Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable phosphatidylglycerophosphatase, mitochondrial

Gene

gep4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Phosphatidylglycerophosphatase involved in the biosynthesis of cardiolipin (CL), a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes and which has important functions for cellular energy metabolism, mitochondrial dynamics and the initiation of apoptotic pathways.By similarity

Catalytic activityi

Phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.

Pathwayi: phosphatidylglycerol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (pgs1)
  2. Probable phosphatidylglycerophosphatase, mitochondrial (gep4)
This subpathway is part of the pathway phosphatidylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol, the pathway phosphatidylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00084; UER00504.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphatidylglycerophosphatase, mitochondrial (EC:3.1.3.27)
Alternative name(s):
PGP phosphatase
Gene namesi
Name:gep4
ORF Names:SPCC645.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC645.02.
PomBaseiSPCC645.02. gep4.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrial matrix Source: PomBase
  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003514271 – 209Probable phosphatidylglycerophosphatase, mitochondrialAdd BLAST209

Proteomic databases

MaxQBiQ9Y7U3.
PRIDEiQ9Y7U3.

Interactioni

Protein-protein interaction databases

MINTiMINT-4719200.

Structurei

3D structure databases

ProteinModelPortaliQ9Y7U3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi57 – 61Phosphoryl acceptor5

Sequence similaritiesi

Belongs to the GEP4 family.Curated

Phylogenomic databases

InParanoidiQ9Y7U3.
KOiK01094.
OMAiDKDDCFA.
OrthoDBiEOG092C2933.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006549. HAD-SF_hydro_IIIA.
IPR027706. PGP_Pase.
[Graphical view]
PfamiPF09419. PGP_phosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01662. HAD-SF-IIIA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y7U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLINIEGIQA FCQTIRNPRR IIPHATFPTF SQIPCNINYF LEQKFQVPVD
60 70 80 90 100
IRALVLDKDN CITLPNETTI AEAELKKIRE FQNIYGEKNV ILLSNSIGTR
110 120 130 140 150
KLDPTGELAA HFQQKWNIPV VRHSKLKPLC TEELYTYLSN NSHVSSASQI
160 170 180 190 200
LFIGDRLLTD ITLANIMGSW GVWLTRGVGN TTNMMMEVES WLYKRIHTQN

PYIPTNRKS
Length:209
Mass (Da):23,992
Last modified:July 11, 2012 - v2
Checksum:iDD99C64B73CF1043
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB39898.2.
PIRiT41519.
RefSeqiNP_588111.2. NM_001023101.2.

Genome annotation databases

EnsemblFungiiSPCC645.02.1; SPCC645.02.1:pep; SPCC645.02.
GeneIDi2539038.
KEGGispo:SPCC645.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB39898.2.
PIRiT41519.
RefSeqiNP_588111.2. NM_001023101.2.

3D structure databases

ProteinModelPortaliQ9Y7U3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4719200.

Proteomic databases

MaxQBiQ9Y7U3.
PRIDEiQ9Y7U3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC645.02.1; SPCC645.02.1:pep; SPCC645.02.
GeneIDi2539038.
KEGGispo:SPCC645.02.

Organism-specific databases

EuPathDBiFungiDB:SPCC645.02.
PomBaseiSPCC645.02. gep4.

Phylogenomic databases

InParanoidiQ9Y7U3.
KOiK01094.
OMAiDKDDCFA.
OrthoDBiEOG092C2933.

Enzyme and pathway databases

UniPathwayiUPA00084; UER00504.

Miscellaneous databases

PROiQ9Y7U3.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006549. HAD-SF_hydro_IIIA.
IPR027706. PGP_Pase.
[Graphical view]
PfamiPF09419. PGP_phosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01662. HAD-SF-IIIA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGEP4_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: July 11, 2012
Last modified: November 30, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.