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Q9Y6Y1

- CMTA1_HUMAN

UniProt

Q9Y6Y1 - CMTA1_HUMAN

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Protein

Calmodulin-binding transcription activator 1

Gene
CAMTA1, KIAA0833, MSTP023
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional activator. May act as a tumor suppressor.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi63 – 188126CG-1Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-binding transcription activator 1
Gene namesi
Name:CAMTA1
Synonyms:KIAA0833
ORF Names:MSTP023
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18806. CAMTA1.

Subcellular locationi

Nucleus Inferred. Cytoplasm 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Cerebellar ataxia, non-progressive, with mental retardation (CANPMR) [MIM:614756]: A neurodevelopmental disorder characterized by mildly delayed psychomotor development, early onset of cerebellar ataxia, and intellectual disability later in childhood and adult life. Other features may include neonatal hypotonia, dysarthria, and dysmetria. Brain imaging in some patients shows cerebellar atrophy. Dysmorphic facial features are variable.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Mental retardation

Organism-specific databases

MIMi614756. phenotype.
Orphaneti314647. Non-progressive cerebellar ataxia with intellectual disability.
PharmGKBiPA38688.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16731673Calmodulin-binding transcription activator 1PRO_0000235820Add
BLAST

Proteomic databases

PaxDbiQ9Y6Y1.
PRIDEiQ9Y6Y1.

PTM databases

PhosphoSiteiQ9Y6Y1.

Expressioni

Tissue specificityi

Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by half in oligodendroglioma and astrocytoma cases with 1p loss of heterozygosity. Detected in neuroblastic-type cultured neuroblastoma cells. Expressed in heart and kidney.3 Publications

Inductioni

Detected at low levels at interphase and in resting cells. Up-regulated during S phase and mitosis. Levels decrease at the end of mitosis.1 Publication

Gene expression databases

ArrayExpressiQ9Y6Y1.
BgeeiQ9Y6Y1.
CleanExiHS_CAMTA1.
GenevestigatoriQ9Y6Y1.

Organism-specific databases

HPAiHPA036343.

Interactioni

Subunit structurei

May interact with calmodulin Reviewed prediction.1 Publication

Protein-protein interaction databases

BioGridi116863. 2 interactions.
IntActiQ9Y6Y1. 1 interaction.
STRINGi9606.ENSP00000306522.

Structurei

Secondary structure

1
1673
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi875 – 8773
Beta strandi879 – 8813
Beta strandi888 – 8947
Beta strandi902 – 9065
Beta strandi909 – 9124
Beta strandi914 – 9174
Beta strandi920 – 9245
Beta strandi930 – 93910
Beta strandi948 – 9525

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CXKX-ray1.85A/B/C/D/E872-953[»]
ProteinModelPortaliQ9Y6Y1.
SMRiQ9Y6Y1. Positions 872-954, 1065-1163.

Miscellaneous databases

EvolutionaryTraceiQ9Y6Y1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini873 – 95381IPT/TIGAdd
BLAST
Repeati1064 – 109330ANK 1Add
BLAST
Repeati1109 – 112921ANK 2Add
BLAST
Repeati1143 – 117230ANK 3Add
BLAST
Domaini1547 – 157630IQ 1Add
BLAST
Domaini1577 – 159923IQ 2Add
BLAST
Domaini1600 – 162223IQ 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi112 – 1198Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi499 – 5024Poly-Gly
Compositional biasi1038 – 10414Poly-Val

