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Q9Y6Y1

- CMTA1_HUMAN

UniProt

Q9Y6Y1 - CMTA1_HUMAN

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Protein

Calmodulin-binding transcription activator 1

Gene

CAMTA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator. May act as a tumor suppressor.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi63 – 188126CG-1PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-binding transcription activator 1
Gene namesi
Name:CAMTA1
Synonyms:KIAA0833
ORF Names:MSTP023
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18806. CAMTA1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Cerebellar ataxia, non-progressive, with mental retardation (CANPMR) [MIM:614756]: A neurodevelopmental disorder characterized by mildly delayed psychomotor development, early onset of cerebellar ataxia, and intellectual disability later in childhood and adult life. Other features may include neonatal hypotonia, dysarthria, and dysmetria. Brain imaging in some patients shows cerebellar atrophy. Dysmorphic facial features are variable.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Keywords - Diseasei

Mental retardation

Organism-specific databases

MIMi614756. phenotype.
Orphaneti314647. Non-progressive cerebellar ataxia with intellectual disability.
PharmGKBiPA38688.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16731673Calmodulin-binding transcription activator 1PRO_0000235820Add
BLAST

Proteomic databases

PaxDbiQ9Y6Y1.
PRIDEiQ9Y6Y1.

PTM databases

PhosphoSiteiQ9Y6Y1.

Expressioni

Tissue specificityi

Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by half in oligodendroglioma and astrocytoma cases with 1p loss of heterozygosity. Detected in neuroblastic-type cultured neuroblastoma cells. Expressed in heart and kidney.3 Publications

Inductioni

Detected at low levels at interphase and in resting cells. Up-regulated during S phase and mitosis. Levels decrease at the end of mitosis.1 Publication

Gene expression databases

BgeeiQ9Y6Y1.
CleanExiHS_CAMTA1.
ExpressionAtlasiQ9Y6Y1. baseline and differential.
GenevestigatoriQ9Y6Y1.

Organism-specific databases

HPAiHPA036343.

Interactioni

Subunit structurei

May interact with calmodulin.Curated

Protein-protein interaction databases

BioGridi116863. 2 interactions.
IntActiQ9Y6Y1. 1 interaction.
STRINGi9606.ENSP00000306522.

Structurei

Secondary structure

1
1673
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi875 – 8773Combined sources
Beta strandi879 – 8813Combined sources
Beta strandi888 – 8947Combined sources
Beta strandi902 – 9065Combined sources
Beta strandi909 – 9124Combined sources
Beta strandi914 – 9174Combined sources
Beta strandi920 – 9245Combined sources
Beta strandi930 – 93910Combined sources
Beta strandi948 – 9525Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CXKX-ray1.85A/B/C/D/E872-953[»]
ProteinModelPortaliQ9Y6Y1.
SMRiQ9Y6Y1. Positions 872-954, 1065-1163.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6Y1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini873 – 95381IPT/TIGAdd
BLAST
Repeati1064 – 109330ANK 1Add
BLAST
Repeati1109 – 112921ANK 2Add
BLAST
Repeati1143 – 117230ANK 3Add
BLAST
Domaini1547 – 157630IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini1577 – 159923IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini1600 – 162223IQ 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi112 – 1198Nuclear localization signalPROSITE-ProRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi499 – 5024Poly-Gly
Compositional biasi1038 – 10414Poly-Val

