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Q9Y7K2

- TOR2_SCHPO

UniProt

Q9Y7K2 - TOR2_SCHPO

Protein

Phosphatidylinositol 3-kinase tor2

Gene

tor2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (06 Dec 2002)
      Previous versions | rss
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    Functioni

    Phosphatidylinositol 3-kinase homolog required for G1 progression.By similarity

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. drug binding Source: InterPro
    4. protein binding Source: IntAct

    GO - Biological processi

    1. cell cycle arrest in response to nitrogen starvation Source: PomBase
    2. cellular response to nutrient Source: PomBase
    3. negative regulation of autophagy Source: PomBase
    4. negative regulation of cell cycle arrest in response to nitrogen starvation Source: PomBase
    5. negative regulation of induction of conjugation with cellular fusion Source: PomBase
    6. signal transduction Source: PomBase
    7. TOR signaling Source: PomBase

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_188268. CD28 dependent PI3K/Akt signaling.
    REACT_188279. PIP3 activates AKT signaling.
    REACT_207307. HSF1-dependent transactivation.
    REACT_227968. Constitutive PI3K/AKT Signaling in Cancer.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 3-kinase tor2 (EC:2.7.1.137)
    Short name:
    PI3-kinase tor2
    Short name:
    PI3K tor2
    Short name:
    PtdIns-3-kinase tor2
    Gene namesi
    Name:tor2
    ORF Names:SPBC216.07c, SPBC646.01c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC216.07c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. Tor2-Mei2-Ste11 complex Source: PomBase
    4. TORC1 complex Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 23372337Phosphatidylinositol 3-kinase tor2PRO_0000088814Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2238 – 22381Phosphoserine1 Publication
    Modified residuei2240 – 22401Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y7K2.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    tel2Q9P3W53EBI-2014299,EBI-2014377

    Protein-protein interaction databases

    BioGridi277243. 32 interactions.
    IntActiQ9Y7K2. 7 interactions.
    MINTiMINT-4716528.
    STRINGi4896.SPBC216.07c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y7K2.
    SMRiQ9Y7K2. Positions 1817-1916, 2306-2337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati163 – 20038HEAT 1Add
    BLAST
    Repeati249 – 28638HEAT 2Add
    BLAST
    Repeati290 – 32637HEAT 3Add
    BLAST
    Repeati409 – 44638HEAT 4Add
    BLAST
    Repeati474 – 51239HEAT 5Add
    BLAST
    Repeati559 – 59638HEAT 6Add
    BLAST
    Repeati642 – 67938HEAT 7Add
    BLAST
    Repeati683 – 72139HEAT 8Add
    BLAST
    Repeati727 – 76539HEAT 9Add
    BLAST
    Repeati802 – 84039HEAT 10Add
    BLAST
    Repeati844 – 88037HEAT 11Add
    BLAST
    Repeati881 – 92141HEAT 12Add
    BLAST
    Repeati965 – 100440HEAT 13Add
    BLAST
    Repeati1006 – 104338HEAT 14Add
    BLAST
    Domaini1228 – 1784557FATPROSITE-ProRule annotationAdd
    BLAST
    Domaini1990 – 2304315PI3K/PI4KPROSITE-ProRule annotationAdd
    BLAST
    Domaini2305 – 233733FATCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PI3/PI4-kinase family.Curated
    Contains 1 FAT domain.PROSITE-ProRule annotation
    Contains 1 FATC domain.PROSITE-ProRule annotation
    Contains 14 HEAT repeats.PROSITE-ProRule annotation
    Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5032.
    HOGENOMiHOG000163215.
    KOiK07203.
    OMAiTYKQNIG.
    OrthoDBiEOG7Z3FCR.
    PhylomeDBiQ9Y7K2.

