Q9Y7Q2 (GST1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase 1
EC=2.5.1.18

Alternative name(s):
GST-I

Gene names

Name:	gst1
ORF Names:	SPCC191.09c

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the oxidative stress response and detoxification.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Induction	By heavy metals such as cadmium.
Sequence similarities	Belongs to the GST superfamily. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to oxidative stress Traceable author statement PubMed 12063243. Source: PomBase response to drug Traceable author statement PubMed 12063243. Source: PomBase
Cellular_component	cytosol Inferred from direct assay PubMed 16823372. Source: PomBase nucleus Inferred from direct assay PubMed 12063243PubMed 16823372. Source: PomBase
Molecular_function	glutathione transferase activity Inferred from direct assay PubMed 12063243. Source: PomBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Glutathione S-transferase 1		PRO_0000185984
Regions
	Domain	2 – 86	85	GST N-terminal
	Domain	93 – 229	137	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	Q9Y7Q2 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 9A302350C5FD3CD7	FASTA	229	27,017
	10 20 30 40 50 60 MAQFTLWSHA HGPNPWKVVQ ALKELDLTYE TRYVNFSKNE QKSPEHLALN PNGRVPTLID 70 80 90 100 110 120 HHNNDYTIWE SDAILIYLAD KYDTERKISL PRDHPEYYKV IQYLFFQASG QGIIWGQAGW 130 140 150 160 170 180 FSVYHQELVI SAITRYRNEI KRVLGVLEDI LKDRDYLVAN RFTIADLSFI SWNNFLEIIF 190 200 210 220 AEGKFSIEEE VPQLDFEKEF PRTYSWHQRL LARPASKATF EERSKALDN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization and regulation of glutathione S-transferase gene from Schizosaccharomyces pombe." Kim H.-G., Park K.-N., Cho Y.-W., Park E.-H., Fuchs J.A., Lim C.-J. Biochim. Biophys. Acta 1520:179-185(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF213355 Genomic DNA. Translation: AAF21054.1. CU329672 Genomic DNA. Translation: CAB41055.1.
PIR	T41222.
RefSeq	NP_588298.1. NM_001023288.2.
3D structure databases
ProteinModelPortal	Q9Y7Q2.
ModBase	Search...
Protein-protein interaction databases
STRING	4896.SPCC191.09c-1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPCC191.09c.1; SPCC191.09c.1:pep; SPCC191.09c.
GeneID	2538694.
KEGG	spo:SPCC191.09c.
Organism-specific databases
PomBase	SPCC191.09c.
Phylogenomic databases
eggNOG	COG0625.
HOGENOM	HOG000125752.
KO	K00799.
OMA	WAKLWER.
OrthoDB	EOG4BP4MZ.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20799880.

Entry information

Entry name

GST1_SCHPO

Accession

Primary (citable) accession number: Q9Y7Q2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program