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Protein

Influenza virus NS1A-binding protein

Gene

IVNS1ABP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.By similarity1 Publication

GO - Biological processi

  • negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  • response to virus Source: ProtInc
  • RNA splicing Source: ProtInc
  • transcription from RNA polymerase III promoter Source: ProtInc
  • viral process Source: UniProtKB-KW

Keywordsi

Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Influenza virus NS1A-binding protein
Short name:
NS1-BP
Short name:
NS1-binding protein
Alternative name(s):
Aryl hydrocarbon receptor-associated protein 3
Gene namesi
Name:IVNS1ABP
Synonyms:ARA3, FLARA3, KIAA0850, NS1, NS1BP
ORF Names:HSPC068
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116679.15.
HGNCiHGNC:16951. IVNS1ABP.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi198V → M: Significant inhibition of interaction with AHR; partial decrease of AHR signaling induced by IVNS1ABP. 1 Publication1
Mutagenesisi288E → K: Significant inhibition of interaction with AHR; partial decrease of AHR signaling induced by IVNS1ABP. 1 Publication1

Organism-specific databases

DisGeNETi10625.
OpenTargetsiENSG00000116679.
PharmGKBiPA134875300.

Polymorphism and mutation databases

BioMutaiIVNS1ABP.
DMDMi146325015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002850771 – 642Influenza virus NS1A-binding proteinAdd BLAST642

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei246PhosphoserineCombined sources1
Modified residuei277PhosphoserineCombined sources1
Modified residuei322PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y6Y0.
MaxQBiQ9Y6Y0.
PaxDbiQ9Y6Y0.
PeptideAtlasiQ9Y6Y0.
PRIDEiQ9Y6Y0.

PTM databases

iPTMnetiQ9Y6Y0.
PhosphoSitePlusiQ9Y6Y0.

Expressioni

Gene expression databases

BgeeiENSG00000116679.
CleanExiHS_IVNS1ABP.
ExpressionAtlasiQ9Y6Y0. baseline and differential.
GenevisibleiQ9Y6Y0. HS.

Organism-specific databases

HPAiHPA003405.

Interactioni

Subunit structurei

Homodimer; through the BTB domain (By similarity). Interacts with NS/Influenza virus NS1A protein and with AHR/Aryl hydrocarbon receptor.By similarity2 Publications

Protein-protein interaction databases

BioGridi115869. 73 interactors.
IntActiQ9Y6Y0. 36 interactors.
MINTiMINT-1371090.
STRINGi9606.ENSP00000356468.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6Y0.
SMRiQ9Y6Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 99BTBPROSITE-ProRule annotationAdd BLAST68
Domaini134 – 233BACKAdd BLAST100
Repeati369 – 415Kelch 1Add BLAST47
Repeati416 – 463Kelch 2Add BLAST48
Repeati465 – 512Kelch 3Add BLAST48
Repeati513 – 559Kelch 4Add BLAST47
Repeati560 – 606Kelch 5Add BLAST47
Repeati608 – 642Kelch 6Add BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 368Sufficient for AHR interaction and signalingAdd BLAST205

Domaini

When the BTB domain is lacking, AHR signaling induction promoted by IVNS1ABP is massively increased; Thus, the BTB domain inhibits AHR signaling induced by IVNS1ABP.1 Publication