Sequence similaritiesi

Belongs to the CAMTA family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation
Contains 1 CG-1 DNA-binding domain.PROSITE-ProRule annotation
Contains 1 IPT/TIG domain.Curated
Contains 3 IQ domains.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiNOG294285.
GeneTreeiENSGT00390000001446.
HOGENOMiHOG000111813.
HOVERGENiHBG080107.
InParanoidiQ9Y6Y1.
OMAiAYMHVAE.
OrthoDBiEOG74R1PX.
PhylomeDBiQ9Y6Y1.
TreeFamiTF323452.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03859. CG-1. 1 hit.
PF00612. IQ. 2 hits.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM01076. CG-1. 1 hit.
SM00015. IQ. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y6Y1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWRAEGKWLP KTSRKSVSQS VFCGTSTYCV LNTVPPIEDD HGNSNSSHVK
60 70 80 90 100
IFLPKKLLEC LPKCSSLPKE RHRWNTNEEI AAYLITFEKH EEWLTTSPKT
110 120 130 140 150
RPQNGSMILY NRKKVKYRKD GYCWKKRKDG KTTREDHMKL KVQGVECLYG
160 170 180 190 200
CYVHSSIIPT FHRRCYWLLQ NPDIVLVHYL NVPAIEDCGK PCGPILCSIN
210 220 230 240 250
TDKKEWAKWT KEELIGQLKP MFHGIKWTCS NGNSSSGFSV EQLVQQILDS
260 270 280 290 300
HQTKPQPRTH NCLCTGSLGA GGSVHHKCNS AKHRIISPKV EPRTGGYGSH
310 320 330 340 350
SEVQHNDVSE GKHEHSHSKG SSREKRNGKV AKPVLLHQSS TEVSSTNQVE
360 370 380 390 400
VPDTTQSSPV SISSGLNSDP DMVDSPVVTG VSGMAVASVM GSLSQSATVF
410 420 430 440 450
MSEVTNEAVY TMSPTAGPNH HLLSPDASQG LVLAVSSDGH KFAFPTTGSS
460 470 480 490 500
ESLSMLPTNV SEELVLSTTL DGGRKIPETT MNFDPDCFLN NPKQGQTYGG
510 520 530 540 550
GGLKAEMVSS NIRHSPPGER SFSFTTVLTK EIKTEDTSFE QQMAKEAYSS
560 570 580 590 600
SAAAVAASSL TLTAGSSLLP SGGGLSPSTT LEQMDFSAID SNKDYTSSFS
610 620 630 640 650
QTGHSPHIHQ TPSPSFFLQD ASKPLPVEQN THSSLSDSGG TFVMPTVKTE
660 670 680 690 700
ASSQTSSCSG HVETRIESTS SLHLMQFQAN FQAMTAEGEV TMETSQAAEG
710 720 730 740 750
SEVLLKSGEL QACSSEHYLQ PETNGVIRSA GGVPILPGNV VQGLYPVAQP
760 770 780 790 800
SLGNASNMEL SLDHFDISFS NQFSDLINDF ISVEGGSSTI YGHQLVSGDS
810 820 830 840 850
TALSQSEDGA RAPFTQAEMC LPCCSPQQGS LQLSSSEGGA STMAYMHVAE
860 870 880 890 900
VVSAASAQGT LGMLQQSGRV FMVTDYSPEW SYPEGGVKVL ITGPWQEASN
910 920 930 940 950
NYSCLFDQIS VPASLIQPGV LRCYCPAHDT GLVTLQVAFN NQIISNSVVF
960 970 980 990 1000
EYKARALPTL PSSQHDWLSL DDNQFRMSIL ERLEQMERRM AEMTGSQQHK
1010 1020 1030 1040 1050
QASGGGSSGG GSGSGNGGSQ AQCASGTGAL GSCFESRVVV VCEKMMSRAC
1060 1070 1080 1090 1100
WAKSKHLIHS KTFRGMTLLH LAAAQGYATL IQTLIKWRTK HADSIDLELE
1110 1120 1130 1140 1150
VDPLNVDHFS CTPLMWACAL GHLEAAVVLY KWDRRAISIP DSLGRLPLGI
1160 1170 1180 1190 1200
ARSRGHVKLA ECLEHLQRDE QAQLGQNPRI HCPASEEPST ESWMAQWHSE
1210 1220 1230 1240 1250
AISSPEIPKG VTVIASTNPE LRRPRSEPSN YYSSESHKDY PAPKKHKLNP
1260 1270 1280 1290 1300
EYFQTRQEKL LPTALSLEEP NIRKQSPSSK QSVPETLSPS EGVRDFSREL
1310 1320 1330 1340 1350
SPPTPETAAF QASGSQPVGK WNSKDLYIGV STVQVTGNPK GTSVGKEAAP
1360 1370 1380 1390 1400
SQVRPREPMS VLMMANREVV NTELGSYRDS AENEECGQPM DDIQVNMMTL
1410 1420 1430 1440 1450
AEHIIEATPD RIKQENFVPM ESSGLERTDP ATISSTMSWL ASYLADADCL
1460 1470 1480 1490 1500
PSAAQIRSAY NEPLTPSSNT SLSPVGSPVS EIAFEKPNLP SAADWSEFLS
1510 1520 1530 1540 1550
ASTSEKVENE FAQLTLSDHE QRELYEAARL VQTAFRKYKG RPLREQQEVA
1560 1570 1580 1590 1600
AAVIQRCYRK YKQYALYKKM TQAAILIQSK FRSYYEQKKF QQSRRAAVLI
1610 1620 1630 1640 1650
QKYYRSYKKC GKRRQARRTA VIVQQKLRSS LLTKKQDQAA RKIMRFLRRC
1660 1670
RHSPLVDHRL YKRSERIEKG QGT
Length:1,673
Mass (Da):183,672
Last modified:May 16, 2006 - v4
Checksum:i008AA6A906374C00
GO
Isoform 2 (identifier: Q9Y6Y1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1458-1471: Missing.
     1653-1673: SPLVDHRLYKRSERIEKGQGT → RVKELKKAKELEDIQQHPLAM

