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Q9Y7R4

- SET1_SCHPO

UniProt

Q9Y7R4 - SET1_SCHPO

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Protein
Histone-lysine N-methyltransferase, H3 lysine-4 specific
Gene
set1, kmt2, SPCC306.04c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic component of the Set1 complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Methylation promotes maintenance of active chromatin states at euchromatic chromosomal domains and is present throughout the cell cycle. Plays a role in telomere maintenance and DNA repair in an ATM kinase rad3-dependent pathway. Required for efficient telomeric and centromeric silencing.3 Publications

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].1 Publication

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. histone methyltransferase activity (H3-K4 specific) Source: PomBase
  3. histone-lysine N-methyltransferase activity Source: PomBase
  4. nucleotide binding Source: InterPro
  5. protein binding Source: IntAct

GO - Biological processi

  1. chromatin remodeling Source: PomBase
  2. histone H3-K4 methylation Source: PomBase
  3. mitotic DNA damage checkpoint Source: PomBase
  4. telomere maintenance Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC:2.1.1.43)
Alternative name(s):
COMPASS component set1
Lysine N-methyltransferase 2
SET domain-containing protein 1
Set1 complex component set1
Short name:
Set1C component set1
Spset1
Gene namesi
Name:set1
Synonyms:kmt2
ORF Names:SPCC306.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC306.04c.

Subcellular locationi

Nucleus Inferred. Chromosome Inferred

GO - Cellular componenti

  1. Set1C/COMPASS complex Source: PomBase
  2. cytoplasm Source: PomBase
  3. nuclear chromatin Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 920920Histone-lysine N-methyltransferase, H3 lysine-4 specific
PRO_0000186085Add
BLAST

Proteomic databases

MaxQBiQ9Y7R4.

Interactioni

Subunit structurei

Component of the Set1 complex composed of ash2, sdc1, set1, shg1, spp1, swd1, swd2 and swd3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
lid2Q9HDV42EBI-2106005,EBI-2105919

Protein-protein interaction databases

BioGridi275345. 358 interactions.
IntActiQ9Y7R4. 1 interaction.
MINTiMINT-4718299.
STRINGi4896.SPCC306.04c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9Y7R4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 17986RRM
Add
BLAST
Domaini781 – 898118SET
Add
BLAST
Domaini904 – 92017Post-SET
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi469 – 4746Poly-Arg

Domaini

A construct containing set1 C-terminal fragment of 692-920 is able to form H3K4me.1 Publication

Sequence similaritiesi

Contains 1 post-SET domain.
Contains 1 SET domain.

Phylogenomic databases

eggNOGiCOG2940.
KOiK11422.
OMAiCGAPGCK.
OrthoDBiEOG7P8PH3.
PhylomeDBiQ9Y7R4.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y7R4-1 [UniParc]FASTAAdd to Basket

« Hide

MDFNTSTRSK SQPVQRNNYK VLYDPELGIK ENLGRKIIYR FNGVSKPPLV    50
VRDPRLKNPI YARGIPKSGR PFLKSLQTIN YDYNENSLGP EPPTQVFVSN 100
ISPLVTSEQL RYHFKSFGEV FDLDLKLNPY TGTSLGLCCI SFDKRSSISV 150
AAHSAKIAVQ QANGLRFSGK PLSVVLDRDG SLCEEAFKKA LNAVEKQFQE 200
ETLQKQRFER EDESSRQKLS AAMNEDIPPW RQPSKNSQTL SNGDLQHSKV 250
QNVDQKSGFL TSSETDVPKN INDYIYLLID DRFVPPDRVY YTDIKHHFRK 300
FLYEKIYMNK DGFYITFNNY REASNCYRAL DRTYVQNCRI KLKFHDIPSR 350
TKEDGKKSAV RRVVLPPEEA YAEATSVVLR DLEAALLRDV KSKIIGPAIF 400
KYLHSMPKPS VKEELQENLL VSSTSVPDVP LKIESTVGKL PSLPKFKKRV 450
DSSKMNLSAG SKTKSKLQRR RRRRHEARPL HYQLNQMYNS SASEAESDQE 500
LLLSSGDERV ERGKIGSIKS VKSDEATPVF SDTSDENDKF HRFRTKSKIS 550
KKKYEKMEVD YTSSSETESD ASILSPSAAI PKSGSAIKDE LISPKKEIDE 600
VLALAPKWRI NEFDETGSVY YGALPYNYPE DDVLLDLDGL QYLVKNDEDY 650
SYLQEALKDE PLMDINDPNF WAYERKSCKF KNGDVKYGDT AILPEPKGYF 700
RSNTSGSAKS EGYYIIPTTE KSLYLPLRNR STIDTISHST SRITSRMNRV 750
NNRRLAAGVE KSQLPAEADL LRFNALKARK KQLHFGPSRI HTLGLFAMEN 800
IDKNDMVIEY IGEIIRQRVA DNREKNYVRE GIGDSYLFRI DEDVIVDATK 850
KGNIARFINH SCAPNCIARI IRVEGKRKIV IYADRDIMHG EELTYDYKFP 900
EEADKIPCLC GAPTCRGYLN 920
Length:920
Mass (Da):105,038
Last modified:November 1, 1999 - v1
Checksum:iC4AD7E6C3ECFF8BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB41652.1.
PIRiT41282.
RefSeqiNP_587812.1. NM_001022805.2.

Genome annotation databases

EnsemblFungiiSPCC306.04c.1; SPCC306.04c.1:pep; SPCC306.04c.
GeneIDi2538762.
KEGGispo:SPCC306.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB41652.1 .
PIRi T41282.
RefSeqi NP_587812.1. NM_001022805.2.

3D structure databases

ProteinModelPortali Q9Y7R4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275345. 358 interactions.
IntActi Q9Y7R4. 1 interaction.
MINTi MINT-4718299.
STRINGi 4896.SPCC306.04c-1.

Proteomic databases

MaxQBi Q9Y7R4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC306.04c.1 ; SPCC306.04c.1:pep ; SPCC306.04c .
GeneIDi 2538762.
KEGGi spo:SPCC306.04c.

Organism-specific databases

PomBasei SPCC306.04c.

Phylogenomic databases

eggNOGi COG2940.
KOi K11422.
OMAi CGAPGCK.
OrthoDBi EOG7P8PH3.
PhylomeDBi Q9Y7R4.

Miscellaneous databases

NextBioi 20799946.
PROi Q9Y7R4.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast."
    Noma K., Grewal S.I.S.
    Proc. Natl. Acad. Sci. U.S.A. 99:16438-16445(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts."
    Roguev A., Schaft D., Shevchenko A., Aasland R., Shevchenko A., Stewart A.F.
    J. Biol. Chem. 278:8487-8493(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE SET1 COMPLEX.
  4. "The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway."
    Kanoh J., Francesconi S., Collura A., Schramke V., Ishikawa F., Baldacci G., Geli V.
    J. Mol. Biol. 326:1081-1094(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.
  5. "A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe."
    Roguev A., Shevchenko A., Schaft D., Thomas H., Stewart A.F., Shevchenko A.
    Mol. Cell. Proteomics 3:125-132(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SET1 COMPLEX.

Entry informationi

Entry nameiSET1_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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