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Protein

Squalene synthase

Gene

SQS1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol.1 Publication

Catalytic activityi

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactori

Mg2+By similarity

Pathwayi: lanosterol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes lanosterol from farnesyl diphosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Squalene synthase (SQS1)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway lanosterol biosynthesis, which is itself part of Terpene metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lanosterol from farnesyl diphosphate, the pathway lanosterol biosynthesis and in Terpene metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMultifunctional enzyme, Transferase
Biological processIsoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandMagnesium, NADP

Enzyme and pathway databases

UniPathwayiUPA00767; UER00751

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene synthase (EC:2.5.1.21)
Short name:
SQS
Short name:
SS
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
Gene namesi
Name:SQS1
Ordered Locus Names:YALI0A10076g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674531 – 445Squalene synthaseAdd BLAST445

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_499929.1

Structurei

3D structure databases

ProteinModelPortaliQ9Y753
SMRiQ9Y753
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000186940
KOiK00801
OMAiFNFVAIP
OrthoDBiEOG092C2IU6

Family and domain databases

CDDicd00683 Trans_IPPS_HH, 1 hit
Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR002060 Squ/phyt_synthse
IPR006449 Squal_synth-like
IPR019845 Squalene/phytoene_synthase_CS
IPR033904 Trans_IPPS_HH
PfamiView protein in Pfam
PF00494 SQS_PSY, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
TIGRFAMsiTIGR01559 squal_synth, 1 hit
PROSITEiView protein in PROSITE
PS01044 SQUALEN_PHYTOEN_SYN_1, 1 hit
PS01045 SQUALEN_PHYTOEN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLIELLLH PSELSAAIHY KLWRQPLHPR DLSKESTELR RCYELLDVCS
60 70 80 90 100
RSFAAVIREL HPEVRDAVML FYLILRALDT IEDDMTLSRD IKIPILRDFT
110 120 130 140 150
KCMKTPGWKF TDSDPNERDR VVLQEFPVVM TEFNKLKPKY QEVIYDITDR
160 170 180 190 200
MGNGMADYVI DDDFNNNGVD TIAAYDLYCH HVAGIVGEGL TRITILAGFG
210 220 230 240 250
TDVLHENPRL QESMGLFLQK VNIIRDYRED IDVNRAFWPR EIWHKYAEEM
260 270 280 290 300
RDFKDPKYSK KALHCTSDLV ANALGHATDC LDYLDNVTDP STFTFCAIPQ
310 320 330 340 350
VMAIATLDLV YRNPDVFQKN VKLRKGTTVS LILEASNVSG VCDIFTRYAR
360 370 380 390 400
KVYKKSDPND PNYFRVSVLC GKIEQHAALI KRQRGPPAKT IAQLEGERKE
410 420 430 440
MALSLIVCLA VIFSMSGLMA YIAYVSGFRW SPREIFDSKM FPLRD
Length:445
Mass (Da):51,145
Last modified:November 1, 1999 - v1
Checksum:i5028E55F0A66DC7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092497 Genomic DNA Translation: AAD22408.1
CR382127 Genomic DNA Translation: CAG83856.1
RefSeqiXP_499929.1, XM_499929.1

Genome annotation databases

EnsemblFungiiCAG83856; CAG83856; YALI0_A10076g
GeneIDi2906604
KEGGiyli:YALI0A10076g

Similar proteinsi

Entry informationi

Entry nameiFDFT_YARLI
AccessioniPrimary (citable) accession number: Q9Y753
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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