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Protein

Collectin-10

Gene

COLEC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine (PubMed:10224141). Acts as a chemoattractant, probably involved in the regulation of cell migration (PubMed:28301481).2 Publications

GO - Molecular functioni

  • chemoattractant activity Source: UniProtKB
  • mannose binding Source: ProtInc
  • serine-type endopeptidase activity Source: Reactome

GO - Biological processi

  • complement activation Source: Reactome
  • complement activation, lectin pathway Source: Reactome
  • cranial skeletal system development Source: UniProtKB

Keywordsi

LigandCalcium, Lectin, Mannose-binding

Enzyme and pathway databases

ReactomeiR-HSA-166662. Lectin pathway of complement activation.
R-HSA-166663. Initial triggering of complement.

Names & Taxonomyi

Protein namesi
Recommended name:
Collectin-10
Alternative name(s):
Collectin liver protein 1
Short name:
CL-L1
Collectin-34
Short name:
CL-34
Gene namesi
Name:COLEC10
Synonyms:CLL1
ORF Names:UNQ366/PRO702
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000184374.2.
HGNCiHGNC:2220. COLEC10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Secreted

Pathology & Biotechi

Involvement in diseasei

3MC syndrome 3 (3MC3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of 3MC syndrome, an autosomal recessive disorder characterized by facial dysmorphism, craniosynostosis, learning disability, and genital, limb and vesicorenal anomalies. Facial features include hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes.
See also OMIM:248340
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0788119 – 277Missing in 3MC3; results in lack of protein. 1 PublicationAdd BLAST269
Natural variantiVAR_078812176C → W in 3MC3; severely decreased secretion. 1 PublicationCorresponds to variant dbSNP:rs773764995Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi10584.
MalaCardsiCOLEC10.
MIMi248340. phenotype.
OpenTargetsiENSG00000184374.
PharmGKBiPA26736.

Polymorphism and mutation databases

BioMutaiCOLEC10.
DMDMi166218411.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000031423328 – 277Collectin-10Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi176 ↔ 270PROSITE-ProRule annotation
Disulfide bondi248 ↔ 262PROSITE-ProRule annotation
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Y6Z7.
PaxDbiQ9Y6Z7.
PeptideAtlasiQ9Y6Z7.
PRIDEiQ9Y6Z7.

PTM databases

iPTMnetiQ9Y6Z7.
PhosphoSitePlusiQ9Y6Z7.

Expressioni

Tissue specificityi

Highly expressed in liver, placenta and adrenal gland. Moderately expressed in small intestine, lung, stomach and prostate. Weakly expressed in trachea and spleen.1 Publication

Gene expression databases

BgeeiENSG00000184374.
CleanExiHS_COLEC10.
ExpressionAtlasiQ9Y6Z7. baseline and differential.
GenevisibleiQ9Y6Z7. HS.

Interactioni

GO - Molecular functioni

  • chemoattractant activity Source: UniProtKB

Protein-protein interaction databases

BioGridi115833. 15 interactors.
STRINGi9606.ENSP00000332723.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6Z7.
SMRiQ9Y6Z7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 112Collagen-likeAdd BLAST60
Domaini155 – 271C-type lectinPROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Belongs to the COLEC10/COLEC11 family.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IS26. Eukaryota.
ENOG410ZPF3. LUCA.
GeneTreeiENSGT00700000104102.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiQ9Y6Z7.
KOiK10065.
OMAiQNYSNWK.
OrthoDBiEOG091G0EGC.
PhylomeDBiQ9Y6Z7.
TreeFamiTF330481.

Family and domain databases

CDDicd03591. CLECT_collectin_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link_sf.
IPR018378. C-type_lectin_CS.
IPR008160. Collagen.
IPR033990. Collectin_CTLD.
IPR016187. CTDL_fold.
PfamiView protein in Pfam
PF01391. Collagen. 2 hits.
PF00059. Lectin_C. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGFASLLRR NQFILLVLFL LQIQSLGLDI DSRPTAEVCA THTISPGPKG
60 70 80 90 100
DDGEKGDPGE EGKHGKVGRM GPKGIKGELG DMGDQGNIGK TGPIGKKGDK
110 120 130 140 150
GEKGLLGIPG EKGKAGTVCD CGRYRKFVGQ LDISIARLKT SMKFVKNVIA
160 170 180 190 200
GIRETEEKFY YIVQEEKNYR ESLTHCRIRG GMLAMPKDEA ANTLIADYVA
210 220 230 240 250
KSGFFRVFIG VNDLEREGQY MFTDNTPLQN YSNWNEGEPS DPYGHEDCVE
260 270
MLSSGRWNDT ECHLTMYFVC EFIKKKK
Length:277
Mass (Da):30,705
Last modified:January 15, 2008 - v2
Checksum:i392B570025C18C27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85Q → R in BAA81747 (PubMed:10224141).Curated1
Sequence conflicti222F → S in AAQ89397 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0788119 – 277Missing in 3MC3; results in lack of protein. 1 PublicationAdd BLAST269
Natural variantiVAR_078812176C → W in 3MC3; severely decreased secretion. 1 PublicationCorresponds to variant dbSNP:rs773764995Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002631 mRNA. Translation: BAA81747.1.
AY359038 mRNA. Translation: AAQ89397.1.
AK291791 mRNA. Translation: BAF84480.1.
CH471060 Genomic DNA. Translation: EAW91979.1.
BC103815 mRNA. Translation: AAI03816.1.
BC103816 mRNA. Translation: AAI03817.1.
CCDSiCCDS6327.1.
RefSeqiNP_001311024.1. NM_001324095.1.
NP_006429.2. NM_006438.4.
UniGeneiHs.176615.

Genome annotation databases

EnsembliENST00000332843; ENSP00000332723; ENSG00000184374.
GeneIDi10584.
KEGGihsa:10584.
UCSCiuc003yoo.4. human.

Similar proteinsi

Entry informationi

Entry nameiCOL10_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6Z7
Secondary accession number(s): Q3SYH6, Q6UW19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 22, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families