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Q9Y6Y1

- CMTA1_HUMAN

UniProt

Q9Y6Y1 - CMTA1_HUMAN

Protein

Calmodulin-binding transcription activator 1

Gene

CAMTA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 4 (16 May 2006)
      Previous versions | rss
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    Functioni

    Transcriptional activator. May act as a tumor suppressor.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi63 – 188126CG-1PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calmodulin-binding transcription activator 1
    Gene namesi
    Name:CAMTA1
    Synonyms:KIAA0833
    ORF Names:MSTP023
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18806. CAMTA1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Cerebellar ataxia, non-progressive, with mental retardation (CANPMR) [MIM:614756]: A neurodevelopmental disorder characterized by mildly delayed psychomotor development, early onset of cerebellar ataxia, and intellectual disability later in childhood and adult life. Other features may include neonatal hypotonia, dysarthria, and dysmetria. Brain imaging in some patients shows cerebellar atrophy. Dysmorphic facial features are variable.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Mental retardation

    Organism-specific databases

    MIMi614756. phenotype.
    Orphaneti314647. Non-progressive cerebellar ataxia with intellectual disability.
    PharmGKBiPA38688.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16731673Calmodulin-binding transcription activator 1PRO_0000235820Add
    BLAST

    Proteomic databases

    PaxDbiQ9Y6Y1.
    PRIDEiQ9Y6Y1.

    PTM databases

    PhosphoSiteiQ9Y6Y1.

    Expressioni

    Tissue specificityi

    Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by half in oligodendroglioma and astrocytoma cases with 1p loss of heterozygosity. Detected in neuroblastic-type cultured neuroblastoma cells. Expressed in heart and kidney.3 Publications

    Inductioni

    Detected at low levels at interphase and in resting cells. Up-regulated during S phase and mitosis. Levels decrease at the end of mitosis.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y6Y1.
    BgeeiQ9Y6Y1.
    CleanExiHS_CAMTA1.
    GenevestigatoriQ9Y6Y1.

    Organism-specific databases

    HPAiHPA036343.

    Interactioni

    Subunit structurei

    May interact with calmodulin.Curated

    Protein-protein interaction databases

    BioGridi116863. 2 interactions.
    IntActiQ9Y6Y1. 1 interaction.
    STRINGi9606.ENSP00000306522.

    Structurei

    Secondary structure

    1
    1673
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi875 – 8773
    Beta strandi879 – 8813
    Beta strandi888 – 8947
    Beta strandi902 – 9065
    Beta strandi909 – 9124
    Beta strandi914 – 9174
    Beta strandi920 – 9245
    Beta strandi930 – 93910
    Beta strandi948 – 9525

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CXKX-ray1.85A/B/C/D/E872-953[»]
    ProteinModelPortaliQ9Y6Y1.
    SMRiQ9Y6Y1. Positions 872-954, 1065-1163.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y6Y1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini873 – 95381IPT/TIGAdd
    BLAST
    Repeati1064 – 109330ANK 1Add
    BLAST
    Repeati1109 – 112921ANK 2Add
    BLAST
    Repeati1143 – 117230ANK 3Add
    BLAST
    Domaini1547 – 157630IQ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1577 – 159923IQ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1600 – 162223IQ 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi112 – 1198Nuclear localization signalPROSITE-ProRule annotation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi499 – 5024Poly-Gly
    Compositional biasi1038 – 10414Poly-Val

    Sequence similaritiesi

    Belongs to the CAMTA family.Curated
    Contains 3 ANK repeats.PROSITE-ProRule annotation
    Contains 1 CG-1 DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 IPT/TIG domain.Curated
    Contains 3 IQ domains.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG294285.
    HOGENOMiHOG000111813.
    HOVERGENiHBG080107.
    InParanoidiQ9Y6Y1.
    OMAiAYMHVAE.
    OrthoDBiEOG74R1PX.
    PhylomeDBiQ9Y6Y1.
    TreeFamiTF323452.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    2.60.40.10. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005559. CG-1_dom.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF03859. CG-1. 1 hit.
    PF00612. IQ. 2 hits.
    PF01833. TIG. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 2 hits.
    SM01076. CG-1. 1 hit.
    SM00015. IQ. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS51437. CG_1. 1 hit.
    PS50096. IQ. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y6Y1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWRAEGKWLP KTSRKSVSQS VFCGTSTYCV LNTVPPIEDD HGNSNSSHVK     50
    IFLPKKLLEC LPKCSSLPKE RHRWNTNEEI AAYLITFEKH EEWLTTSPKT 100
    RPQNGSMILY NRKKVKYRKD GYCWKKRKDG KTTREDHMKL KVQGVECLYG 150
    CYVHSSIIPT FHRRCYWLLQ NPDIVLVHYL NVPAIEDCGK PCGPILCSIN 200
    TDKKEWAKWT KEELIGQLKP MFHGIKWTCS NGNSSSGFSV EQLVQQILDS 250
    HQTKPQPRTH NCLCTGSLGA GGSVHHKCNS AKHRIISPKV EPRTGGYGSH 300
    SEVQHNDVSE GKHEHSHSKG SSREKRNGKV AKPVLLHQSS TEVSSTNQVE 350
    VPDTTQSSPV SISSGLNSDP DMVDSPVVTG VSGMAVASVM GSLSQSATVF 400
    MSEVTNEAVY TMSPTAGPNH HLLSPDASQG LVLAVSSDGH KFAFPTTGSS 450
    ESLSMLPTNV SEELVLSTTL DGGRKIPETT MNFDPDCFLN NPKQGQTYGG 500
    GGLKAEMVSS NIRHSPPGER SFSFTTVLTK EIKTEDTSFE QQMAKEAYSS 550
    SAAAVAASSL TLTAGSSLLP SGGGLSPSTT LEQMDFSAID SNKDYTSSFS 600
    QTGHSPHIHQ TPSPSFFLQD ASKPLPVEQN THSSLSDSGG TFVMPTVKTE 650
    ASSQTSSCSG HVETRIESTS SLHLMQFQAN FQAMTAEGEV TMETSQAAEG 700
    SEVLLKSGEL QACSSEHYLQ PETNGVIRSA GGVPILPGNV VQGLYPVAQP 750
    SLGNASNMEL SLDHFDISFS NQFSDLINDF ISVEGGSSTI YGHQLVSGDS 800
    TALSQSEDGA RAPFTQAEMC LPCCSPQQGS LQLSSSEGGA STMAYMHVAE 850
    VVSAASAQGT LGMLQQSGRV FMVTDYSPEW SYPEGGVKVL ITGPWQEASN 900
    NYSCLFDQIS VPASLIQPGV LRCYCPAHDT GLVTLQVAFN NQIISNSVVF 950
    EYKARALPTL PSSQHDWLSL DDNQFRMSIL ERLEQMERRM AEMTGSQQHK 1000
    QASGGGSSGG GSGSGNGGSQ AQCASGTGAL GSCFESRVVV VCEKMMSRAC 1050
    WAKSKHLIHS KTFRGMTLLH LAAAQGYATL IQTLIKWRTK HADSIDLELE 1100
    VDPLNVDHFS CTPLMWACAL GHLEAAVVLY KWDRRAISIP DSLGRLPLGI 1150
    ARSRGHVKLA ECLEHLQRDE QAQLGQNPRI HCPASEEPST ESWMAQWHSE 1200
    AISSPEIPKG VTVIASTNPE LRRPRSEPSN YYSSESHKDY PAPKKHKLNP 1250
    EYFQTRQEKL LPTALSLEEP NIRKQSPSSK QSVPETLSPS EGVRDFSREL 1300
    SPPTPETAAF QASGSQPVGK WNSKDLYIGV STVQVTGNPK GTSVGKEAAP 1350
    SQVRPREPMS VLMMANREVV NTELGSYRDS AENEECGQPM DDIQVNMMTL 1400
    AEHIIEATPD RIKQENFVPM ESSGLERTDP ATISSTMSWL ASYLADADCL 1450
    PSAAQIRSAY NEPLTPSSNT SLSPVGSPVS EIAFEKPNLP SAADWSEFLS 1500
    ASTSEKVENE FAQLTLSDHE QRELYEAARL VQTAFRKYKG RPLREQQEVA 1550
    AAVIQRCYRK YKQYALYKKM TQAAILIQSK FRSYYEQKKF QQSRRAAVLI 1600
    QKYYRSYKKC GKRRQARRTA VIVQQKLRSS LLTKKQDQAA RKIMRFLRRC 1650
    RHSPLVDHRL YKRSERIEKG QGT 1673
    Length:1,673
    Mass (Da):183,672
    Last modified:May 16, 2006 - v4
    Checksum:i008AA6A906374C00
    GO
    Isoform 2 (identifier: Q9Y6Y1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1458-1471: Missing.
         1653-1673: SPLVDHRLYKRSERIEKGQGT → RVKELKKAKELEDIQQHPLAM

