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Protein

Calmodulin-binding transcription activator 1

Gene

CAMTA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator. May act as a tumor suppressor.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi63 – 188CG-1PROSITE-ProRule annotationAdd BLAST126

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-binding transcription activator 1
Gene namesi
Name:CAMTA1
Synonyms:KIAA0833
ORF Names:MSTP023
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18806. CAMTA1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Cerebellar ataxia, non-progressive, with mental retardation (CANPMR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodevelopmental disorder characterized by mildly delayed psychomotor development, early onset of cerebellar ataxia, and intellectual disability later in childhood and adult life. Other features may include neonatal hypotonia, dysarthria, and dysmetria. Brain imaging in some patients shows cerebellar atrophy. Dysmorphic facial features are variable.
See also OMIM:614756

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNETi23261.
MalaCardsiCAMTA1.
MIMi614756. phenotype.
OpenTargetsiENSG00000171735.
Orphaneti314647. Non-progressive cerebellar ataxia with intellectual disability.
PharmGKBiPA38688.

Polymorphism and mutation databases

BioMutaiCAMTA1.
DMDMi97046872.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002358201 – 1673Calmodulin-binding transcription activator 1Add BLAST1673

Proteomic databases

PaxDbiQ9Y6Y1.
PRIDEiQ9Y6Y1.

PTM databases

iPTMnetiQ9Y6Y1.
PhosphoSitePlusiQ9Y6Y1.

Expressioni

Tissue specificityi

Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by half in oligodendroglioma and astrocytoma cases with 1p loss of heterozygosity. Detected in neuroblastic-type cultured neuroblastoma cells. Expressed in heart and kidney.3 Publications

Inductioni

Detected at low levels at interphase and in resting cells. Up-regulated during S phase and mitosis. Levels decrease at the end of mitosis.1 Publication

Gene expression databases

BgeeiENSG00000171735.
CleanExiHS_CAMTA1.
ExpressionAtlasiQ9Y6Y1. baseline and differential.
GenevisibleiQ9Y6Y1. HS.

Organism-specific databases

HPAiHPA036342.
HPA036343.

Interactioni

Subunit structurei

May interact with calmodulin.Curated

Protein-protein interaction databases

BioGridi116863. 1 interactor.
IntActiQ9Y6Y1. 1 interactor.
STRINGi9606.ENSP00000306522.

Structurei

Secondary structure

11673
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi875 – 877Combined sources3
Beta strandi879 – 881Combined sources3
Beta strandi888 – 894Combined sources7
Beta strandi902 – 906Combined sources5
Beta strandi909 – 912Combined sources4
Beta strandi914 – 917Combined sources4
Beta strandi920 – 924Combined sources5
Beta strandi930 – 939Combined sources10
Beta strandi948 – 952Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CXKX-ray1.85A/B/C/D/E872-953[»]
ProteinModelPortaliQ9Y6Y1.
SMRiQ9Y6Y1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6Y1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini873 – 953IPT/TIGAdd BLAST81
Repeati1064 – 1093ANK 1Add BLAST30
Repeati1109 – 1129ANK 2Add BLAST21
Repeati1143 – 1172ANK 3Add BLAST30
Domaini1547 – 1576IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini1577 – 1599IQ 2PROSITE-ProRule annotationAdd BLAST23
Domaini1600 – 1622IQ 3PROSITE-ProRule annotationAdd BLAST23

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi112 – 119Nuclear localization signalPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi499 – 502Poly-Gly4
Compositional biasi1038 – 1041Poly-Val4

