Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

AP-2 complex subunit sigma

Gene

aps2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processEndocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-SPO-8866427 VLDLR internalisation and degradation
R-SPO-8964038 LDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
AP-2 complex subunit sigma
Alternative name(s):
Adaptin small chain
Clathrin assembly protein 2 sigma small chain
Sigma2-adaptin
Gene namesi
Name:aps2
ORF Names:SPBC685.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC685.04c
PomBaseiSPBC685.04c aps2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938131 – 143AP-2 complex subunit sigmaAdd BLAST143

Proteomic databases

MaxQBiQ9Y7L6
PaxDbiQ9Y7L6
PRIDEiQ9Y7L6

Interactioni

Subunit structurei

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit apl3 and beta-type subunit apl1), a medium chain (mu-type subunit apm4) and a small adaptin (sigma-type subunit aps2).By similarity

Protein-protein interaction databases

BioGridi277601, 11 interactors
STRINGi4896.SPBC685.04c.1

Structurei

3D structure databases

ProteinModelPortaliQ9Y7L6
SMRiQ9Y7L6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000185228
InParanoidiQ9Y7L6
KOiK11827
OMAiSFFDNVC
OrthoDBiEOG092C59LG
PhylomeDBiQ9Y7L6

Family and domain databases

InterProiView protein in InterPro
IPR016635 AP_complex_ssu
IPR022775 AP_mu_sigma_su
IPR027156 APS2
IPR000804 Clathrin_sm-chain_CS
IPR011012 Longin-like_dom_sf
PANTHERiPTHR11753 PTHR11753, 1 hit
PTHR11753:SF6 PTHR11753:SF6, 1 hit
PfamiView protein in Pfam
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF015588 AP_complex_sigma, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00989 CLAT_ADAPTOR_S, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y7L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQFILIQNR HGKNRLSKYY VPFDDDEKVR LKARIHQLIS QRNQKFQANF
60 70 80 90 100
LEWENSKLVY RRYAGLYFCF CVDSTDNDLA ILEMIHFFVE ILDSFFGNVC
110 120 130 140
ELDLIFNFYK VSAILDEIIL GGEIGESNKK SVLERIEALE KLE
Length:143
Mass (Da):16,939
Last modified:November 1, 1999 - v1
Checksum:i87E1A6945A741121
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB39361.1
PIRiT40635
RefSeqiNP_596138.1, NM_001022056.2

Genome annotation databases

EnsemblFungiiSPBC685.04c.1; SPBC685.04c.1:pep; SPBC685.04c
GeneIDi2541086
KEGGispo:SPBC685.04c

Similar proteinsi

Entry informationi

Entry nameiAP2S_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health