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Q9Y753

- FDFT_YARLI

UniProt

Q9Y753 - FDFT_YARLI

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Protein
Squalene synthase
Gene
SQS1, YALI0A10076g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol.1 Publication

Catalytic activityi

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactori

Magnesium By similarity.

Pathwayi

GO - Molecular functioni

  1. farnesyl-diphosphate farnesyltransferase activity Source: UniProtKB-EC
  2. oxidoreductase activity Source: UniProtKB-KW
  3. squalene synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoprenoid biosynthetic process Source: UniProtKB-KW
  2. sterol biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Transferase

Keywords - Biological processi

Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

Magnesium, NADP

Enzyme and pathway databases

UniPathwayiUPA00767; UER00751.

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene synthase (EC:2.5.1.21)
Short name:
SQS
Short name:
SS
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
Gene namesi
Name:SQS1
Ordered Locus Names:YALI0A10076g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome A

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei291 – 31121Helical; Reviewed prediction
Add
BLAST
Transmembranei405 – 42521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Squalene synthase
PRO_0000067453Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4952.Q9Y753.

Structurei

3D structure databases

ProteinModelPortaliQ9Y753.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1562.
HOGENOMiHOG000186940.
KOiK00801.
OMAiEMRHAVC.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR002060. Squ/phyt_synthse.
IPR006449. Squal_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR01559. squal_synth. 1 hit.
PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y753-1 [UniParc]FASTAAdd to Basket

« Hide

MGKLIELLLH PSELSAAIHY KLWRQPLHPR DLSKESTELR RCYELLDVCS    50
RSFAAVIREL HPEVRDAVML FYLILRALDT IEDDMTLSRD IKIPILRDFT 100
KCMKTPGWKF TDSDPNERDR VVLQEFPVVM TEFNKLKPKY QEVIYDITDR 150
MGNGMADYVI DDDFNNNGVD TIAAYDLYCH HVAGIVGEGL TRITILAGFG 200
TDVLHENPRL QESMGLFLQK VNIIRDYRED IDVNRAFWPR EIWHKYAEEM 250
RDFKDPKYSK KALHCTSDLV ANALGHATDC LDYLDNVTDP STFTFCAIPQ 300
VMAIATLDLV YRNPDVFQKN VKLRKGTTVS LILEASNVSG VCDIFTRYAR 350
KVYKKSDPND PNYFRVSVLC GKIEQHAALI KRQRGPPAKT IAQLEGERKE 400
MALSLIVCLA VIFSMSGLMA YIAYVSGFRW SPREIFDSKM FPLRD 445
Length:445
Mass (Da):51,145
Last modified:November 1, 1999 - v1
Checksum:i5028E55F0A66DC7D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF092497 Genomic DNA. Translation: AAD22408.1.
CR382127 Genomic DNA. Translation: CAG83856.1.
RefSeqiXP_499929.1. XM_499929.1.

Genome annotation databases

EnsemblFungiiCAG83856; CAG83856; YALI0_A10076g.
GeneIDi2906604.
KEGGiyli:YALI0A10076g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF092497 Genomic DNA. Translation: AAD22408.1 .
CR382127 Genomic DNA. Translation: CAG83856.1 .
RefSeqi XP_499929.1. XM_499929.1.

3D structure databases

ProteinModelPortali Q9Y753.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q9Y753.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG83856 ; CAG83856 ; YALI0_A10076g .
GeneIDi 2906604.
KEGGi yli:YALI0A10076g.

Phylogenomic databases

eggNOGi COG1562.
HOGENOMi HOG000186940.
KOi K00801.
OMAi EMRHAVC.

Enzyme and pathway databases

UniPathwayi UPA00767 ; UER00751 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR001623. DnaJ_domain.
IPR002060. Squ/phyt_synthse.
IPR006449. Squal_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SMARTi SM00271. DnaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
TIGRFAMsi TIGR01559. squal_synth. 1 hit.
PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the Yarrowia lipolytica squalene synthase (SQS1) gene and functional complementation of the Saccharomyces cerevisiae erg9 mutation."
    Merkulov S., van Assema F., Springer J., Fernandez Del Carmen A., Mooibroek H.
    Yeast 16:197-206(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIB 122 / E 150.

Entry informationi

Entry nameiFDFT_YARLI
AccessioniPrimary (citable) accession number: Q9Y753
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3