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Q9Y7Y5 (RT109_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase rtt109

EC=2.3.1.48
Gene names
Name:rtt109
Synonyms:kat11
ORF Names:SPBC342.06c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for acetylation of 'Lys-56' of histone H3 (H3K56ac), which occurs predominantly in newly synthesized H3 molecule during G1, S-phase and G2/M of cell cycle. Histone H3 'Lys-56' acetylation is required for S-phase-linked DNA damage tolerance and proper silencing in pericentromeric heterochromatin. Ref.3 Ref.4

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subcellular location

Nucleus Ref.2.

Sequence similarities

Belongs to the RTT109 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Histone acetyltransferase rtt109
PRO_0000353836

Sequences

Sequence LengthMass (Da)Tools
Q9Y7Y5 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 4031DC6370CDF54B

FASTA36942,373
        10         20         30         40         50         60 
MPDLWSESIL EGRKLSIYHL KSTLEKCPFL FGQSKKSKDF QFGSHLFLVE EQNVFIFGME 

        70         80         90        100        110        120 
CIVYEKNKEF IVFVSKADST GFGSKGVSCN SLAFCCLVTL IDGLRKQGAE NVTLTLFAIA 

       130        140        150        160        170        180 
QGQYLFPESV DNGQKHVLND SGLLRWWVNC LEKLRKYYTD SEAPNDSEKQ KNSTLLPKAY 

       190        200        210        220        230        240 
LFVPGLENIR SYLPNRHWIE SNAITTGKAV EELPRFPDDP KCRYLCELQD EKSDMSVEEF 

       250        260        270        280        290        300 
WDTLTYRQEC SSGKLVGFFT LQLQFYQTRE FIAKDNFGDS GVMIPAKLYR VTYDTLLKHP 

       310        320        330        340        350        360 
FGSLSDAQSS TEKFLSNTLS AVQNLKDFHY KRYKLDICGL AKRDDRKNHN HSKPATQANI 


LQPRKKVKK 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[3]"Regulation of histone H3 lysine 56 acetylation in Schizosaccharomyces pombe."
Xhemalce B., Miller K.M., Driscoll R., Masumoto H., Jackson S.P., Kouzarides T., Verreault A., Arcangioli B.
J. Biol. Chem. 282:15040-15047(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity."
Han J., Zhou H., Li Z., Xu R.-M., Zhang Z.
J. Biol. Chem. 282:28587-28596(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329671 Genomic DNA. Translation: CAB46776.1.
PIRT40279.
RefSeqNP_596749.1. NM_001023769.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid277461. 63 interactions.
MINTMINT-4720082.
STRING4896.SPBC342.06c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC342.06c.1; SPBC342.06c.1:pep; SPBC342.06c.
GeneID2540945.
KEGGspo:SPBC342.06c.

Organism-specific databases

PomBaseSPBC342.06c.

Phylogenomic databases

eggNOGCOG5087.
KOK11309.
OMAPANGLES.
OrthoDBEOG79PJZ1.
PhylomeDBQ9Y7Y5.

Family and domain databases

InterProIPR013178. Histone_H3-K56_AcTrfase_RTT109.
[Graphical view]
PfamPF08214. KAT11. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802060.

Entry information

Entry nameRT109_SCHPO
AccessionPrimary (citable) accession number: Q9Y7Y5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names