Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y7Y5

- RT109_SCHPO

UniProt

Q9Y7Y5 - RT109_SCHPO

Protein

Histone acetyltransferase rtt109

Gene

rtt109

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for acetylation of 'Lys-56' of histone H3 (H3K56ac), which occurs predominantly in newly synthesized H3 molecule during G1, S-phase and G2/M of cell cycle. Histone H3 'Lys-56' acetylation is required for S-phase-linked DNA damage tolerance and proper silencing in pericentromeric heterochromatin.2 Publications

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. histone acetyltransferase activity (H3-K56 specific) Source: PomBase

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: PomBase
    2. chromatin silencing at centromere Source: PomBase
    3. histone H3-K56 acetylation Source: PomBase
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    DNA damage, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase rtt109 (EC:2.3.1.48)
    Gene namesi
    Name:rtt109
    Synonyms:kat11
    ORF Names:SPBC342.06c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC342.06c.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: PomBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Histone acetyltransferase rtt109PRO_0000353836Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y7Y5.

    Interactioni

    Protein-protein interaction databases

    BioGridi277461. 63 interactions.
    MINTiMINT-4720082.
    STRINGi4896.SPBC342.06c-1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RTT109 family.Curated

    Phylogenomic databases

    eggNOGiCOG5087.
    KOiK11309.
    OMAiPANGLES.
    OrthoDBiEOG79PJZ1.
    PhylomeDBiQ9Y7Y5.

    Family and domain databases

    InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
    [Graphical view]
    PfamiPF08214. KAT11. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y7Y5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDLWSESIL EGRKLSIYHL KSTLEKCPFL FGQSKKSKDF QFGSHLFLVE    50
    EQNVFIFGME CIVYEKNKEF IVFVSKADST GFGSKGVSCN SLAFCCLVTL 100
    IDGLRKQGAE NVTLTLFAIA QGQYLFPESV DNGQKHVLND SGLLRWWVNC 150
    LEKLRKYYTD SEAPNDSEKQ KNSTLLPKAY LFVPGLENIR SYLPNRHWIE 200
    SNAITTGKAV EELPRFPDDP KCRYLCELQD EKSDMSVEEF WDTLTYRQEC 250
    SSGKLVGFFT LQLQFYQTRE FIAKDNFGDS GVMIPAKLYR VTYDTLLKHP 300
    FGSLSDAQSS TEKFLSNTLS AVQNLKDFHY KRYKLDICGL AKRDDRKNHN 350
    HSKPATQANI LQPRKKVKK 369
    Length:369
    Mass (Da):42,373
    Last modified:November 1, 1999 - v1
    Checksum:i4031DC6370CDF54B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB46776.1.
    PIRiT40279.
    RefSeqiNP_596749.1. NM_001023769.2.

    Genome annotation databases

    EnsemblFungiiSPBC342.06c.1; SPBC342.06c.1:pep; SPBC342.06c.
    GeneIDi2540945.
    KEGGispo:SPBC342.06c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB46776.1 .
    PIRi T40279.
    RefSeqi NP_596749.1. NM_001023769.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277461. 63 interactions.
    MINTi MINT-4720082.
    STRINGi 4896.SPBC342.06c-1.

    Proteomic databases

    MaxQBi Q9Y7Y5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC342.06c.1 ; SPBC342.06c.1:pep ; SPBC342.06c .
    GeneIDi 2540945.
    KEGGi spo:SPBC342.06c.

    Organism-specific databases

    PomBasei SPBC342.06c.

    Phylogenomic databases

    eggNOGi COG5087.
    KOi K11309.
    OMAi PANGLES.
    OrthoDBi EOG79PJZ1.
    PhylomeDBi Q9Y7Y5.

    Miscellaneous databases

    NextBioi 20802060.

    Family and domain databases

    InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
    [Graphical view ]
    Pfami PF08214. KAT11. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    3. Cited for: FUNCTION.
    4. "Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity."
      Han J., Zhou H., Li Z., Xu R.-M., Zhang Z.
      J. Biol. Chem. 282:28587-28596(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiRT109_SCHPO
    AccessioniPrimary (citable) accession number: Q9Y7Y5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 4, 2008
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3