Sequence similaritiesi

Belongs to the CAMTA family.
Contains 3 ANK repeats.
Contains 1 IPT/TIG domain.
Contains 3 IQ domains.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiNOG294285.
HOGENOMiHOG000111813.
HOVERGENiHBG080107.
InParanoidiQ9Y6Y1.
OMAiAYMHVAE.
OrthoDBiEOG74R1PX.
PhylomeDBiQ9Y6Y1.
TreeFamiTF323452.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03859. CG-1. 1 hit.
PF00612. IQ. 2 hits.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM01076. CG-1. 1 hit.
SM00015. IQ. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y6Y1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWRAEGKWLP KTSRKSVSQS VFCGTSTYCV LNTVPPIEDD HGNSNSSHVK     50
IFLPKKLLEC LPKCSSLPKE RHRWNTNEEI AAYLITFEKH EEWLTTSPKT 100
RPQNGSMILY NRKKVKYRKD GYCWKKRKDG KTTREDHMKL KVQGVECLYG 150
CYVHSSIIPT FHRRCYWLLQ NPDIVLVHYL NVPAIEDCGK PCGPILCSIN 200
TDKKEWAKWT KEELIGQLKP MFHGIKWTCS NGNSSSGFSV EQLVQQILDS 250
HQTKPQPRTH NCLCTGSLGA GGSVHHKCNS AKHRIISPKV EPRTGGYGSH 300
SEVQHNDVSE GKHEHSHSKG SSREKRNGKV AKPVLLHQSS TEVSSTNQVE 350
VPDTTQSSPV SISSGLNSDP DMVDSPVVTG VSGMAVASVM GSLSQSATVF 400
MSEVTNEAVY TMSPTAGPNH HLLSPDASQG LVLAVSSDGH KFAFPTTGSS 450
ESLSMLPTNV SEELVLSTTL DGGRKIPETT MNFDPDCFLN NPKQGQTYGG 500
GGLKAEMVSS NIRHSPPGER SFSFTTVLTK EIKTEDTSFE QQMAKEAYSS 550
SAAAVAASSL TLTAGSSLLP SGGGLSPSTT LEQMDFSAID SNKDYTSSFS 600
QTGHSPHIHQ TPSPSFFLQD ASKPLPVEQN THSSLSDSGG TFVMPTVKTE 650
ASSQTSSCSG HVETRIESTS SLHLMQFQAN FQAMTAEGEV TMETSQAAEG 700
SEVLLKSGEL QACSSEHYLQ PETNGVIRSA GGVPILPGNV VQGLYPVAQP 750
SLGNASNMEL SLDHFDISFS NQFSDLINDF ISVEGGSSTI YGHQLVSGDS 800
TALSQSEDGA RAPFTQAEMC LPCCSPQQGS LQLSSSEGGA STMAYMHVAE 850
VVSAASAQGT LGMLQQSGRV FMVTDYSPEW SYPEGGVKVL ITGPWQEASN 900
NYSCLFDQIS VPASLIQPGV LRCYCPAHDT GLVTLQVAFN NQIISNSVVF 950
EYKARALPTL PSSQHDWLSL DDNQFRMSIL ERLEQMERRM AEMTGSQQHK 1000
QASGGGSSGG GSGSGNGGSQ AQCASGTGAL GSCFESRVVV VCEKMMSRAC 1050
WAKSKHLIHS KTFRGMTLLH LAAAQGYATL IQTLIKWRTK HADSIDLELE 1100
VDPLNVDHFS CTPLMWACAL GHLEAAVVLY KWDRRAISIP DSLGRLPLGI 1150
ARSRGHVKLA ECLEHLQRDE QAQLGQNPRI HCPASEEPST ESWMAQWHSE 1200
AISSPEIPKG VTVIASTNPE LRRPRSEPSN YYSSESHKDY PAPKKHKLNP 1250
EYFQTRQEKL LPTALSLEEP NIRKQSPSSK QSVPETLSPS EGVRDFSREL 1300
SPPTPETAAF QASGSQPVGK WNSKDLYIGV STVQVTGNPK GTSVGKEAAP 1350
SQVRPREPMS VLMMANREVV NTELGSYRDS AENEECGQPM DDIQVNMMTL 1400
AEHIIEATPD RIKQENFVPM ESSGLERTDP ATISSTMSWL ASYLADADCL 1450
PSAAQIRSAY NEPLTPSSNT SLSPVGSPVS EIAFEKPNLP SAADWSEFLS 1500
ASTSEKVENE FAQLTLSDHE QRELYEAARL VQTAFRKYKG RPLREQQEVA 1550
AAVIQRCYRK YKQYALYKKM TQAAILIQSK FRSYYEQKKF QQSRRAAVLI 1600
QKYYRSYKKC GKRRQARRTA VIVQQKLRSS LLTKKQDQAA RKIMRFLRRC 1650
RHSPLVDHRL YKRSERIEKG QGT 1673
Length:1,673
Mass (Da):183,672
Last modified:May 16, 2006 - v4
Checksum:i008AA6A906374C00
GO
Isoform 2 (identifier: Q9Y6Y1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1458-1471: Missing.
     1653-1673: SPLVDHRLYKRSERIEKGQGT → RVKELKKAKELEDIQQHPLAM

Show »
Length:1,659
Mass (Da):182,257
Checksum:iE03DDA09EEB25873
GO
Isoform 3 (identifier: Q9Y6Y1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-80: EI → RS
     81-1673: Missing.

Note: No experimental confirmation available.

Show »
Length:80
Mass (Da):9,173
Checksum:i4745CB6B383AB10A
GO
Isoform 4 (identifier: Q9Y6Y1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-101: EIAAYLITFEKHEEWLTTSPKTR → ALTTHLFMGAAKKRDPQSWSHEG
     102-1673: Missing.

Note: No experimental confirmation available.

Show »
Length:101
Mass (Da):11,480
Checksum:iDF1CD8DF69AAE9E2
GO

Sequence cautioni

The sequence AAL39006.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAA74856.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence EAW71580.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1177 – 11771N → K.1 Publication
Corresponds to variant rs41278952 [ dbSNP | Ensembl ].
VAR_047824
Natural varianti1218 – 12181N → T.1 Publication
Corresponds to variant rs41278954 [ dbSNP | Ensembl ].
VAR_047825
Natural varianti1336 – 13361T → I.1 Publication
Corresponds to variant rs137974312 [ dbSNP | Ensembl ].
VAR_047826

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei79 – 10123EIAAY…SPKTR → ALTTHLFMGAAKKRDPQSWS HEG in isoform 4. VSP_046358Add
BLAST
Alternative sequencei79 – 802EI → RS in isoform 3. VSP_043842
Alternative sequencei81 – 16731593Missing in isoform 3. VSP_043843Add
BLAST
Alternative sequencei102 – 16731572Missing in isoform 4. VSP_046359Add
BLAST
Alternative sequencei1458 – 147114Missing in isoform 2. VSP_035936Add
BLAST
Alternative sequencei1653 – 167321SPLVD…KGQGT → RVKELKKAKELEDIQQHPLA M in isoform 2. VSP_035937Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020640 mRNA. Translation: BAA74856.3. Different initiation.
AY037153 mRNA. Translation: AAK67633.1.
AL590128
, AL359881, AL365194, AL596210, Z97635, Z98052, Z98884 Genomic DNA. Translation: CAH72347.1.
AL359881
, AL365194, AL590128, AL596210, Z97635, Z98884, Z98052 Genomic DNA. Translation: CAH72663.1.
AL596210
, AL359881, AL365194, AL590128, Z97635, Z98052, Z98884 Genomic DNA. Translation: CAI17064.1.
Z97635
, Z98884, Z98052, AL596210, AL590128, AL365194, AL359881 Genomic DNA. Translation: CAI20961.1.
Z98884
, Z98052, Z97635, AL359881, AL365194, AL596210, AL590128 Genomic DNA. Translation: CAI21433.1.
Z98052
, Z98884, Z97635, AL359881, AL596210, AL590128, AL365194 Genomic DNA. Translation: CAI21596.1.
AL365194
, AL359881, AL590128, AL596210, Z97635, Z98052, Z98884 Genomic DNA. Translation: CAI21790.1.
CH471130 Genomic DNA. Translation: EAW71580.1. Sequence problems.
BC116457 mRNA. Translation: AAI16458.1.
BC151835 mRNA. Translation: AAI51836.1.
CD103791 mRNA. No translation available.
AF111804 mRNA. Translation: AAL39006.1. Different initiation.
AY349360 mRNA. Translation: AAQ56724.1.
CCDSiCCDS30576.1. [Q9Y6Y1-1]
CCDS55574.1. [Q9Y6Y1-3]
CCDS55575.1. [Q9Y6Y1-4]
RefSeqiNP_001182492.1. NM_001195563.1. [Q9Y6Y1-3]
NP_001229630.1. NM_001242701.1. [Q9Y6Y1-4]
NP_056030.1. NM_015215.3. [Q9Y6Y1-1]
UniGeneiHs.397705.
Hs.671020.

Genome annotation databases

EnsembliENST00000303635; ENSP00000306522; ENSG00000171735. [Q9Y6Y1-1]
ENST00000439411; ENSP00000402561; ENSG00000171735. [Q9Y6Y1-2]
ENST00000473578; ENSP00000451388; ENSG00000171735. [Q9Y6Y1-3]
ENST00000476864; ENSP00000452319; ENSG00000171735.
ENST00000557126; ENSP00000451510; ENSG00000171735. [Q9Y6Y1-4]
GeneIDi23261.
KEGGihsa:23261.
UCSCiuc001aoh.3. human. [Q9Y6Y1-3]
uc001aoi.3. human. [Q9Y6Y1-1]

Polymorphism databases

DMDMi97046872.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020640 mRNA. Translation: BAA74856.3 . Different initiation.
AY037153 mRNA. Translation: AAK67633.1 .
AL590128
, AL359881 , AL365194 , AL596210 , Z97635 , Z98052 , Z98884 Genomic DNA. Translation: CAH72347.1 .
AL359881
, AL365194 , AL590128 , AL596210 , Z97635 , Z98884 , Z98052 Genomic DNA. Translation: CAH72663.1 .
AL596210
, AL359881 , AL365194 , AL590128 , Z97635 , Z98052 , Z98884 Genomic DNA. Translation: CAI17064.1 .
Z97635
, Z98884 , Z98052 , AL596210 , AL590128 , AL365194 , AL359881 Genomic DNA. Translation: CAI20961.1 .
Z98884
, Z98052 , Z97635 , AL359881 , AL365194 , AL596210 , AL590128 Genomic DNA. Translation: CAI21433.1 .
Z98052
, Z98884 , Z97635 , AL359881 , AL596210 , AL590128 , AL365194 Genomic DNA. Translation: CAI21596.1 .
AL365194
, AL359881 , AL590128 , AL596210 , Z97635 , Z98052 , Z98884 Genomic DNA. Translation: CAI21790.1 .
CH471130 Genomic DNA. Translation: EAW71580.1 . Sequence problems.
BC116457 mRNA. Translation: AAI16458.1 .
BC151835 mRNA. Translation: AAI51836.1 .
CD103791 mRNA. No translation available.
AF111804 mRNA. Translation: AAL39006.1 . Different initiation.
AY349360 mRNA. Translation: AAQ56724.1 .
CCDSi CCDS30576.1. [Q9Y6Y1-1 ]
CCDS55574.1. [Q9Y6Y1-3 ]
CCDS55575.1. [Q9Y6Y1-4 ]
RefSeqi NP_001182492.1. NM_001195563.1. [Q9Y6Y1-3 ]
NP_001229630.1. NM_001242701.1. [Q9Y6Y1-4 ]
NP_056030.1. NM_015215.3. [Q9Y6Y1-1 ]
UniGenei Hs.397705.
Hs.671020.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CXK X-ray 1.85 A/B/C/D/E 872-953 [» ]
ProteinModelPortali Q9Y6Y1.
SMRi Q9Y6Y1. Positions 872-954, 1065-1163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116863. 2 interactions.
IntActi Q9Y6Y1. 1 interaction.
STRINGi 9606.ENSP00000306522.

PTM databases

PhosphoSitei Q9Y6Y1.

Polymorphism databases

DMDMi 97046872.

