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Reviewed, UniProtKB/Swiss-Prot Q9Y7Q2 (GST1_SCHPO)

Last modified June 16, 2009. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glutathione S-transferase 1
    EC=2.5.1.18
Alternative name(s):
    GST-I
Gene names
Name: gst1
ORF Names: SPCC191.09c
OrganismSchizosaccharomyces pombe (Fission yeast) [Complete proteome]
Taxonomic identifier4896 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

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Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Involved in the oxidative stress response and detoxification.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Induction

By heavy metals such as cadmium.

Sequence similarities

Belongs to the GST superfamily.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

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Ontologies

Keywords
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcellular response to oxidative stress

Traceable author statement. Source: GeneDB_SPombe

response to drug

Traceable author statement. Source: GeneDB_SPombe

   Cellular componentcytosol

Inferred from direct assay. Source: GeneDB_SPombe

nucleus

Inferred from direct assay. Source: GeneDB_SPombe

   Molecular functionglutathione transferase activity

Inferred from direct assay. Source: GeneDB_SPombe

protein heterodimerization activity

Inferred from physical interaction. Source: GeneDB_SPombe

protein homodimerization activity

Inferred from physical interaction. Source: GeneDB_SPombe

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Glutathione S-transferase 1
PRO_0000185984

Regions

Domain2 – 8685GST N-terminal
Domain93 – 229137GST C-terminal

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Sequences

Sequence LengthMass (Da)Tools
Q9Y7Q2-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 9A302350C5FD3CD7

FASTA22927,017
        10         20         30         40         50         60 
MAQFTLWSHA HGPNPWKVVQ ALKELDLTYE TRYVNFSKNE QKSPEHLALN PNGRVPTLID 

        70         80         90        100        110        120 
HHNNDYTIWE SDAILIYLAD KYDTERKISL PRDHPEYYKV IQYLFFQASG QGIIWGQAGW 

       130        140        150        160        170        180 
FSVYHQELVI SAITRYRNEI KRVLGVLEDI LKDRDYLVAN RFTIADLSFI SWNNFLEIIF 

       190        200        210        220 
AEGKFSIEEE VPQLDFEKEF PRTYSWHQRL LARPASKATF EERSKALDN

« Hide

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References

« Hide 'large scale' references
[1]"Characterization and regulation of glutathione S-transferase gene from Schizosaccharomyces pombe."
Kim H.-G., Park K.-N., Cho Y.-W., Park E.-H., Fuchs J.A., Lim C.-J.
Biochim. Biophys. Acta 1520:179-185(2001) [PubMed: 11513961] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 38366 / 972.

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Cross-references

Sequence databases

AF213355 Genomic DNA. Translation: AAF21054.1.
CU329672 Genomic DNA. Translation: CAB41055.1.
PIRT41222.
RefSeqNP_588298.1.

3D structure databases

HSSPHSSP built from PDB template 1K0D based on UniProtKB P23202.
ModBaseSearch...

Genome annotation databases

GeneID2538694.
KEGGspo:SPCC191.09c.
NMPDRfig|4896.1.peg.636.

Organism-specific databases

GeneDB_SpombeSPCC191.09c.

Phylogenomic databases

OMAQ9Y7Q2. ITRKWPA.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-000224-MON.
BRENDA2.5.1.18. 653.

Gene expression databases

ArrayExpressQ9Y7Q2.

Family and domain databases

InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR017933. Glutathione_S_Trfase/Cl_chnl_C.
IPR004046. GST_C.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:1.20.1050.10. GST_C_like. 1 hit.
G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGST1_SCHPO
AccessionPrimary (citable) accession number: Q9Y7Q2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1999
Last modified: June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents