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Q9Y7R8

- MDHM_SCHPO

UniProt

Q9Y7R8 - MDHM_SCHPO

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Protein

Malate dehydrogenase, mitochondrial

Gene

MDH1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611NADBy similarity
Binding sitei109 – 1091SubstrateBy similarity
Binding sitei115 – 1151SubstrateBy similarity
Binding sitei122 – 1221NADBy similarity
Binding sitei147 – 1471SubstrateBy similarity
Binding sitei181 – 1811SubstrateBy similarity
Active sitei205 – 2051Proton acceptorBy similarity
Binding sitei254 – 2541NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 417NADBy similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: PomBase

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: PomBase
  3. tricarboxylic acid cycle Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_213505. Citric acid cycle (TCA cycle).
REACT_218730. Gluconeogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, mitochondrial (EC:1.1.1.37)
Gene namesi
Name:MDH1
ORF Names:SPCC306.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC306.08c.

Subcellular locationi

Mitochondrion matrix 1 Publication

GO - Cellular componenti

  1. mitochondrial matrix Source: PomBase
  2. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 341Malate dehydrogenase, mitochondrialPRO_0000310436
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

MaxQBiQ9Y7R8.
PaxDbiQ9Y7R8.
PRIDEiQ9Y7R8.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi275349. 3 interactions.
MINTiMINT-4718476.
STRINGi4896.SPCC306.08c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9Y7R8.
SMRiQ9Y7R8. Positions 30-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213792.
InParanoidiQ9Y7R8.
KOiK00026.
OMAiPLYKSEG.
OrthoDBiEOG7GJ6Q7.
PhylomeDBiQ9Y7R8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y7R8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFAKVAFKNF TPLKSIAPRS FSTTSSRAFK VAVLGAGGGI GQPLSMLLKL
60 70 80 90 100
NDKVSELALF DIRGAPGVAA DIGHINTTSN VVGYAPDDKG LEKALNGADV
110 120 130 140 150
VIIPAGVPRK PGMTRDDLFA TNASIVRDLA FAAGETCPEA KYLVVTNPVN
160 170 180 190 200
STVPIFKKAL ERVGVHQPKH LFGVTTLDSV RASRFTSQVT NGKAELLHIP
210 220 230 240 250
VVGGHSGATI VPLLSQGGVE LTGEKRDALI HRIQFGGDEV VKAKAGAGSA
260 270 280 290 300
TLSMAYAGAR MASSVLRALA GESGVEECTF VESPLYKDQG IDFFASRVTL
310 320 330 340
GKDGVDTIHP VGKINDYEES LLKVALGELK KSITKGEQFV A
Length:341
Mass (Da):35,787
Last modified:November 1, 1999 - v1
Checksum:i4681EBFD2B1F7716
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB41656.1.
PIRiT41286.
RefSeqiNP_587816.1. NM_001022809.2.

Genome annotation databases

EnsemblFungiiSPCC306.08c.1; SPCC306.08c.1:pep; SPCC306.08c.
GeneIDi2538766.
KEGGispo:SPCC306.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB41656.1 .
PIRi T41286.
RefSeqi NP_587816.1. NM_001022809.2.

3D structure databases

ProteinModelPortali Q9Y7R8.
SMRi Q9Y7R8. Positions 30-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275349. 3 interactions.
MINTi MINT-4718476.
STRINGi 4896.SPCC306.08c-1.

Proteomic databases

MaxQBi Q9Y7R8.
PaxDbi Q9Y7R8.
PRIDEi Q9Y7R8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC306.08c.1 ; SPCC306.08c.1:pep ; SPCC306.08c .
GeneIDi 2538766.
KEGGi spo:SPCC306.08c.

Organism-specific databases

PomBasei SPCC306.08c.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213792.
InParanoidi Q9Y7R8.
KOi K00026.
OMAi PLYKSEG.
OrthoDBi EOG7GJ6Q7.
PhylomeDBi Q9Y7R8.

Enzyme and pathway databases

Reactomei REACT_213505. Citric acid cycle (TCA cycle).
REACT_218730. Gluconeogenesis.

Miscellaneous databases

NextBioi 20799950.
PROi Q9Y7R8.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMDHM_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3