Q9Y753 (FDFT_YARLI) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 79.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Squalene synthase Short name=SQS Short name=SS EC=2.5.1.21 Alternative name(s): FPP:FPP farnesyltransferase Farnesyl-diphosphate farnesyltransferase | ||||
| Gene names |
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| Organism | Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) | ||||
| Taxonomic identifier | 284591 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia |
Protein attributes
| Sequence length | 445 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | 2 farnesyl diphosphate = diphosphate + presqualene diphosphate. Presqualene diphosphate + NAD(P)H = squalene + diphosphate + NAD(P)+. |
| Cofactor | Magnesium. |
| Pathway | Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3. |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the phytoene/squalene synthase family. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and characterization of the Yarrowia lipolytica squalene synthase (SQS1) gene and functional complementation of the Saccharomyces cerevisiae erg9 mutation." Merkulov S., van Assema F., Springer J., Fernandez Del Carmen A., Mooibroek H. Yeast 16:197-206(2000) [PubMed: 10649449] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. Souciet J.-L.Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
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| EMBL GenBank DDBJ | AF092497 Genomic DNA. Translation: AAD22408.1. CR382127 Genomic DNA. Translation: CAG83856.1. |
| RefSeq | XP_499929.1. XM_499929.1. |
3D structure databases | |
| ProteinModelPortal | Q9Y753. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9Y753. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 2906604. |
| GenomeReviews | Gene locus YALI0A10076g in contig CR382127_GR. |
| KEGG | yli:YALI0A10076g. |
Phylogenomic databases | |
| eggNOG | fuNOG05680. |
| HOGENOM | HBG600510. |
| OMA | MGVGMAE. |
| OrthoDB | EOG4BP4MQ. |
Family and domain databases | |
| InterPro | IPR001623. DnaJ_N. IPR002060. Squ/phyt_synthse. IPR006449. Squal_synth. IPR019845. Squalene/phytoene_synthase_CS. IPR008949. Terpenoid_synth. [Graphical view] |
| Gene3D | G3DSA:1.10.600.10. Terpenoid_synth. 1 hit. |
| KO | K00801. |
| Pfam | PF00494. SQS_PSY. 1 hit. [Graphical view] |
| SMART | SM00271. DnaJ. 1 hit. [Graphical view] |
| SUPFAM | SSF48576. Terpenoid_synth. 1 hit. |
| TIGRFAMs | TIGR01559. Squal_synth. 1 hit. |
| PROSITE | PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit. PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FDFT_YARLI | ||||||||
| Accession | Primary (citable) accession number: Q9Y753 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with