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Q9Y7U3

- GEP4_SCHPO

UniProt

Q9Y7U3 - GEP4_SCHPO

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Protein

Probable phosphatidylglycerophosphatase, mitochondrial

Gene

gep4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Phosphatidylglycerophosphatase involved in the biosynthesis of cardiolipin (CL), a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes and which has important functions for cellular energy metabolism, mitochondrial dynamics and the initiation of apoptotic pathways.By similarity

Catalytic activityi

Phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphatidylglycerophosphatase activity Source: PomBase

GO - Biological processi

  1. cardiolipin biosynthetic process Source: PomBase
  2. dephosphorylation Source: GOC
  3. mitochondrial membrane organization Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00084; UER00504.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphatidylglycerophosphatase, mitochondrial (EC:3.1.3.27)
Alternative name(s):
PGP phosphatase
Gene namesi
Name:gep4
ORF Names:SPCC645.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC645.02.

Subcellular locationi

Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Matrix side 1 Publication

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
  2. mitochondrial matrix Source: PomBase
  3. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Probable phosphatidylglycerophosphatase, mitochondrialPRO_0000351427Add
BLAST

Proteomic databases

MaxQBiQ9Y7U3.

Interactioni

Protein-protein interaction databases

MINTiMINT-4719200.
STRINGi4896.SPCC645.02-1.

Structurei

3D structure databases

ProteinModelPortaliQ9Y7U3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi57 – 615Phosphoryl acceptor

Sequence similaritiesi

Belongs to the GEP4 family.Curated

Phylogenomic databases

eggNOGiCOG1011.
InParanoidiQ9Y7U3.
KOiK07025.
OrthoDBiEOG7C5MKN.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006549. HAD-SF_hydro_IIIA.
IPR027706. PGP_Pase.
[Graphical view]
PfamiPF09419. PGP_phosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01662. HAD-SF-IIIA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y7U3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLINIEGIQA FCQTIRNPRR IIPHATFPTF SQIPCNINYF LEQKFQVPVD
60 70 80 90 100
IRALVLDKDN CITLPNETTI AEAELKKIRE FQNIYGEKNV ILLSNSIGTR
110 120 130 140 150
KLDPTGELAA HFQQKWNIPV VRHSKLKPLC TEELYTYLSN NSHVSSASQI
160 170 180 190 200
LFIGDRLLTD ITLANIMGSW GVWLTRGVGN TTNMMMEVES WLYKRIHTQN

PYIPTNRKS
Length:209
Mass (Da):23,992
Last modified:July 11, 2012 - v2
Checksum:iDD99C64B73CF1043
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB39898.2.
PIRiT41519.
RefSeqiNP_588111.2. NM_001023101.2.

Genome annotation databases

EnsemblFungiiSPCC645.02.1; SPCC645.02.1:pep; SPCC645.02.
GeneIDi2539038.
KEGGispo:SPCC645.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB39898.2 .
PIRi T41519.
RefSeqi NP_588111.2. NM_001023101.2.

3D structure databases

ProteinModelPortali Q9Y7U3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4719200.
STRINGi 4896.SPCC645.02-1.

Proteomic databases

MaxQBi Q9Y7U3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC645.02.1 ; SPCC645.02.1:pep ; SPCC645.02 .
GeneIDi 2539038.
KEGGi spo:SPCC645.02.

Organism-specific databases

PomBasei SPCC645.02.

Phylogenomic databases

eggNOGi COG1011.
InParanoidi Q9Y7U3.
KOi K07025.
OrthoDBi EOG7C5MKN.

Enzyme and pathway databases

UniPathwayi UPA00084 ; UER00504 .

Miscellaneous databases

NextBioi 20800212.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR023214. HAD-like_dom.
IPR006549. HAD-SF_hydro_IIIA.
IPR027706. PGP_Pase.
[Graphical view ]
Pfami PF09419. PGP_phosphatase. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 2 hits.
TIGRFAMsi TIGR01662. HAD-SF-IIIA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comparative functional genomics of the fission yeasts."
    Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
    , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
    Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGEP4_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: July 11, 2012
Last modified: October 29, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3