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Q9Y7K2 (TOR2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol 3-kinase tor2

Short name=PI3-kinase tor2
Short name=PI3K tor2
Short name=PtdIns-3-kinase tor2
EC=2.7.1.137
Gene names
Name:tor2
ORF Names:SPBC216.07c, SPBC646.01c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length2337 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Phosphatidylinositol 3-kinase homolog required for G1 progression By similarity.

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

Sequence similarities

Belongs to the PI3/PI4-kinase family.

Contains 1 FAT domain.

Contains 1 FATC domain.

Contains 14 HEAT repeats.

Contains 1 PI3K/PI4K domain.

Ontologies

Keywords
   Biological processCell cycle
   DomainRepeat
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processTOR signaling

Traceable author statement PubMed 18076573. Source: PomBase

cell cycle arrest in response to nitrogen starvation

Inferred from mutant phenotype PubMed 17179073PubMed 18076573. Source: PomBase

cellular response to nutrient

Non-traceable author statement. Source: PomBase

negative regulation of autophagy

Inferred from mutant phenotype PubMed 17121544. Source: PomBase

negative regulation of cell cycle arrest in response to nitrogen starvation

Inferred from mutant phenotype PubMed 17046992PubMed 17121544PubMed 17261596. Source: PomBase

negative regulation of induction of conjugation with cellular fusion

Inferred from mutant phenotype PubMed 17179073. Source: PomBase

signal transduction

Inferred from genetic interaction PubMed 16262791. Source: PomBase

   Cellular_componentTORC1 complex

Inferred from direct assay PubMed 17046992PubMed 17261596. Source: PomBase

Tor2-Mei2-Ste11 complex

Inferred from direct assay PubMed 17046992. Source: PomBase

cytoplasm

Inferred from direct assay PubMed 18076573. Source: PomBase

cytosol

Inferred from direct assay PubMed 16823372. Source: PomBase

   Molecular_function1-phosphatidylinositol-3-kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

drug binding

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction PubMed 18076573. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

tel2Q9P3W53EBI-2014299,EBI-2014377

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 23372337Phosphatidylinositol 3-kinase tor2
PRO_0000088814

Regions

Repeat163 – 20038HEAT 1
Repeat249 – 28638HEAT 2
Repeat290 – 32637HEAT 3
Repeat409 – 44638HEAT 4
Repeat474 – 51239HEAT 5
Repeat559 – 59638HEAT 6
Repeat642 – 67938HEAT 7
Repeat683 – 72139HEAT 8
Repeat727 – 76539HEAT 9
Repeat802 – 84039HEAT 10
Repeat844 – 88037HEAT 11
Repeat881 – 92141HEAT 12
Repeat965 – 100440HEAT 13
Repeat1006 – 104338HEAT 14
Domain1228 – 1784557FAT
Domain1990 – 2304315PI3K/PI4K
Domain2305 – 233733FATC

Amino acid modifications

Modified residue22381Phosphoserine Ref.3
Modified residue22401Phosphoserine Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9Y7K2 [UniParc].

Last modified December 6, 2002. Version 2.
Checksum: 190F448DA04FD2D9

FASTA2,337266,379
        10         20         30         40         50         60 
MKEFPGLKSR NEEIRNKAAN DLYEYVIAYS RELSGEALVQ FNNDVNKYVY TLIHSTDPLD 

        70         80         90        100        110        120 
RLAGVTAINR LIDYEGEDTT RITRFANYLR IILPGTDQKA TVLAAKALGR LAVPGGALTS 

       130        140        150        160        170        180 
EFVNFEVKRA LEWLQGERNE NRRYAAVLIL KELAKNTSTL IYAHIDSIFE LLWHGLRDPK 

       190        200        210        220        230        240 
VTIRIASADA LSEFLKIVRQ RDSSIRLQWY TSILNEAQRG VAQGSSDYIH GSLLVYRQLF 

       250        260        270        280        290        300 
LKAGMFMHER YREVSDIILQ FRDHKDLLIR KTVTELIATL AAYNPDEFVS NYLHVCMLHL 

