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Q9Y7P0

- RISA_SCHPO

UniProt

Q9Y7P0 - RISA_SCHPO

Protein

Riboflavin synthase

Gene

rib5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.1 Publication

    Catalytic activityi

    2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

    Pathwayi

    GO - Molecular functioni

    1. oxidoreductase activity Source: InterPro
    2. riboflavin synthase activity Source: PomBase

    GO - Biological processi

    1. riboflavin biosynthetic process Source: PomBase

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Riboflavin biosynthesis

    Enzyme and pathway databases

    BRENDAi2.5.1.9. 5615.
    UniPathwayiUPA00275; UER00405.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Riboflavin synthase (EC:2.5.1.9)
    Short name:
    RS
    Gene namesi
    Name:rib5
    ORF Names:SPCC1450.13c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC1450.13c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Riboflavin synthasePRO_0000068173Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y7P0.

    Interactioni

    Subunit structurei

    Homotrimer.1 Publication

    Protein-protein interaction databases

    MINTiMINT-4717668.
    STRINGi4896.SPCC1450.13c-1.

    Structurei

    Secondary structure

    1
    208
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi8 – 1811
    Turni19 – 213
    Beta strandi22 – 287
    Helixi30 – 323
    Beta strandi41 – 444
    Beta strandi47 – 548
    Beta strandi56 – 638
    Helixi65 – 706
    Helixi73 – 753
    Beta strandi81 – 866
    Beta strandi94 – 963
    Beta strandi105 – 11511
    Beta strandi118 – 12710
    Helixi128 – 1336
    Beta strandi139 – 1424
    Beta strandi145 – 1528
    Beta strandi157 – 1615
    Helixi163 – 1664
    Helixi170 – 1734
    Beta strandi179 – 1846
    Helixi187 – 19812
    Turni199 – 2013

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KZLX-ray2.10A1-208[»]
    ProteinModelPortaliQ9Y7P0.
    SMRiQ9Y7P0. Positions 1-202.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y7P0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1 – 9797Lumazine-binding 1Add
    BLAST
    Repeati98 – 19598Lumazine-binding 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni81 – 855Lumazine bindingCurated
    Regioni179 – 1835Lumazine bindingCurated

    Sequence similaritiesi

    Contains 2 lumazine-binding repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0307.
    HOGENOMiHOG000151757.
    KOiK00793.
    OMAiVDQIGKY.
    OrthoDBiEOG793BMH.
    PhylomeDBiQ9Y7P0.

    Family and domain databases

    Gene3Di2.40.30.20. 2 hits.
    InterProiIPR023366. ATPase_asu-like.
    IPR001783. Lumazine-bd.
    IPR026017. Lumazine-bd_dom.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view]
    PANTHERiPTHR21098. PTHR21098. 1 hit.
    PfamiPF00677. Lum_binding. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000498. Riboflavin_syn_A. 1 hit.
    SUPFAMiSSF63380. SSF63380. 2 hits.
    TIGRFAMsiTIGR00187. ribE. 1 hit.
    PROSITEiPS51177. LUMAZINE_BIND. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y7P0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFTGLVEAIG VVKDVQGTID NGFAMKIEAP QILDDCHTGD SIAVNGTCLT    50
    VTDFDRYHFT VGIAPESLRL TNLGQCKAGD PVNLERAVLS STRMGGHFVQ 100
    GHVDTVAEIV EKKQDGEAID FTFRPRDPFV LKYIVYKGYI ALDGTSLTIT 150
    HVDDSTFSIM MISYTQSKVI MAKKNVGDLV NVEVDQIGKY TEKLVEAHIA 200
    DWIKKTQA 208
    Length:208
    Mass (Da):22,861
    Last modified:November 1, 1999 - v1
    Checksum:i59C5065DDD4C7B8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF505789 mRNA. Translation: AAM28201.1.
    CU329672 Genomic DNA. Translation: CAB40180.1.
    PIRiT40995.
    RefSeqiNP_588312.1. NM_001023302.2.

    Genome annotation databases

    EnsemblFungiiSPCC1450.13c.1; SPCC1450.13c.1:pep; SPCC1450.13c.
    GeneIDi2539183.
    KEGGispo:SPCC1450.13c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF505789 mRNA. Translation: AAM28201.1 .
    CU329672 Genomic DNA. Translation: CAB40180.1 .
    PIRi T40995.
    RefSeqi NP_588312.1. NM_001023302.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KZL X-ray 2.10 A 1-208 [» ]
    ProteinModelPortali Q9Y7P0.
    SMRi Q9Y7P0. Positions 1-202.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4717668.
    STRINGi 4896.SPCC1450.13c-1.

    Proteomic databases

    MaxQBi Q9Y7P0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC1450.13c.1 ; SPCC1450.13c.1:pep ; SPCC1450.13c .
    GeneIDi 2539183.
    KEGGi spo:SPCC1450.13c.

    Organism-specific databases

    PomBasei SPCC1450.13c.

    Phylogenomic databases

    eggNOGi COG0307.
    HOGENOMi HOG000151757.
    KOi K00793.
    OMAi VDQIGKY.
    OrthoDBi EOG793BMH.
    PhylomeDBi Q9Y7P0.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00405 .
    BRENDAi 2.5.1.9. 5615.

    Miscellaneous databases

    EvolutionaryTracei Q9Y7P0.
    NextBioi 20800354.
    PROi Q9Y7P0.

    Family and domain databases

    Gene3Di 2.40.30.20. 2 hits.
    InterProi IPR023366. ATPase_asu-like.
    IPR001783. Lumazine-bd.
    IPR026017. Lumazine-bd_dom.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view ]
    PANTHERi PTHR21098. PTHR21098. 1 hit.
    Pfami PF00677. Lum_binding. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000498. Riboflavin_syn_A. 1 hit.
    SUPFAMi SSF63380. SSF63380. 2 hits.
    TIGRFAMsi TIGR00187. ribE. 1 hit.
    PROSITEi PS51177. LUMAZINE_BIND. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments."
      Fischer M., Schott A.-K., Kemter K., Feicht R., Richter G., Illarionov B., Eisenreich W., Gerhardt S., Cushman M., Steinbacher S., Huber R., Bacher A.
      BMC Biochem. 4:18-18(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine."
      Gerhardt S., Schott A.-K., Kairies N., Cushman M., Illarionov B., Eisenreich W., Bacher A., Huber R., Steinbacher S., Fischer M.
      Structure 10:1371-1381(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).

    Entry informationi

    Entry nameiRISA_SCHPO
    AccessioniPrimary (citable) accession number: Q9Y7P0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3