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Q9Y726

- PYRF_SACEX

UniProt

Q9Y726 - PYRF_SACEX

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
URA4
Organism
Saccharomyces exiguus (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371Substrate By similarity
Active sitei93 – 931Proton donor By similarity
Binding sitei217 – 2171Substrate By similarity
Binding sitei235 – 2351Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA4
OrganismiSaccharomyces exiguus (Yeast)
Taxonomic identifieri34358 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKazachstania

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Orotidine 5'-phosphate decarboxylase
PRO_0000134680Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9Y726.
SMRiQ9Y726. Positions 1-263.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 613Substrate binding By similarity
Regioni91 – 10010Substrate binding By similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y726-1 [UniParc]FASTAAdd to Basket

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MAFATYEERA SVHASPVASK LLRIMASKKT NLCASLDVRT TAELLSLVDQ    50
VGPYICLLKT HVDILDDFSM EGTVKPLKEL AAKYNFLIFE DRKFADIGNT 100
VKLQYSSGVY KIVQWADITN AHGVTGSGIV KGLKEAAQEN SDEPRGLLML 150
AELSSKGSLA HGEYTTGTVE IAKTDKQFVF GFIAQRGMGG RDEGFDWLIM 200
TPGVGLDDKG DALGQQYRTV DDVVSTGSDI IIVGRGLFGK GRDPTAESRR 250
YRDAGWDAYL KRCNAASN 268
Length:268
Mass (Da):29,187
Last modified:November 1, 1999 - v1
Checksum:iAD53CBB6EAA726F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB021640 Genomic DNA. Translation: BAA76736.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB021640 Genomic DNA. Translation: BAA76736.1 .

3D structure databases

ProteinModelPortali Q9Y726.
SMRi Q9Y726. Positions 1-263.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and DNA analysis of the orotidine-5'-phosphate decarboxylase gene from the yeast Saccharomyces exiguus Yp74L-3."
    Hisatomi T., Kodama T., Toba H., Moto-oka M., Watanabe A., Tsuboi M.
    Curr. Microbiol. 41:421-424(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Yp74L-3.

Entry informationi

Entry nameiPYRF_SACEX
AccessioniPrimary (citable) accession number: Q9Y726
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: October 16, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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