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Q9Y726 (PYRF_SACEX) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA4
OrganismSaccharomyces exiguus (Yeast)
Taxonomic identifier34358 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKazachstania

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Orotidine 5'-phosphate decarboxylase
PRO_0000134680

Regions

Region59 – 613Substrate binding By similarity
Region91 – 10010Substrate binding By similarity

Sites

Active site931Proton donor By similarity
Binding site371Substrate By similarity
Binding site2171Substrate By similarity
Binding site2351Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Y726 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: AD53CBB6EAA726F6

FASTA26829,187
        10         20         30         40         50         60 
MAFATYEERA SVHASPVASK LLRIMASKKT NLCASLDVRT TAELLSLVDQ VGPYICLLKT 

        70         80         90        100        110        120 
HVDILDDFSM EGTVKPLKEL AAKYNFLIFE DRKFADIGNT VKLQYSSGVY KIVQWADITN 

       130        140        150        160        170        180 
AHGVTGSGIV KGLKEAAQEN SDEPRGLLML AELSSKGSLA HGEYTTGTVE IAKTDKQFVF 

       190        200        210        220        230        240 
GFIAQRGMGG RDEGFDWLIM TPGVGLDDKG DALGQQYRTV DDVVSTGSDI IIVGRGLFGK 

       250        260 
GRDPTAESRR YRDAGWDAYL KRCNAASN 

« Hide

References

[1]"Molecular cloning and DNA analysis of the orotidine-5'-phosphate decarboxylase gene from the yeast Saccharomyces exiguus Yp74L-3."
Hisatomi T., Kodama T., Toba H., Moto-oka M., Watanabe A., Tsuboi M.
Curr. Microbiol. 41:421-424(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Yp74L-3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB021640 Genomic DNA. Translation: BAA76736.1.

3D structure databases

ProteinModelPortalQ9Y726.
SMRQ9Y726. Positions 1-263.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_SACEX
AccessionPrimary (citable) accession number: Q9Y726
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: October 16, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways