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Q9Y7Y4 (COX10_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protoheme IX farnesyltransferase, mitochondrial
EC=2.5.1.-
Alternative name(s):
Heme O synthase
Gene names
Name:cox10
ORF Names:SPBC365.02c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts protoheme IX and farnesyl diphosphate to heme O By similarity.

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the UbiA prenyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 387Protoheme IX farnesyltransferase, mitochondrialPRO_0000045420

Regions

Transmembrane95 – 11521Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane212 – 23221Helical; Potential
Transmembrane242 – 26221Helical; Potential
Transmembrane284 – 30623Helical; Potential
Transmembrane311 – 33020Helical; Potential
Transmembrane345 – 36521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9Y7Y4 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 6DB054282CAC41BA

FASTA38743,130
        10         20         30         40         50         60 
MFHILNKGSS KSCIYTRPCL KRFYHQHYEH TGKLSRTFFS PTHIKYNRLS TLDTSTSTAN 

        70         80         90        100        110        120 
AAPDPQVLTF LSKRMQAAPL YPKPSAFLEL GKPRLTVLVV LSTMSSYALA PYPGLSFNTL 

       130        140        150        160        170        180 
AWLTMGTALC SISANAFNQS MEPMLDCQMA RTRSRPIPRG AIRPEYAWLF ATLTGIAGTS 

       190        200        210        220        230        240 
MSFLVNPTVG WLGLGNIVLY MGIYTPLKRI SIVNTWVGSL VGAIPPLMGW AACSGGDLLS 

       250        260        270        280        290        300 
HPGGLITAAM LFAWQFPHFN AFSTMVKDDY KKCGYQMMAW KNPALNARVS LRYALAFLPL 

       310        320        330        340        350        360 
SYAYISTGLV GPWYAVPATG TNMFLIARAW KFYRNRNYQN ARSLFFASLL HLPLLFTLTL 

       370        380 
ACHMIKVWND SDSKNPVLGS EEDTLKY

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329671 Genomic DNA. Translation: CAB44754.1.
PIRT40309.
RefSeqNP_596031.1. NM_001021941.2.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING4896.SPBC365.02c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC365.02c.1; SPBC365.02c.1:pep; SPBC365.02c.
GeneID2540944.
KEGGspo:SPBC365.02c.

Organism-specific databases

PomBaseSPBC365.02c.

Phylogenomic databases

eggNOGCOG0109.
KOK02257.
OMAVPFDSQM.
OrthoDBEOG42JS17.

Family and domain databases

InterProIPR006369. Protohaem_IX_farnesylTrfase.
IPR016315. Protohaem_IX_farnesylTrfase_mt.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamPF01040. UbiA. 1 hit.
[Graphical view]
PIRSFPIRSF001773. COX10. 1 hit.
TIGRFAMsTIGR01473. cyoE_ctaB. 1 hit.
PROSITEPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802059.

Entry information

Entry nameCOX10_SCHPO
AccessionPrimary (citable) accession number: Q9Y7Y4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 1, 1999
Last modified: May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents