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Q9Y7W4

- BUR1_CANAL

UniProt

Q9Y7W4 - BUR1_CANAL

Protein

Serine/threonine-protein kinase BUR1

Gene

CRK1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity. Required for pseudohyphal growth and virulence in mice.By similarity1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei73 – 731ATPPROSITE-ProRule annotation
    Active sitei179 – 1791Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi50 – 589ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. MAP kinase activity Source: CGD
    4. protein kinase activity Source: CGD
    5. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular response to pH Source: CGD
    2. filamentous growth Source: CGD
    3. filamentous growth of a population of unicellular organisms Source: CGD
    4. filamentous growth of a population of unicellular organisms in response to pH Source: CGD
    5. flocculation Source: CGD
    6. MAPK cascade Source: GOC
    7. negative regulation of filamentous growth of a population of unicellular organisms in response to pH Source: CGD
    8. negative regulation of flocculation Source: CGD
    9. pathogenesis Source: CGD
    10. positive regulation of filamentous growth of a population of unicellular organisms Source: CGD
    11. protein phosphorylation Source: CGD

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase BUR1 (EC:2.7.11.22, EC:2.7.11.23)
    Gene namesi
    Name:CRK1
    Synonyms:BUR1
    ORF Names:CaO19.11006, CaO19.3523/3524
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0073553. CRK1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 746746Serine/threonine-protein kinase BUR1PRO_0000085679Add
    BLAST

    Proteomic databases

    PRIDEiQ9Y7W4.

    Interactioni

    Protein-protein interaction databases

    BioGridi1226507. 2 interactions.
    IntActiQ9Y7W4. 2 interactions.
    MINTiMINT-1173580.
    STRINGi5476.CAL0005839.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y7W4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 349306Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    KOiK15562.
    OrthoDBiEOG7K3TWD.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y7W4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVIAGHHVP RSNDQRQYDT PSVPINIAPD SEGHIHEMSR LKDYEVIEKL    50
    GQGTFGVVQK AKSKKDGSLV AIKQLINHSA KEGFPITAMR EITILKQLNH 100
    KNILTIQDMI FEEPKMSNRT DIITMRGSFY TVTPYMSSDL VGLLENPKIK 150
    LELGQIKCIM QQLLKGIQYV HNQKFLHRDI KAANILIGQD GVLKIADFGL 200
    ARIYHGNVPR LGMGPGGGEK AYTGLVVTRW YRPPEILLGE RKYTTAVDLW 250
    GIGCVFAELF TGKPILVGKS DSHQAQIVFE LVGSPLTWTD AAKLPNKNEY 300
    SCGLACKRSL EAKFASIMPT EAIDLLSGLL TLDPFKRLNA LDALNHKFFS 350
    TDPLPLLPTQ MPKFEESHEI DKERFKKLKD KEQAVSELKP PTEIRYDNHS 400
    ESRYNADHST FGGGGVGGKE TSFSSGKSDY IDHYEPRARR DHYEPRIRND 450
    NKDSNDVRGE FESATRQEQR RRDIQNRLDA GGMDTYIPKT TTAKLREHSG 500
    TESLSKKYDN YQPINVSRGS KSPSPSKLSS ISQSKADLIS KPSAPKVASR 550
    ESSLERKQVS NGIRTTTDVE PPRARARRPT DMFGRPLTSN STQAQPTRNK 600
    SVERPKDLEK PTNGVTEDRN KKPVLEEKKE VVKPNLAIPK IKKSSSLVSL 650
    SSRSSTTPVI SNPSKVTKRA ASSVTPPVLP KKPKISKTSS ESEVSDLEED 700
    SDFTGENATV FERFMALEQL QKSPVYKRII NEKMRFEKLS GGHKSM 746
    Length:746
    Mass (Da):83,396
    Last modified:January 10, 2006 - v2
    Checksum:i2E5B86F5EA624D85
    GO

    Sequence cautioni

    The sequence EAK95842.1 differs from that shown. Reason: Frameshift at position 364. Produces 2 separate ORFs.
    The sequence EAK95843.1 differs from that shown. Reason: Frameshift at position 364. Produces 2 separate ORFs.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti249 – 2502LW → QR in AAD25159. (PubMed:11073971)Curated
    Sequence conflicti493 – 4931A → G in AAD25159. (PubMed:11073971)Curated
    Sequence conflicti506 – 5061K → Q in AAD25159. (PubMed:11073971)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti68 – 681S → L in allele CaO19.3523/3524.
    Natural varianti101 – 1011K → Q in allele CaO19.3523/3524.
    Natural varianti189 – 1891Q → H in allele CaO19.3523/3524.
    Natural varianti412 – 4121Missing in allele CaO19.3523/3524.
    Natural varianti463 – 4631S → L in allele CaO19.3523/3524.
    Natural varianti505 – 5051S → L in allele CaO19.3523/3524.
    Natural varianti516 – 5161V → I in allele CaO19.3523/3524.
    Natural varianti529 – 5291S → L in allele CaO19.3523/3524.
    Natural varianti578 – 5781R → G in allele CaO19.3523/3524.
    Natural varianti649 – 6513SLS → LLL in allele CaO19.3523/3524.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U92261 Genomic DNA. Translation: AAD25159.1.
    AACQ01000094 Genomic DNA. Translation: EAK95843.1. Frameshift.
    AACQ01000094 Genomic DNA. Translation: EAK95842.1. Frameshift.
    AACQ01000093 Genomic DNA. Translation: EAK95905.1.
    RefSeqiXP_714882.1. XM_709789.1.
    XP_714883.1. XM_709790.1.
    XP_714945.1. XM_709852.1.

    Genome annotation databases

    GeneIDi3643350.
    3643413.
    3643414.
    KEGGical:CaO19.11006.
    cal:CaO19.3523.
    cal:CaO19.3524.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U92261 Genomic DNA. Translation: AAD25159.1 .
    AACQ01000094 Genomic DNA. Translation: EAK95843.1 . Frameshift.
    AACQ01000094 Genomic DNA. Translation: EAK95842.1 . Frameshift.
    AACQ01000093 Genomic DNA. Translation: EAK95905.1 .
    RefSeqi XP_714882.1. XM_709789.1.
    XP_714883.1. XM_709790.1.
    XP_714945.1. XM_709852.1.

    3D structure databases

    ProteinModelPortali Q9Y7W4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1226507. 2 interactions.
    IntActi Q9Y7W4. 2 interactions.
    MINTi MINT-1173580.
    STRINGi 5476.CAL0005839.

    Proteomic databases

    PRIDEi Q9Y7W4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3643350.
    3643413.
    3643414.
    KEGGi cal:CaO19.11006.
    cal:CaO19.3523.
    cal:CaO19.3524.

    Organism-specific databases

    CGDi CAL0073553. CRK1.

    Phylogenomic databases

    eggNOGi COG0515.
    KOi K15562.
    OrthoDBi EOG7K3TWD.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Crk1, a novel Cdc2-related protein kinase, is required for hyphal development and virulence in Candida albicans."
      Chen J., Zhou S., Wang Q., Chen X., Pan T., Liu H.
      Mol. Cell. Biol. 20:8696-8708(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiBUR1_CANAL
    AccessioniPrimary (citable) accession number: Q9Y7W4
    Secondary accession number(s): Q59ZJ5, Q59ZJ6, Q59ZR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3