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Q9Y720 (PYRF_RHIPU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:PYR4
OrganismRhizomucor pusillus
Taxonomic identifier4840 [NCBI]
Taxonomic lineageEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesMucoromycotinaMucoralesLichtheimiaceaeRhizomucor

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Orotidine 5'-phosphate decarboxylase
PRO_0000134678

Regions

Region60 – 623Substrate binding By similarity
Region91 – 10010Substrate binding By similarity

Sites

Active site931Proton donor By similarity
Binding site381Substrate By similarity
Binding site2131Substrate By similarity
Binding site2321Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Y720 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 6C5D1E999C437B4E

FASTA26329,355
        10         20         30         40         50         60 
MNTFKTYADR AARHPNGCAK ALFELMERKQ TNLSIAADVT TKKELLHIAD ACGPYICILK 

        70         80         90        100        110        120 
THIDIIDDFD EDLVAQLCEL AKKHDFLLFE DRKFADIGNT VKHQYGKGVY KIASWAHITN 

       130        140        150        160        170        180 
AHTVPGEGII TGLREVGLPL GRGLLLLAEM SSKGALTKGS YTTESVEMAR RNQDFVFGFI 

       190        200        210        220        230        240 
AQHKMNEKDD EDFVVMAPGV GLDVKGDGLG QQYRTPYQVI VESGCDVIIV GRGIYGNPDQ 

       250        260 
IEFQAKRYKE AGWNAYLERV QKH 

« Hide

References

[1]"Genetic transformation of a Rhizomucor pusillus mutant defective in asparagine-linked glycosylation: overproduction of a milk-clotting enzyme."
Yamazaki H., Ohnishi Y., Horinouchi S.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: F27.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB019045 Genomic DNA. Translation: BAA76616.1.

3D structure databases

ProteinModelPortalQ9Y720.
SMRQ9Y720. Positions 5-262.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_RHIPU
AccessionPrimary (citable) accession number: Q9Y720
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: October 16, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways