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Q9Y7K2

- TOR2_SCHPO

UniProt

Q9Y7K2 - TOR2_SCHPO

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Protein

Phosphatidylinositol 3-kinase tor2

Gene
tor2, SPBC216.07c, SPBC646.01c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphatidylinositol 3-kinase homolog required for G1 progression By similarity.

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. drug binding Source: InterPro
  4. protein binding Source: IntAct

GO - Biological processi

  1. cell cycle arrest in response to nitrogen starvation Source: PomBase
  2. cellular response to nutrient Source: PomBase
  3. negative regulation of autophagy Source: PomBase
  4. negative regulation of cell cycle arrest in response to nitrogen starvation Source: PomBase
  5. negative regulation of induction of conjugation with cellular fusion Source: PomBase
  6. signal transduction Source: PomBase
  7. TOR signaling Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_188268. CD28 dependent PI3K/Akt signaling.
REACT_188279. PIP3 activates AKT signaling.
REACT_207307. HSF1-dependent transactivation.
REACT_227968. Constitutive PI3K/AKT Signaling in Cancer.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase tor2 (EC:2.7.1.137)
Short name:
PI3-kinase tor2
Short name:
PI3K tor2
Short name:
PtdIns-3-kinase tor2
Gene namesi
Name:tor2
ORF Names:SPBC216.07c, SPBC646.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC216.07c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. Tor2-Mei2-Ste11 complex Source: PomBase
  4. TORC1 complex Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23372337Phosphatidylinositol 3-kinase tor2PRO_0000088814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2238 – 22381Phosphoserine1 Publication
Modified residuei2240 – 22401Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y7K2.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
tel2Q9P3W53EBI-2014299,EBI-2014377

Protein-protein interaction databases

BioGridi277243. 32 interactions.
IntActiQ9Y7K2. 7 interactions.
MINTiMINT-4716528.
STRINGi4896.SPBC216.07c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9Y7K2.
SMRiQ9Y7K2. Positions 1817-1916, 2306-2337.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati163 – 20038HEAT 1Add
BLAST
Repeati249 – 28638HEAT 2Add
BLAST
Repeati290 – 32637HEAT 3Add
BLAST
Repeati409 – 44638HEAT 4Add
BLAST
Repeati474 – 51239HEAT 5Add
BLAST
Repeati559 – 59638HEAT 6Add
BLAST
Repeati642 – 67938HEAT 7Add
BLAST
Repeati683 – 72139HEAT 8Add
BLAST
Repeati727 – 76539HEAT 9Add
BLAST
Repeati802 – 84039HEAT 10Add
BLAST
Repeati844 – 88037HEAT 11Add
BLAST
Repeati881 – 92141HEAT 12Add
BLAST
Repeati965 – 100440HEAT 13Add
BLAST
Repeati1006 – 104338HEAT 14Add
BLAST
Domaini1228 – 1784557FATAdd
BLAST
Domaini1990 – 2304315PI3K/PI4KAdd
BLAST
Domaini2305 – 233733FATCAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.
Contains 1 FAT domain.
Contains 1 FATC domain.
Contains 14 HEAT repeats.
Contains 1 PI3K/PI4K domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5032.
HOGENOMiHOG000163215.
KOiK07203.
OMAiTYKQNIG.
OrthoDBiEOG7Z3FCR.
PhylomeDBiQ9Y7K2.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
1.25.10.10. 6 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC.
IPR021133. HEAT_type_2.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR009076. Rapamycin-bd_dom.
[Graphical view]
PfamiPF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08771. Rapamycin_bind. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 5 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS50077. HEAT_REPEAT. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y7K2-1 [UniParc]FASTAAdd to Basket