    Show »
    Length:1,659
    Mass (Da):182,257
    Checksum:iE03DDA09EEB25873
    GO
    Isoform 3 (identifier: Q9Y6Y1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         79-80: EI → RS
         81-1673: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:80
    Mass (Da):9,173
    Checksum:i4745CB6B383AB10A
    GO
    Isoform 4 (identifier: Q9Y6Y1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         79-101: EIAAYLITFEKHEEWLTTSPKTR → ALTTHLFMGAAKKRDPQSWSHEG
         102-1673: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:101
    Mass (Da):11,480
    Checksum:iDF1CD8DF69AAE9E2
    GO

    Sequence cautioni

    The sequence AAL39006.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAA74856.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence EAW71580.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1177 – 11771N → K.1 Publication
    Corresponds to variant rs41278952 [ dbSNP | Ensembl ].
    VAR_047824
    Natural varianti1218 – 12181N → T.1 Publication
    Corresponds to variant rs41278954 [ dbSNP | Ensembl ].
    VAR_047825
    Natural varianti1336 – 13361T → I.1 Publication
    Corresponds to variant rs137974312 [ dbSNP | Ensembl ].
    VAR_047826

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei79 – 10123EIAAY…SPKTR → ALTTHLFMGAAKKRDPQSWS HEG in isoform 4. 1 PublicationVSP_046358Add
    BLAST
    Alternative sequencei79 – 802EI → RS in isoform 3. 2 PublicationsVSP_043842
    Alternative sequencei81 – 16731593Missing in isoform 3. 2 PublicationsVSP_043843Add
    BLAST
    Alternative sequencei102 – 16731572Missing in isoform 4. 1 PublicationVSP_046359Add
    BLAST
    Alternative sequencei1458 – 147114Missing in isoform 2. 2 PublicationsVSP_035936Add
    BLAST
    Alternative sequencei1653 – 167321SPLVD…KGQGT → RVKELKKAKELEDIQQHPLA M in isoform 2. 2 PublicationsVSP_035937Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020640 mRNA. Translation: BAA74856.3. Different initiation.
    AY037153 mRNA. Translation: AAK67633.1.
    AL590128
    , AL359881, AL365194, AL596210, Z97635, Z98052, Z98884 Genomic DNA. Translation: CAH72347.1.
    AL359881
    , AL365194, AL590128, AL596210, Z97635, Z98884, Z98052 Genomic DNA. Translation: CAH72663.1.
    AL596210
    , AL359881, AL365194, AL590128, Z97635, Z98052, Z98884 Genomic DNA. Translation: CAI17064.1.
    Z97635
    , Z98884, Z98052, AL596210, AL590128, AL365194, AL359881 Genomic DNA. Translation: CAI20961.1.
    Z98884
    , Z98052, Z97635, AL359881, AL365194, AL596210, AL590128 Genomic DNA. Translation: CAI21433.1.
    Z98052
    , Z98884, Z97635, AL359881, AL596210, AL590128, AL365194 Genomic DNA. Translation: CAI21596.1.
    AL365194
    , AL359881, AL590128, AL596210, Z97635, Z98052, Z98884 Genomic DNA. Translation: CAI21790.1.
    CH471130 Genomic DNA. Translation: EAW71580.1. Sequence problems.
    BC116457 mRNA. Translation: AAI16458.1.
    BC151835 mRNA. Translation: AAI51836.1.
    CD103791 mRNA. No translation available.
    AF111804 mRNA. Translation: AAL39006.1. Different initiation.
    AY349360 mRNA. Translation: AAQ56724.1.
    CCDSiCCDS30576.1. [Q9Y6Y1-1]
    CCDS55574.1. [Q9Y6Y1-3]
    CCDS55575.1. [Q9Y6Y1-4]
    RefSeqiNP_001182492.1. NM_001195563.1. [Q9Y6Y1-3]
    NP_001229630.1. NM_001242701.1. [Q9Y6Y1-4]
    NP_056030.1. NM_015215.3. [Q9Y6Y1-1]
    UniGeneiHs.397705.
    Hs.671020.