Sequence similaritiesi

Belongs to the CAMTA family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation
Contains 1 CG-1 DNA-binding domain.PROSITE-ProRule annotation
Contains 1 IPT/TIG domain.Curated
Contains 3 IQ domains.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0520. Eukaryota.
ENOG410XS5M. LUCA.
GeneTreeiENSGT00390000001446.
HOGENOMiHOG000111813.
HOVERGENiHBG080107.
InParanoidiQ9Y6Y1.
OMAiAYMHVAE.
OrthoDBiEOG091G01MB.
PhylomeDBiQ9Y6Y1.
TreeFamiTF323452.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03859. CG-1. 1 hit.
PF00612. IQ. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM01076. CG-1. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y6Y1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWRAEGKWLP KTSRKSVSQS VFCGTSTYCV LNTVPPIEDD HGNSNSSHVK
60 70 80 90 100
IFLPKKLLEC LPKCSSLPKE RHRWNTNEEI AAYLITFEKH EEWLTTSPKT
110 120 130 140 150
RPQNGSMILY NRKKVKYRKD GYCWKKRKDG KTTREDHMKL KVQGVECLYG
160 170 180 190 200
CYVHSSIIPT FHRRCYWLLQ NPDIVLVHYL NVPAIEDCGK PCGPILCSIN
210 220 230 240 250
TDKKEWAKWT KEELIGQLKP MFHGIKWTCS NGNSSSGFSV EQLVQQILDS
260 270 280 290 300
HQTKPQPRTH NCLCTGSLGA GGSVHHKCNS AKHRIISPKV EPRTGGYGSH
310 320 330 340 350
SEVQHNDVSE GKHEHSHSKG SSREKRNGKV AKPVLLHQSS TEVSSTNQVE
360 370 380 390 400
VPDTTQSSPV SISSGLNSDP DMVDSPVVTG VSGMAVASVM GSLSQSATVF
410 420 430 440 450
MSEVTNEAVY TMSPTAGPNH HLLSPDASQG LVLAVSSDGH KFAFPTTGSS
460 470 480 490 500
ESLSMLPTNV SEELVLSTTL DGGRKIPETT MNFDPDCFLN NPKQGQTYGG
510 520 530 540 550
GGLKAEMVSS NIRHSPPGER SFSFTTVLTK EIKTEDTSFE QQMAKEAYSS
560 570 580 590 600
SAAAVAASSL TLTAGSSLLP SGGGLSPSTT LEQMDFSAID SNKDYTSSFS
610 620 630 640 650
QTGHSPHIHQ TPSPSFFLQD ASKPLPVEQN THSSLSDSGG TFVMPTVKTE
660 670 680 690 700
ASSQTSSCSG HVETRIESTS SLHLMQFQAN FQAMTAEGEV TMETSQAAEG
710 720 730 740 750
SEVLLKSGEL QACSSEHYLQ PETNGVIRSA GGVPILPGNV VQGLYPVAQP
760 770 780 790 800
SLGNASNMEL SLDHFDISFS NQFSDLINDF ISVEGGSSTI YGHQLVSGDS
810 820 830 840 850
TALSQSEDGA RAPFTQAEMC LPCCSPQQGS LQLSSSEGGA STMAYMHVAE
860 870 880 890 900
VVSAASAQGT LGMLQQSGRV FMVTDYSPEW SYPEGGVKVL ITGPWQEASN
910 920 930 940 950
NYSCLFDQIS VPASLIQPGV LRCYCPAHDT GLVTLQVAFN NQIISNSVVF
960 970 980 990 1000
EYKARALPTL PSSQHDWLSL DDNQFRMSIL ERLEQMERRM AEMTGSQQHK
1010 1020 1030 1040 1050
QASGGGSSGG GSGSGNGGSQ AQCASGTGAL GSCFESRVVV VCEKMMSRAC
1060 1070 1080 1090 1100
WAKSKHLIHS KTFRGMTLLH LAAAQGYATL IQTLIKWRTK HADSIDLELE
1110 1120 1130 1140 1150
VDPLNVDHFS CTPLMWACAL GHLEAAVVLY KWDRRAISIP DSLGRLPLGI
1160 1170 1180 1190 1200
ARSRGHVKLA ECLEHLQRDE QAQLGQNPRI HCPASEEPST ESWMAQWHSE
1210 1220 1230 1240 1250
AISSPEIPKG VTVIASTNPE LRRPRSEPSN YYSSESHKDY PAPKKHKLNP
1260 1270 1280 1290 1300
EYFQTRQEKL LPTALSLEEP NIRKQSPSSK QSVPETLSPS EGVRDFSREL
1310 1320 1330 1340 1350
SPPTPETAAF QASGSQPVGK WNSKDLYIGV STVQVTGNPK GTSVGKEAAP
1360 1370 1380 1390 1400
SQVRPREPMS VLMMANREVV NTELGSYRDS AENEECGQPM DDIQVNMMTL
1410 1420 1430 1440 1450
AEHIIEATPD RIKQENFVPM ESSGLERTDP ATISSTMSWL ASYLADADCL
1460 1470 1480 1490 1500
PSAAQIRSAY NEPLTPSSNT SLSPVGSPVS EIAFEKPNLP SAADWSEFLS
1510 1520 1530 1540 1550
ASTSEKVENE FAQLTLSDHE QRELYEAARL VQTAFRKYKG RPLREQQEVA
1560 1570 1580 1590 1600
AAVIQRCYRK YKQYALYKKM TQAAILIQSK FRSYYEQKKF QQSRRAAVLI
1610 1620 1630 1640 1650
QKYYRSYKKC GKRRQARRTA VIVQQKLRSS LLTKKQDQAA RKIMRFLRRC
1660 1670
RHSPLVDHRL YKRSERIEKG QGT
Length:1,673
Mass (Da):183,672
Last modified:May 16, 2006 - v4
Checksum:i008AA6A906374C00
GO
Isoform 2 (identifier: Q9Y6Y1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1458-1471: Missing.
     1653-1673: SPLVDHRLYKRSERIEKGQGT → RVKELKKAKELEDIQQHPLAM

Show »
Length:1,659
Mass (Da):182,257
Checksum:iE03DDA09EEB25873
GO
Isoform 3 (identifier: Q9Y6Y1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-80: EI → RS
     81-1673: Missing.