Proteomic databases

PaxDbi Q9Y6Y1.
PRIDEi Q9Y6Y1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303635 ; ENSP00000306522 ; ENSG00000171735 . [Q9Y6Y1-1 ]
ENST00000439411 ; ENSP00000402561 ; ENSG00000171735 . [Q9Y6Y1-2 ]
ENST00000473578 ; ENSP00000451388 ; ENSG00000171735 . [Q9Y6Y1-3 ]
ENST00000476864 ; ENSP00000452319 ; ENSG00000171735 .
ENST00000557126 ; ENSP00000451510 ; ENSG00000171735 . [Q9Y6Y1-4 ]
GeneIDi 23261.
KEGGi hsa:23261.
UCSCi uc001aoh.3. human. [Q9Y6Y1-3 ]
uc001aoi.3. human. [Q9Y6Y1-1 ]

Organism-specific databases

CTDi 23261.
GeneCardsi GC01P006845.
HGNCi HGNC:18806. CAMTA1.
HPAi HPA036343.
MIMi 611501. gene.
614756. phenotype.
neXtProti NX_Q9Y6Y1.
Orphaneti 314647. Non-progressive cerebellar ataxia with intellectual disability.
PharmGKBi PA38688.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG294285.
HOGENOMi HOG000111813.
HOVERGENi HBG080107.
InParanoidi Q9Y6Y1.
OMAi AYMHVAE.
OrthoDBi EOG74R1PX.
PhylomeDBi Q9Y6Y1.
TreeFami TF323452.

Miscellaneous databases

ChiTaRSi CAMTA1. human.
EvolutionaryTracei Q9Y6Y1.
GeneWikii CAMTA1.
GenomeRNAii 23261.
NextBioi 44996.
PROi Q9Y6Y1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y6Y1.
Bgeei Q9Y6Y1.
CleanExi HS_CAMTA1.
Genevestigatori Q9Y6Y1.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF03859. CG-1. 1 hit.
PF00612. IQ. 2 hits.
PF01833. TIG. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
SM01076. CG-1. 1 hit.
SM00015. IQ. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Li N., Zhang M., Wan T., Zhang W., Cao X.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
    Tissue: Skin.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1422-1673 (ISOFORM 2).
    Tissue: Heart.
  8. Li H., Li S., Yu R., Shen C., Zhou G., Ke R., Lin L., Yang S.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1437-1673 (ISOFORM 2).
  9. "A novel family of calmodulin-binding transcription activators in multicellular organisms."
    Bouche N., Scharlat A., Snedden W., Bouchez D., Fromm H.
    J. Biol. Chem. 277:21851-21861(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  10. "Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells."
    Nakatani K., Nishioka J., Itakura T., Nakanishi Y., Horinouchi J., Abe Y., Wada H., Nobori T.
    Int. J. Oncol. 24:1407-1412(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  11. "Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene."
    Barbashina V., Salazar P., Holland E.C., Rosenblum M.K., Ladanyi M.
    Clin. Cancer Res. 11:1119-1128(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  12. Cited for: INVOLVEMENT IN CANPMR.
  13. "Crystal structure of the TIG domain of human calmodulin-binding transcription activator 1 (CAMTA1)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (DEC-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 872-953.
  14. "Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma."
    Henrich K.-O., Claas A., Praml C., Benner A., Mollenhauer J., Poustka A., Schwab M., Westermann F.
    Eur. J. Cancer 43:607-616(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LYS-1177; THR-1218 AND ILE-1336.

Entry informationi

Entry nameiCMTA1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6Y1
Secondary accession number(s): A7MBM4
, G3V3Z7, Q5VUE1, Q6V701, Q8WYI3, Q96S92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: July 9, 2014
This is version 116 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

A very small segment of 1p36 located within CAMTA1 is deleted in all oligodendroglial tumors with 1p LOH. This minimal deleted region (MDR) also overlaps the neuroblastoma 1p36 MDR. CAMTA1 shows no evidence of inactivation by somatic mutations.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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