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Q9Y780

- Q9Y780_COPCI

UniProt

Q9Y780 - Q9Y780_COPCI

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Protein
Submitted name:

Laccase 1

Gene
lcc1
Organism
Coprinopsis cinerea (Inky cap fungus) (Hormographiella aspergillata)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Copper 1; via pros nitrogenImported
Metal bindingi127 – 1271Copper 1; via tele nitrogenImported
Metal bindingi129 – 1291Copper 2; via tele nitrogenImported
Binding sitei175 – 1751Mannose; via carbonyl oxygenImported
Metal bindingi414 – 4141Copper 3; via pros nitrogenImported
Metal bindingi417 – 4171Copper 2; via tele nitrogenImported
Metal bindingi419 – 4191Copper 2; via tele nitrogenImported
Metal bindingi469 – 4691Copper 2; via tele nitrogenImported
Sitei469 – 4691Important for catalytic activityImported
Metal bindingi470 – 4701Copper 3Imported
Sitei470 – 4701Important for catalytic activityImported
Metal bindingi471 – 4711Copper 1; via tele nitrogenImported
Sitei471 – 4711Important for catalytic activityImported
Metal bindingi475 – 4751Copper 3; via pros nitrogenImported
Binding sitei520 – 5201MannoseImported

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotationsImported

Keywords - Ligandi

CopperSAAS annotationsImported, Metal-bindingSAAS annotationsImported

Names & Taxonomyi

Protein namesi
Submitted name:
Laccase 1Imported (EC:1.10.3.2Imported)
Gene namesi
Name:lcc1Imported
OrganismiCoprinopsis cinerea (Inky cap fungus) (Hormographiella aspergillata)Imported
Taxonomic identifieri5346 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinopsis

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi361 – 3611N-linked (GlcNAc...)

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A65X-ray2.23A19-522[»]
1HFUX-ray1.68A20-521[»]

Miscellaneous databases

EvolutionaryTraceiQ9Y780.

Family & Domainsi

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 2 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y780-1 [UniParc]FASTAAdd to Basket

« Hide

MFKNLLSFAL LAISVANAQI VNSVDTMTLT NANVSPDGFT RAGILVNGVH    50
GPLIRGGKND NFELNVVNDL DNPTMLRPTS IHWHGLFQRG TNWADGADGV 100
NQCPISPGHA FLYKFTPAGH AGTFWYHSHF GTQYCDGLRG PMVIYDDNDP 150
HAALYDEDDE NTIITLADWY HIPAPSIQGA AQPDATLING KGRYVGGPAA 200
ELSIVNVEQG KKYRMRLISL SCDPNWQFSI DGHELTIIEV DGQLTEPHTV 250
DRLQIFTGQR YSFVLDANQP VDNYWIRAQP NKGRNGLAGT FANGVNSAIL 300
RYAGAANADP TTSANPNPAQ LNEADLHALI DPAAPGIPTP GAADVNLRFQ 350
LGFSGGRFTI NGTAYESPSV PTLLQIMSGA QSANDLLPAG SVYELPRNQV 400
VELVVPAGVL GGPHPFHLHG HAFSVVRSAG SSTYNFVNPV KRDVVSLGVT 450
GDEVTIRFVT DNPGPWFFHC HIEFHLMNGL AIVFAEDMAN TVDANNPPVE 500
WAQLCEIYDD LPPEATSIQT VVRRAEPTGF SAKFRREGL 539
Length:539
Mass (Da):58,385
Last modified:November 1, 1999 - v1
Checksum:iFC45584BBE6142A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF118267 Genomic DNA. Translation: AAD30964.1.
AY338756 Genomic DNA. Translation: AAR01241.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF118267 Genomic DNA. Translation: AAD30964.1 .
AY338756 Genomic DNA. Translation: AAR01241.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A65 X-ray 2.23 A 19-522 [» ]
1HFU X-ray 1.68 A 20-521 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q9Y780.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 2 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Crystal structure of the type-2 Cu depleted laccase from Coprinus cinereus at 2.2 A resolution."
    Ducros V., Brzozowski A.M., Wilson K.S., Brown S.H., Ostergaard P., Schneider P., Yaver D.S., Pedersen A.H., Davies G.J.
    Nat. Struct. Biol. 5:310-316(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) OF 19-522 IN COMPLEX WITH COPPER, ACTIVE SITE, GLYCOSYLATION AT ASN-361.
  2. "Molecular characterization of laccase genes from the basidiomycete Coprinus cinereus and heterologous expression of the laccase lcc1."
    Yaver D.S., Overjero M.D., Xu F., Nelson B.A., Brown K.M., Halkier T., Bernauer S., Brown S.H., Kauppinen S.
    Appl. Environ. Microbiol. 65:4943-4948(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A3387Imported.
  3. "Structure of the laccase from Coprinus cinereus at 1.68 A resolution: evidence for different 'type 2 Cu-depleted' isoforms."
    Ducros V., Brzozowski A.M., Wilson K.S., Ostergaard P., Schneider P., Svendson A., Davies G.J.
    Acta Crystallogr. D 57:333-336(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.68 ANGSTROMS) OF 20-521 IN COMPLEX WITH COPPER AND MANNOSE.
  4. "The laccase gene family in Coprinopsis cinerea (Coprinus cinereus)."
    Hoegger P.J., Navarro-Gonzalez M., Kilaru S., Hoffmann M., Westbrook E.D., Kues U.
    Curr. Genet. 45:9-18(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AT8Imported.

Entry informationi

Entry nameiQ9Y780_COPCI
AccessioniPrimary (citable) accession number: Q9Y780
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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