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Q9Y7J6 (PPK21_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase ppk21

EC=2.7.11.1
Gene names
Name:ppk21
ORF Names:SPBC1778.10c, SPBC4C3.11
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cytoplasm. Nucleus. Cytoplasmcytoskeletonmicrotubule organizing centerspindle pole body. Note: Located at the cell tips and septum. Ref.4

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Serine/threonine-protein kinase ppk21
PRO_0000086157

Regions

Domain55 – 315261Protein kinase
Nucleotide binding61 – 699ATP By similarity

Sites

Active site1791Proton acceptor By similarity
Binding site841ATP By similarity

Amino acid modifications

Modified residue2201Phosphoserine; by autocatalysis By similarity
Modified residue5381Phosphoserine Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q9Y7J6 [UniParc].

Last modified July 11, 2012. Version 3.
Checksum: C591925366133DCF

FASTA55162,716
        10         20         30         40         50         60 
MMDLEHKRIS RSTLPDYADP DYFEARGERN PVKPQSSNVV PGTSHIGSIK SPADYVFGDI 

        70         80         90        100        110        120 
IGDGSFSKVR RATDKKSWKE YAIKVLDKKY IVKENKVKYV NIERDSMMRL NGFPGISRLF 

       130        140        150        160        170        180 
HTFQDDLKLY YVLELAPNGE LLQYIKKYRF LDENCVRFYA AEILSSIEYM HSCGIIHRDL 

       190        200        210        220        230        240 
KPENILFDGN MHVKITDFGT AKILPPKYVN SPDYTTFPSS FVGTAEYVAP ELLSRQVVSK 

       250        260        270        280        290        300 
SSDLWAFACV VYQMIVGSPP FHGSNPNNIF KKIMSLEYEL PKLLPPDIVP LFSHLFRIQP 

       310        320        330        340        350        360 
SDRSTTQQIK QFPFFATITW DNLWTQDPPP MQSFRPNYNI AIPNAPAYYR SNVTAAAAAN 

       370        380        390        400        410        420 
AAAAFASASI VKHQETARRQ ELPTVNRFTA PTAHYGYASL RSHQMPVDRL YYKLVPSSES 

       430        440        450        460        470        480 
IIESTSVFVS PIPSVPEGNK FPSGLSKMFL KRKQRVMLLT DVGRCAFVCK GKHERLFIEM 

       490        500        510        520        530        540 
EVNLKDSSVV VIFDENSSKR FLIEDKVQSW IIEDSSGDVT KYKDKILKFA DVASSHQSRS 

       550 
SEENVEENEE E 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Comparative functional genomics of the fission yeasts."
Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K. expand/collapse author list , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: REVISION OF GENE MODEL.
[3]"Systematic deletion analysis of fission yeast protein kinases."
Bimbo A., Jia Y., Poh S.L., Karuturi R.K.M., den Elzen N., Peng X., Zheng L., O'Connell M., Liu E.T., Balasubramanian M.K., Liu J.
Eukaryot. Cell 4:799-813(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329671 Genomic DNA. Translation: CAB39805.3.
PIRT40486.
RefSeqXP_001713142.2. XM_001713090.2.

3D structure databases

ProteinModelPortalQ9Y7J6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid276357. 53 interactions.
MINTMINT-4716341.
STRING4896.SPBC1778.10c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC1778.10c.1; SPBC1778.10c.1:pep; SPBC1778.10c.
GeneID2539807.
KEGGspo:SPBC1778.10c.

Organism-specific databases

PomBaseSPBC1778.10c.

Phylogenomic databases

eggNOGCOG0515.
OrthoDBEOG7354B2.

Family and domain databases

Gene3D2.30.29.30. 3 hits.
InterProIPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800956.

Entry information

Entry namePPK21_SCHPO
AccessionPrimary (citable) accession number: Q9Y7J6
Secondary accession number(s): O43064
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: July 11, 2012
Last modified: April 16, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names