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Q9Y7Y5

- RT109_SCHPO

UniProt

Q9Y7Y5 - RT109_SCHPO

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Protein

Histone acetyltransferase rtt109

Gene
rtt109, kat11, SPBC342.06c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Required for acetylation of 'Lys-56' of histone H3 (H3K56ac), which occurs predominantly in newly synthesized H3 molecule during G1, S-phase and G2/M of cell cycle. Histone H3 'Lys-56' acetylation is required for S-phase-linked DNA damage tolerance and proper silencing in pericentromeric heterochromatin.2 Publications

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. histone acetyltransferase activity (H3-K56 specific) Source: PomBase

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: PomBase
  2. chromatin silencing at centromere Source: PomBase
  3. histone H3-K56 acetylation Source: PomBase
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

DNA damage, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase rtt109 (EC:2.3.1.48)
Gene namesi
Name:rtt109
Synonyms:kat11
ORF Names:SPBC342.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC342.06c.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Histone acetyltransferase rtt109PRO_0000353836Add
BLAST

Proteomic databases

MaxQBiQ9Y7Y5.

Interactioni

Protein-protein interaction databases

BioGridi277461. 63 interactions.
MINTiMINT-4720082.
STRINGi4896.SPBC342.06c-1.

Family & Domainsi

Sequence similaritiesi

Belongs to the RTT109 family.

Phylogenomic databases

eggNOGiCOG5087.
KOiK11309.
OMAiPANGLES.
OrthoDBiEOG79PJZ1.
PhylomeDBiQ9Y7Y5.

Family and domain databases

InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
[Graphical view]
PfamiPF08214. KAT11. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y7Y5-1 [UniParc]FASTAAdd to Basket

« Hide

MPDLWSESIL EGRKLSIYHL KSTLEKCPFL FGQSKKSKDF QFGSHLFLVE    50
EQNVFIFGME CIVYEKNKEF IVFVSKADST GFGSKGVSCN SLAFCCLVTL 100
IDGLRKQGAE NVTLTLFAIA QGQYLFPESV DNGQKHVLND SGLLRWWVNC 150
LEKLRKYYTD SEAPNDSEKQ KNSTLLPKAY LFVPGLENIR SYLPNRHWIE 200
SNAITTGKAV EELPRFPDDP KCRYLCELQD EKSDMSVEEF WDTLTYRQEC 250
SSGKLVGFFT LQLQFYQTRE FIAKDNFGDS GVMIPAKLYR VTYDTLLKHP 300
FGSLSDAQSS TEKFLSNTLS AVQNLKDFHY KRYKLDICGL AKRDDRKNHN 350
HSKPATQANI LQPRKKVKK 369
Length:369
Mass (Da):42,373
Last modified:November 1, 1999 - v1
Checksum:i4031DC6370CDF54B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB46776.1.
PIRiT40279.
RefSeqiNP_596749.1. NM_001023769.2.

Genome annotation databases

EnsemblFungiiSPBC342.06c.1; SPBC342.06c.1:pep; SPBC342.06c.
GeneIDi2540945.
KEGGispo:SPBC342.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB46776.1 .
PIRi T40279.
RefSeqi NP_596749.1. NM_001023769.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277461. 63 interactions.
MINTi MINT-4720082.
STRINGi 4896.SPBC342.06c-1.

Proteomic databases

MaxQBi Q9Y7Y5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC342.06c.1 ; SPBC342.06c.1:pep ; SPBC342.06c .
GeneIDi 2540945.
KEGGi spo:SPBC342.06c.

Organism-specific databases

PomBasei SPBC342.06c.

Phylogenomic databases

eggNOGi COG5087.
KOi K11309.
OMAi PANGLES.
OrthoDBi EOG79PJZ1.
PhylomeDBi Q9Y7Y5.

Miscellaneous databases

NextBioi 20802060.

Family and domain databases

InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
[Graphical view ]
Pfami PF08214. KAT11. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. Cited for: FUNCTION.
  4. "Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity."
    Han J., Zhou H., Li Z., Xu R.-M., Zhang Z.
    J. Biol. Chem. 282:28587-28596(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiRT109_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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