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Q9Y7K2

- TOR2_SCHPO

UniProt

Q9Y7K2 - TOR2_SCHPO

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Protein

Phosphatidylinositol 3-kinase tor2

Gene

tor2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Phosphatidylinositol 3-kinase homolog required for G1 progression.By similarity

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. drug binding Source: InterPro

GO - Biological processi

  1. cell cycle arrest in response to nitrogen starvation Source: PomBase
  2. cellular response to nutrient Source: PomBase
  3. negative regulation of autophagy Source: PomBase
  4. negative regulation of cell cycle arrest in response to nitrogen starvation Source: PomBase
  5. negative regulation of induction of conjugation with cellular fusion Source: PomBase
  6. signal transduction Source: PomBase
  7. TOR signaling Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_188268. CD28 dependent PI3K/Akt signaling.
REACT_188279. PIP3 activates AKT signaling.
REACT_207307. HSF1-dependent transactivation.
REACT_227968. Constitutive PI3K/AKT Signaling in Cancer.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase tor2 (EC:2.7.1.137)
Short name:
PI3-kinase tor2
Short name:
PI3K tor2
Short name:
PtdIns-3-kinase tor2
Gene namesi
Name:tor2
ORF Names:SPBC216.07c, SPBC646.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC216.07c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. Tor2-Mei2-Ste11 complex Source: PomBase
  4. TORC1 complex Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23372337Phosphatidylinositol 3-kinase tor2PRO_0000088814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2238 – 22381Phosphoserine1 Publication
Modified residuei2240 – 22401Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y7K2.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
tel2Q9P3W53EBI-2014299,EBI-2014377

Protein-protein interaction databases

BioGridi277243. 34 interactions.
IntActiQ9Y7K2. 7 interactions.
MINTiMINT-4716528.
STRINGi4896.SPBC216.07c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9Y7K2.
SMRiQ9Y7K2. Positions 1817-1916, 2306-2337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati163 – 20038HEAT 1Add
BLAST
Repeati249 – 28638HEAT 2Add
BLAST
Repeati290 – 32637HEAT 3Add
BLAST
Repeati409 – 44638HEAT 4Add
BLAST
Repeati474 – 51239HEAT 5Add
BLAST
Repeati559 – 59638HEAT 6Add
BLAST
Repeati642 – 67938HEAT 7Add
BLAST
Repeati683 – 72139HEAT 8Add
BLAST
Repeati727 – 76539HEAT 9Add
BLAST
Repeati802 – 84039HEAT 10Add
BLAST
Repeati844 – 88037HEAT 11Add
BLAST
Repeati881 – 92141HEAT 12Add
BLAST
Repeati965 – 100440HEAT 13Add
BLAST
Repeati1006 – 104338HEAT 14Add
BLAST
Domaini1228 – 1784557FATPROSITE-ProRule annotationAdd
BLAST
Domaini1990 – 2304315PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST
Domaini2305 – 233733FATCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 14 HEAT repeats.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5032.
HOGENOMiHOG000163215.
InParanoidiQ9Y7K2.
KOiK07203.
OMAiTYKQNIG.
OrthoDBiEOG7Z3FCR.
PhylomeDBiQ9Y7K2.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
1.25.10.10. 6 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC.
IPR021133. HEAT_type_2.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR009076. Rapamycin-bd_dom.
[Graphical view]
PfamiPF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08771. Rapamycin_bind. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 5 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS50077. HEAT_REPEAT. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y7K2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEFPGLKSR NEEIRNKAAN DLYEYVIAYS RELSGEALVQ FNNDVNKYVY
60 70 80 90 100
TLIHSTDPLD RLAGVTAINR LIDYEGEDTT RITRFANYLR IILPGTDQKA
110 120 130 140 150
TVLAAKALGR LAVPGGALTS EFVNFEVKRA LEWLQGERNE NRRYAAVLIL
160 170 180 190 200
KELAKNTSTL IYAHIDSIFE LLWHGLRDPK VTIRIASADA LSEFLKIVRQ
210 220 230 240 250
RDSSIRLQWY TSILNEAQRG VAQGSSDYIH GSLLVYRQLF LKAGMFMHER
260 270 280 290 300
YREVSDIILQ FRDHKDLLIR KTVTELIATL AAYNPDEFVS NYLHVCMLHL
310 320 330 340 350
LNLLKKENVK MLAFATIGKV AVAITNSIIP YLDPICDSIK ESLKIHIRNK
360 370 380 390 400
SASDAAIFQC ISLLSIALGQ AFSNYAYDLF DLIFASGLSE ASYRALSDLA
410 420 430 440 450
HNIPPLLPVI QERLLDMLSK ILSGRPFIPP GCPPQYVARS LKSSKSASLK
460 470 480 490 500
TGFFPNDVYI LALKVLGNFD FSGYILNEFV KDCVVVYLEN NDPEVRKTAS
510 520 530 540 550
ITCSQLFARD PILSQTSDHA IQVVAEVLEK LLTVGICDTV PDIRLTVLNS
560 570 580 590 600
LDSRFNKHLA QADKIRLLFI AINDENFAVR ESALRIIGRL NVYNPAYVMP
610 620 630 640 650
YLRKIMLKTL TILDYSTIIR TKEENAKLLC LLIAAAPRLI ESHVEPILQI
660 670 680 690 700
LLPKAKDSSS IVAASIVNSL GEICQISGEV IVPFIKDLMP LIIEALQDQS
710 720 730 740 750
SPIRRAAALK ALGNLSSSTG YVIDPYIEFP SLLDILIGIT KTEQDITIRR
760 770 780 790 800
ETIKLIGTLG ALDPNRHRVL EKGTEKVVPE QKNIPPDISL LMSGIGPSSD
810 820 830 840 850
EYYPTVVITA LMSILKDPSL TIHHTAVIQA VMYIFKTMGL RCAPFLSQII
860 870 880 890 900
PEFIAVMRTC PTNILEFYFQ QLSILVLIVR QHIRSFLPDL FKLIKDFWNP
910 920 930 940 950
HSNLQFTILS LIESLARAMQ GEFKPYLPSL LVMMLQIFDS DVSVDSVSTK
960 970 980 990 1000
KVLHAFIVFG DTLADYFHML LDPILRLYER NDVSIGIKES IMITIGRLSM
1010 1020 1030 1040 1050
VINLSEYASR IIHPVMRMLS CNNASLIRVS MDTVCALIYQ LNVDFAIFIP
1060 1070 1080 1090 1100
MIDKCLKMNG VTHETYSILV EQFLQEQPLP IKLNPYEKYD KPKLDVVASA
1110 1120 1130 1140 1150
ADITSKKLPV NQEILRNAWE ASQRSTKDDW QEWIRRLGVA LLRESPSHAL
1160 1170 1180 1190 1200
RACAALAAAY QPLARDLFNA SFVSCWSELY DHFQEELVKS IEIALTSPHI
1210 1220 1230 1240 1250
SPEIIQILLN LAEFMEHDDK PLPIDIRTLG AYAAKCHAFA KALHYKELEF
1260 1270 1280 1290 1300
IEEELVTKPS VDTIEALISI NNQLQQPDAA IGILKHAQQH DKMNLKETWY
1310 1320 1330 1340 1350
EKLQRWEDAL SAYEKREAAG AGNFEITMGK LRCLHALGEW DRLSQLAQEN
1360 1370 1380 1390 1400
WIHAGHDARR YIAPLSVAAA WGLGQWEQMD EYISVMKSES PDKAFFNAIV
1410 1420 1430 1440 1450
ALHRSQFEEA ASYITRARDL LDTELTALVG ESYNRAYSVA VRVQMLSELE
1460 1470 1480 1490 1500
EIITYKKAED KPEVREMIKK TWVRRLKGCQ RNVDVWQRML RIRSLVISPR
1510 1520 1530 1540 1550
DNMEMWIKFA NLCRKSGRIS LAKKSLNLLL EDDENLDNSL VLKKTHPSIV
1560 1570 1580 1590 1600
YANLKFLWAV DDKRKALNSM QEFTSQLISD INVDPALFVQ STSVNTQKSQ
1610 1620 1630 1640 1650
EEIQYYFHLL ARCYHKQGQW QQEIENNWSE GSFDGVLQSY MYATQFDSKW
1660 1670 1680 1690 1700
YKAWHSWALA NFEAVKFLEQ SEEQIPSAAY EQYIIPAVKG FFKSIALSKG
1710 1720 1730 1740 1750
NLQDTLRLLN LWFKFGNNSN VINTLNVGIS TVNIDIWLDV IPQLIARIHA
1760 1770 1780 1790 1800
SSLSVRKSVH QLLSDVGRAH PQALVYPLTV AAKSQSSARQ NAALAIMDSL
1810 1820 1830 1840 1850
KTHSPRLVEQ ARLVSHELIR AAILWHEQWH EGLEEASRLY FGDHNIEGMF
1860 1870 1880 1890 1900
AVLRPLHEML ERGPETLREI SFQQAFGRDL VEARDCCIRF EQTGDISDLN
1910 1920 1930 1940 1950
QAWDLYYQVF KKIRKQLPQL TTLDLQYVSP KLLHVHDLEL AVPGTYVSGK
1960 1970 1980 1990 2000
PVIRIVKFYP TFNVITSKQR PRRLSIKGSD GKDYQYVLKG HEDIRQDERV
2010 2020 2030 2040 2050
MQLFGLCNNL LLADPETFKR LLSIQRYPVI PLSPDSGLLG WVLDSDTLHV
2060 2070 2080 2090 2100
LIRDYRESRK ILLNIEHRLI IQMAPDYDRL TLLQKVEVFE YALLSTTGQD
2110 2120 2130 2140 2150
LYRVLWLKSR SSEAWLNRRT NYSRTLAVMS MVGYILGLGD RHPSNLMLDR
2160 2170 2180 2190 2200
YTGNIIHIDF GDCFEVAMHR EKFPEKIPFR LTRMLVNAME VSGIEGTFRI
2210 2220 2230 2240 2250
TCEHVMRVLR TNKESVMAVL EAFVYDPLIN WRLAPAYSPS IDEKQSNEPN
2260 2270 2280 2290 2300
TLLGETIDGL HRKRLNEEGI TLEERQKPEI LNQRAITVLN RVSNKLTGRD
2310 2320 2330
FKPQQQLDVP SQVEKLILQA TSIENLCLCY IGWCSFW
Length:2,337
Mass (Da):266,379
Last modified:December 6, 2002 - v2
Checksum:i190F448DA04FD2D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB40167.1.
PIRiT39913. T40577.
RefSeqiNP_595359.2. NM_001021266.3.

