UniProtKB - Q9Y6Y9 (LY96_HUMAN)
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Protein
Lymphocyte antigen 96
Gene
LY96
Organism
Homo sapiens (Human)
Status
Functioni
Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).5 Publications
GO - Molecular functioni
- coreceptor activity Source: ProtInc
- lipopolysaccharide receptor activity Source: UniProtKB
GO - Biological processi
- apoptotic signaling pathway Source: Reactome
- cell surface receptor signaling pathway Source: ProtInc
- cellular defense response Source: ProtInc
- detection of lipopolysaccharide Source: UniProtKB
- I-kappaB kinase/NF-kappaB signaling Source: Reactome
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- MyD88-dependent toll-like receptor signaling pathway Source: Reactome
- MyD88-independent toll-like receptor signaling pathway Source: Reactome
- necroptotic process Source: Reactome
- negative regulation of MyD88-independent toll-like receptor signaling pathway Source: Reactome
- positive regulation of lipopolysaccharide-mediated signaling pathway Source: Ensembl
- positive regulation of tumor necrosis factor production Source: UniProtKB
- response to lipopolysaccharide Source: MGI
- toll-like receptor 4 signaling pathway Source: UniProtKB
- toll-like receptor signaling pathway Source: Reactome
- TRIF-dependent toll-like receptor signaling pathway Source: Reactome
Keywordsi
Biological process | Immunity, Inflammatory response, Innate immunity |
Enzyme and pathway databases
Reactomei | R-HSA-1236974. ER-Phagosome pathway. R-HSA-140534. Ligand-dependent caspase activation. R-HSA-166016. Toll Like Receptor 4 (TLR4) Cascade. R-HSA-166058. MyD88:Mal cascade initiated on plasma membrane. R-HSA-166166. MyD88-independent TLR4 cascade. R-HSA-2562578. TRIF-mediated programmed cell death. R-HSA-5602498. MyD88 deficiency (TLR2/4). R-HSA-5603041. IRAK4 deficiency (TLR2/4). R-HSA-5686938. Regulation of TLR by endogenous ligand. R-HSA-9014325. TICAM1,TRAF6-dependent induction of TAK1 complex. R-HSA-936964. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon. R-HSA-937041. IKK complex recruitment mediated by RIP1. R-HSA-937072. TRAF6-mediated induction of TAK1 complex within TLR4 complex. R-HSA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation. |
SIGNORi | Q9Y6Y9. |
Names & Taxonomyi
Protein namesi | Recommended name: Lymphocyte antigen 96Short name: Ly-96 Alternative name(s): ESOP-11 Publication Protein MD-21 Publication |
Gene namesi | Name:LY96 Synonyms:ESOP1, MD2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000154589.6. |
HGNCi | HGNC:17156. LY96. |
MIMi | 605243. gene. |
neXtProti | NX_Q9Y6Y9. |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 95 | C → Y: Abolishes LPS-response. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 23643. |
OpenTargetsi | ENSG00000154589. |
PharmGKBi | PA134924906. |
Chemistry databases
ChEMBLi | CHEMBL2375202. |
DrugBanki | DB02767. 3-Hydroxy-Myristic Acid. DB03017. Lauric Acid. DB08231. MYRISTIC ACID. |
GuidetoPHARMACOLOGYi | 2890. |
Polymorphism and mutation databases
BioMutai | LY96. |
DMDMi | 296434574. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000018619 | 19 – 160 | Lymphocyte antigen 96Add BLAST | 142 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 25 ↔ 51 | Combined sources2 Publications | ||
Glycosylationi | 26 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 37 ↔ 148 | Combined sources2 Publications | ||
Disulfide bondi | 95 ↔ 105 | Combined sources2 Publications | ||
Glycosylationi | 114 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 |
Post-translational modificationi
N-glycosylated; high-mannose.2 Publications
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9Y6Y9. |
PeptideAtlasi | Q9Y6Y9. |
PRIDEi | Q9Y6Y9. |
PTM databases
iPTMneti | Q9Y6Y9. |
PhosphoSitePlusi | Q9Y6Y9. |
Expressioni
Gene expression databases
Bgeei | ENSG00000154589. |
CleanExi | HS_LY96. |
Genevisiblei | Q9Y6Y9. HS. |
Organism-specific databases
HPAi | HPA053060. |
Interactioni
Subunit structurei
Heterogeneous homopolymer formed from homodimers; disulfide-linked (PubMed:11593030, PubMed:12642668). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Binds to the extracellular domains of TLR2 and TLR4 (PubMed:10359581, PubMed:11593030, PubMed:17803912). Ligand binding induces interaction with TLR4 and oligomerization of the complex.5 Publications
Binary interactionsi
Protein-protein interaction databases
BioGridi | 117170. 4 interactors. |
DIPi | DIP-38571N. |
IntActi | Q9Y6Y9. 7 interactors. |
STRINGi | 9606.ENSP00000284818. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 22 – 26 | Combined sources | 5 | |
Beta strandi | 28 – 36 | Combined sources | 9 | |
Beta strandi | 38 – 40 | Combined sources | 3 | |
Beta strandi | 45 – 50 | Combined sources | 6 | |
Beta strandi | 57 – 65 | Combined sources | 9 | |
Beta strandi | 75 – 82 | Combined sources | 8 | |
Beta strandi | 90 – 93 | Combined sources | 4 | |
Beta strandi | 97 – 101 | Combined sources | 5 | |
Helixi | 103 – 106 | Combined sources | 4 | |
Beta strandi | 113 – 121 | Combined sources | 9 | |
Beta strandi | 129 – 139 | Combined sources | 11 | |
Turni | 140 – 143 | Combined sources | 4 | |
Beta strandi | 144 – 155 | Combined sources | 12 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1T2Z | model | - | A | 19-160 | [»] | |
2E56 | X-ray | 2.00 | A | 17-160 | [»] | |
2E59 | X-ray | 2.21 | A | 17-160 | [»] | |
2Z65 | X-ray | 2.70 | C/D | 19-158 | [»] | |
3FXI | X-ray | 3.10 | C/D | 19-160 | [»] | |
3ULA | X-ray | 3.60 | B/D | 19-158 | [»] | |
4G8A | X-ray | 2.40 | C/D | 17-160 | [»] | |
ProteinModelPortali | Q9Y6Y9. | |||||
SMRi | Q9Y6Y9. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y6Y9. |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 119 – 123 | Interaction with lipopolysaccharideCombined sources2 Publications | 5 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG410J4Q5. Eukaryota. ENOG411154R. LUCA. |
GeneTreei | ENSGT00390000000742. |
HOGENOMi | HOG000001152. |
HOVERGENi | HBG032514. |
InParanoidi | Q9Y6Y9. |
KOi | K05400. |
OMAi | YIPRRDI. |
OrthoDBi | EOG091G0T85. |
PhylomeDBi | Q9Y6Y9. |
TreeFami | TF335876. |
Family and domain databases
InterProi | View protein in InterPro IPR014756. Ig_E-set. IPR003172. ML_dom. |
Pfami | View protein in Pfam PF02221. E1_DerP2_DerF2. 1 hit. |
SMARTi | View protein in SMART SM00737. ML. 1 hit. |
SUPFAMi | SSF81296. SSF81296. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y6Y9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MLPFLFFSTL FSSIFTEAQK QYWVCNSSDA SISYTYCDKM QYPISINVNP
60 70 80 90 100
CIELKRSKGL LHIFYIPRRD LKQLYFNLYI TVNTMNLPKR KEVICRGSDD
110 120 130 140 150
DYSFCRALKG ETVNTTISFS FKGIKFSKGK YKCVVEAISG SPEEMLFCLE
160
FVILHQPNSN
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050030 | 56 | R → G5 PublicationsCorresponds to variant dbSNP:rs6472812Ensembl. | 1 | |
Natural variantiVAR_024532 | 157 | P → S. Corresponds to variant dbSNP:rs11466004Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055045 | 38 – 68 | DKMQY…FYIPR → G in isoform 2. CuratedAdd BLAST | 31 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB018549 mRNA. Translation: BAA78717.1. AF168121 mRNA. Translation: AAF89635.1. AB446498 mRNA. Translation: BAG55275.1. AC022868 Genomic DNA. No translation available. AC087672 Genomic DNA. No translation available. BC020690 mRNA. Translation: AAH20690.1. |
CCDSi | CCDS56540.1. [Q9Y6Y9-2] CCDS6216.1. [Q9Y6Y9-1] |
RefSeqi | NP_001182726.1. NM_001195797.1. [Q9Y6Y9-2] NP_056179.3. NM_015364.4. |
UniGenei | Hs.726603. |
Genome annotation databases
Ensembli | ENST00000284818; ENSP00000284818; ENSG00000154589. [Q9Y6Y9-1] ENST00000518893; ENSP00000430533; ENSG00000154589. [Q9Y6Y9-2] |
GeneIDi | 23643. |
KEGGi | hsa:23643. |
UCSCi | uc003yad.4. human. [Q9Y6Y9-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | LY96_HUMAN | |
Accessioni | Q9Y6Y9Primary (citable) accession number: Q9Y6Y9 Secondary accession number(s): B3Y6A5, E5RJJ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 28, 2018 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |