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Protein

Zuotin

Gene

zuo1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Zuotin
Alternative name(s):
DnaJ-related protein zuo1
Short name:
J protein zuo1
Ribosome-associated complex subunit zuo1
Gene namesi
Name:zuo1
ORF Names:SPBC1778.01c, SPBC30D10.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1778.01c.
PomBaseiSPBC1778.01c. zuo1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442ZuotinPRO_0000071159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551Phosphothreonine1 Publication
Modified residuei57 – 571Phosphoserine1 Publication
Modified residuei76 – 761Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y7I8.

PTM databases

iPTMnetiQ9Y7I8.

Interactioni

Subunit structurei

RAC is a heterodimer of the Hsp70/DnaK-type chaperone ssz1 and the Hsp40/DnaJ-type chaperone zuo1. RAC associates with ribosomes via zuo1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-4716051.

Structurei

3D structure databases

ProteinModelPortaliQ9Y7I8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 16771JPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi294 – 34249Ala/Lys-richAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000171054.
InParanoidiQ9Y7I8.
KOiK09522.
OMAiRTFSEDD.
OrthoDBiEOG7K3TX9.
PhylomeDBiQ9Y7I8.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR032003. RAC_head.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF16717. RAC_head. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y7I8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGDSIQLF PPTTKQAIEA SFVPHGKISP LIKRAVEPVG PLFLAHARRQ
60 70 80 90 100
RHGRTFSEDE RLEVKNKVQE EVKEESEDEE EDPAMLRADP KEWKQQDHYA
110 120 130 140 150
VLGLSKYRYK ADTEQIKKAH LKKVLKHHPD KKAASGNIND DSFFKCIQKA
160 170 180 190 200
YEILSDPVRR RQFDSVDENA DVEPPESTTK ETFFELWTPV FESEARFSKK
210 220 230 240 250
QPVPSLGTIE STRAEVDNFY NFWYNFDSWR SFEYLDKDIP DDGESRDNKR
260 270 280 290 300
FQEKKNRSER QKNKARDNAR LRNLVDTALA SDPRIKLFKE QEKAAKAARK
310 320 330 340 350
WEREAGAREA AAAAQKKKEE EERRAAEEAA AKASAAAANK KAKEDKKKAQ
360 370 380 390 400
KRDKKVVKNA LKDFNYFSAT DVPSAEHVDS VLKDVDVIMS KLGEGELGQL
410 420 430 440
AADINAEKAA GAASVQAVFD KFAKMFIERG SMSSADVVFF AQ
Length:442
Mass (Da):50,209
Last modified:May 23, 2003 - v2
Checksum:iF4EC924871B7318B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB10796.1.
PIRiT39683.
RefSeqiNP_596284.2. NM_001022205.3.

Genome annotation databases

EnsemblFungiiSPBC1778.01c.1; SPBC1778.01c.1:pep; SPBC1778.01c.
GeneIDi2539801.
KEGGispo:SPBC1778.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB10796.1.
PIRiT39683.
RefSeqiNP_596284.2. NM_001022205.3.

3D structure databases

ProteinModelPortaliQ9Y7I8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4716051.

PTM databases

iPTMnetiQ9Y7I8.

Proteomic databases

MaxQBiQ9Y7I8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1778.01c.1; SPBC1778.01c.1:pep; SPBC1778.01c.
GeneIDi2539801.
KEGGispo:SPBC1778.01c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1778.01c.
PomBaseiSPBC1778.01c. zuo1.

Phylogenomic databases

HOGENOMiHOG000171054.
InParanoidiQ9Y7I8.
KOiK09522.
OMAiRTFSEDD.
OrthoDBiEOG7K3TX9.
PhylomeDBiQ9Y7I8.

Miscellaneous databases

NextBioi20800950.
PROiQ9Y7I8.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR032003. RAC_head.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF16717. RAC_head. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-55; SER-57 AND SER-76, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiZUO1_SCHPO
AccessioniPrimary (citable) accession number: Q9Y7I8
Secondary accession number(s): O14347
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 23, 2003
Last modified: January 20, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.