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Q9Y7W4

- BUR1_CANAL

UniProt

Q9Y7W4 - BUR1_CANAL

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Protein

Serine/threonine-protein kinase BUR1

Gene

CRK1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice.By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei73 – 731ATPPROSITE-ProRule annotation
Active sitei179 – 1791Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 589ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. protein kinase activity Source: CGD
  4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular response to pH Source: CGD
  2. filamentous growth Source: CGD
  3. filamentous growth of a population of unicellular organisms Source: CGD
  4. filamentous growth of a population of unicellular organisms in response to pH Source: CGD
  5. flocculation Source: CGD
  6. negative regulation of filamentous growth of a population of unicellular organisms in response to pH Source: CGD
  7. negative regulation of flocculation Source: CGD
  8. pathogenesis Source: CGD
  9. positive regulation of filamentous growth of a population of unicellular organisms Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase BUR1 (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:CRK1
Synonyms:BUR1
ORF Names:CaO19.11006, CaO19.3523/3524
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0073553. CRK1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 746746Serine/threonine-protein kinase BUR1PRO_0000085679Add
BLAST

Proteomic databases

PRIDEiQ9Y7W4.

Interactioni

Protein-protein interaction databases

BioGridi1226507. 2 interactions.
IntActiQ9Y7W4. 2 interactions.
MINTiMINT-1173580.
STRINGi5476.CAL0005839.

Structurei

3D structure databases

ProteinModelPortaliQ9Y7W4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 349306Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ9Y7W4.
KOiK15562.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y7W4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVIAGHHVP RSNDQRQYDT PSVPINIAPD SEGHIHEMSR LKDYEVIEKL
60 70 80 90 100
GQGTFGVVQK AKSKKDGSLV AIKQLINHSA KEGFPITAMR EITILKQLNH
110 120 130 140 150
KNILTIQDMI FEEPKMSNRT DIITMRGSFY TVTPYMSSDL VGLLENPKIK
160 170 180 190 200
LELGQIKCIM QQLLKGIQYV HNQKFLHRDI KAANILIGQD GVLKIADFGL
210 220 230 240 250
ARIYHGNVPR LGMGPGGGEK AYTGLVVTRW YRPPEILLGE RKYTTAVDLW
260 270 280 290 300
GIGCVFAELF TGKPILVGKS DSHQAQIVFE LVGSPLTWTD AAKLPNKNEY
310 320 330 340 350
SCGLACKRSL EAKFASIMPT EAIDLLSGLL TLDPFKRLNA LDALNHKFFS
360 370 380 390 400
TDPLPLLPTQ MPKFEESHEI DKERFKKLKD KEQAVSELKP PTEIRYDNHS
410 420 430 440 450
ESRYNADHST FGGGGVGGKE TSFSSGKSDY IDHYEPRARR DHYEPRIRND
460 470 480 490 500
NKDSNDVRGE FESATRQEQR RRDIQNRLDA GGMDTYIPKT TTAKLREHSG
510 520 530 540 550
TESLSKKYDN YQPINVSRGS KSPSPSKLSS ISQSKADLIS KPSAPKVASR
560 570 580 590 600
ESSLERKQVS NGIRTTTDVE PPRARARRPT DMFGRPLTSN STQAQPTRNK
610 620 630 640 650
SVERPKDLEK PTNGVTEDRN KKPVLEEKKE VVKPNLAIPK IKKSSSLVSL
660 670 680 690 700
SSRSSTTPVI SNPSKVTKRA ASSVTPPVLP KKPKISKTSS ESEVSDLEED
710 720 730 740
SDFTGENATV FERFMALEQL QKSPVYKRII NEKMRFEKLS GGHKSM
Length:746
Mass (Da):83,396
Last modified:January 10, 2006 - v2
Checksum:i2E5B86F5EA624D85
GO

Sequence cautioni

The sequence EAK95842.1 differs from that shown. Reason: Frameshift at position 364. Produces 2 separate ORFs.
The sequence EAK95843.1 differs from that shown. Reason: Frameshift at position 364. Produces 2 separate ORFs.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti249 – 2502LW → QR in AAD25159. (PubMed:11073971)Curated
Sequence conflicti493 – 4931A → G in AAD25159. (PubMed:11073971)Curated
Sequence conflicti506 – 5061K → Q in AAD25159. (PubMed:11073971)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681S → L in allele CaO19.3523/3524.
Natural varianti101 – 1011K → Q in allele CaO19.3523/3524.
Natural varianti189 – 1891Q → H in allele CaO19.3523/3524.
Natural varianti412 – 4121Missing in allele CaO19.3523/3524.
Natural varianti463 – 4631S → L in allele CaO19.3523/3524.
Natural varianti505 – 5051S → L in allele CaO19.3523/3524.
Natural varianti516 – 5161V → I in allele CaO19.3523/3524.
Natural varianti529 – 5291S → L in allele CaO19.3523/3524.
Natural varianti578 – 5781R → G in allele CaO19.3523/3524.
Natural varianti649 – 6513SLS → LLL in allele CaO19.3523/3524.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92261 Genomic DNA. Translation: AAD25159.1.
AACQ01000094 Genomic DNA. Translation: EAK95843.1. Frameshift.
AACQ01000094 Genomic DNA. Translation: EAK95842.1. Frameshift.
AACQ01000093 Genomic DNA. Translation: EAK95905.1.
RefSeqiXP_714882.1. XM_709789.1.
XP_714883.1. XM_709790.1.
XP_714945.1. XM_709852.1.

Genome annotation databases

GeneIDi3643350.
3643413.
3643414.
KEGGical:CaO19.11006.
cal:CaO19.3523.
cal:CaO19.3524.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92261 Genomic DNA. Translation: AAD25159.1 .
AACQ01000094 Genomic DNA. Translation: EAK95843.1 . Frameshift.
AACQ01000094 Genomic DNA. Translation: EAK95842.1 . Frameshift.
AACQ01000093 Genomic DNA. Translation: EAK95905.1 .
RefSeqi XP_714882.1. XM_709789.1.
XP_714883.1. XM_709790.1.
XP_714945.1. XM_709852.1.

3D structure databases

ProteinModelPortali Q9Y7W4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1226507. 2 interactions.
IntActi Q9Y7W4. 2 interactions.
MINTi MINT-1173580.
STRINGi 5476.CAL0005839.

Proteomic databases

PRIDEi Q9Y7W4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3643350.
3643413.
3643414.
KEGGi cal:CaO19.11006.
cal:CaO19.3523.
cal:CaO19.3524.

Organism-specific databases

CGDi CAL0073553. CRK1.

Phylogenomic databases

eggNOGi COG0515.
InParanoidi Q9Y7W4.
KOi K15562.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Crk1, a novel Cdc2-related protein kinase, is required for hyphal development and virulence in Candida albicans."
    Chen J., Zhou S., Wang Q., Chen X., Pan T., Liu H.
    Mol. Cell. Biol. 20:8696-8708(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiBUR1_CANAL
AccessioniPrimary (citable) accession number: Q9Y7W4
Secondary accession number(s): Q59ZJ5, Q59ZJ6, Q59ZR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: October 29, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3