Note: No experimental confirmation available.
Show »
Length:80
Mass (Da):9,173
Checksum:i4745CB6B383AB10A
GO
Isoform 4 (identifier: Q9Y6Y1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-101: EIAAYLITFEKHEEWLTTSPKTR → ALTTHLFMGAAKKRDPQSWSHEG
     102-1673: Missing.

Note: No experimental confirmation available.
Show »
Length:101
Mass (Da):11,480
Checksum:iDF1CD8DF69AAE9E2
GO

Sequence cautioni

The sequence AAL39006 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA74856 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW71580 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0478241177N → K.1 PublicationCorresponds to variant rs41278952dbSNPEnsembl.1
Natural variantiVAR_0478251218N → T.1 PublicationCorresponds to variant rs41278954dbSNPEnsembl.1
Natural variantiVAR_0478261336T → I.1 PublicationCorresponds to variant rs137974312dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04635879 – 101EIAAY…SPKTR → ALTTHLFMGAAKKRDPQSWS HEG in isoform 4. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_04384279 – 80EI → RS in isoform 3. 2 Publications2
Alternative sequenceiVSP_04384381 – 1673Missing in isoform 3. 2 PublicationsAdd BLAST1593
Alternative sequenceiVSP_046359102 – 1673Missing in isoform 4. 1 PublicationAdd BLAST1572
Alternative sequenceiVSP_0359361458 – 1471Missing in isoform 2. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_0359371653 – 1673SPLVD…KGQGT → RVKELKKAKELEDIQQHPLA M in isoform 2. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020640 mRNA. Translation: BAA74856.3. Different initiation.
AY037153 mRNA. Translation: AAK67633.1.
AL590128
, AL359881, AL365194, AL596210, Z97635, Z98052, Z98884 Genomic DNA. Translation: CAH72347.1.
AL359881
, AL365194, AL590128, AL596210, Z97635, Z98884, Z98052 Genomic DNA. Translation: CAH72663.1.
AL596210
, AL359881, AL365194, AL590128, Z97635, Z98052, Z98884 Genomic DNA. Translation: CAI17064.1.
Z97635
, Z98884, Z98052, AL596210, AL590128, AL365194, AL359881 Genomic DNA. Translation: CAI20961.1.
Z98884
, Z98052, Z97635, AL359881, AL365194, AL596210, AL590128 Genomic DNA. Translation: CAI21433.1.
Z98052
, Z98884, Z97635, AL359881, AL596210, AL590128, AL365194 Genomic DNA. Translation: CAI21596.1.
AL365194
, AL359881, AL590128, AL596210, Z97635, Z98052, Z98884 Genomic DNA. Translation: CAI21790.1.
CH471130 Genomic DNA. Translation: EAW71580.1. Sequence problems.
BC116457 mRNA. Translation: AAI16458.1.
BC151835 mRNA. Translation: AAI51836.1.
CD103791 mRNA. No translation available.
AF111804 mRNA. Translation: AAL39006.1. Different initiation.
AY349360 mRNA. Translation: AAQ56724.1.
CCDSiCCDS30576.1. [Q9Y6Y1-1]
CCDS55574.1. [Q9Y6Y1-3]
CCDS55575.1. [Q9Y6Y1-4]
RefSeqiNP_001182492.1. NM_001195563.1. [Q9Y6Y1-3]
NP_001229630.1. NM_001242701.1. [Q9Y6Y1-4]
NP_056030.1. NM_015215.3. [Q9Y6Y1-1]
UniGeneiHs.397705.
Hs.671020.