    Family and domain databases

    Gene3Di1.10.1070.11. 3 hits.
    1.25.10.10. 6 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR024585. DUF3385_TOR.
    IPR003152. FATC.
    IPR021133. HEAT_type_2.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003151. PIK-rel_kinase_FAT.
    IPR014009. PIK_FAT.
    IPR009076. Rapamycin-bd_dom.
    [Graphical view]
    PfamiPF11865. DUF3385. 1 hit.
    PF02259. FAT. 1 hit.
    PF02260. FATC. 1 hit.
    PF00454. PI3_PI4_kinase. 1 hit.
    PF08771. Rapamycin_bind. 1 hit.
    [Graphical view]
    SMARTiSM00146. PI3Kc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47212. SSF47212. 1 hit.
    SSF48371. SSF48371. 5 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS51189. FAT. 1 hit.
    PS51190. FATC. 1 hit.
    PS50077. HEAT_REPEAT. 1 hit.
    PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y7K2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEFPGLKSR NEEIRNKAAN DLYEYVIAYS RELSGEALVQ FNNDVNKYVY     50
    TLIHSTDPLD RLAGVTAINR LIDYEGEDTT RITRFANYLR IILPGTDQKA 100
    TVLAAKALGR LAVPGGALTS EFVNFEVKRA LEWLQGERNE NRRYAAVLIL 150
    KELAKNTSTL IYAHIDSIFE LLWHGLRDPK VTIRIASADA LSEFLKIVRQ 200
    RDSSIRLQWY TSILNEAQRG VAQGSSDYIH GSLLVYRQLF LKAGMFMHER 250
    YREVSDIILQ FRDHKDLLIR KTVTELIATL AAYNPDEFVS NYLHVCMLHL 300
    LNLLKKENVK MLAFATIGKV AVAITNSIIP YLDPICDSIK ESLKIHIRNK 350
    SASDAAIFQC ISLLSIALGQ AFSNYAYDLF DLIFASGLSE ASYRALSDLA 400
    HNIPPLLPVI QERLLDMLSK ILSGRPFIPP GCPPQYVARS LKSSKSASLK 450
    TGFFPNDVYI LALKVLGNFD FSGYILNEFV KDCVVVYLEN NDPEVRKTAS 500
    ITCSQLFARD PILSQTSDHA IQVVAEVLEK LLTVGICDTV PDIRLTVLNS 550
    LDSRFNKHLA QADKIRLLFI AINDENFAVR ESALRIIGRL NVYNPAYVMP 600
    YLRKIMLKTL TILDYSTIIR TKEENAKLLC LLIAAAPRLI ESHVEPILQI 650
    LLPKAKDSSS IVAASIVNSL GEICQISGEV IVPFIKDLMP LIIEALQDQS 700
    SPIRRAAALK ALGNLSSSTG YVIDPYIEFP SLLDILIGIT KTEQDITIRR 750
    ETIKLIGTLG ALDPNRHRVL EKGTEKVVPE QKNIPPDISL LMSGIGPSSD 800
    EYYPTVVITA LMSILKDPSL TIHHTAVIQA VMYIFKTMGL RCAPFLSQII 850
    PEFIAVMRTC PTNILEFYFQ QLSILVLIVR QHIRSFLPDL FKLIKDFWNP 900
    HSNLQFTILS LIESLARAMQ GEFKPYLPSL LVMMLQIFDS DVSVDSVSTK 950
    KVLHAFIVFG DTLADYFHML LDPILRLYER NDVSIGIKES IMITIGRLSM 1000
    VINLSEYASR IIHPVMRMLS CNNASLIRVS MDTVCALIYQ LNVDFAIFIP 1050
    MIDKCLKMNG VTHETYSILV EQFLQEQPLP IKLNPYEKYD KPKLDVVASA 1100
    ADITSKKLPV NQEILRNAWE ASQRSTKDDW QEWIRRLGVA LLRESPSHAL 1150
    RACAALAAAY QPLARDLFNA SFVSCWSELY DHFQEELVKS IEIALTSPHI 1200
    SPEIIQILLN LAEFMEHDDK PLPIDIRTLG AYAAKCHAFA KALHYKELEF 1250
    IEEELVTKPS VDTIEALISI NNQLQQPDAA IGILKHAQQH DKMNLKETWY 1300
    EKLQRWEDAL SAYEKREAAG AGNFEITMGK LRCLHALGEW DRLSQLAQEN 1350
    WIHAGHDARR YIAPLSVAAA WGLGQWEQMD EYISVMKSES PDKAFFNAIV 1400
    ALHRSQFEEA ASYITRARDL LDTELTALVG ESYNRAYSVA VRVQMLSELE 1450
    EIITYKKAED KPEVREMIKK TWVRRLKGCQ RNVDVWQRML RIRSLVISPR 1500
    DNMEMWIKFA NLCRKSGRIS LAKKSLNLLL EDDENLDNSL VLKKTHPSIV 1550
    YANLKFLWAV DDKRKALNSM QEFTSQLISD INVDPALFVQ STSVNTQKSQ 1600
    EEIQYYFHLL ARCYHKQGQW QQEIENNWSE GSFDGVLQSY MYATQFDSKW 1650
    YKAWHSWALA NFEAVKFLEQ SEEQIPSAAY EQYIIPAVKG FFKSIALSKG 1700
    NLQDTLRLLN LWFKFGNNSN VINTLNVGIS TVNIDIWLDV IPQLIARIHA 1750
    SSLSVRKSVH QLLSDVGRAH PQALVYPLTV AAKSQSSARQ NAALAIMDSL 1800
    KTHSPRLVEQ ARLVSHELIR AAILWHEQWH EGLEEASRLY FGDHNIEGMF 1850
    AVLRPLHEML ERGPETLREI SFQQAFGRDL VEARDCCIRF EQTGDISDLN 1900
    QAWDLYYQVF KKIRKQLPQL TTLDLQYVSP KLLHVHDLEL AVPGTYVSGK 1950
    PVIRIVKFYP TFNVITSKQR PRRLSIKGSD GKDYQYVLKG HEDIRQDERV 2000
    MQLFGLCNNL LLADPETFKR LLSIQRYPVI PLSPDSGLLG WVLDSDTLHV 2050
    LIRDYRESRK ILLNIEHRLI IQMAPDYDRL TLLQKVEVFE YALLSTTGQD 2100
    LYRVLWLKSR SSEAWLNRRT NYSRTLAVMS MVGYILGLGD RHPSNLMLDR 2150
    YTGNIIHIDF GDCFEVAMHR EKFPEKIPFR LTRMLVNAME VSGIEGTFRI 2200
    TCEHVMRVLR TNKESVMAVL EAFVYDPLIN WRLAPAYSPS IDEKQSNEPN 2250
    TLLGETIDGL HRKRLNEEGI TLEERQKPEI LNQRAITVLN RVSNKLTGRD 2300
    FKPQQQLDVP SQVEKLILQA TSIENLCLCY IGWCSFW 2337
    Length:2,337
    Mass (Da):266,379
    Last modified:December 6, 2002 - v2
    Checksum:i190F448DA04FD2D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB40167.1.
    PIRiT39913. T40577.
    RefSeqiNP_595359.2. NM_001021266.3.

