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Protein

Calpain-like protease palB/RIM13

Gene

palB

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH. Probably is the signaling protease that mediates the first proteolytic cleavage within the signaling protease box of pacC (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei199PROSITE-ProRule annotation1
Active sitei364PROSITE-ProRule annotation1
Active sitei384PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC02.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-like protease palB/RIM13 (EC:3.4.22.-)
Alternative name(s):
Cysteine protease palB
Gene namesi
Name:palB
Synonyms:palBory
ORF Names:AO090005000756
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002077371 – 854Calpain-like protease palB/RIM13Add BLAST854

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00002680.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6Z8.
SMRiQ9Y6Z8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 83MITAdd BLAST82
Domaini118 – 437Calpain catalyticPROSITE-ProRule annotationAdd BLAST320

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000212111.
OrthoDBiEOG092C185F.

Family and domain databases

CDDicd00044. CysPc. 1 hit.
InterProiView protein in InterPro
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00745. MIT. 1 hit.
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF49758. SSF49758. 2 hits.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y6Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPNASAQK SFITQALKAE RDVSSATSQR QALEAAIDAA EHYMKALNLA
60 70 80 90 100
SVQKDKHALD AKCKEWLTRA EKIKESKDWQ AAARFHDKTV PEPRLPVSTR
110 120 130 140 150
KLTTREEIIL LEGAKLNGFI FPPWSTSPGS DEFKREDGES PFTDKPDLHL
160 170 180 190 200
SYPQRKVFDG WKRPSELLAK DTEDVYTKVV PVMSVPGKTD LVQDMLTDCS
210 220 230 240 250
VVASLCATTS MLERGQCTHF LPMIYPSRGS SQPSPSGKYI FRFYFNGCFR
260 270 280 290 300
KVIIDDRLPS SKTSRSLHVI DRKNPNFLWP ALVEKAYLKL RGGYDFPGSN
310 320 330 340 350
SGTDLWVLTG WIPEQVFLHN DDVTGDQLWK RLYRSFHQGD VLLTIGTGEL
360 370 380 390 400
TEREQRELGL VSEHDYAILD MKESKGRRQL LVKNPWAGAD TAPGDNGSLS
410 420 430 440 450
ASQDLPHNPP SFEPGTFWMD CEKLLQHFEN LYLNWNPEIF KYREDVHFTW
460 470 480 490 500
DLNNGRGVAG CFVNNPQFAV STENGGIVWL LLGKHFRTTG QPERPLDEYQ
510 520 530 540 550
ANEESAFISI YVFNADGKRV SLSDGALHRG PYVDSPNTLM RLEMPPRTTY
560 570 580 590 600
TVVVSEQSLP SLNQNFTLSA FSTCPVRMAK AQDKYMCVRK IQGSWTPSTA
610 620 630 640 650
GGNAESSRYP LNPQFRLEIE NDTDVSLLLE CPNTELATHV KLFWSNGNRV
660 670 680 690 700
SRVRSRDIIA DSGDYRRGGS LVEKKALEPG SYTIVCSTFA PDQLGRFTLW
710 720 730 740 750
VSSLVPCKTS PLPPEAAGRR TVISDIGVLP PGRDRMLASL QVPRLTRIKL
760 770 780 790 800
ITRSRQSIIG SHPVGPSPVL MTVELGQGPY KQILATSEDG THSDAVSGVR
810 820 830 840 850
VEDFDLQPGL EESGGIWIVI ERIGGPGGQV EDHFEVEALA EERVEIGEWI

LEDA
Length:854
Mass (Da):95,470
Last modified:November 1, 1999 - v1
Checksum:i48055DAD2E814567
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3 – 17RPNAS…ITQAL → SILHAALVKILPGLP in BAE55782 (PubMed:16372010).CuratedAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020321 Genomic DNA. Translation: BAA77364.1.
AF133087 Genomic DNA. Translation: AAD28472.1.
AP007151 Genomic DNA. Translation: BAE55782.1.

Genome annotation databases

EnsemblFungiiBAE55782; BAE55782; AO090005000756.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPALB_ASPOR
AccessioniPrimary (citable) accession number: Q9Y6Z8
Secondary accession number(s): Q2URN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 1, 1999
Last modified: July 5, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families