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Protein

Serine/threonine-protein kinase ppk21

Gene

ppk21

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei84ATPBy similarity1
Binding sitei140ATPBy similarity1
Active sitei179Proton acceptorPROSITE-ProRule annotation1
Binding sitei183ATP; via carbonyl oxygenBy similarity1
Binding sitei197ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 67ATPBy similarity3
Nucleotide bindingi134 – 136ATPBy similarity3

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-114604 GPVI-mediated activation cascade
R-SPO-1257604 PIP3 activates AKT signaling
R-SPO-165158 Activation of AKT2
R-SPO-202424 Downstream TCR signaling
R-SPO-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-SPO-389357 CD28 dependent PI3K/Akt signaling
R-SPO-5218920 VEGFR2 mediated vascular permeability
R-SPO-5625740 RHO GTPases activate PKNs
R-SPO-6804757 Regulation of TP53 Degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ppk21 (EC:2.7.11.1)
Gene namesi
Name:ppk21
ORF Names:SPBC1778.10c, SPBC4C3.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1778.10c
PomBaseiSPBC1778.10c ppk21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000861571 – 551Serine/threonine-protein kinase ppk21Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei220Phosphoserine; by autocatalysisBy similarity1
Modified residuei538Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y7J6
PaxDbiQ9Y7J6
PRIDEiQ9Y7J6

PTM databases

iPTMnetiQ9Y7J6

Interactioni

Protein-protein interaction databases

BioGridi276357, 52 interactors
STRINGi4896.SPBC1778.10c.1

Structurei

3D structure databases

ProteinModelPortaliQ9Y7J6
SMRiQ9Y7J6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 315Protein kinasePROSITE-ProRule annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni86 – 131PIF-pocketBy similarityAdd BLAST46

Domaini

The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.By similarity

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ9Y7J6
OrthoDBiEOG092C0HH3

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y7J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDLEHKRIS RSTLPDYADP DYFEARGERN PVKPQSSNVV PGTSHIGSIK
60 70 80 90 100
SPADYVFGDI IGDGSFSKVR RATDKKSWKE YAIKVLDKKY IVKENKVKYV
110 120 130 140 150
NIERDSMMRL NGFPGISRLF HTFQDDLKLY YVLELAPNGE LLQYIKKYRF
160 170 180 190 200
LDENCVRFYA AEILSSIEYM HSCGIIHRDL KPENILFDGN MHVKITDFGT
210 220 230 240 250
AKILPPKYVN SPDYTTFPSS FVGTAEYVAP ELLSRQVVSK SSDLWAFACV
260 270 280 290 300
VYQMIVGSPP FHGSNPNNIF KKIMSLEYEL PKLLPPDIVP LFSHLFRIQP
310 320 330 340 350
SDRSTTQQIK QFPFFATITW DNLWTQDPPP MQSFRPNYNI AIPNAPAYYR
360 370 380 390 400
SNVTAAAAAN AAAAFASASI VKHQETARRQ ELPTVNRFTA PTAHYGYASL
410 420 430 440 450
RSHQMPVDRL YYKLVPSSES IIESTSVFVS PIPSVPEGNK FPSGLSKMFL
460 470 480 490 500
KRKQRVMLLT DVGRCAFVCK GKHERLFIEM EVNLKDSSVV VIFDENSSKR
510 520 530 540 550
FLIEDKVQSW IIEDSSGDVT KYKDKILKFA DVASSHQSRS SEENVEENEE

E
Length:551
Mass (Da):62,716
Last modified:July 11, 2012 - v3
Checksum:iC591925366133DCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB39805.3
PIRiT40486
RefSeqiXP_001713142.2, XM_001713090.2

Genome annotation databases

EnsemblFungiiSPBC1778.10c.1; SPBC1778.10c.1:pep; SPBC1778.10c
KEGGispo:SPBC1778.10c

Similar proteinsi

Entry informationi

Entry nameiPPK21_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7J6
Secondary accession number(s): O43064
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: July 11, 2012
Last modified: May 23, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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