source: PomBase
  • mitotic sister chromatid segregation Source: GO_Central
  • nucleosome assembly Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H3-like centromeric protein cnp1
Short name:
Centromere protein 1
Alternative name(s):
CENP-A homolog
Silencing in the middle of the centromere protein 2
Gene namesi
Name:cnp1
Synonyms:sim2
ORF Names:SPBC1105.17
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1105.17.
PomBaseiSPBC1105.17. cnp1.

Subcellular locationi

  • Nucleus 1 Publication
  • Chromosomecentromerekinetochore 1 Publication

  • Note: Localizes exclusively in the kinetochore domain of centromeres.

GO - Cellular componenti

  • CENP-A containing nucleosome Source: PomBase
  • chromosome, centromeric core domain Source: PomBase
  • chromosome, centromeric region Source: PomBase
  • condensed chromosome kinetochore Source: UniProtKB-SubCell
  • condensed nuclear chromosome, centromeric region Source: PomBase
  • kinetochore Source: GO_Central
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002213751 – 120Histone H3-like centromeric protein cnp1Add BLAST120

Post-translational modificationi

Ubiquitinated. Is degraded through ubiquitin mediated proteolysis when not protected by its association to the kinetochore. This may ensure exclusive localization of cnp1 to the kinetochore.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ9Y812.

Interactioni

Subunit structurei

Component of the core kinetochore. Interacts with mis6 and sim4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
mis12Q9Y7383EBI-1153281,EBI-1002822

Protein-protein interaction databases

BioGridi276213. 35 interactors.
IntActiQ9Y812. 6 interactors.
MINTiMINT-4720855.

Structurei

3D structure databases

ProteinModelPortaliQ9Y812.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 120H3-likeAdd BLAST107

Sequence similaritiesi

Belongs to the histone H3 family.Curated

Phylogenomic databases

HOGENOMiHOG000155290.
InParanoidiQ9Y812.
KOiK11495.
OMAiGEAMRWQ.
OrthoDBiEOG092C5B6S.
PhylomeDBiQ9Y812.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000164. Histone_H3/CENP-A.
[Graphical view]
PANTHERiPTHR11426. PTHR11426. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00622. HISTONEH3.
SMARTiSM00428. H3. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKSLMAEP GDPIPRPRKK RYRPGTTALR EIRKYQRSTD LLIQRLPFSR
60 70 80 90 100
IVREISSEFV ANFSTDVGLR WQSTALQCLQ EAAEAFLVHL FEDTNLCAIH
110 120
AKRVTIMQRD MQLARRIRGA
Length:120
Mass (Da):13,884
Last modified:November 1, 1999 - v1
Checksum:iD013696368AE4601
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041724 Genomic DNA. Translation: BAA94760.1.
CU329671 Genomic DNA. Translation: CAB50980.1.
PIRiT39294.
RefSeqiNP_596473.1. NM_001022392.2.

Genome annotation databases

EnsemblFungiiSPBC1105.17.1; SPBC1105.17.1:pep; SPBC1105.17.
GeneIDi2539658.
KEGGispo:SPBC1105.17.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041724 Genomic DNA. Translation: BAA94760.1.
CU329671 Genomic DNA. Translation: CAB50980.1.
PIRiT39294.
RefSeqiNP_596473.1. NM_001022392.2.

3D structure databases

ProteinModelPortaliQ9Y812.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276213. 35 interactors.
IntActiQ9Y812. 6 interactors.
MINTiMINT-4720855.

Proteomic databases

PRIDEiQ9Y812.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1105.17.1; SPBC1105.17.1:pep; SPBC1105.17.
GeneIDi2539658.
KEGGispo:SPBC1105.17.

Organism-specific databases

EuPathDBiFungiDB:SPBC1105.17.
PomBaseiSPBC1105.17. cnp1.

Phylogenomic databases

HOGENOMiHOG000155290.
InParanoidiQ9Y812.
KOiK11495.
OMAiGEAMRWQ.
OrthoDBiEOG092C5B6S.
PhylomeDBiQ9Y812.

Miscellaneous databases

PROiQ9Y812.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000164. Histone_H3/CENP-A.
[Graphical view]
PANTHERiPTHR11426. PTHR11426. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00622. HISTONEH3.
SMARTiSM00428. H3. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCENPA_SCHPO
AccessioniPrimary (citable) accession number: Q9Y812
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.