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Protein

Malate dehydrogenase, mitochondrial

Gene

MDH1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61NADBy similarity1
Binding sitei109SubstrateBy similarity1
Binding sitei115SubstrateBy similarity1
Binding sitei122NADBy similarity1
Binding sitei147SubstrateBy similarity1
Binding sitei181SubstrateBy similarity1
Active sitei205Proton acceptorBy similarity1
Binding sitei254NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi35 – 41NADBy similarity7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

ReactomeiR-SPO-70263 Gluconeogenesis
R-SPO-71403 Citric acid cycle (TCA cycle)

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, mitochondrial (EC:1.1.1.37)
Gene namesi
Name:MDH1
ORF Names:SPCC306.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC306.08c
PomBaseiSPCC306.08c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000310436? – 341Malate dehydrogenase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiQ9Y7R8
PaxDbiQ9Y7R8
PRIDEiQ9Y7R8

PTM databases

iPTMnetiQ9Y7R8

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi275349, 1 interactor
STRINGi4896.SPCC306.08c.1

Structurei

3D structure databases

ProteinModelPortaliQ9Y7R8
SMRiQ9Y7R8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000213792
InParanoidiQ9Y7R8
KOiK00026
OMAiQCTPKVE
OrthoDBiEOG092C34N7
PhylomeDBiQ9Y7R8

Family and domain databases

Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR010097 Malate_DH_type1
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01772 MDH_euk_gproteo, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y7R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAKVAFKNF TPLKSIAPRS FSTTSSRAFK VAVLGAGGGI GQPLSMLLKL
60 70 80 90 100
NDKVSELALF DIRGAPGVAA DIGHINTTSN VVGYAPDDKG LEKALNGADV
110 120 130 140 150
VIIPAGVPRK PGMTRDDLFA TNASIVRDLA FAAGETCPEA KYLVVTNPVN
160 170 180 190 200
STVPIFKKAL ERVGVHQPKH LFGVTTLDSV RASRFTSQVT NGKAELLHIP
210 220 230 240 250
VVGGHSGATI VPLLSQGGVE LTGEKRDALI HRIQFGGDEV VKAKAGAGSA
260 270 280 290 300
TLSMAYAGAR MASSVLRALA GESGVEECTF VESPLYKDQG IDFFASRVTL
310 320 330 340
GKDGVDTIHP VGKINDYEES LLKVALGELK KSITKGEQFV A
Length:341
Mass (Da):35,787
Last modified:November 1, 1999 - v1
Checksum:i4681EBFD2B1F7716
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAB41656.1
PIRiT41286
RefSeqiNP_587816.1, NM_001022809.2

Genome annotation databases

EnsemblFungiiSPCC306.08c.1; SPCC306.08c.1:pep; SPCC306.08c
KEGGispo:SPCC306.08c

Similar proteinsi

Entry informationi

Entry nameiMDHM_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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