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Q9Y7J6

- PPK21_SCHPO

UniProt

Q9Y7J6 - PPK21_SCHPO

Protein

Serine/threonine-protein kinase ppk21

Gene

ppk21

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (11 Jul 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei84 – 841ATPPROSITE-ProRule annotation
    Active sitei179 – 1791Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi61 – 699ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. mitotic cytokinesis Source: PomBase
    2. protein phosphorylation Source: PomBase
    3. signal transduction Source: PomBase

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_188268. CD28 dependent PI3K/Akt signaling.
    REACT_188279. PIP3 activates AKT signaling.
    REACT_188599. GPVI-mediated activation cascade.
    REACT_193541. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_204926. Activation of PKB.
    REACT_227968. Constitutive PI3K/AKT Signaling in Cancer.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase ppk21 (EC:2.7.11.1)
    Gene namesi
    Name:ppk21
    ORF Names:SPBC1778.10c, SPBC4C3.11
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC1778.10c.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centerspindle pole body 1 Publication
    Note: Located at the cell tips and septum.

    GO - Cellular componenti

    1. cell division site Source: PomBase
    2. cell tip Source: PomBase
    3. cytosol Source: PomBase
    4. mitotic spindle pole body Source: PomBase
    5. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Serine/threonine-protein kinase ppk21PRO_0000086157Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei220 – 2201Phosphoserine; by autocatalysisBy similarity
    Modified residuei538 – 5381Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y7J6.

    Interactioni

    Protein-protein interaction databases

    BioGridi276357. 53 interactions.
    MINTiMINT-4716341.
    STRINGi4896.SPBC1778.10c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y7J6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 315261Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    OrthoDBiEOG7354B2.

    Family and domain databases

    Gene3Di2.30.29.30. 3 hits.
    InterProiIPR011009. Kinase-like_dom.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y7J6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMDLEHKRIS RSTLPDYADP DYFEARGERN PVKPQSSNVV PGTSHIGSIK    50
    SPADYVFGDI IGDGSFSKVR RATDKKSWKE YAIKVLDKKY IVKENKVKYV 100
    NIERDSMMRL NGFPGISRLF HTFQDDLKLY YVLELAPNGE LLQYIKKYRF 150
    LDENCVRFYA AEILSSIEYM HSCGIIHRDL KPENILFDGN MHVKITDFGT 200
    AKILPPKYVN SPDYTTFPSS FVGTAEYVAP ELLSRQVVSK SSDLWAFACV 250
    VYQMIVGSPP FHGSNPNNIF KKIMSLEYEL PKLLPPDIVP LFSHLFRIQP 300
    SDRSTTQQIK QFPFFATITW DNLWTQDPPP MQSFRPNYNI AIPNAPAYYR 350
    SNVTAAAAAN AAAAFASASI VKHQETARRQ ELPTVNRFTA PTAHYGYASL 400
    RSHQMPVDRL YYKLVPSSES IIESTSVFVS PIPSVPEGNK FPSGLSKMFL 450
    KRKQRVMLLT DVGRCAFVCK GKHERLFIEM EVNLKDSSVV VIFDENSSKR 500
    FLIEDKVQSW IIEDSSGDVT KYKDKILKFA DVASSHQSRS SEENVEENEE 550
    E 551
    Length:551
    Mass (Da):62,716
    Last modified:July 11, 2012 - v3
    Checksum:iC591925366133DCF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB39805.3.
    PIRiT40486.
    RefSeqiXP_001713142.2. XM_001713090.2.

    Genome annotation databases

    EnsemblFungiiSPBC1778.10c.1; SPBC1778.10c.1:pep; SPBC1778.10c.
    GeneIDi2539807.
    KEGGispo:SPBC1778.10c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB39805.3 .
    PIRi T40486.
    RefSeqi XP_001713142.2. XM_001713090.2.

    3D structure databases

    ProteinModelPortali Q9Y7J6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276357. 53 interactions.
    MINTi MINT-4716341.
    STRINGi 4896.SPBC1778.10c-1.

    Proteomic databases

    MaxQBi Q9Y7J6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC1778.10c.1 ; SPBC1778.10c.1:pep ; SPBC1778.10c .
    GeneIDi 2539807.
    KEGGi spo:SPBC1778.10c.

    Organism-specific databases

    PomBasei SPBC1778.10c.

    Phylogenomic databases

    eggNOGi COG0515.
    OrthoDBi EOG7354B2.

    Enzyme and pathway databases

    Reactomei REACT_188268. CD28 dependent PI3K/Akt signaling.
    REACT_188279. PIP3 activates AKT signaling.
    REACT_188599. GPVI-mediated activation cascade.
    REACT_193541. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_204926. Activation of PKB.
    REACT_227968. Constitutive PI3K/AKT Signaling in Cancer.

    Miscellaneous databases

    NextBioi 20800956.

    Family and domain databases

    Gene3Di 2.30.29.30. 3 hits.
    InterProi IPR011009. Kinase-like_dom.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Comparative functional genomics of the fission yeasts."
      Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
      , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
      Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVISION OF GENE MODEL.
    3. Cited for: IDENTIFICATION.
    4. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiPPK21_SCHPO
    AccessioniPrimary (citable) accession number: Q9Y7J6
    Secondary accession number(s): O43064
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: July 11, 2012
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3