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Q9Y7Q2

- GST1_SCHPO

UniProt

Q9Y7Q2 - GST1_SCHPO

Protein

Glutathione S-transferase 1

Gene

gst1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Involved in the oxidative stress response and detoxification.

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione transferase activity Source: PomBase

    GO - Biological processi

    1. cellular response to oxidative stress Source: PomBase
    2. metabolic process Source: GOC
    3. response to drug Source: PomBase

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase 1 (EC:2.5.1.18)
    Alternative name(s):
    GST-I
    Gene namesi
    Name:gst1
    ORF Names:SPCC191.09c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC191.09c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Glutathione S-transferase 1PRO_0000185984Add
    BLAST

    Expressioni

    Inductioni

    By heavy metals such as cadmium.

    Interactioni

    Protein-protein interaction databases

    BioGridi275279. 29 interactions.
    MINTiMINT-4717984.
    STRINGi4896.SPCC191.09c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y7Q2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 8685GST N-terminalAdd
    BLAST
    Domaini93 – 229137GST C-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GST superfamily.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    HOGENOMiHOG000125752.
    KOiK00799.
    OMAiHEILPSV.
    OrthoDBiEOG7KWSWX.
    PhylomeDBiQ9Y7Q2.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y7Q2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQFTLWSHA HGPNPWKVVQ ALKELDLTYE TRYVNFSKNE QKSPEHLALN    50
    PNGRVPTLID HHNNDYTIWE SDAILIYLAD KYDTERKISL PRDHPEYYKV 100
    IQYLFFQASG QGIIWGQAGW FSVYHQELVI SAITRYRNEI KRVLGVLEDI 150
    LKDRDYLVAN RFTIADLSFI SWNNFLEIIF AEGKFSIEEE VPQLDFEKEF 200
    PRTYSWHQRL LARPASKATF EERSKALDN 229
    Length:229
    Mass (Da):27,017
    Last modified:November 1, 1999 - v1
    Checksum:i9A302350C5FD3CD7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF213355 Genomic DNA. Translation: AAF21054.1.
    CU329672 Genomic DNA. Translation: CAB41055.1.
    PIRiT41222.
    RefSeqiNP_588298.1. NM_001023288.2.

    Genome annotation databases

    EnsemblFungiiSPCC191.09c.1; SPCC191.09c.1:pep; SPCC191.09c.
    GeneIDi2538694.
    KEGGispo:SPCC191.09c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF213355 Genomic DNA. Translation: AAF21054.1 .
    CU329672 Genomic DNA. Translation: CAB41055.1 .
    PIRi T41222.
    RefSeqi NP_588298.1. NM_001023288.2.

    3D structure databases

    ProteinModelPortali Q9Y7Q2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275279. 29 interactions.
    MINTi MINT-4717984.
    STRINGi 4896.SPCC191.09c-1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC191.09c.1 ; SPCC191.09c.1:pep ; SPCC191.09c .
    GeneIDi 2538694.
    KEGGi spo:SPCC191.09c.

    Organism-specific databases

    PomBasei SPCC191.09c.

    Phylogenomic databases

    eggNOGi COG0625.
    HOGENOMi HOG000125752.
    KOi K00799.
    OMAi HEILPSV.
    OrthoDBi EOG7KWSWX.
    PhylomeDBi Q9Y7Q2.

    Miscellaneous databases

    NextBioi 20799880.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and regulation of glutathione S-transferase gene from Schizosaccharomyces pombe."
      Kim H.-G., Park K.-N., Cho Y.-W., Park E.-H., Fuchs J.A., Lim C.-J.
      Biochim. Biophys. Acta 1520:179-185(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiGST1_SCHPO
    AccessioniPrimary (citable) accession number: Q9Y7Q2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3