Genome annotation databases

EnsemblFungiiSPBC216.07c.1; SPBC216.07c.1:pep; SPBC216.07c.
GeneIDi2540720.
KEGGispo:SPBC216.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB40167.1 .
PIRi T39913. T40577.
RefSeqi NP_595359.2. NM_001021266.3.

3D structure databases

ProteinModelPortali Q9Y7K2.
SMRi Q9Y7K2. Positions 1817-1916, 2306-2337.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277243. 34 interactions.
IntActi Q9Y7K2. 7 interactions.
MINTi MINT-4716528.
STRINGi 4896.SPBC216.07c-1.

Proteomic databases

MaxQBi Q9Y7K2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC216.07c.1 ; SPBC216.07c.1:pep ; SPBC216.07c .
GeneIDi 2540720.
KEGGi spo:SPBC216.07c.

Organism-specific databases

PomBasei SPBC216.07c.

Phylogenomic databases

eggNOGi COG5032.
HOGENOMi HOG000163215.
InParanoidi Q9Y7K2.
KOi K07203.
OMAi TYKQNIG.
OrthoDBi EOG7Z3FCR.
PhylomeDBi Q9Y7K2.

Enzyme and pathway databases

Reactomei REACT_188268. CD28 dependent PI3K/Akt signaling.
REACT_188279. PIP3 activates AKT signaling.
REACT_207307. HSF1-dependent transactivation.
REACT_227968. Constitutive PI3K/AKT Signaling in Cancer.

Miscellaneous databases

NextBioi 20801842.
PROi Q9Y7K2.

Family and domain databases

Gene3Di 1.10.1070.11. 3 hits.
1.25.10.10. 6 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC.
IPR021133. HEAT_type_2.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR009076. Rapamycin-bd_dom.
[Graphical view ]
Pfami PF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08771. Rapamycin_bind. 1 hit.
[Graphical view ]
SMARTi SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 5 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS50077. HEAT_REPEAT. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine."
    Weisman R., Choder M.
    J. Biol. Chem. 276:7027-7032(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2238 AND SER-2240, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiTOR2_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7K2
Secondary accession number(s): O94507
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3