Show »
Length:1,659
Mass (Da):182,257
Checksum:iE03DDA09EEB25873
GO
Isoform 3 (identifier: Q9Y6Y1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-80: EI → RS
     81-1673: Missing.

Note: No experimental confirmation available.

Show »
Length:80
Mass (Da):9,173
Checksum:i4745CB6B383AB10A
GO
Isoform 4 (identifier: Q9Y6Y1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-101: EIAAYLITFEKHEEWLTTSPKTR → ALTTHLFMGAAKKRDPQSWSHEG
     102-1673: Missing.

Note: No experimental confirmation available.

Show »
Length:101
Mass (Da):11,480
Checksum:iDF1CD8DF69AAE9E2
GO

Sequence cautioni

The sequence AAL39006.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA74856.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW71580.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1177 – 11771N → K.1 Publication
Corresponds to variant rs41278952 [ dbSNP | Ensembl ].
VAR_047824
Natural varianti1218 – 12181N → T.1 Publication
Corresponds to variant rs41278954 [ dbSNP | Ensembl ].
VAR_047825
Natural varianti1336 – 13361T → I.1 Publication
Corresponds to variant rs137974312 [ dbSNP | Ensembl ].
VAR_047826

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei79 – 10123EIAAY…SPKTR → ALTTHLFMGAAKKRDPQSWS HEG in isoform 4. 1 PublicationVSP_046358Add
BLAST
Alternative sequencei79 – 802EI → RS in isoform 3. 2 PublicationsVSP_043842
Alternative sequencei81 – 16731593Missing in isoform 3. 2 PublicationsVSP_043843Add
BLAST
Alternative sequencei102 – 16731572Missing in isoform 4. 1 PublicationVSP_046359Add
BLAST
Alternative sequencei1458 – 147114Missing in isoform 2. 2 PublicationsVSP_035936Add
BLAST
Alternative sequencei1653 – 167321SPLVD…KGQGT → RVKELKKAKELEDIQQHPLA M in isoform 2. 2 PublicationsVSP_035937Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020640 mRNA. Translation: BAA74856.3. Different initiation.
AY037153 mRNA. Translation: AAK67633.1.
AL590128
, AL359881, AL365194, AL596210, Z97635, Z98052, Z98884 Genomic DNA. Translation: CAH72347.1.
AL359881
, AL365194, AL590128, AL596210, Z97635, Z98884, Z98052 Genomic DNA. Translation: CAH72663.1.
AL596210
, AL359881, AL365194, AL590128, Z97635, Z98052, Z98884 Genomic DNA. Translation: CAI17064.1.
Z97635
, Z98884, Z98052, AL596210, AL590128, AL365194, AL359881 Genomic DNA. Translation: CAI20961.1.
Z98884
, Z98052, Z97635, AL359881, AL365194, AL596210, AL590128 Genomic DNA. Translation: CAI21433.1.
Z98052
, Z98884, Z97635, AL359881, AL596210, AL590128, AL365194 Genomic DNA. Translation: CAI21596.1.
AL365194
, AL359881, AL590128, AL596210, Z97635, Z98052, Z98884 Genomic DNA. Translation: CAI21790.1.
CH471130 Genomic DNA. Translation: EAW71580.1. Sequence problems.
BC116457 mRNA. Translation: AAI16458.1.
BC151835 mRNA. Translation: AAI51836.1.
CD103791 mRNA. No translation available.
AF111804 mRNA. Translation: AAL39006.1. Different initiation.
AY349360 mRNA. Translation: AAQ56724.1.
CCDSiCCDS30576.1. [Q9Y6Y1-1]
CCDS55574.1. [Q9Y6Y1-3]
CCDS55575.1. [Q9Y6Y1-4]
RefSeqiNP_001182492.1. NM_001195563.1. [Q9Y6Y1-3]
NP_001229630.1. NM_001242701.1. [Q9Y6Y1-4]
NP_056030.1. NM_015215.3. [Q9Y6Y1-1]
UniGeneiHs.397705.
Hs.671020.