    Genome annotation databases

    EnsemblFungiiSPBC216.07c.1; SPBC216.07c.1:pep; SPBC216.07c.
    GeneIDi2540720.
    KEGGispo:SPBC216.07c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB40167.1 .
    PIRi T39913. T40577.
    RefSeqi NP_595359.2. NM_001021266.3.

    3D structure databases

    ProteinModelPortali Q9Y7K2.
    SMRi Q9Y7K2. Positions 1817-1916, 2306-2337.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277243. 32 interactions.
    IntActi Q9Y7K2. 7 interactions.
    MINTi MINT-4716528.
    STRINGi 4896.SPBC216.07c-1.

    Proteomic databases

    MaxQBi Q9Y7K2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC216.07c.1 ; SPBC216.07c.1:pep ; SPBC216.07c .
    GeneIDi 2540720.
    KEGGi spo:SPBC216.07c.

    Organism-specific databases

    PomBasei SPBC216.07c.

    Phylogenomic databases

    eggNOGi COG5032.
    HOGENOMi HOG000163215.
    KOi K07203.
    OMAi TYKQNIG.
    OrthoDBi EOG7Z3FCR.
    PhylomeDBi Q9Y7K2.

    Enzyme and pathway databases

    Reactomei REACT_188268. CD28 dependent PI3K/Akt signaling.
    REACT_188279. PIP3 activates AKT signaling.
    REACT_207307. HSF1-dependent transactivation.
    REACT_227968. Constitutive PI3K/AKT Signaling in Cancer.

    Miscellaneous databases

    NextBioi 20801842.
    PROi Q9Y7K2.

    Family and domain databases

    Gene3Di 1.10.1070.11. 3 hits.
    1.25.10.10. 6 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR024585. DUF3385_TOR.
    IPR003152. FATC.
    IPR021133. HEAT_type_2.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003151. PIK-rel_kinase_FAT.
    IPR014009. PIK_FAT.
    IPR009076. Rapamycin-bd_dom.
    [Graphical view ]
    Pfami PF11865. DUF3385. 1 hit.
    PF02259. FAT. 1 hit.
    PF02260. FATC. 1 hit.
    PF00454. PI3_PI4_kinase. 1 hit.
    PF08771. Rapamycin_bind. 1 hit.
    [Graphical view ]
    SMARTi SM00146. PI3Kc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47212. SSF47212. 1 hit.
    SSF48371. SSF48371. 5 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS51189. FAT. 1 hit.
    PS51190. FATC. 1 hit.
    PS50077. HEAT_REPEAT. 1 hit.
    PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine."
      Weisman R., Choder M.
      J. Biol. Chem. 276:7027-7032(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2238 AND SER-2240, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiTOR2_SCHPO
    AccessioniPrimary (citable) accession number: Q9Y7K2
    Secondary accession number(s): O94507
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: December 6, 2002
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3