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Q9Y7R4

- SET1_SCHPO

UniProt

Q9Y7R4 - SET1_SCHPO

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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

set1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic component of the Set1 complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Methylation promotes maintenance of active chromatin states at euchromatic chromosomal domains and is present throughout the cell cycle. Plays a role in telomere maintenance and DNA repair in an ATM kinase rad3-dependent pathway. Required for efficient telomeric and centromeric silencing.3 Publications

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].1 Publication

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: PomBase
  2. histone methyltransferase activity (H3-K4 specific) Source: PomBase
  3. nucleotide binding Source: InterPro
  4. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. chromatin remodeling Source: PomBase
  2. histone H3-K4 methylation Source: PomBase
  3. mitotic DNA damage checkpoint Source: PomBase
  4. telomere maintenance Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC:2.1.1.43)
Alternative name(s):
COMPASS component set1
Lysine N-methyltransferase 2
SET domain-containing protein 1
Set1 complex component set1
Short name:
Set1C component set1
Spset1
Gene namesi
Name:set1Imported
Synonyms:kmt2
ORF Names:SPCC306.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC306.04c.

Subcellular locationi

Nucleus Curated. Chromosome Curated

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. nuclear chromatin Source: PomBase
  3. Set1C/COMPASS complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 920920Histone-lysine N-methyltransferase, H3 lysine-4 specificPRO_0000186085Add
BLAST

Proteomic databases

MaxQBiQ9Y7R4.

Interactioni

Subunit structurei

Component of the Set1 complex composed of ash2, sdc1, set1, shg1, spp1, swd1, swd2 and swd3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
lid2Q9HDV42EBI-2106005,EBI-2105919

Protein-protein interaction databases

BioGridi275345. 359 interactions.
IntActiQ9Y7R4. 1 interaction.
MINTiMINT-4718299.
STRINGi4896.SPCC306.04c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9Y7R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 17986RRMPROSITE-ProRule annotationAdd
BLAST
Domaini781 – 898118SETPROSITE-ProRule annotationAdd
BLAST
Domaini904 – 92017Post-SETPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi469 – 4746Poly-ArgSequence Analysis

Domaini

A construct containing set1 C-terminal fragment of 692-920 is able to form H3K4me.

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiQ9Y7R4.
KOiK11422.
OMAiCGAPGCK.
OrthoDBiEOG7P8PH3.
PhylomeDBiQ9Y7R4.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y7R4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFNTSTRSK SQPVQRNNYK VLYDPELGIK ENLGRKIIYR FNGVSKPPLV
60 70 80 90 100
VRDPRLKNPI YARGIPKSGR PFLKSLQTIN YDYNENSLGP EPPTQVFVSN
110 120 130 140 150
ISPLVTSEQL RYHFKSFGEV FDLDLKLNPY TGTSLGLCCI SFDKRSSISV
160 170 180 190 200
AAHSAKIAVQ QANGLRFSGK PLSVVLDRDG SLCEEAFKKA LNAVEKQFQE
210 220 230 240 250
ETLQKQRFER EDESSRQKLS AAMNEDIPPW RQPSKNSQTL SNGDLQHSKV
260 270 280 290 300
QNVDQKSGFL TSSETDVPKN INDYIYLLID DRFVPPDRVY YTDIKHHFRK
310 320 330 340 350
FLYEKIYMNK DGFYITFNNY REASNCYRAL DRTYVQNCRI KLKFHDIPSR
360 370 380 390 400
TKEDGKKSAV RRVVLPPEEA YAEATSVVLR DLEAALLRDV KSKIIGPAIF
410 420 430 440 450
KYLHSMPKPS VKEELQENLL VSSTSVPDVP LKIESTVGKL PSLPKFKKRV
460 470 480 490 500
DSSKMNLSAG SKTKSKLQRR RRRRHEARPL HYQLNQMYNS SASEAESDQE
510 520 530 540 550
LLLSSGDERV ERGKIGSIKS VKSDEATPVF SDTSDENDKF HRFRTKSKIS
560 570 580 590 600
KKKYEKMEVD YTSSSETESD ASILSPSAAI PKSGSAIKDE LISPKKEIDE
610 620 630 640 650
VLALAPKWRI NEFDETGSVY YGALPYNYPE DDVLLDLDGL QYLVKNDEDY
660 670 680 690 700
SYLQEALKDE PLMDINDPNF WAYERKSCKF KNGDVKYGDT AILPEPKGYF
710 720 730 740 750
RSNTSGSAKS EGYYIIPTTE KSLYLPLRNR STIDTISHST SRITSRMNRV
760 770 780 790 800
NNRRLAAGVE KSQLPAEADL LRFNALKARK KQLHFGPSRI HTLGLFAMEN
810 820 830 840 850
IDKNDMVIEY IGEIIRQRVA DNREKNYVRE GIGDSYLFRI DEDVIVDATK
860 870 880 890 900
KGNIARFINH SCAPNCIARI IRVEGKRKIV IYADRDIMHG EELTYDYKFP
910 920
EEADKIPCLC GAPTCRGYLN
Length:920
Mass (Da):105,038
Last modified:November 1, 1999 - v1
Checksum:iC4AD7E6C3ECFF8BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB41652.1.
PIRiT41282.
RefSeqiNP_587812.1. NM_001022805.2.

Genome annotation databases

EnsemblFungiiSPCC306.04c.1; SPCC306.04c.1:pep; SPCC306.04c.
GeneIDi2538762.
KEGGispo:SPCC306.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB41652.1 .
PIRi T41282.
RefSeqi NP_587812.1. NM_001022805.2.

3D structure databases

ProteinModelPortali Q9Y7R4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275345. 359 interactions.
IntActi Q9Y7R4. 1 interaction.
MINTi MINT-4718299.
STRINGi 4896.SPCC306.04c-1.

Proteomic databases

MaxQBi Q9Y7R4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC306.04c.1 ; SPCC306.04c.1:pep ; SPCC306.04c .
GeneIDi 2538762.
KEGGi spo:SPCC306.04c.

Organism-specific databases

PomBasei SPCC306.04c.

Phylogenomic databases

eggNOGi COG2940.
InParanoidi Q9Y7R4.
KOi K11422.
OMAi CGAPGCK.
OrthoDBi EOG7P8PH3.
PhylomeDBi Q9Y7R4.

Miscellaneous databases

NextBioi 20799946.
PROi Q9Y7R4.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast."
    Noma K., Grewal S.I.S.
    Proc. Natl. Acad. Sci. U.S.A. 99:16438-16445(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts."
    Roguev A., Schaft D., Shevchenko A., Aasland R., Shevchenko A., Stewart A.F.
    J. Biol. Chem. 278:8487-8493(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE SET1 COMPLEX.
  4. "The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway."
    Kanoh J., Francesconi S., Collura A., Schramke V., Ishikawa F., Baldacci G., Geli V.
    J. Mol. Biol. 326:1081-1094(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.
  5. "A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe."
    Roguev A., Shevchenko A., Schaft D., Thomas H., Stewart A.F., Shevchenko A.
    Mol. Cell. Proteomics 3:125-132(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SET1 COMPLEX.

Entry informationi

Entry nameiSET1_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3