Genome annotation databases

EnsembliENST00000303635; ENSP00000306522; ENSG00000171735. [Q9Y6Y1-1]
ENST00000473578; ENSP00000451388; ENSG00000171735. [Q9Y6Y1-3]
ENST00000476864; ENSP00000452319; ENSG00000171735.
ENST00000557126; ENSP00000451510; ENSG00000171735. [Q9Y6Y1-4]
GeneIDi23261.
KEGGihsa:23261.
UCSCiuc001aoh.3. human. [Q9Y6Y1-3]
uc001aoi.3. human. [Q9Y6Y1-1]

Polymorphism databases

DMDMi97046872.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020640 mRNA. Translation: BAA74856.3 . Different initiation.
AY037153 mRNA. Translation: AAK67633.1 .
AL590128
, AL359881 , AL365194 , AL596210 , Z97635 , Z98052 , Z98884 Genomic DNA. Translation: CAH72347.1 .
AL359881
, AL365194 , AL590128 , AL596210 , Z97635 , Z98884 , Z98052 Genomic DNA. Translation: CAH72663.1 .
AL596210
, AL359881 , AL365194 , AL590128 , Z97635 , Z98052 , Z98884 Genomic DNA. Translation: CAI17064.1 .
Z97635
, Z98884 , Z98052 , AL596210 , AL590128 , AL365194 , AL359881 Genomic DNA. Translation: CAI20961.1 .
Z98884
, Z98052 , Z97635 , AL359881 , AL365194 , AL596210 , AL590128 Genomic DNA. Translation: CAI21433.1 .
Z98052
, Z98884 , Z97635 , AL359881 , AL596210 , AL590128 , AL365194 Genomic DNA. Translation: CAI21596.1 .
AL365194
, AL359881 , AL590128 , AL596210 , Z97635 , Z98052 , Z98884 Genomic DNA. Translation: CAI21790.1 .
CH471130 Genomic DNA. Translation: EAW71580.1 . Sequence problems.
BC116457 mRNA. Translation: AAI16458.1 .
BC151835 mRNA. Translation: AAI51836.1 .
CD103791 mRNA. No translation available.
AF111804 mRNA. Translation: AAL39006.1 . Different initiation.
AY349360 mRNA. Translation: AAQ56724.1 .
CCDSi CCDS30576.1. [Q9Y6Y1-1 ]
CCDS55574.1. [Q9Y6Y1-3 ]
CCDS55575.1. [Q9Y6Y1-4 ]
RefSeqi NP_001182492.1. NM_001195563.1. [Q9Y6Y1-3 ]
NP_001229630.1. NM_001242701.1. [Q9Y6Y1-4 ]
NP_056030.1. NM_015215.3. [Q9Y6Y1-1 ]
UniGenei Hs.397705.
Hs.671020.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CXK X-ray 1.85 A/B/C/D/E 872-953 [» ]
ProteinModelPortali Q9Y6Y1.
SMRi Q9Y6Y1. Positions 872-954, 1065-1163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116863. 2 interactions.
IntActi Q9Y6Y1. 1 interaction.
STRINGi 9606.ENSP00000306522.

PTM databases

PhosphoSitei Q9Y6Y1.

Polymorphism databases

DMDMi 97046872.

Proteomic databases

PaxDbi Q9Y6Y1.
PRIDEi Q9Y6Y1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303635 ; ENSP00000306522 ; ENSG00000171735 . [Q9Y6Y1-1 ]
ENST00000473578 ; ENSP00000451388 ; ENSG00000171735 . [Q9Y6Y1-3 ]
ENST00000476864 ; ENSP00000452319 ; ENSG00000171735 .
ENST00000557126 ; ENSP00000451510 ; ENSG00000171735 . [Q9Y6Y1-4 ]
GeneIDi 23261.
KEGGi hsa:23261.
UCSCi uc001aoh.3. human. [Q9Y6Y1-3 ]
uc001aoi.3. human. [Q9Y6Y1-1 ]

Organism-specific databases

CTDi 23261.
GeneCardsi GC01P006845.
HGNCi HGNC:18806. CAMTA1.
HPAi HPA036343.
MIMi 611501. gene.
614756. phenotype.
neXtProti NX_Q9Y6Y1.
Orphaneti 314647. Non-progressive cerebellar ataxia with intellectual disability.
PharmGKBi PA38688.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG294285.
GeneTreei ENSGT00390000001446.
HOGENOMi HOG000111813.
HOVERGENi HBG080107.
InParanoidi Q9Y6Y1.
OMAi AYMHVAE.
OrthoDBi EOG74R1PX.
PhylomeDBi Q9Y6Y1.
TreeFami TF323452.

Miscellaneous databases

ChiTaRSi CAMTA1. human.
EvolutionaryTracei Q9Y6Y1.
GeneWikii CAMTA1.
GenomeRNAii 23261.
NextBioi 44996.
PROi Q9Y6Y1.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y6Y1.
CleanExi HS_CAMTA1.
ExpressionAtlasi Q9Y6Y1. baseline and differential.
Genevestigatori Q9Y6Y1.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF03859. CG-1. 1 hit.
PF00612. IQ. 2 hits.
PF01833. TIG. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
SM01076. CG-1. 1 hit.
SM00015. IQ. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Li N., Zhang M., Wan T., Zhang W., Cao X.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
    Tissue: Skin.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1422-1673 (ISOFORM 2).
    Tissue: Heart.
  8. Li H., Li S., Yu R., Shen C., Zhou G., Ke R., Lin L., Yang S.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1437-1673 (ISOFORM 2).
  9. "A novel family of calmodulin-binding transcription activators in multicellular organisms."
    Bouche N., Scharlat A., Snedden W., Bouchez D., Fromm H.
    J. Biol. Chem. 277:21851-21861(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  10. "Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells."
    Nakatani K., Nishioka J., Itakura T., Nakanishi Y., Horinouchi J., Abe Y., Wada H., Nobori T.
    Int. J. Oncol. 24:1407-1412(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  11. "Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene."
    Barbashina V., Salazar P., Holland E.C., Rosenblum M.K., Ladanyi M.
    Clin. Cancer Res. 11:1119-1128(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  12. Cited for: INVOLVEMENT IN CANPMR.
  13. "Crystal structure of the TIG domain of human calmodulin-binding transcription activator 1 (CAMTA1)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (DEC-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 872-953.
  14. "Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma."
    Henrich K.-O., Claas A., Praml C., Benner A., Mollenhauer J., Poustka A., Schwab M., Westermann F.
    Eur. J. Cancer 43:607-616(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LYS-1177; THR-1218 AND ILE-1336.

Entry informationi

Entry nameiCMTA1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6Y1
Secondary accession number(s): A7MBM4
, G3V3Z7, Q5VUE1, Q6V701, Q8WYI3, Q96S92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: November 26, 2014
This is version 119 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

A very small segment of 1p36 located within CAMTA1 is deleted in all oligodendroglial tumors with 1p LOH. This minimal deleted region (MDR) also overlaps the neuroblastoma 1p36 MDR. CAMTA1 shows no evidence of inactivation by somatic mutations.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3