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Q9Y7Q2

- GST1_SCHPO

UniProt

Q9Y7Q2 - GST1_SCHPO

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Protein

Glutathione S-transferase 1

Gene

gst1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the oxidative stress response and detoxification.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: PomBase

GO - Biological processi

  1. cellular response to oxidative stress Source: PomBase
  2. metabolic process Source: GOC
  3. response to drug Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1 (EC:2.5.1.18)
Alternative name(s):
GST-I
Gene namesi
Name:gst1
ORF Names:SPCC191.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC191.09c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Glutathione S-transferase 1PRO_0000185984Add
BLAST

Expressioni

Inductioni

By heavy metals such as cadmium.

Interactioni

Protein-protein interaction databases

BioGridi275279. 29 interactions.
MINTiMINT-4717984.
STRINGi4896.SPCC191.09c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9Y7Q2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8685GST N-terminalAdd
BLAST
Domaini93 – 229137GST C-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the GST superfamily.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125752.
InParanoidiQ9Y7Q2.
KOiK00799.
OMAiHEILPSV.
OrthoDBiEOG7KWSWX.
PhylomeDBiQ9Y7Q2.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y7Q2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQFTLWSHA HGPNPWKVVQ ALKELDLTYE TRYVNFSKNE QKSPEHLALN
60 70 80 90 100
PNGRVPTLID HHNNDYTIWE SDAILIYLAD KYDTERKISL PRDHPEYYKV
110 120 130 140 150
IQYLFFQASG QGIIWGQAGW FSVYHQELVI SAITRYRNEI KRVLGVLEDI
160 170 180 190 200
LKDRDYLVAN RFTIADLSFI SWNNFLEIIF AEGKFSIEEE VPQLDFEKEF
210 220
PRTYSWHQRL LARPASKATF EERSKALDN
Length:229
Mass (Da):27,017
Last modified:November 1, 1999 - v1
Checksum:i9A302350C5FD3CD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF213355 Genomic DNA. Translation: AAF21054.1.
CU329672 Genomic DNA. Translation: CAB41055.1.
PIRiT41222.
RefSeqiNP_588298.1. NM_001023288.2.

Genome annotation databases

EnsemblFungiiSPCC191.09c.1; SPCC191.09c.1:pep; SPCC191.09c.
GeneIDi2538694.
KEGGispo:SPCC191.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF213355 Genomic DNA. Translation: AAF21054.1 .
CU329672 Genomic DNA. Translation: CAB41055.1 .
PIRi T41222.
RefSeqi NP_588298.1. NM_001023288.2.

3D structure databases

ProteinModelPortali Q9Y7Q2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275279. 29 interactions.
MINTi MINT-4717984.
STRINGi 4896.SPCC191.09c-1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC191.09c.1 ; SPCC191.09c.1:pep ; SPCC191.09c .
GeneIDi 2538694.
KEGGi spo:SPCC191.09c.

Organism-specific databases

PomBasei SPCC191.09c.

Phylogenomic databases

eggNOGi COG0625.
HOGENOMi HOG000125752.
InParanoidi Q9Y7Q2.
KOi K00799.
OMAi HEILPSV.
OrthoDBi EOG7KWSWX.
PhylomeDBi Q9Y7Q2.

Miscellaneous databases

NextBioi 20799880.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and regulation of glutathione S-transferase gene from Schizosaccharomyces pombe."
    Kim H.-G., Park K.-N., Cho Y.-W., Park E.-H., Fuchs J.A., Lim C.-J.
    Biochim. Biophys. Acta 1520:179-185(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiGST1_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3