LY96

Functionⁱ

Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).5 Publications

GO - Molecular functionⁱ

coreceptor activity
Source: ProtInc
Traceable author statementⁱ
- 10359581
lipopolysaccharide receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19252480

Complete GO annotation...

GO - Biological processⁱ

apoptotic signaling pathway Source: Reactome
cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 10359581
cellular defense response
Source: ProtInc
Traceable author statementⁱ
- 10359581
detection of lipopolysaccharide
Source: UniProtKB
Inferred from direct assayⁱ
- 19252480
I-kappaB kinase/NF-kappaB signaling Source: Reactome
inflammatory response Source: UniProtKB-KW
innate immune response Source: UniProtKB-KW
MyD88-dependent toll-like receptor signaling pathway Source: Reactome
MyD88-independent toll-like receptor signaling pathway Source: Reactome
necroptotic process Source: Reactome
negative regulation of MyD88-independent toll-like receptor signaling pathway Source: Reactome
positive regulation of lipopolysaccharide-mediated signaling pathway Source: Ensembl
positive regulation of tumor necrosis factor production Source: UniProtKB
response to lipopolysaccharide
Source: MGI
Inferred from direct assayⁱ
- 12594207
toll-like receptor 4 signaling pathway Source: UniProtKB
toll-like receptor signaling pathway Source: Reactome
TRIF-dependent toll-like receptor signaling pathway Source: Reactome

Complete GO annotation...

Keywordsⁱ

Biological process	Immunity, Inflammatory response, Innate immunity

Biological process

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974. ER-Phagosome pathway. R-HSA-140534. Ligand-dependent caspase activation. R-HSA-166016. Toll Like Receptor 4 (TLR4) Cascade. R-HSA-166058. MyD88:Mal cascade initiated on plasma membrane. R-HSA-166166. MyD88-independent TLR3/TLR4 cascade. R-HSA-2562578. TRIF-mediated programmed cell death. R-HSA-5602498. MyD88 deficiency (TLR2/4). R-HSA-5603041. IRAK4 deficiency (TLR2/4). R-HSA-5686938. Regulation of TLR by endogenous ligand. R-HSA-936964. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon. R-HSA-937041. IKK complex recruitment mediated by RIP1. R-HSA-937072. TRAF6 mediated induction of TAK1 complex. R-HSA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
SIGNORⁱ	Q9Y6Y9.

Reactomeⁱ

R-HSA-1236974. ER-Phagosome pathway.
R-HSA-140534. Ligand-dependent caspase activation.
R-HSA-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-HSA-166058. MyD88:Mal cascade initiated on plasma membrane.
R-HSA-166166. MyD88-independent TLR3/TLR4 cascade.
R-HSA-2562578. TRIF-mediated programmed cell death.
R-HSA-5602498. MyD88 deficiency (TLR2/4).
R-HSA-5603041. IRAK4 deficiency (TLR2/4).
R-HSA-5686938. Regulation of TLR by endogenous ligand.
R-HSA-936964. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
R-HSA-937041. IKK complex recruitment mediated by RIP1.
R-HSA-937072. TRAF6 mediated induction of TAK1 complex.
R-HSA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.

SIGNORⁱ

Q9Y6Y9.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lymphocyte antigen 96 Short name: Ly-96 Alternative name(s): ESOP-11 Publication Protein MD-21 Publication
Gene namesⁱ	Name:LY96 Synonyms:ESOP1, MD2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000154589.6.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17156. LY96.

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	95	C → Y: Abolishes LPS-response. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23643.
Open Targets More...OpenTargetsⁱ	ENSG00000154589.
PharmGKBⁱ	PA134924906.

Chemistry databases

ChEMBLⁱ	CHEMBL2375202.
Drug and drug target database More...DrugBankⁱ	DB02767. 3-Hydroxy-Myristic Acid. DB03017. Lauric Acid. DB08231. MYRISTIC ACID.
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2890.

Polymorphism and mutation databases

BioMutaⁱ	LY96.
DMDMⁱ	296434574.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000018619	19 – 160	Lymphocyte antigen 96Add BLAST		142

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	25 ↔ 51	Combined sources2 Publications
Glycosylationⁱ	26	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1
Disulfide bondⁱ	37 ↔ 148	Combined sources2 Publications
Disulfide bondⁱ	95 ↔ 105	Combined sources2 Publications
Glycosylationⁱ	114	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1

Post-translational modificationⁱ

N-glycosylated; high-mannose.2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9Y6Y9.
PeptideAtlas More...PeptideAtlasⁱ	Q9Y6Y9.
PRIDEⁱ	Q9Y6Y9.