       310        320        330        340        350        360 
LNLLKKENVK MLAFATIGKV AVAITNSIIP YLDPICDSIK ESLKIHIRNK SASDAAIFQC 

       370        380        390        400        410        420 
ISLLSIALGQ AFSNYAYDLF DLIFASGLSE ASYRALSDLA HNIPPLLPVI QERLLDMLSK 

       430        440        450        460        470        480 
ILSGRPFIPP GCPPQYVARS LKSSKSASLK TGFFPNDVYI LALKVLGNFD FSGYILNEFV 

       490        500        510        520        530        540 
KDCVVVYLEN NDPEVRKTAS ITCSQLFARD PILSQTSDHA IQVVAEVLEK LLTVGICDTV 

       550        560        570        580        590        600 
PDIRLTVLNS LDSRFNKHLA QADKIRLLFI AINDENFAVR ESALRIIGRL NVYNPAYVMP 

       610        620        630        640        650        660 
YLRKIMLKTL TILDYSTIIR TKEENAKLLC LLIAAAPRLI ESHVEPILQI LLPKAKDSSS 

       670        680        690        700        710        720 
IVAASIVNSL GEICQISGEV IVPFIKDLMP LIIEALQDQS SPIRRAAALK ALGNLSSSTG 

       730        740        750        760        770        780 
YVIDPYIEFP SLLDILIGIT KTEQDITIRR ETIKLIGTLG ALDPNRHRVL EKGTEKVVPE 

       790        800        810        820        830        840 
QKNIPPDISL LMSGIGPSSD EYYPTVVITA LMSILKDPSL TIHHTAVIQA VMYIFKTMGL 

       850        860        870        880        890        900 
RCAPFLSQII PEFIAVMRTC PTNILEFYFQ QLSILVLIVR QHIRSFLPDL FKLIKDFWNP 

       910        920        930        940        950        960 
HSNLQFTILS LIESLARAMQ GEFKPYLPSL LVMMLQIFDS DVSVDSVSTK KVLHAFIVFG 

       970        980        990       1000       1010       1020 
DTLADYFHML LDPILRLYER NDVSIGIKES IMITIGRLSM VINLSEYASR IIHPVMRMLS 

      1030       1040       1050       1060       1070       1080 
CNNASLIRVS MDTVCALIYQ LNVDFAIFIP MIDKCLKMNG VTHETYSILV EQFLQEQPLP 

      1090       1100       1110       1120       1130       1140 
IKLNPYEKYD KPKLDVVASA ADITSKKLPV NQEILRNAWE ASQRSTKDDW QEWIRRLGVA 

      1150       1160       1170       1180       1190       1200 
LLRESPSHAL RACAALAAAY QPLARDLFNA SFVSCWSELY DHFQEELVKS IEIALTSPHI 

      1210       1220       1230       1240       1250       1260 
SPEIIQILLN LAEFMEHDDK PLPIDIRTLG AYAAKCHAFA KALHYKELEF IEEELVTKPS 

      1270       1280       1290       1300       1310       1320 
VDTIEALISI NNQLQQPDAA IGILKHAQQH DKMNLKETWY EKLQRWEDAL SAYEKREAAG 

      1330       1340       1350       1360       1370       1380 
AGNFEITMGK LRCLHALGEW DRLSQLAQEN WIHAGHDARR YIAPLSVAAA WGLGQWEQMD 

      1390       1400       1410       1420       1430       1440 
EYISVMKSES PDKAFFNAIV ALHRSQFEEA ASYITRARDL LDTELTALVG ESYNRAYSVA 

      1450       1460       1470       1480       1490       1500 
VRVQMLSELE EIITYKKAED KPEVREMIKK TWVRRLKGCQ RNVDVWQRML RIRSLVISPR 

      1510       1520       1530       1540       1550       1560 
DNMEMWIKFA NLCRKSGRIS LAKKSLNLLL EDDENLDNSL VLKKTHPSIV YANLKFLWAV 

      1570       1580       1590       1600       1610       1620 
DDKRKALNSM QEFTSQLISD INVDPALFVQ STSVNTQKSQ EEIQYYFHLL ARCYHKQGQW 

      1630       1640       1650       1660       1670       1680 
QQEIENNWSE GSFDGVLQSY MYATQFDSKW YKAWHSWALA NFEAVKFLEQ SEEQIPSAAY 

      1690       1700       1710       1720       1730       1740 
EQYIIPAVKG FFKSIALSKG NLQDTLRLLN LWFKFGNNSN VINTLNVGIS TVNIDIWLDV 

      1750       1760       1770       1780       1790       1800 
IPQLIARIHA SSLSVRKSVH QLLSDVGRAH PQALVYPLTV AAKSQSSARQ NAALAIMDSL 

      1810       1820       1830       1840       1850       1860 
KTHSPRLVEQ ARLVSHELIR AAILWHEQWH EGLEEASRLY FGDHNIEGMF AVLRPLHEML 

      1870       1880       1890       1900       1910       1920 
ERGPETLREI SFQQAFGRDL VEARDCCIRF EQTGDISDLN QAWDLYYQVF KKIRKQLPQL 

      1930       1940       1950       1960       1970       1980 
TTLDLQYVSP KLLHVHDLEL AVPGTYVSGK PVIRIVKFYP TFNVITSKQR PRRLSIKGSD 

      1990       2000       2010       2020       2030       2040 
GKDYQYVLKG HEDIRQDERV MQLFGLCNNL LLADPETFKR LLSIQRYPVI PLSPDSGLLG 

      2050       2060       2070       2080       2090       2100 
WVLDSDTLHV LIRDYRESRK ILLNIEHRLI IQMAPDYDRL TLLQKVEVFE YALLSTTGQD 

      2110       2120       2130       2140       2150       2160 
LYRVLWLKSR SSEAWLNRRT NYSRTLAVMS MVGYILGLGD RHPSNLMLDR YTGNIIHIDF 

      2170       2180       2190       2200       2210       2220 
GDCFEVAMHR EKFPEKIPFR LTRMLVNAME VSGIEGTFRI TCEHVMRVLR TNKESVMAVL 

      2230       2240       2250       2260       2270       2280 
EAFVYDPLIN WRLAPAYSPS IDEKQSNEPN TLLGETIDGL HRKRLNEEGI TLEERQKPEI 

      2290       2300       2310       2320       2330 
LNQRAITVLN RVSNKLTGRD FKPQQQLDVP SQVEKLILQA TSIENLCLCY IGWCSFW 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine."
Weisman R., Choder M.
J. Biol. Chem. 276:7027-7032(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2238 AND SER-2240, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329671 Genomic DNA. Translation: CAB40167.1.
PIRT40577. T39913.
RefSeqNP_595359.2. NM_001021266.3.

3D structure databases

ProteinModelPortalQ9Y7K2.
SMRQ9Y7K2. Positions 1817-1916, 2306-2337.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid277243. 32 interactions.
IntActQ9Y7K2. 7 interactions.
MINTMINT-4716528.
STRING4896.SPBC216.07c-1.

Proteomic databases

MaxQBQ9Y7K2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC216.07c.1; SPBC216.07c.1:pep; SPBC216.07c.
GeneID2540720.
KEGGspo:SPBC216.07c.

Organism-specific databases

PomBaseSPBC216.07c.

Phylogenomic databases

eggNOGCOG5032.
HOGENOMHOG000163215.
KOK07203.
OMATYKQNIG.
OrthoDBEOG7Z3FCR.
PhylomeDBQ9Y7K2.

Family and domain databases

Gene3D1.10.1070.11. 3 hits.
1.25.10.10. 6 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC.
IPR021133. HEAT_type_2.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR009076. Rapamycin-bd_dom.
[Graphical view]
PfamPF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08771. Rapamycin_bind. 1 hit.
[Graphical view]
SMARTSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMSSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 5 hits.
SSF56112. SSF56112. 2 hits.
PROSITEPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS50077. HEAT_REPEAT. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20801842.
PROQ9Y7K2.

Entry information

Entry nameTOR2_SCHPO
AccessionPrimary (citable) accession number: Q9Y7K2
Secondary accession number(s): O94507
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: June 11, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names