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Protein

Histone acetyltransferase rtt109

Gene

rtt109

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Required for acetylation of 'Lys-56' of histone H3 (H3K56ac), which occurs predominantly in newly synthesized H3 molecule during G1, S-phase and G2/M of cell cycle. Histone H3 'Lys-56' acetylation is required for S-phase-linked DNA damage tolerance and proper silencing in pericentromeric heterochromatin.2 Publications

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  • histone acetyltransferase activity (H3-K56 specific) Source: PomBase

GO - Biological processi

  • cellular response to DNA damage stimulus Source: PomBase
  • chromatin silencing at centromere Source: PomBase
  • histone H3-K56 acetylation Source: PomBase
  • regulation of transcription from RNA polymerase II promoter in response to stress Source: InterPro
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

DNA damage, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase rtt109 (EC:2.3.1.48)
Gene namesi
Name:rtt109
Synonyms:kat11
ORF Names:SPBC342.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC342.06c.
PomBaseiSPBC342.06c.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Histone acetyltransferase rtt109PRO_0000353836Add
BLAST

Proteomic databases

MaxQBiQ9Y7Y5.

Interactioni

Protein-protein interaction databases

BioGridi277461. 65 interactions.
MINTiMINT-4720082.
STRINGi4896.SPBC342.06c-1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 346346Rtt109-type HATPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RTT109 family.Curated
Contains 1 Rtt109-type HAT (histone acetyltransferase) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5087.
InParanoidiQ9Y7Y5.
KOiK11309.
OMAiPANGLES.
OrthoDBiEOG79PJZ1.
PhylomeDBiQ9Y7Y5.

Family and domain databases

InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR016849. Rtt109.
[Graphical view]
PANTHERiPTHR31571:SF2. PTHR31571:SF2. 1 hit.
PfamiPF08214. KAT11. 1 hit.
[Graphical view]
PROSITEiPS51728. RTT109_HAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y7Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDLWSESIL EGRKLSIYHL KSTLEKCPFL FGQSKKSKDF QFGSHLFLVE
60 70 80 90 100
EQNVFIFGME CIVYEKNKEF IVFVSKADST GFGSKGVSCN SLAFCCLVTL
110 120 130 140 150
IDGLRKQGAE NVTLTLFAIA QGQYLFPESV DNGQKHVLND SGLLRWWVNC
160 170 180 190 200
LEKLRKYYTD SEAPNDSEKQ KNSTLLPKAY LFVPGLENIR SYLPNRHWIE
210 220 230 240 250
SNAITTGKAV EELPRFPDDP KCRYLCELQD EKSDMSVEEF WDTLTYRQEC
260 270 280 290 300
SSGKLVGFFT LQLQFYQTRE FIAKDNFGDS GVMIPAKLYR VTYDTLLKHP
310 320 330 340 350
FGSLSDAQSS TEKFLSNTLS AVQNLKDFHY KRYKLDICGL AKRDDRKNHN
360
HSKPATQANI LQPRKKVKK
Length:369
Mass (Da):42,373
Last modified:November 1, 1999 - v1
Checksum:i4031DC6370CDF54B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB46776.1.
PIRiT40279.
RefSeqiNP_596749.1. NM_001023769.2.

Genome annotation databases

EnsemblFungiiSPBC342.06c.1; SPBC342.06c.1:pep; SPBC342.06c.
GeneIDi2540945.
KEGGispo:SPBC342.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB46776.1.
PIRiT40279.
RefSeqiNP_596749.1. NM_001023769.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277461. 65 interactions.
MINTiMINT-4720082.
STRINGi4896.SPBC342.06c-1.

Proteomic databases

MaxQBiQ9Y7Y5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC342.06c.1; SPBC342.06c.1:pep; SPBC342.06c.
GeneIDi2540945.
KEGGispo:SPBC342.06c.

Organism-specific databases

EuPathDBiFungiDB:SPBC342.06c.
PomBaseiSPBC342.06c.

Phylogenomic databases

eggNOGiCOG5087.
InParanoidiQ9Y7Y5.
KOiK11309.
OMAiPANGLES.
OrthoDBiEOG79PJZ1.
PhylomeDBiQ9Y7Y5.

Miscellaneous databases

NextBioi20802060.
PROiQ9Y7Y5.

Family and domain databases

InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR016849. Rtt109.
[Graphical view]
PANTHERiPTHR31571:SF2. PTHR31571:SF2. 1 hit.
PfamiPF08214. KAT11. 1 hit.
[Graphical view]
PROSITEiPS51728. RTT109_HAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. Cited for: FUNCTION.
  4. "Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity."
    Han J., Zhou H., Li Z., Xu R.-M., Zhang Z.
    J. Biol. Chem. 282:28587-28596(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiRT109_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: November 1, 1999
Last modified: May 27, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.