PTM databases

iPTMnetⁱ	Q9Y6Y9.
PhosphoSitePlusⁱ	Q9Y6Y9.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000154589.
CleanExⁱ	HS_LY96.
Genevisibleⁱ	Q9Y6Y9. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA053060.

HPAⁱ

HPA053060.

Interactionⁱ

Subunit structureⁱ

Heterogeneous homopolymer formed from homodimers; disulfide-linked (PubMed:11593030, PubMed:12642668). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Binds to the extracellular domains of TLR2 and TLR4 (PubMed:10359581, PubMed:11593030, PubMed:17803912). Ligand binding induces interaction with TLR4 and oligomerization of the complex.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TLR4	O00206	5	EBI-1539247,EBI-528701

With

Entry

#Exp.

IntAct

Notes

TLR4

O00206

5

EBI-1539247,EBI-528701

Protein-protein interaction databases

BioGridⁱ	117170. 4 interactors.
Database of interacting proteins More...DIPⁱ	DIP-38571N.
IntActⁱ	Q9Y6Y9. 4 interactors.
STRINGⁱ	9606.ENSP00000284818.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	22 – 26	Combined sources	5
Beta strandⁱ	28 – 36	Combined sources	9
Beta strandⁱ	38 – 40	Combined sources	3
Beta strandⁱ	45 – 50	Combined sources	6
Beta strandⁱ	57 – 65	Combined sources	9
Beta strandⁱ	75 – 82	Combined sources	8
Beta strandⁱ	90 – 93	Combined sources	4
Beta strandⁱ	97 – 101	Combined sources	5
Helixⁱ	103 – 106	Combined sources	4
Beta strandⁱ	113 – 121	Combined sources	9
Beta strandⁱ	129 – 139	Combined sources	11
Turnⁱ	140 – 143	Combined sources	4
Beta strandⁱ	144 – 155	Combined sources	12

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1T2Z	model	-	A	19-160	[»]
	2E56	X-ray	2.00	A	17-160	[»]
	2E59	X-ray	2.21	A	17-160	[»]
	2Z65	X-ray	2.70	C/D	19-158	[»]
	3FXI	X-ray	3.10	C/D	19-160	[»]
	3ULA	X-ray	3.60	B/D	19-158	[»]
	4G8A	X-ray	2.40	C/D	17-160	[»]
ProteinModelPortalⁱ	Q9Y6Y9.
SMRⁱ	Q9Y6Y9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9Y6Y9.

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	119 – 123	Interaction with lipopolysaccharideCombined sources2 Publications		5

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J4Q5. Eukaryota. ENOG411154R. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000742.
HOGENOMⁱ	HOG000001152.
HOVERGENⁱ	HBG032514.
InParanoidⁱ	Q9Y6Y9.
KEGG Orthology (KO) More...KOⁱ	K05400.
OMAⁱ	YIPRRDI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0T85.
PhylomeDBⁱ	Q9Y6Y9.
TreeFamⁱ	TF335876.

Family and domain databases

InterProⁱ	View protein in InterPro IPR014756. Ig_E-set. IPR003172. ML_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02221. E1_DerP2_DerF2. 1 hit.
SMARTⁱ	View protein in SMART SM00737. ML. 1 hit.
SUPFAMⁱ	SSF81296. SSF81296. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9Y6Y9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPFLFFSTL FSSIFTEAQK QYWVCNSSDA SISYTYCDKM QYPISINVNP 
        60         70         80         90        100
CIELKRSKGL LHIFYIPRRD LKQLYFNLYI TVNTMNLPKR KEVICRGSDD 
       110        120        130        140        150
DYSFCRALKG ETVNTTISFS FKGIKFSKGK YKCVVEAISG SPEEMLFCLE 
       160
FVILHQPNSN

Length:160

Mass (Da):18,546

Last modified:May 18, 2010 - v2

Checksum:ⁱ0F92AFF583637C6B

GO

Isoform 2 (identifier: Q9Y6Y9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
38-68: DKMQYPISINVNPCIELKRSKGLLHIFYIPR → G

« Hide

        10         20         30         40         50
MLPFLFFSTL FSSIFTEAQK QYWVCNSSDA SISYTYCGRD LKQLYFNLYI 
        60         70         80         90        100
TVNTMNLPKR KEVICRGSDD DYSFCRALKG ETVNTTISFS FKGIKFSKGK 
       110        120        130
YKCVVEAISG SPEEMLFCLE FVILHQPNSN

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »

Length:130

Mass (Da):14,933

Checksum:ⁱ7D92D168412B21C7

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050030	56	R → G5 PublicationsCorresponds to variant dbSNP:rs6472812Ensembl.		1
Natural variantⁱVAR_024532	157	P → S. Corresponds to variant dbSNP:rs11466004Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055045	38 – 68	DKMQY…FYIPR → G in isoform 2. CuratedAdd BLAST		31

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB018549 mRNA. Translation: BAA78717.1. AF168121 mRNA. Translation: AAF89635.1. AB446498 mRNA. Translation: BAG55275.1. AC022868 Genomic DNA. No translation available. AC087672 Genomic DNA. No translation available. BC020690 mRNA. Translation: AAH20690.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS56540.1. [Q9Y6Y9-2] CCDS6216.1. [Q9Y6Y9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001182726.1. NM_001195797.1. [Q9Y6Y9-2] NP_056179.3. NM_015364.4.
UniGeneⁱ	Hs.726603.

Genome annotation databases

Ensemblⁱ	ENST00000284818; ENSP00000284818; ENSG00000154589. [Q9Y6Y9-1] ENST00000518893; ENSP00000430533; ENSG00000154589. [Q9Y6Y9-2]
GeneIDⁱ	23643.
KEGGⁱ	hsa:23643.
UCSC genome browser More...UCSCⁱ	uc003yad.4. human. [Q9Y6Y9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9Y6Y9	B3Y6B1 B3Y6B0 D6PT91 H2PQL0 B3Y6A9 A0A0D9RM29 G1QM11 UPI00027F3D9F UPI0005334C55 UPI0005F3778B +7	Homo sapiens (Human) Macaca mulatta (Rhesus macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Macaca nemestrina (Pig-tailed macaque) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pongo pygmaeus (Bornean orangutan) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Papio anubis (Olive baboon) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) And more	160	UniRef90_Q9Y6Y9	Cluster: Lymphocyte antigen 96	18
Q9Y6Y9-2	F6VNC5 UPI00020ACF6B UPI0005F388D3 UPI0005F49EA8 UPI0008F49E59	Macaca mulatta (Rhesus macaque) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Colobus angolensis palliatus (Peters' Angolan colobus) Gorilla gorilla gorilla (Western lowland gorilla)	130	UniRef90_Q9Y6Y9-2	Cluster: Isoform 2 of Lymphocyte antigen 96	6

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9Y6Y9	G1QM11 UPI0005F43A7A A0A0D9RM29 UPI0005F5873C H2PQL0 B3Y6A9 UPI0005334C55 B3Y6B1 B3Y6B0 D6PT91 +95	Homo sapiens (Human) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Colobus angolensis palliatus (Peters' Angolan colobus) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pongo pygmaeus (Bornean orangutan) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Macaca mulatta (Rhesus macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) And more	160	UniRef50_Q9Y6Y9	Cluster: Lymphocyte antigen 96	106
Q9Y6Y9-2	UPI0005F388D3 UPI00020ACF6B F6VNC5 UPI0005F49EA8 UPI0008F49E59 UPI0003EDD6D6 UPI00053FEDD8 UPI0006442819 A0A1S3G513 UPI0007046416 +10	Mandrillus leucophaeus (Drill) (Papio leucophaeus) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Macaca mulatta (Rhesus macaque) Colobus angolensis palliatus (Peters' Angolan colobus) Gorilla gorilla gorilla (Western lowland gorilla) Leptonychotes weddellii (Weddell seal) Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis) Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Dipodomys ordii (Ord's kangaroo rat) Tupaia chinensis (Chinese tree shrew) And more	130	UniRef50_Q9Y6Y9-2	Cluster: Isoform 2 of Lymphocyte antigen 96	21

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB018549 mRNA. Translation: BAA78717.1. AF168121 mRNA. Translation: AAF89635.1. AB446498 mRNA. Translation: BAG55275.1. AC022868 Genomic DNA. No translation available. AC087672 Genomic DNA. No translation available. BC020690 mRNA. Translation: AAH20690.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS56540.1. [Q9Y6Y9-2] CCDS6216.1. [Q9Y6Y9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001182726.1. NM_001195797.1. [Q9Y6Y9-2] NP_056179.3. NM_015364.4.
UniGeneⁱ	Hs.726603.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1T2Z	model	-	A	19-160	[»]
	2E56	X-ray	2.00	A	17-160	[»]
	2E59	X-ray	2.21	A	17-160	[»]
	2Z65	X-ray	2.70	C/D	19-158	[»]
	3FXI	X-ray	3.10	C/D	19-160	[»]
	3ULA	X-ray	3.60	B/D	19-158	[»]
	4G8A	X-ray	2.40	C/D	17-160	[»]
ProteinModelPortalⁱ	Q9Y6Y9.
SMRⁱ	Q9Y6Y9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117170. 4 interactors.
Database of interacting proteins More...DIPⁱ	DIP-38571N.
IntActⁱ	Q9Y6Y9. 4 interactors.
STRINGⁱ	9606.ENSP00000284818.