« Hide

MKEFPGLKSR NEEIRNKAAN DLYEYVIAYS RELSGEALVQ FNNDVNKYVY     50
TLIHSTDPLD RLAGVTAINR LIDYEGEDTT RITRFANYLR IILPGTDQKA 100
TVLAAKALGR LAVPGGALTS EFVNFEVKRA LEWLQGERNE NRRYAAVLIL 150
KELAKNTSTL IYAHIDSIFE LLWHGLRDPK VTIRIASADA LSEFLKIVRQ 200
RDSSIRLQWY TSILNEAQRG VAQGSSDYIH GSLLVYRQLF LKAGMFMHER 250
YREVSDIILQ FRDHKDLLIR KTVTELIATL AAYNPDEFVS NYLHVCMLHL 300
LNLLKKENVK MLAFATIGKV AVAITNSIIP YLDPICDSIK ESLKIHIRNK 350
SASDAAIFQC ISLLSIALGQ AFSNYAYDLF DLIFASGLSE ASYRALSDLA 400
HNIPPLLPVI QERLLDMLSK ILSGRPFIPP GCPPQYVARS LKSSKSASLK 450
TGFFPNDVYI LALKVLGNFD FSGYILNEFV KDCVVVYLEN NDPEVRKTAS 500
ITCSQLFARD PILSQTSDHA IQVVAEVLEK LLTVGICDTV PDIRLTVLNS 550
LDSRFNKHLA QADKIRLLFI AINDENFAVR ESALRIIGRL NVYNPAYVMP 600
YLRKIMLKTL TILDYSTIIR TKEENAKLLC LLIAAAPRLI ESHVEPILQI 650
LLPKAKDSSS IVAASIVNSL GEICQISGEV IVPFIKDLMP LIIEALQDQS 700
SPIRRAAALK ALGNLSSSTG YVIDPYIEFP SLLDILIGIT KTEQDITIRR 750
ETIKLIGTLG ALDPNRHRVL EKGTEKVVPE QKNIPPDISL LMSGIGPSSD 800
EYYPTVVITA LMSILKDPSL TIHHTAVIQA VMYIFKTMGL RCAPFLSQII 850
PEFIAVMRTC PTNILEFYFQ QLSILVLIVR QHIRSFLPDL FKLIKDFWNP 900
HSNLQFTILS LIESLARAMQ GEFKPYLPSL LVMMLQIFDS DVSVDSVSTK 950
KVLHAFIVFG DTLADYFHML LDPILRLYER NDVSIGIKES IMITIGRLSM 1000
VINLSEYASR IIHPVMRMLS CNNASLIRVS MDTVCALIYQ LNVDFAIFIP 1050
MIDKCLKMNG VTHETYSILV EQFLQEQPLP IKLNPYEKYD KPKLDVVASA 1100
ADITSKKLPV NQEILRNAWE ASQRSTKDDW QEWIRRLGVA LLRESPSHAL 1150
RACAALAAAY QPLARDLFNA SFVSCWSELY DHFQEELVKS IEIALTSPHI 1200
SPEIIQILLN LAEFMEHDDK PLPIDIRTLG AYAAKCHAFA KALHYKELEF 1250
IEEELVTKPS VDTIEALISI NNQLQQPDAA IGILKHAQQH DKMNLKETWY 1300
EKLQRWEDAL SAYEKREAAG AGNFEITMGK LRCLHALGEW DRLSQLAQEN 1350
WIHAGHDARR YIAPLSVAAA WGLGQWEQMD EYISVMKSES PDKAFFNAIV 1400
ALHRSQFEEA ASYITRARDL LDTELTALVG ESYNRAYSVA VRVQMLSELE 1450
EIITYKKAED KPEVREMIKK TWVRRLKGCQ RNVDVWQRML RIRSLVISPR 1500
DNMEMWIKFA NLCRKSGRIS LAKKSLNLLL EDDENLDNSL VLKKTHPSIV 1550
YANLKFLWAV DDKRKALNSM QEFTSQLISD INVDPALFVQ STSVNTQKSQ 1600
EEIQYYFHLL ARCYHKQGQW QQEIENNWSE GSFDGVLQSY MYATQFDSKW 1650
YKAWHSWALA NFEAVKFLEQ SEEQIPSAAY EQYIIPAVKG FFKSIALSKG 1700
NLQDTLRLLN LWFKFGNNSN VINTLNVGIS TVNIDIWLDV IPQLIARIHA 1750
SSLSVRKSVH QLLSDVGRAH PQALVYPLTV AAKSQSSARQ NAALAIMDSL 1800
KTHSPRLVEQ ARLVSHELIR AAILWHEQWH EGLEEASRLY FGDHNIEGMF 1850
AVLRPLHEML ERGPETLREI SFQQAFGRDL VEARDCCIRF EQTGDISDLN 1900
QAWDLYYQVF KKIRKQLPQL TTLDLQYVSP KLLHVHDLEL AVPGTYVSGK 1950
PVIRIVKFYP TFNVITSKQR PRRLSIKGSD GKDYQYVLKG HEDIRQDERV 2000
MQLFGLCNNL LLADPETFKR LLSIQRYPVI PLSPDSGLLG WVLDSDTLHV 2050
LIRDYRESRK ILLNIEHRLI IQMAPDYDRL TLLQKVEVFE YALLSTTGQD 2100
LYRVLWLKSR SSEAWLNRRT NYSRTLAVMS MVGYILGLGD RHPSNLMLDR 2150
YTGNIIHIDF GDCFEVAMHR EKFPEKIPFR LTRMLVNAME VSGIEGTFRI 2200
TCEHVMRVLR TNKESVMAVL EAFVYDPLIN WRLAPAYSPS IDEKQSNEPN 2250
TLLGETIDGL HRKRLNEEGI TLEERQKPEI LNQRAITVLN RVSNKLTGRD 2300
FKPQQQLDVP SQVEKLILQA TSIENLCLCY IGWCSFW 2337
Length:2,337
Mass (Da):266,379
Last modified:December 6, 2002 - v2
Checksum:i190F448DA04FD2D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB40167.1.
PIRiT39913. T40577.
RefSeqiNP_595359.2. NM_001021266.3.

Genome annotation databases

EnsemblFungiiSPBC216.07c.1; SPBC216.07c.1:pep; SPBC216.07c.
GeneIDi2540720.
KEGGispo:SPBC216.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB40167.1 .
PIRi T39913. T40577.
RefSeqi NP_595359.2. NM_001021266.3.

3D structure databases

ProteinModelPortali Q9Y7K2.
SMRi Q9Y7K2. Positions 1817-1916, 2306-2337.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277243. 32 interactions.
IntActi Q9Y7K2. 7 interactions.
MINTi MINT-4716528.
STRINGi 4896.SPBC216.07c-1.

Proteomic databases

MaxQBi Q9Y7K2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC216.07c.1 ; SPBC216.07c.1:pep ; SPBC216.07c .
GeneIDi 2540720.
KEGGi spo:SPBC216.07c.

Organism-specific databases

PomBasei SPBC216.07c.

Phylogenomic databases

eggNOGi COG5032.
HOGENOMi HOG000163215.
KOi K07203.
OMAi TYKQNIG.
OrthoDBi EOG7Z3FCR.
PhylomeDBi Q9Y7K2.

Enzyme and pathway databases

Reactomei REACT_188268. CD28 dependent PI3K/Akt signaling.
REACT_188279. PIP3 activates AKT signaling.
REACT_207307. HSF1-dependent transactivation.
REACT_227968. Constitutive PI3K/AKT Signaling in Cancer.

Miscellaneous databases

NextBioi 20801842.
PROi Q9Y7K2.

Family and domain databases

Gene3Di 1.10.1070.11. 3 hits.
1.25.10.10. 6 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC.
IPR021133. HEAT_type_2.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR009076. Rapamycin-bd_dom.
[Graphical view ]
Pfami PF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08771. Rapamycin_bind. 1 hit.
[Graphical view ]
SMARTi SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 5 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS50077. HEAT_REPEAT. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine."
    Weisman R., Choder M.
    J. Biol. Chem. 276:7027-7032(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2238 AND SER-2240, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiTOR2_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7K2
Secondary accession number(s): O94507
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: September 3, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi