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Protein

Collectin-10

Gene

COLEC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine.1 Publication

GO - Molecular functioni

  • mannose binding Source: ProtInc
  • serine-type endopeptidase activity Source: Reactome

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin, Mannose-binding

Enzyme and pathway databases

ReactomeiR-HSA-166663. Initial triggering of complement.

Names & Taxonomyi

Protein namesi
Recommended name:
Collectin-10
Alternative name(s):
Collectin liver protein 1
Short name:
CL-L1
Collectin-34
Short name:
CL-34
Gene namesi
Name:COLEC10
Synonyms:CLL1
ORF Names:UNQ366/PRO702
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:2220. COLEC10.

Subcellular locationi

GO - Cellular componenti

  • collagen trimer Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB
  • extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26736.

Polymorphism and mutation databases

BioMutaiCOLEC10.
DMDMi166218411.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 277250Collectin-10PRO_0000314233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi176 ↔ 270PROSITE-ProRule annotation
Disulfide bondi248 ↔ 262PROSITE-ProRule annotation
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Y6Z7.
PaxDbiQ9Y6Z7.
PRIDEiQ9Y6Z7.

PTM databases

iPTMnetiQ9Y6Z7.
PhosphoSiteiQ9Y6Z7.

Expressioni

Tissue specificityi

Highly expressed in liver, placenta and adrenal gland. Moderately expressed in small intestine, lung, stomach and prostate. Weakly expressed in trachea and spleen.1 Publication

Gene expression databases

BgeeiQ9Y6Z7.
CleanExiHS_COLEC10.
ExpressionAtlasiQ9Y6Z7. baseline and differential.
GenevisibleiQ9Y6Z7. HS.

Organism-specific databases

HPAiHPA024511.

Interactioni

Protein-protein interaction databases

BioGridi115833. 14 interactions.
STRINGi9606.ENSP00000332723.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6Z7.
SMRiQ9Y6Z7. Positions 125-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 11260Collagen-likeAdd
BLAST
Domaini155 – 271117C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the COLEC10/COLEC11 family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IS26. Eukaryota.
ENOG410ZPF3. LUCA.
GeneTreeiENSGT00700000104102.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiQ9Y6Z7.
KOiK10065.
OMAiYVAKSGF.
OrthoDBiEOG7HXCVB.
PhylomeDBiQ9Y6Z7.
TreeFamiTF330481.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGFASLLRR NQFILLVLFL LQIQSLGLDI DSRPTAEVCA THTISPGPKG
60 70 80 90 100
DDGEKGDPGE EGKHGKVGRM GPKGIKGELG DMGDQGNIGK TGPIGKKGDK
110 120 130 140 150
GEKGLLGIPG EKGKAGTVCD CGRYRKFVGQ LDISIARLKT SMKFVKNVIA
160 170 180 190 200
GIRETEEKFY YIVQEEKNYR ESLTHCRIRG GMLAMPKDEA ANTLIADYVA
210 220 230 240 250
KSGFFRVFIG VNDLEREGQY MFTDNTPLQN YSNWNEGEPS DPYGHEDCVE
260 270
MLSSGRWNDT ECHLTMYFVC EFIKKKK
Length:277
Mass (Da):30,705
Last modified:January 15, 2008 - v2
Checksum:i392B570025C18C27
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851Q → R in BAA81747 (PubMed:10224141).Curated
Sequence conflicti222 – 2221F → S in AAQ89397 (PubMed:12975309).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002631 mRNA. Translation: BAA81747.1.
AY359038 mRNA. Translation: AAQ89397.1.
AK291791 mRNA. Translation: BAF84480.1.
CH471060 Genomic DNA. Translation: EAW91979.1.
BC103815 mRNA. Translation: AAI03816.1.
BC103816 mRNA. Translation: AAI03817.1.
CCDSiCCDS6327.1.
RefSeqiNP_006429.2. NM_006438.3.
UniGeneiHs.176615.

Genome annotation databases

EnsembliENST00000332843; ENSP00000332723; ENSG00000184374.
GeneIDi10584.
KEGGihsa:10584.
UCSCiuc003yoo.4. human.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Collectin L1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002631 mRNA. Translation: BAA81747.1.
AY359038 mRNA. Translation: AAQ89397.1.
AK291791 mRNA. Translation: BAF84480.1.
CH471060 Genomic DNA. Translation: EAW91979.1.
BC103815 mRNA. Translation: AAI03816.1.
BC103816 mRNA. Translation: AAI03817.1.
CCDSiCCDS6327.1.
RefSeqiNP_006429.2. NM_006438.3.
UniGeneiHs.176615.

3D structure databases

ProteinModelPortaliQ9Y6Z7.
SMRiQ9Y6Z7. Positions 125-275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115833. 14 interactions.
STRINGi9606.ENSP00000332723.

PTM databases

iPTMnetiQ9Y6Z7.
PhosphoSiteiQ9Y6Z7.

Polymorphism and mutation databases

BioMutaiCOLEC10.
DMDMi166218411.

Proteomic databases

MaxQBiQ9Y6Z7.
PaxDbiQ9Y6Z7.
PRIDEiQ9Y6Z7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332843; ENSP00000332723; ENSG00000184374.
GeneIDi10584.
KEGGihsa:10584.
UCSCiuc003yoo.4. human.

Organism-specific databases

CTDi10584.
GeneCardsiCOLEC10.
H-InvDBHIX0034230.
HGNCiHGNC:2220. COLEC10.
HPAiHPA024511.
MIMi607620. gene.
neXtProtiNX_Q9Y6Z7.
PharmGKBiPA26736.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS26. Eukaryota.
ENOG410ZPF3. LUCA.
GeneTreeiENSGT00700000104102.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiQ9Y6Z7.
KOiK10065.
OMAiYVAKSGF.
OrthoDBiEOG7HXCVB.
PhylomeDBiQ9Y6Z7.
TreeFamiTF330481.

Enzyme and pathway databases

ReactomeiR-HSA-166663. Initial triggering of complement.

Miscellaneous databases

ChiTaRSiCOLEC10. human.
GenomeRNAii10584.
PROiQ9Y6Z7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y6Z7.
CleanExiHS_COLEC10.
ExpressionAtlasiQ9Y6Z7. baseline and differential.
GenevisibleiQ9Y6Z7. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCOL10_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6Z7
Secondary accession number(s): Q3SYH6, Q6UW19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 8, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.