    Genome annotation databases

    EnsembliENST00000303635; ENSP00000306522; ENSG00000171735. [Q9Y6Y1-1]
    ENST00000473578; ENSP00000451388; ENSG00000171735. [Q9Y6Y1-3]
    ENST00000476864; ENSP00000452319; ENSG00000171735.
    ENST00000557126; ENSP00000451510; ENSG00000171735. [Q9Y6Y1-4]
    GeneIDi23261.
    KEGGihsa:23261.
    UCSCiuc001aoh.3. human. [Q9Y6Y1-3]
    uc001aoi.3. human. [Q9Y6Y1-1]

    Polymorphism databases

    DMDMi97046872.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020640 mRNA. Translation: BAA74856.3 . Different initiation.
    AY037153 mRNA. Translation: AAK67633.1 .
    AL590128
    , AL359881 , AL365194 , AL596210 , Z97635 , Z98052 , Z98884 Genomic DNA. Translation: CAH72347.1 .
    AL359881
    , AL365194 , AL590128 , AL596210 , Z97635 , Z98884 , Z98052 Genomic DNA. Translation: CAH72663.1 .
    AL596210
    , AL359881 , AL365194 , AL590128 , Z97635 , Z98052 , Z98884 Genomic DNA. Translation: CAI17064.1 .
    Z97635
    , Z98884 , Z98052 , AL596210 , AL590128 , AL365194 , AL359881 Genomic DNA. Translation: CAI20961.1 .
    Z98884
    , Z98052 , Z97635 , AL359881 , AL365194 , AL596210 , AL590128 Genomic DNA. Translation: CAI21433.1 .
    Z98052
    , Z98884 , Z97635 , AL359881 , AL596210 , AL590128 , AL365194 Genomic DNA. Translation: CAI21596.1 .
    AL365194
    , AL359881 , AL590128 , AL596210 , Z97635 , Z98052 , Z98884 Genomic DNA. Translation: CAI21790.1 .
    CH471130 Genomic DNA. Translation: EAW71580.1 . Sequence problems.
    BC116457 mRNA. Translation: AAI16458.1 .
    BC151835 mRNA. Translation: AAI51836.1 .
    CD103791 mRNA. No translation available.
    AF111804 mRNA. Translation: AAL39006.1 . Different initiation.
    AY349360 mRNA. Translation: AAQ56724.1 .
    CCDSi CCDS30576.1. [Q9Y6Y1-1 ]
    CCDS55574.1. [Q9Y6Y1-3 ]
    CCDS55575.1. [Q9Y6Y1-4 ]
    RefSeqi NP_001182492.1. NM_001195563.1. [Q9Y6Y1-3 ]
    NP_001229630.1. NM_001242701.1. [Q9Y6Y1-4 ]
    NP_056030.1. NM_015215.3. [Q9Y6Y1-1 ]
    UniGenei Hs.397705.
    Hs.671020.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CXK X-ray 1.85 A/B/C/D/E 872-953 [» ]
    ProteinModelPortali Q9Y6Y1.
    SMRi Q9Y6Y1. Positions 872-954, 1065-1163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116863. 2 interactions.
    IntActi Q9Y6Y1. 1 interaction.
    STRINGi 9606.ENSP00000306522.

    PTM databases

    PhosphoSitei Q9Y6Y1.

    Polymorphism databases

    DMDMi 97046872.