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000119153.
HOVERGENiHBG082407.
InParanoidiQ9Y6Y0.
KOiK15046.
OMAiPNIDDWI.
OrthoDBiEOG091G024F.
PhylomeDBiQ9Y6Y0.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
2.130.10.80. 1 hit.
InterProiView protein in InterPro
IPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR029849. NS1BP.
IPR011333. SKP1/BTB/POZ.
PANTHERiPTHR24411:SF46. PTHR24411:SF46. 1 hit.
PfamiView protein in Pfam
PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiView protein in SMART
SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y6Y0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPNGYLMFE DENFIESSVA KLNALRKSGQ FCDVRLQVCG HEMLAHRAVL
60 70 80 90 100
ACCSPYLFEI FNSDSDPHGI SHVKFDDLNP EAVEVLLNYA YTAQLKADKE
110 120 130 140 150
LVKDVYSAAK KLKMDRVKQV CGDYLLSRMD VTSCISYRNF ASCMGDSRLL
160 170 180 190 200
NKVDAYIQEH LLQISEEEEF LKLPRLKLEV MLEDNVCLPS NGKLYTKVIN
210 220 230 240 250
WVQRSIWENG DSLEELMEEV QTLYYSADHK LLDGNLLDGQ AEVFGSDDDH
260 270 280 290 300
IQFVQKKPPR ENGHKQISSS STGCLSSPNA TVQSPKHEWK IVASEKTSNN
310 320 330 340 350
TYLCLAVLDG IFCVIFLHGR NSPQSSPTST PKLSKSLSFE MQQDELIEKP
360 370 380 390 400
MSPMQYARSG LGTAEMNGKL IAAGGYNREE CLRTVECYNP HTDHWSFLAP
410 420 430 440 450
MRTPRARFQM AVLMGQLYVV GGSNGHSDDL SCGEMYDSNI DDWIPVPELR
460 470 480 490 500
TNRCNAGVCA LNGKLYIVGG SDPYGQKGLK NCDVFDPVTK LWTSCAPLNI
510 520 530 540 550
RRHQSAVCEL GGYLYIIGGA ESWNCLNTVE RYNPENNTWT LIAPMNVARR
560 570 580 590 600
GAGVAVLNGK LFVCGGFDGS HAISCVEMYD PTRNEWKMMG NMTSPRSNAG
610 620 630 640
IATVGNTIYA VGGFDGNEFL NTVEVYNLES NEWSPYTKIF QF
Length:642
Mass (Da):71,729
Last modified:May 1, 2007 - v3
Checksum:i456E30DC4E351CCD
GO

Sequence cautioni

The sequence AAF29040 differs from that shown. Reason: Frameshift at positions 100 and 102.Curated
The sequence BAA74873 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA10029 differs from that shown. Reason: Frameshift at position 612.Curated
The sequence CAI17867 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111K → E in CAA10029 (PubMed:9696811).Curated1
Sequence conflicti148R → H in CAA10029 (PubMed:9696811).Curated1
Sequence conflicti218E → G in AAH67739 (PubMed:15489334).Curated1
Sequence conflicti579Y → H in ABE03889 (PubMed:16582008).Curated1
Sequence conflicti579Y → H in ABE03890 (PubMed:16582008).Curated1
Sequence conflicti591N → H in CAA10029 (PubMed:9696811).Curated1
Sequence conflicti623V → A in CAA10029 (PubMed:9696811).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012449 mRNA. Translation: CAA10029.1. Frameshift.
DQ443528 mRNA. Translation: ABE03889.1.
DQ443529 mRNA. Translation: ABE03890.1.
AF205218 mRNA. Translation: AAG43485.1.
AB020657 mRNA. Translation: BAA74873.2. Different initiation.
AF161553 mRNA. Translation: AAF29040.1. Frameshift.
AL078644, AL356273 Genomic DNA. Translation: CAB72329.1.
AK292431 mRNA. Translation: BAF85120.1.
AL078644 Genomic DNA. Translation: CAI17867.1. Sequence problems.
AL356273, AL078644 Genomic DNA. Translation: CAI22094.1.
CH471067 Genomic DNA. Translation: EAW91194.1.
BC067739 mRNA. Translation: AAH67739.1.
CCDSiCCDS1368.1.
RefSeqiNP_006460.2. NM_006469.4.
UniGeneiHs.497183.
Hs.662668.

Genome annotation databases

EnsembliENST00000367498; ENSP00000356468; ENSG00000116679.
GeneIDi10625.
KEGGihsa:10625.
UCSCiuc001grl.4. human.

Similar proteinsi

Entry informationi

Entry nameiNS1BP_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6Y0
Secondary accession number(s): A8K8R6
, Q1G4T6, Q1G4T7, Q5TF75, Q6NW38, Q7LCG2, Q9NZX0, Q9Y480
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: September 27, 2017
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot