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Protein

AP-2 complex subunit sigma

Gene

aps2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Endocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-2 complex subunit sigma
Alternative name(s):
Adaptin small chain
Clathrin assembly protein 2 sigma small chain
Sigma2-adaptin
Gene namesi
Name:aps2
ORF Names:SPBC685.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC685.04c.
PomBaseiSPBC685.04c. aps2.

Subcellular locationi

GO - Cellular componenti

  • AP-2 adaptor complex Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143AP-2 complex subunit sigmaPRO_0000193813Add
BLAST

Proteomic databases

MaxQBiQ9Y7L6.

Interactioni

Subunit structurei

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit apl3 and beta-type subunit apl1), a medium chain (mu-type subunit apm4) and a small adaptin (sigma-type subunit aps2).By similarity

Protein-protein interaction databases

BioGridi277601. 11 interactions.
MINTiMINT-4716853.

Structurei

3D structure databases

ProteinModelPortaliQ9Y7L6.
SMRiQ9Y7L6. Positions 1-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000185228.
InParanoidiQ9Y7L6.
KOiK11827.
OMAiSFFDNVC.
OrthoDBiEOG092C59LG.
PhylomeDBiQ9Y7L6.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF015588. AP_complex_sigma. 1 hit.
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y7L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQFILIQNR HGKNRLSKYY VPFDDDEKVR LKARIHQLIS QRNQKFQANF
60 70 80 90 100
LEWENSKLVY RRYAGLYFCF CVDSTDNDLA ILEMIHFFVE ILDSFFGNVC
110 120 130 140
ELDLIFNFYK VSAILDEIIL GGEIGESNKK SVLERIEALE KLE
Length:143
Mass (Da):16,939
Last modified:November 1, 1999 - v1
Checksum:i87E1A6945A741121
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB39361.1.
PIRiT40635.
RefSeqiNP_596138.1. NM_001022056.2.

Genome annotation databases

EnsemblFungiiSPBC685.04c.1; SPBC685.04c.1:pep; SPBC685.04c.
GeneIDi2541086.
KEGGispo:SPBC685.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB39361.1.
PIRiT40635.
RefSeqiNP_596138.1. NM_001022056.2.

3D structure databases

ProteinModelPortaliQ9Y7L6.
SMRiQ9Y7L6. Positions 1-143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277601. 11 interactions.
MINTiMINT-4716853.

Proteomic databases

MaxQBiQ9Y7L6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC685.04c.1; SPBC685.04c.1:pep; SPBC685.04c.
GeneIDi2541086.
KEGGispo:SPBC685.04c.

Organism-specific databases

EuPathDBiFungiDB:SPBC685.04c.
PomBaseiSPBC685.04c. aps2.

Phylogenomic databases

HOGENOMiHOG000185228.
InParanoidiQ9Y7L6.
KOiK11827.
OMAiSFFDNVC.
OrthoDBiEOG092C59LG.
PhylomeDBiQ9Y7L6.

Miscellaneous databases

PROiQ9Y7L6.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF015588. AP_complex_sigma. 1 hit.
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP2S_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.