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Q9Y7Q2 (GST1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase 1

EC=2.5.1.18
Alternative name(s):
GST-I
Gene names
Name:gst1
ORF Names:SPCC191.09c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the oxidative stress response and detoxification.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Induction

By heavy metals such as cadmium.

Sequence similarities

Belongs to the GST superfamily.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Glutathione S-transferase 1
PRO_0000185984

Regions

Domain2 – 8685GST N-terminal
Domain93 – 229137GST C-terminal

Sequences

Sequence LengthMass (Da)Tools
Q9Y7Q2 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 9A302350C5FD3CD7

FASTA22927,017
        10         20         30         40         50         60 
MAQFTLWSHA HGPNPWKVVQ ALKELDLTYE TRYVNFSKNE QKSPEHLALN PNGRVPTLID 

        70         80         90        100        110        120 
HHNNDYTIWE SDAILIYLAD KYDTERKISL PRDHPEYYKV IQYLFFQASG QGIIWGQAGW 

       130        140        150        160        170        180 
FSVYHQELVI SAITRYRNEI KRVLGVLEDI LKDRDYLVAN RFTIADLSFI SWNNFLEIIF 

       190        200        210        220 
AEGKFSIEEE VPQLDFEKEF PRTYSWHQRL LARPASKATF EERSKALDN 

« Hide

References

« Hide 'large scale' references
[1]"Characterization and regulation of glutathione S-transferase gene from Schizosaccharomyces pombe."
Kim H.-G., Park K.-N., Cho Y.-W., Park E.-H., Fuchs J.A., Lim C.-J.
Biochim. Biophys. Acta 1520:179-185(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF213355 Genomic DNA. Translation: AAF21054.1.
CU329672 Genomic DNA. Translation: CAB41055.1.
PIRT41222.
RefSeqNP_588298.1. NM_001023288.2.

3D structure databases

ProteinModelPortalQ9Y7Q2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid275279. 29 interactions.
MINTMINT-4717984.
STRING4896.SPCC191.09c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC191.09c.1; SPCC191.09c.1:pep; SPCC191.09c.
GeneID2538694.
KEGGspo:SPCC191.09c.

Organism-specific databases

PomBaseSPCC191.09c.

Phylogenomic databases

eggNOGCOG0625.
HOGENOMHOG000125752.
KOK00799.
OMAHEILPSV.
OrthoDBEOG7KWSWX.
PhylomeDBQ9Y7Q2.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20799880.

Entry information

Entry nameGST1_SCHPO
AccessionPrimary (citable) accession number: Q9Y7Q2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names