    Proteomic databases

    PaxDbi Q9Y6Y1.
    PRIDEi Q9Y6Y1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303635 ; ENSP00000306522 ; ENSG00000171735 . [Q9Y6Y1-1 ]
    ENST00000473578 ; ENSP00000451388 ; ENSG00000171735 . [Q9Y6Y1-3 ]
    ENST00000476864 ; ENSP00000452319 ; ENSG00000171735 .
    ENST00000557126 ; ENSP00000451510 ; ENSG00000171735 . [Q9Y6Y1-4 ]
    GeneIDi 23261.
    KEGGi hsa:23261.
    UCSCi uc001aoh.3. human. [Q9Y6Y1-3 ]
    uc001aoi.3. human. [Q9Y6Y1-1 ]

    Organism-specific databases

    CTDi 23261.
    GeneCardsi GC01P006845.
    HGNCi HGNC:18806. CAMTA1.
    HPAi HPA036343.
    MIMi 611501. gene.
    614756. phenotype.
    neXtProti NX_Q9Y6Y1.
    Orphaneti 314647. Non-progressive cerebellar ataxia with intellectual disability.
    PharmGKBi PA38688.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG294285.
    HOGENOMi HOG000111813.
    HOVERGENi HBG080107.
    InParanoidi Q9Y6Y1.
    OMAi AYMHVAE.
    OrthoDBi EOG74R1PX.
    PhylomeDBi Q9Y6Y1.
    TreeFami TF323452.

    Miscellaneous databases

    ChiTaRSi CAMTA1. human.
    EvolutionaryTracei Q9Y6Y1.
    GeneWikii CAMTA1.
    GenomeRNAii 23261.
    NextBioi 44996.
    PROi Q9Y6Y1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y6Y1.
    Bgeei Q9Y6Y1.
    CleanExi HS_CAMTA1.
    Genevestigatori Q9Y6Y1.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    2.60.40.10. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005559. CG-1_dom.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF03859. CG-1. 1 hit.
    PF00612. IQ. 2 hits.
    PF01833. TIG. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 2 hits.
    SM01076. CG-1. 1 hit.
    SM00015. IQ. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS51437. CG_1. 1 hit.
    PS50096. IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. Li N., Zhang M., Wan T., Zhang W., Cao X.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
      Tissue: Skin.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1422-1673 (ISOFORM 2).
      Tissue: Heart.
    8. Li H., Li S., Yu R., Shen C., Zhou G., Ke R., Lin L., Yang S.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1437-1673 (ISOFORM 2).
    9. "A novel family of calmodulin-binding transcription activators in multicellular organisms."
      Bouche N., Scharlat A., Snedden W., Bouchez D., Fromm H.
      J. Biol. Chem. 277:21851-21861(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    10. "Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells."
      Nakatani K., Nishioka J., Itakura T., Nakanishi Y., Horinouchi J., Abe Y., Wada H., Nobori T.
      Int. J. Oncol. 24:1407-1412(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    11. "Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene."
      Barbashina V., Salazar P., Holland E.C., Rosenblum M.K., Ladanyi M.
      Clin. Cancer Res. 11:1119-1128(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    12. Cited for: INVOLVEMENT IN CANPMR.
    13. "Crystal structure of the TIG domain of human calmodulin-binding transcription activator 1 (CAMTA1)."
      RIKEN structural genomics initiative (RSGI)
      Submitted (DEC-2005) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 872-953.
    14. "Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma."
      Henrich K.-O., Claas A., Praml C., Benner A., Mollenhauer J., Poustka A., Schwab M., Westermann F.
      Eur. J. Cancer 43:607-616(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LYS-1177; THR-1218 AND ILE-1336.

    Entry informationi

    Entry nameiCMTA1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6Y1
    Secondary accession number(s): A7MBM4
    , G3V3Z7, Q5VUE1, Q6V701, Q8WYI3, Q96S92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 117 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    A very small segment of 1p36 located within CAMTA1 is deleted in all oligodendroglial tumors with 1p LOH. This minimal deleted region (MDR) also overlaps the neuroblastoma 1p36 MDR. CAMTA1 shows no evidence of inactivation by somatic mutations.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3