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Protein

Protein transport protein sec22

Gene

sec22

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Nonessential SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-SPO-5694530. Cargo concentration in the ER.
R-SPO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein sec22
Gene namesi
Name:sec22
ORF Names:SPBC2A9.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC2A9.08c.
PomBaseiSPBC2A9.08c. sec22.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 194194CytoplasmicSequence analysisAdd
BLAST
Transmembranei195 – 21521Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Leads to sensitivity to thiabendazole, camptothecin, DNA damaging agents, and microtubule depolymerizing drugs.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Protein transport protein sec22PRO_0000206767Add
BLAST

Proteomic databases

MaxQBiQ9Y7L0.

Interactioni

Subunit structurei

Component of two distinct SNARE complexes consisting of sed5, bos1, bet1 and sec22 or ufe1, use1, sec20 and sec22. Ykt6 can probably replace sec22 as subunit of either complex (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9Y7L0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 118110LonginPROSITE-ProRule annotationAdd
BLAST
Domaini133 – 19361v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 longin domain.PROSITE-ProRule annotation
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000044957.
InParanoidiQ9Y7L0.
KOiK08517.
OMAiQYGPIGG.
OrthoDBiEOG092C4MCV.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y7L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKSTTVTRL DGLPLAASVD DESTERNLES HKKQAKLILK RLSPTSEKRA
60 70 80 90 100
SIESGDYTFH YLIDNGICYL CICEQSYPRK LAFSYLEELA GEFWNSFGEE
110 120 130 140 150
ALQPGLRPYA FVQFDTFMQK SKRVYNTPRA NDNLDKLNTE LKDVTRVMTK
160 170 180 190 200
NIEDLLYRGD SLEKMADLSS DLRYSSAKYK KAARRVNLEA LWRQYGPVSI
210
IALLFLIFVY WRFFA
Length:215
Mass (Da):24,903
Last modified:July 11, 2012 - v2
Checksum:i666A803AC412CC39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB39850.2.
PIRiT40099.
RefSeqiNP_596218.2. NM_001022137.2.

Genome annotation databases

EnsemblFungiiSPBC2A9.08c.1; SPBC2A9.08c.1:pep; SPBC2A9.08c.
GeneIDi2540308.
KEGGispo:SPBC2A9.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB39850.2.
PIRiT40099.
RefSeqiNP_596218.2. NM_001022137.2.

3D structure databases

ProteinModelPortaliQ9Y7L0.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ9Y7L0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC2A9.08c.1; SPBC2A9.08c.1:pep; SPBC2A9.08c.
GeneIDi2540308.
KEGGispo:SPBC2A9.08c.

Organism-specific databases

EuPathDBiFungiDB:SPBC2A9.08c.
PomBaseiSPBC2A9.08c. sec22.

Phylogenomic databases

HOGENOMiHOG000044957.
InParanoidiQ9Y7L0.
KOiK08517.
OMAiQYGPIGG.
OrthoDBiEOG092C4MCV.

Enzyme and pathway databases

ReactomeiR-SPO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-SPO-5694530. Cargo concentration in the ER.
R-SPO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiQ9Y7L0.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEC22_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 11, 2012
Last modified: September 7, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.