Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable proteasome subunit beta type-3

Gene

pup3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-SPO-382556 ABC-family proteins mediated transport
R-SPO-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-SPO-5689603 UCH proteinases
R-SPO-5689880 Ub-specific processing proteases
R-SPO-68949 Orc1 removal from chromatin
R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit beta type-3 (EC:3.4.25.1)
Gene namesi
Name:pup3
ORF Names:SPCC63.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC63.12c
PomBaseiSPCC63.12c pup3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001480691 – 204Probable proteasome subunit beta type-3Add BLAST204

Proteomic databases

MaxQBiQ9Y7T8
PaxDbiQ9Y7T8
PRIDEiQ9Y7T8

PTM databases

iPTMnetiQ9Y7T8

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi275966, 3 interactors
STRINGi4896.SPCC63.12c.1

Structurei

3D structure databases

ProteinModelPortaliQ9Y7T8
SMRiQ9Y7T8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000090523
InParanoidiQ9Y7T8
KOiK02735
OMAiEQLFGMC
OrthoDBiEOG092C4N9L
PhylomeDBiQ9Y7T8

Family and domain databases

CDDicd03759 proteasome_beta_type_3, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR033811 Proteasome_beta_3
IPR016050 Proteasome_bsu_CS
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR11599:SF62 PTHR11599:SF62, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854 PROTEASOME_BETA_1, 1 hit
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y7T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIMEYNGGS CVAMAGKNCV AIASDLRLGV QSISLTNNFP KVFAMGDKTY
60 70 80 90 100
LGLTGLATDV QTLYELFRYK VNLYKFREER QIQPKTFANL VSSTLYEKRF
110 120 130 140 150
GPYFSFPVVA GVSNDNTPFI CGFDSIGCID FAEDFIVSGT ATEQLYGMCE
160 170 180 190 200
SVYEPNLEPD DLFETISQAL LNAQDRDCIS GWGCVVYVIT ADKCIKRLVK

GRQD
Length:204
Mass (Da):22,661
Last modified:November 1, 1999 - v1
Checksum:i80C3964E8A40A00E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAB40016.1
PIRiT41513
RefSeqiNP_587985.1, NM_001022976.2

Genome annotation databases

EnsemblFungiiSPCC63.12c.1; SPCC63.12c.1:pep; SPCC63.12c
GeneIDi2539401
KEGGispo:SPCC63.12c

Similar proteinsi

Entry informationi

Entry nameiPSB3_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health