Reviewed, UniProtKB/Swiss-Prot Q9Y7B1 (ACOX_PICPA)

Names and origin

Protein names

Recommended name:
    Acyl-coenzyme A oxidase
      Short name=Acyl-CoA oxidase
    EC=1.3.3.6

Gene names

Name:

POX1

Organism

Pichia pastoris (Yeast)

Taxonomic identifier

4922 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Pichia

Protein attributes

Sequence length	719 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.
Cofactor	FAD By similarity.
Pathway	Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Subcellular location	Peroxisome. Ref.1
Sequence similarities	Belongs to the acyl-CoA oxidase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	fatty acid beta-oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro acyl-CoA oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 719	719	Acyl-coenzyme A oxidase		PRO_0000204700
Regions
	Motif	716 – 719	4	Microbody targeting signal

Sequences

	Sequence		Length	Mass (Da)
	Q9Y7B1-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 252DC1E03BD978F0	FASTA	719	80,519
	10 20 30 40 50 60 MFKIESIKSQ SPQVAIDKER KATKFDINKM FEFLESGKDE AALTKSLMQQ IERDTILKTN 70 80 90 100 110 120 ASYYDLTKDQ HRELTAQKIA RLASYIEKDA PFFENFQKRL NLIAIVDPQL GTRVGVHLGL 130 140 150 160 170 180 FLSAIRGNGT EEQFKYWAFE RGAAYLKDVY GCFGMTELAH GSNVAGLETT ATFDQKTKEF 190 200 210 220 230 240 EINTPHLGAT KWWIGGAAHS ANHCVVYARL IVSGKDYGVK TFVVPIRDRN HNLHSGVAIG 250 260 270 280 290 300 DIGAKMGRDG IDNGWIQLTN VRIPMNYMRS KFTKVTQRQE IVEVPPLEQL AYGALLGGRV 310 320 330 340 350 360 TMVTDSFRMA QRFITIALRY SVGRRQFGAK NSSEELKLID YPLHQRRLLP YLALTYALSI 370 380 390 400 410 420 SSFDLSQTYD SVLSNLDAAG KSQDFSKLGQ AIAGLKNLFC ASASLKSTAT WYVAQLIDEC 430 440 450 460 470 480 RQACGGHGYS SYSGFGKAYN DWVVQCTWEG DNNILASNAG RLLCNLLSSC KKKEKKIKGD 490 500 510 520 530 540 LSYLNGISNI DKEAICWNKQ SMTNLSNSNI DKELFCFNKQ VCTVKLINAI QGTIIRLGVR 550 560 570 580 590 600 VPNIGSKKST WDDIAAQRVV LSKLNAVLYM LQHLVLKIKQ LGDEEAHKQY LVQIAALFAT 610 620 630 640 650 660 SQIEMNFASY FLQFKAIDSL EPVADVVSEL CLSVRDQVIG LTDSFQFSDY FINSALGSHS 670 680 690 700 710 GDIYNTYFDT VNNLNNPQVR DGKAAYSEAL EAMLRRDPLE VRECFEKSDK VLKKLAPKI

References

[1]

"Analysis of the peroxisomal acyl-CoA oxidase gene product from Pichia pastoris and determination of its targeting signal." Koller A., Spong A.P., Luers G.H., Subramani S. Yeast 15:1035-1044(1999) [PubMed: 10455228] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, TARGETING SIGNAL.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF133102 Genomic DNA. Translation: AAD31029.1.
3D structure databases
HSSP	HSSP built from PDB template 1IS2 based on UniProtKB P07872.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.3.3.6. 390.
Family and domain databases
InterPro	IPR006091. Acyl-CoA_Oxase/DH_M. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHER	PTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
Pfam	PF01756. ACOX. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
PIRSF	PIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACOX_PICPA

Accession

Primary (citable) accession number: Q9Y7B1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)