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Q9Y753 (FDFT_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Squalene synthase

Short name=SQS
Short name=SS
EC=2.5.1.21
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
Gene names
Name:SQS1
Ordered Locus Names:YALI0A10076g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol. Ref.1

Catalytic activity

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactor

Magnesium By similarity.

Pathway

Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the phytoene/squalene synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Squalene synthase
PRO_0000067453

Regions

Transmembrane291 – 31121Helical; Potential
Transmembrane405 – 42521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9Y753 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 5028E55F0A66DC7D

FASTA44551,145
        10         20         30         40         50         60 
MGKLIELLLH PSELSAAIHY KLWRQPLHPR DLSKESTELR RCYELLDVCS RSFAAVIREL 

        70         80         90        100        110        120 
HPEVRDAVML FYLILRALDT IEDDMTLSRD IKIPILRDFT KCMKTPGWKF TDSDPNERDR 

       130        140        150        160        170        180 
VVLQEFPVVM TEFNKLKPKY QEVIYDITDR MGNGMADYVI DDDFNNNGVD TIAAYDLYCH 

       190        200        210        220        230        240 
HVAGIVGEGL TRITILAGFG TDVLHENPRL QESMGLFLQK VNIIRDYRED IDVNRAFWPR 

       250        260        270        280        290        300 
EIWHKYAEEM RDFKDPKYSK KALHCTSDLV ANALGHATDC LDYLDNVTDP STFTFCAIPQ 

       310        320        330        340        350        360 
VMAIATLDLV YRNPDVFQKN VKLRKGTTVS LILEASNVSG VCDIFTRYAR KVYKKSDPND 

       370        380        390        400        410        420 
PNYFRVSVLC GKIEQHAALI KRQRGPPAKT IAQLEGERKE MALSLIVCLA VIFSMSGLMA 

       430        440 
YIAYVSGFRW SPREIFDSKM FPLRD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF092497 Genomic DNA. Translation: AAD22408.1.
CR382127 Genomic DNA. Translation: CAG83856.1.
RefSeqXP_499929.1. XM_499929.1.

3D structure databases

ProteinModelPortalQ9Y753.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q9Y753.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG83856; CAG83856; YALI0_A10076g.
GeneID2906604.
KEGGyli:YALI0A10076g.

Phylogenomic databases

eggNOGCOG1562.
HOGENOMHOG000186940.
KOK00801.
OMAEMRHAVC.

Enzyme and pathway databases

UniPathwayUPA00767; UER00751.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR001623. DnaJ_domain.
IPR002060. Squ/phyt_synthse.
IPR006449. Squal_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR01559. squal_synth. 1 hit.
PROSITEPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDFT_YARLI
AccessionPrimary (citable) accession number: Q9Y753
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways