Reviewed, UniProtKB/Swiss-Prot Q9Y7T4 (ATG1_SCHPO)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase atg1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1
    Serine/threonine-protein kinase ppk36

Gene names

Name:	atg1
Synonyms:	ppk36
ORF Names:	SPCC63.08c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	830 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytosol Ref.3 Inferred from direct assay. Source: GeneDB_SPombe nucleus Ref.3 Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	protein serine/threonine kinase activity Ref.2 Traceable author statement. Source: GeneDB_SPombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 830	830	Serine/threonine-protein kinase atg1		PRO_0000085652
Regions
	Domain	14 – 307	294	Protein kinase
	Nucleotide binding	20 – 28	9	ATP By similarity
Sites
	Active site	157	1	Proton acceptor By similarity
	Binding site	43	1	ATP By similarity
Amino acid modifications
	Modified residue	346	1	Phosphoserine

Sequences

	Sequence		Length	Mass (Da)
	Q9Y7T4-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 8DB76C502BD83425	FASTA	830	91,585
	10 20 30 40 50 60 MNLQTSTNQT IGPYVIRSEI GRGSFAIVYK GKHTETNRVI SIKSVLTKKL TKKLLENLES 70 80 90 100 110 120 EISILKEIRH VHVVELIDCI KAGRFIHLVM EYCSLGDLSY FIRKREKFNS IPSLAWINID 130 140 150 160 170 180 HPPVYKAGLN ETLVRHFTQQ LASALQFLRS RSLIHRDVKP QNLLLQPPPT AAYLEEHPQF 190 200 210 220 230 240 VGSPKLPMLK LADFGFARYL QTSSMAETLC GSPLYMAPEI LRYEKYDAKA DLWSVGAVLY 250 260 270 280 290 300 EMAVGKPPFK APNHVELLRR IQKAKDVIKF PEEAFIHPDI KTLICALLKQ NPADRIDYDG 310 320 330 340 350 360 FFSSIVVTTP LDDASTLTGS DIQDAVKEIN IPSSSPAYIT DFFPKSNPGA PAPPGGLLRQ 370 380 390 400 410 420 AFQAQGSSIQ PSEITGRRVP HRYAQDGNTL PYTPVFPPES APAASIFPPR LTSKQPIPMA 430 440 450 460 470 480 SPAKLTSDTS NKSSAYVVVD HHPIISSTQL SNESLTHEQS INGNSPSPNE GVFQGSFSPE 490 500 510 520 530 540 SAPVNNHAFP HTSRMQIPYM KPNAFPSNPT YIASTPVTQL RRAFEQATAH VPQSGGGARN 550 560 570 580 590 600 KSALERALNV ANARLNEVVV DGMTDNGNTS LPTKESNLDN NVNIIQPSLP DTGKRLLDVL 610 620 630 640 650 660 ESIAMKSNSV YHLAEVKLAQ IIPSLSDEMK PGDTLLDRPL TPFSLVMLAK ESYVLYERDI 670 680 690 700 710 720 ELLQVAFDGV AAFWANSEER ASPDCQQAIE WFRQRYSESL EKSQFLREII ISQSAAHSLP 730 740 750 760 770 780 TTKPVSASQL IYHRALDLSR NAATSELSGN DAQACLQNYR LAAHLLESLL ESNFSTPDGA 790 800 810 820 830 NDSNNSVTIR NLIALITKRQ ELLQSKQIQA NVANKVTESV AKITLAPNLA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.
[2]	"Systematic deletion analysis of fission yeast protein kinases." Bimbo A., Jia Y., Poh S.L., Karuturi R.K.M., den Elzen N., Peng X., Zheng L., O'Connell M., Liu E.T., Balasubramanian M.K., Liu J. Eukaryot. Cell 4:799-813(2005) [PubMed: 15821139] [Abstract] Cited for: IDENTIFICATION.
[3]	"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Phosphoproteome analysis of fission yeast." Wilson-Grady J.T., Villen J., Gygi S.P. J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-346, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329672 Genomic DNA. Translation: CAB40012.1.
PIR	T41509.
RefSeq	NP_587982.1.
3D structure databases
HSSP	HSSP built from PDB template 1MQ4 based on UniProtKB O14965.
ModBase	Search...
Genome annotation databases
GeneID	2539461.
KEGG	spo:SPCC63.08c.
NMPDR	fig|4896.1.peg.320.
Organism-specific databases
GeneDB_Spombe	SPCC63.08c.
Gene expression databases
ArrayExpress	Q9Y7T4.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

ATG1_SCHPO

Accession

Primary (citable) accession number: Q9Y7T4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	November 1, 1999
Last modified:	July 22, 2008
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)