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Protein

Protein transport protein sec22

Gene

sec22

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nonessential SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-204005 COPII-mediated vesicle transport
R-SPO-5694530 Cargo concentration in the ER
R-SPO-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein sec22
Gene namesi
Name:sec22
ORF Names:SPBC2A9.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC2A9.08c
PomBaseiSPBC2A9.08c sec22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 194CytoplasmicSequence analysisAdd BLAST194
Transmembranei195 – 215Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Leads to sensitivity to thiabendazole, camptothecin, DNA damaging agents, and microtubule depolymerizing drugs.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002067671 – 215Protein transport protein sec22Add BLAST215

Proteomic databases

MaxQBiQ9Y7L0
PaxDbiQ9Y7L0
PRIDEiQ9Y7L0

PTM databases

iPTMnetiQ9Y7L0

Interactioni

Subunit structurei

Component of two distinct SNARE complexes consisting of sed5, bos1, bet1 and sec22 or ufe1, use1, sec20 and sec22. Ykt6 can probably replace sec22 as subunit of either complex (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi4896.SPBC2A9.08c.1

Structurei

3D structure databases

ProteinModelPortaliQ9Y7L0
SMRiQ9Y7L0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 118LonginPROSITE-ProRule annotationAdd BLAST110
Domaini133 – 193v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000044957
InParanoidiQ9Y7L0
KOiK08517
OMAiMLCASVD
OrthoDBiEOG092C4MCV

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom
IPR001388 Synaptobrevin
PfamiView protein in Pfam
PF13774 Longin, 1 hit
PF00957 Synaptobrevin, 1 hit
SMARTiView protein in SMART
SM01270 Longin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS50859 LONGIN, 1 hit
PS50892 V_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y7L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKSTTVTRL DGLPLAASVD DESTERNLES HKKQAKLILK RLSPTSEKRA
60 70 80 90 100
SIESGDYTFH YLIDNGICYL CICEQSYPRK LAFSYLEELA GEFWNSFGEE
110 120 130 140 150
ALQPGLRPYA FVQFDTFMQK SKRVYNTPRA NDNLDKLNTE LKDVTRVMTK
160 170 180 190 200
NIEDLLYRGD SLEKMADLSS DLRYSSAKYK KAARRVNLEA LWRQYGPVSI
210
IALLFLIFVY WRFFA
Length:215
Mass (Da):24,903
Last modified:July 11, 2012 - v2
Checksum:i666A803AC412CC39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB39850.2
PIRiT40099
RefSeqiNP_596218.2, NM_001022137.2

Genome annotation databases

EnsemblFungiiSPBC2A9.08c.1; SPBC2A9.08c.1:pep; SPBC2A9.08c
GeneIDi2540308
KEGGispo:SPBC2A9.08c

Similar proteinsi

Entry informationi

Entry nameiSEC22_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7L0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 11, 2012
Last modified: May 23, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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