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Protein

Serine/threonine-protein kinase BUR1

Gene

CRK1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice.By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73ATPPROSITE-ProRule annotation1
Active sitei179Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 58ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • cellular response to pH Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms Source: CGD
  • filamentous growth of a population of unicellular organisms in response to pH Source: CGD
  • flocculation Source: CGD
  • negative regulation of filamentous growth of a population of unicellular organisms in response to pH Source: CGD
  • negative regulation of flocculation Source: CGD
  • pathogenesis Source: CGD
  • positive regulation of filamentous growth of a population of unicellular organisms Source: CGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase BUR1 (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:CRK1
Synonyms:BUR1
Ordered Locus Names:CAALFM_C204930CA
ORF Names:CaO19.11006, CaO19.3523/3524
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 2

Organism-specific databases

CGDiCAL0000191033. CRK1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856791 – 745Serine/threonine-protein kinase BUR1Add BLAST745

Proteomic databases

PRIDEiQ9Y7W4.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC37Q8X1E65EBI-7148532,EBI-7148504

Protein-protein interaction databases

BioGridi1226444. 2 interactors.
IntActiQ9Y7W4. 1 interactor.
MINTiMINT-1173580.

Structurei

3D structure databases

ProteinModelPortaliQ9Y7W4.
SMRiQ9Y7W4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 349Protein kinasePROSITE-ProRule annotationAdd BLAST306

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ9Y7W4.
KOiK15562.
OrthoDBiEOG092C2FL8.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y7W4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVIAGHHVP RSNDQRQYDT PSVPINIAPD SEGHIHEMSR LKDYEVIEKL
60 70 80 90 100
GQGTFGVVQK AKSKKDGSLV AIKQLINHSA KEGFPITAMR EITILKQLNH
110 120 130 140 150
KNILTIQDMI FEEPKMSNRT DIITMRGSFY TVTPYMSSDL VGLLENPKIK
160 170 180 190 200
LELGQIKCIM QQLLKGIQYV HNQKFLHRDI KAANILIGQD GVLKIADFGL
210 220 230 240 250
ARIYHGNVPR LGMGPGGGEK AYTGLVVTRW YRPPEILLGE RKYTTAVDLW
260 270 280 290 300
GIGCVFAELF TGKPILVGKS DSHQAQIVFE LVGSPLTWTD AAKLPNKNEY
310 320 330 340 350
SCGLACKRSL EAKFASIMPT EAIDLLSGLL TLDPFKRLNA LDALNHKFFS
360 370 380 390 400
TDPLPLLPTQ MPKFEESHEI DKERFKKLKD KEQAVSELKP PTEIRYDNHS
410 420 430 440 450
ESRYNADHST FGGGVGGKET SFSSGKSDYI DHYEPRARRD HYEPRIRNDN
460 470 480 490 500
KDSNDVRGEF ESATRQEQRR RDIQNRLDAG GMDTYIPKTT TAKLREHSGT
510 520 530 540 550
ESLSKKYDNY QPINVSRGSK SPSPSKLSSI SQSKADLISK PSAPKVASRE
560 570 580 590 600
SSLERKQVSN GIRTTTDVEP PRARARRPTD MFGRPLTSNS TQAQPTRNKS
610 620 630 640 650
VERPKDLEKP TNGVTEDRNK KPVLEEKKEV VKPNLAIPKI KKSSSLVSLS
660 670 680 690 700
SRSSTTPVIS NPSKVTKRAA SSVTPPVLPK KPKISKTSSE SEVSDLEEDS
710 720 730 740
DFTGENATVF ERFMALEQLQ KSPVYKRIIN EKMRFEKLSG GHKSM
Length:745
Mass (Da):83,339
Last modified:May 10, 2017 - v3
Checksum:i8D0006B955C239FB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti249 – 250LW → QR in AAD25159 (PubMed:11073971).Curated2
Sequence conflicti414G → GG in AAD25159 (PubMed:11073971).Curated1
Sequence conflicti492A → G in AAD25159 (PubMed:11073971).Curated1
Sequence conflicti505K → Q in AAD25159 (PubMed:11073971).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92261 Genomic DNA. Translation: AAD25159.1.
CP017624 Genomic DNA. Translation: AOW27512.1.
RefSeqiXP_714883.2. XM_709790.2.

Genome annotation databases

GeneIDi3643414.
KEGGical:CAALFM_C204930CA.

Similar proteinsi

Entry informationi

Entry nameiBUR1_CANAL
AccessioniPrimary (citable) accession number: Q9Y7W4
Secondary accession number(s): A0A1D8PH82
, Q59ZJ5, Q59ZJ6, Q59ZR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: May 10, 2017
Last modified: September 27, 2017
This is version 105 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families