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Q9Y720

- PYRF_RHIPU

UniProt

Q9Y720 - PYRF_RHIPU

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
PYR4
Organism
Rhizomucor pusillus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381Substrate By similarity
Active sitei93 – 931Proton donor By similarity
Binding sitei213 – 2131Substrate By similarity
Binding sitei232 – 2321Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:PYR4
OrganismiRhizomucor pusillus
Taxonomic identifieri4840 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesMucoromycotinaMucoralesLichtheimiaceaeRhizomucor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Orotidine 5'-phosphate decarboxylasePRO_0000134678Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9Y720.
SMRiQ9Y720. Positions 5-262.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 623Substrate binding By similarity
Regioni91 – 10010Substrate binding By similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y720-1 [UniParc]FASTAAdd to Basket

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MNTFKTYADR AARHPNGCAK ALFELMERKQ TNLSIAADVT TKKELLHIAD    50
ACGPYICILK THIDIIDDFD EDLVAQLCEL AKKHDFLLFE DRKFADIGNT 100
VKHQYGKGVY KIASWAHITN AHTVPGEGII TGLREVGLPL GRGLLLLAEM 150
SSKGALTKGS YTTESVEMAR RNQDFVFGFI AQHKMNEKDD EDFVVMAPGV 200
GLDVKGDGLG QQYRTPYQVI VESGCDVIIV GRGIYGNPDQ IEFQAKRYKE 250
AGWNAYLERV QKH 263
Length:263
Mass (Da):29,355
Last modified:November 1, 1999 - v1
Checksum:i6C5D1E999C437B4E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB019045 Genomic DNA. Translation: BAA76616.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB019045 Genomic DNA. Translation: BAA76616.1 .

3D structure databases

ProteinModelPortali Q9Y720.
SMRi Q9Y720. Positions 5-262.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genetic transformation of a Rhizomucor pusillus mutant defective in asparagine-linked glycosylation: overproduction of a milk-clotting enzyme."
    Yamazaki H., Ohnishi Y., Horinouchi S.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: F27.

Entry informationi

Entry nameiPYRF_RHIPU
AccessioniPrimary (citable) accession number: Q9Y720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: October 16, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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