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Q9Y7R4

- SET1_SCHPO

UniProt

Q9Y7R4 - SET1_SCHPO

Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

set1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalytic component of the Set1 complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Methylation promotes maintenance of active chromatin states at euchromatic chromosomal domains and is present throughout the cell cycle. Plays a role in telomere maintenance and DNA repair in an ATM kinase rad3-dependent pathway. Required for efficient telomeric and centromeric silencing.3 Publications

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].1 Publication

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: PomBase
    2. histone methyltransferase activity (H3-K4 specific) Source: PomBase
    3. nucleotide binding Source: InterPro
    4. protein binding Source: IntAct
    5. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. chromatin remodeling Source: PomBase
    2. histone H3-K4 methylation Source: PomBase
    3. mitotic DNA damage checkpoint Source: PomBase
    4. telomere maintenance Source: PomBase

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Transferase

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC:2.1.1.43)
    Alternative name(s):
    COMPASS component set1
    Lysine N-methyltransferase 2
    SET domain-containing protein 1
    Set1 complex component set1
    Short name:
    Set1C component set1
    Spset1
    Gene namesi
    Name:set1Imported
    Synonyms:kmt2
    ORF Names:SPCC306.04c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC306.04c.

    Subcellular locationi

    Nucleus Curated. Chromosome Curated

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. nuclear chromatin Source: PomBase
    3. Set1C/COMPASS complex Source: PomBase

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 920920Histone-lysine N-methyltransferase, H3 lysine-4 specificPRO_0000186085Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y7R4.

    Interactioni

    Subunit structurei

    Component of the Set1 complex composed of ash2, sdc1, set1, shg1, spp1, swd1, swd2 and swd3.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    lid2Q9HDV42EBI-2106005,EBI-2105919

    Protein-protein interaction databases

    BioGridi275345. 358 interactions.
    IntActiQ9Y7R4. 1 interaction.
    MINTiMINT-4718299.
    STRINGi4896.SPCC306.04c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y7R4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini94 – 17986RRMPROSITE-ProRule annotationAdd
    BLAST
    Domaini781 – 898118SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini904 – 92017Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi469 – 4746Poly-ArgSequence Analysis

    Domaini

    A construct containing set1 C-terminal fragment of 692-920 is able to form H3K4me.

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    KOiK11422.
    OMAiCGAPGCK.
    OrthoDBiEOG7P8PH3.
    PhylomeDBiQ9Y7R4.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTiSM00508. PostSET. 1 hit.
    SM00360. RRM. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS50102. RRM. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y7R4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFNTSTRSK SQPVQRNNYK VLYDPELGIK ENLGRKIIYR FNGVSKPPLV    50
    VRDPRLKNPI YARGIPKSGR PFLKSLQTIN YDYNENSLGP EPPTQVFVSN 100
    ISPLVTSEQL RYHFKSFGEV FDLDLKLNPY TGTSLGLCCI SFDKRSSISV 150
    AAHSAKIAVQ QANGLRFSGK PLSVVLDRDG SLCEEAFKKA LNAVEKQFQE 200
    ETLQKQRFER EDESSRQKLS AAMNEDIPPW RQPSKNSQTL SNGDLQHSKV 250
    QNVDQKSGFL TSSETDVPKN INDYIYLLID DRFVPPDRVY YTDIKHHFRK 300
    FLYEKIYMNK DGFYITFNNY REASNCYRAL DRTYVQNCRI KLKFHDIPSR 350
    TKEDGKKSAV RRVVLPPEEA YAEATSVVLR DLEAALLRDV KSKIIGPAIF 400
    KYLHSMPKPS VKEELQENLL VSSTSVPDVP LKIESTVGKL PSLPKFKKRV 450
    DSSKMNLSAG SKTKSKLQRR RRRRHEARPL HYQLNQMYNS SASEAESDQE 500
    LLLSSGDERV ERGKIGSIKS VKSDEATPVF SDTSDENDKF HRFRTKSKIS 550
    KKKYEKMEVD YTSSSETESD ASILSPSAAI PKSGSAIKDE LISPKKEIDE 600
    VLALAPKWRI NEFDETGSVY YGALPYNYPE DDVLLDLDGL QYLVKNDEDY 650
    SYLQEALKDE PLMDINDPNF WAYERKSCKF KNGDVKYGDT AILPEPKGYF 700
    RSNTSGSAKS EGYYIIPTTE KSLYLPLRNR STIDTISHST SRITSRMNRV 750
    NNRRLAAGVE KSQLPAEADL LRFNALKARK KQLHFGPSRI HTLGLFAMEN 800
    IDKNDMVIEY IGEIIRQRVA DNREKNYVRE GIGDSYLFRI DEDVIVDATK 850
    KGNIARFINH SCAPNCIARI IRVEGKRKIV IYADRDIMHG EELTYDYKFP 900
    EEADKIPCLC GAPTCRGYLN 920
    Length:920
    Mass (Da):105,038
    Last modified:November 1, 1999 - v1
    Checksum:iC4AD7E6C3ECFF8BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAB41652.1.
    PIRiT41282.
    RefSeqiNP_587812.1. NM_001022805.2.

    Genome annotation databases

    EnsemblFungiiSPCC306.04c.1; SPCC306.04c.1:pep; SPCC306.04c.
    GeneIDi2538762.
    KEGGispo:SPCC306.04c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAB41652.1 .
    PIRi T41282.
    RefSeqi NP_587812.1. NM_001022805.2.

    3D structure databases

    ProteinModelPortali Q9Y7R4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275345. 358 interactions.
    IntActi Q9Y7R4. 1 interaction.
    MINTi MINT-4718299.
    STRINGi 4896.SPCC306.04c-1.

    Proteomic databases

    MaxQBi Q9Y7R4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC306.04c.1 ; SPCC306.04c.1:pep ; SPCC306.04c .
    GeneIDi 2538762.
    KEGGi spo:SPCC306.04c.

    Organism-specific databases

    PomBasei SPCC306.04c.

    Phylogenomic databases

    eggNOGi COG2940.
    KOi K11422.
    OMAi CGAPGCK.
    OrthoDBi EOG7P8PH3.
    PhylomeDBi Q9Y7R4.

    Miscellaneous databases

    NextBioi 20799946.
    PROi Q9Y7R4.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTi SM00508. PostSET. 1 hit.
    SM00360. RRM. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS50102. RRM. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast."
      Noma K., Grewal S.I.S.
      Proc. Natl. Acad. Sci. U.S.A. 99:16438-16445(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts."
      Roguev A., Schaft D., Shevchenko A., Aasland R., Shevchenko A., Stewart A.F.
      J. Biol. Chem. 278:8487-8493(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE SET1 COMPLEX.
    4. "The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway."
      Kanoh J., Francesconi S., Collura A., Schramke V., Ishikawa F., Baldacci G., Geli V.
      J. Mol. Biol. 326:1081-1094(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY.
    5. "A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe."
      Roguev A., Shevchenko A., Schaft D., Thomas H., Stewart A.F., Shevchenko A.
      Mol. Cell. Proteomics 3:125-132(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE SET1 COMPLEX.

    Entry informationi

    Entry nameiSET1_SCHPO
    AccessioniPrimary (citable) accession number: Q9Y7R4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3