Chemistry databases

ChEMBLⁱ	CHEMBL2375202.
Drug and drug target database More...DrugBankⁱ	DB02767. 3-Hydroxy-Myristic Acid. DB03017. Lauric Acid. DB08231. MYRISTIC ACID.
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2890.

PTM databases

iPTMnetⁱ	Q9Y6Y9.
PhosphoSitePlusⁱ	Q9Y6Y9.

Polymorphism and mutation databases

BioMutaⁱ	LY96.
DMDMⁱ	296434574.

Proteomic databases

PaxDbⁱ	Q9Y6Y9.
PeptideAtlas More...PeptideAtlasⁱ	Q9Y6Y9.
PRIDEⁱ	Q9Y6Y9.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000284818; ENSP00000284818; ENSG00000154589. [Q9Y6Y9-1] ENST00000518893; ENSP00000430533; ENSG00000154589. [Q9Y6Y9-2]
GeneIDⁱ	23643.
KEGGⁱ	hsa:23643.
UCSC genome browser More...UCSCⁱ	uc003yad.4. human. [Q9Y6Y9-1]

Organism-specific databases

CTDⁱ	23643.
DisGeNET More...DisGeNETⁱ	23643.
EuPathDBⁱ	HostDB:ENSG00000154589.6.
GeneCardsⁱ	LY96.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17156. LY96.
Human Protein Atlas More...HPAⁱ	HPA053060.
MIMⁱ	605243. gene.
neXtProtⁱ	NX_Q9Y6Y9.
Open Targets More...OpenTargetsⁱ	ENSG00000154589.
PharmGKBⁱ	PA134924906.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J4Q5. Eukaryota. ENOG411154R. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000742.
HOGENOMⁱ	HOG000001152.
HOVERGENⁱ	HBG032514.
InParanoidⁱ	Q9Y6Y9.
KEGG Orthology (KO) More...KOⁱ	K05400.
OMAⁱ	YIPRRDI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0T85.
PhylomeDBⁱ	Q9Y6Y9.
TreeFamⁱ	TF335876.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974. ER-Phagosome pathway. R-HSA-140534. Ligand-dependent caspase activation. R-HSA-166016. Toll Like Receptor 4 (TLR4) Cascade. R-HSA-166058. MyD88:Mal cascade initiated on plasma membrane. R-HSA-166166. MyD88-independent TLR3/TLR4 cascade. R-HSA-2562578. TRIF-mediated programmed cell death. R-HSA-5602498. MyD88 deficiency (TLR2/4). R-HSA-5603041. IRAK4 deficiency (TLR2/4). R-HSA-5686938. Regulation of TLR by endogenous ligand. R-HSA-936964. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon. R-HSA-937041. IKK complex recruitment mediated by RIP1. R-HSA-937072. TRAF6 mediated induction of TAK1 complex. R-HSA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
SIGNORⁱ	Q9Y6Y9.

Reactomeⁱ

R-HSA-1236974. ER-Phagosome pathway.
R-HSA-140534. Ligand-dependent caspase activation.
R-HSA-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-HSA-166058. MyD88:Mal cascade initiated on plasma membrane.
R-HSA-166166. MyD88-independent TLR3/TLR4 cascade.
R-HSA-2562578. TRIF-mediated programmed cell death.
R-HSA-5602498. MyD88 deficiency (TLR2/4).
R-HSA-5603041. IRAK4 deficiency (TLR2/4).
R-HSA-5686938. Regulation of TLR by endogenous ligand.
R-HSA-936964. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
R-HSA-937041. IKK complex recruitment mediated by RIP1.
R-HSA-937072. TRAF6 mediated induction of TAK1 complex.
R-HSA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.

SIGNORⁱ

Q9Y6Y9.

Miscellaneous databases

EvolutionaryTraceⁱ	Q9Y6Y9.
GeneWikiⁱ	Lymphocyte_antigen_96.
GenomeRNAiⁱ	23643.
Protein Ontology More...PROⁱ	PR:Q9Y6Y9.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000154589.
CleanExⁱ	HS_LY96.
Genevisibleⁱ	Q9Y6Y9. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR014756. Ig_E-set. IPR003172. ML_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02221. E1_DerP2_DerF2. 1 hit.
SMARTⁱ	View protein in SMART SM00737. ML. 1 hit.
SUPFAMⁱ	SSF81296. SSF81296. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LY96_HUMAN
Accessionⁱ	Q9Y6Y9Primary (citable) accession number: Q9Y6Y9 Secondary accession number(s): B3Y6A5, E5RJJ7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
	Last sequence update:	May 18, 2010
	Last modified:	September 27, 2017
	This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y6Y9 (LY96_HUMAN)

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Lymphocyte antigen 96

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endosome

Extracellular region or secreted

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