Genome annotation databases

EnsembliENST00000303635; ENSP00000306522; ENSG00000171735. [Q9Y6Y1-1]
ENST00000473578; ENSP00000451388; ENSG00000171735. [Q9Y6Y1-3]
ENST00000557126; ENSP00000451510; ENSG00000171735. [Q9Y6Y1-4]
GeneIDi23261.
KEGGihsa:23261.
UCSCiuc001aoh.4. human. [Q9Y6Y1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020640 mRNA. Translation: BAA74856.3. Different initiation.
AY037153 mRNA. Translation: AAK67633.1.
AL590128
, AL359881, AL365194, AL596210, Z97635, Z98052, Z98884 Genomic DNA. Translation: CAH72347.1.
AL359881
, AL365194, AL590128, AL596210, Z97635, Z98884, Z98052 Genomic DNA. Translation: CAH72663.1.
AL596210
, AL359881, AL365194, AL590128, Z97635, Z98052, Z98884 Genomic DNA. Translation: CAI17064.1.
Z97635
, Z98884, Z98052, AL596210, AL590128, AL365194, AL359881 Genomic DNA. Translation: CAI20961.1.
Z98884
, Z98052, Z97635, AL359881, AL365194, AL596210, AL590128 Genomic DNA. Translation: CAI21433.1.
Z98052
, Z98884, Z97635, AL359881, AL596210, AL590128, AL365194 Genomic DNA. Translation: CAI21596.1.
AL365194
, AL359881, AL590128, AL596210, Z97635, Z98052, Z98884 Genomic DNA. Translation: CAI21790.1.
CH471130 Genomic DNA. Translation: EAW71580.1. Sequence problems.
BC116457 mRNA. Translation: AAI16458.1.
BC151835 mRNA. Translation: AAI51836.1.
CD103791 mRNA. No translation available.
AF111804 mRNA. Translation: AAL39006.1. Different initiation.
AY349360 mRNA. Translation: AAQ56724.1.
CCDSiCCDS30576.1. [Q9Y6Y1-1]
CCDS55574.1. [Q9Y6Y1-3]
CCDS55575.1. [Q9Y6Y1-4]
RefSeqiNP_001182492.1. NM_001195563.1. [Q9Y6Y1-3]
NP_001229630.1. NM_001242701.1. [Q9Y6Y1-4]
NP_056030.1. NM_015215.3. [Q9Y6Y1-1]
UniGeneiHs.397705.
Hs.671020.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CXKX-ray1.85A/B/C/D/E872-953[»]
ProteinModelPortaliQ9Y6Y1.
SMRiQ9Y6Y1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116863. 1 interactor.
IntActiQ9Y6Y1. 1 interactor.
STRINGi9606.ENSP00000306522.

PTM databases

iPTMnetiQ9Y6Y1.
PhosphoSitePlusiQ9Y6Y1.

Polymorphism and mutation databases

BioMutaiCAMTA1.
DMDMi97046872.

Proteomic databases

PaxDbiQ9Y6Y1.
PRIDEiQ9Y6Y1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303635; ENSP00000306522; ENSG00000171735. [Q9Y6Y1-1]
ENST00000473578; ENSP00000451388; ENSG00000171735. [Q9Y6Y1-3]
ENST00000557126; ENSP00000451510; ENSG00000171735. [Q9Y6Y1-4]
GeneIDi23261.
KEGGihsa:23261.
UCSCiuc001aoh.4. human. [Q9Y6Y1-1]

Organism-specific databases

CTDi23261.
DisGeNETi23261.
GeneCardsiCAMTA1.
HGNCiHGNC:18806. CAMTA1.
HPAiHPA036342.
HPA036343.
MalaCardsiCAMTA1.
MIMi611501. gene.
614756. phenotype.
neXtProtiNX_Q9Y6Y1.
OpenTargetsiENSG00000171735.
Orphaneti314647. Non-progressive cerebellar ataxia with intellectual disability.
PharmGKBiPA38688.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0520. Eukaryota.
ENOG410XS5M. LUCA.
GeneTreeiENSGT00390000001446.
HOGENOMiHOG000111813.
HOVERGENiHBG080107.
InParanoidiQ9Y6Y1.
OMAiAYMHVAE.
OrthoDBiEOG091G01MB.
PhylomeDBiQ9Y6Y1.
TreeFamiTF323452.

Miscellaneous databases

ChiTaRSiCAMTA1. human.
EvolutionaryTraceiQ9Y6Y1.
GeneWikiiCAMTA1.
GenomeRNAii23261.
PROiQ9Y6Y1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171735.
CleanExiHS_CAMTA1.
ExpressionAtlasiQ9Y6Y1. baseline and differential.
GenevisibleiQ9Y6Y1. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03859. CG-1. 1 hit.
PF00612. IQ. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM01076. CG-1. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCMTA1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6Y1
Secondary accession number(s): A7MBM4
, G3V3Z7, Q5VUE1, Q6V701, Q8WYI3, Q96S92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: November 2, 2016
This is version 137 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

A very small segment of 1p36 located within CAMTA1 is deleted in all oligodendroglial tumors with 1p LOH. This minimal deleted region (MDR) also overlaps the neuroblastoma 1p36 MDR. CAMTA1 shows no evidence of inactivation by somatic mutations.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.